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Volumn 105, Issue 1, 2011, Pages 74-82

D-Glucuronyl C5-epimerase suppresses small-cell lung cancer cell proliferation in vitro and tumour growth in vivo

Author keywords

angiogenesis; D Glucuronyl C5 epimerase; heparan sulphate proteoglycan; metastasis; small cell lung cancer; tumour suppressor gene

Indexed keywords

ANTINEOPLASTIC AGENT; DEXTRO GLUCURONYL C5 EPIMERASE; FIBROBLAST GROWTH FACTOR RECEPTOR 2; GELATINASE A; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN A;

EID: 79959727731     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2011.170     Document Type: Article
Times cited : (22)

References (50)
  • 1
  • 3
    • 77953223359 scopus 로고    scopus 로고
    • Angiogenesis inhibition in cancer therapy: Platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors: Biological functions and role in malignancy
    • Appelmann I, Liersch R, Kessler T, Mesters RM, Berdel WE (2010) Angiogenesis inhibition in cancer therapy: platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors: biological functions and role in malignancy. Recent Results Cancer Res 180: 51-81
    • (2010) Recent Results Cancer Res , vol.180 , pp. 51-81
    • Appelmann, I.1    Liersch, R.2    Kessler, T.3    Mesters, R.M.4    Berdel, W.E.5
  • 4
    • 77951667987 scopus 로고    scopus 로고
    • Mechanisms of resistance to antiangiogenesis therapy
    • Azam F, Mehta S, Harris AL (2010) Mechanisms of resistance to antiangiogenesis therapy. Eur J Cancer 46(8): 1323-1332
    • (2010) Eur J Cancer , vol.46 , Issue.8 , pp. 1323-1332
    • Azam, F.1    Mehta, S.2    Harris, A.L.3
  • 6
    • 43249096491 scopus 로고    scopus 로고
    • Increased vascular-endothelial growth factor (VEGF) tumor expression and response to epidermal growth factor receptor (EGF-R) inhibitor erlotinib in non-small cell lung cancer (NSCLC)
    • DOI 10.1097/JTO.0b013e3181654423, PII 0124389420080300000018
    • Brueckl WM, Schoeberl A, Wirtz RM, Murray S, Hahn EG, Wiest GH (2008) Increased vascular-endothelial growth factor (VEGF) tumor expression and response to epidermal growth factor receptor (EGF-R) inhibitor erlotinib in non-small cell lung cancer (NSCLC). J Thorac Oncol 3: 314-316 (Pubitemid 351654333)
    • (2008) Journal of Thoracic Oncology , vol.3 , Issue.3 , pp. 314-316
    • Brueckl, W.M.1    Schoeberl, A.2    Wirtz, R.M.3    Murray, S.4    Hahn, E.G.5    Wiest, G.H.6
  • 7
    • 41949105981 scopus 로고    scopus 로고
    • Interactions of hepatocyte growth factor/scatter factor with various glycosaminoglycans reveal an important interplay between the presence of iduronate and sulfate density
    • Catlow KR, Deakin JA, Wei Z, Delehedde M, Fernig DG, Gherardi E, Gallagher JT, Pavão MS, Lyon M (2008) Interactions of hepatocyte growth factor/scatter factor with various glycosaminoglycans reveal an important interplay between the presence of iduronate and sulfate density. J Biol Chem 283: 5235-5248
    • (2008) J Biol Chem , vol.283 , pp. 5235-5248
    • Catlow, K.R.1    Deakin, J.A.2    Wei, Z.3    Delehedde, M.4    Fernig, D.G.5    Gherardi, E.6    Gallagher, J.T.7    Pavão, M.S.8    Lyon, M.9
  • 8
    • 0035877596 scopus 로고    scopus 로고
    • Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase
    • Crawford BE, Olson SK, Esko JD, Pinhal MA (2001) Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase. J Biol Chem 276: 21538-21543
    • (2001) J Biol Chem , vol.276 , pp. 21538-21543
    • Crawford, B.E.1    Olson, S.K.2    Esko, J.D.3    Ma, P.4
  • 12
    • 33947632458 scopus 로고    scopus 로고
    • Fast, hungry and unstable: finding the Achilles' heel of small-cell lung cancer
    • DOI 10.1016/j.molmed.2007.02.003, PII S1471491407000238
    • Hann CL, Rudin CM (2007) Fast, hungry and unstable: finding the Achilles' heel of small-cell lung cancer. Trends Mol Med 13: 150-157 (Pubitemid 46498831)
    • (2007) Trends in Molecular Medicine , vol.13 , Issue.4 , pp. 150-157
    • Hann, C.L.1    Rudin, C.M.2
  • 13
    • 1642375334 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1: Novel tumor-derived factors with a high prognostic and predictive impact in breast cancer
    • Harbeck N, Kates RE, Gauger K, Willems A, Kiechle M, Magdolen V, Schmitt M (2004) Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-I: novel tumor-derived factors with a high prognostic and predictive impact in breast cancer. Thromb Haemost 91: 450-456 (Pubitemid 38396866)
    • (2004) Thrombosis and Haemostasis , vol.91 , Issue.3 , pp. 450-456
    • Harbeck, N.1    Kates, R.E.2    Gauger, K.3    Willems, A.4    Kiechle, M.5    Magdolen, V.6    Schmitt, M.7
  • 14
    • 21244446530 scopus 로고    scopus 로고
    • The metastasis associated protein S100A4: Role in tumour progression and metastasis
    • DOI 10.1038/sj.bjc.6602613
    • Helfman DM, Kim EJ, Lukanidin E, Grigorian M (2005) The metastasis associated protein S100A4: role in tumour progression and metastasis. Br J Cancer 92: 1955-1958 (Pubitemid 40897415)
    • (2005) British Journal of Cancer , vol.92 , Issue.11 , pp. 1955-1958
    • Helfman, D.M.1    Kim, E.J.2    Lukanidin, E.3    Grigorian, M.4
  • 15
    • 23144436642 scopus 로고    scopus 로고
    • Basement membrane proteoglycans: From cellar to ceiling
    • DOI 10.1038/nrm1702
    • Iozzo RV (2005) Basement membrane proteoglycans: from cellar to ceiling. Nat Rev Mol Cell Biol 6: 646-656 (Pubitemid 41081268)
    • (2005) Nature Reviews Molecular Cell Biology , vol.6 , Issue.8 , pp. 646-656
    • Iozzo, R.V.1
  • 16
    • 66749098832 scopus 로고    scopus 로고
    • Basement membrane proteoglycans: Modulators Par Excellence of cancer growth and angiogenesis
    • Iozzo RV, Zoeller JJ, Nyström A (2009) Basement membrane proteoglycans: modulators Par Excellence of cancer growth and angiogenesis. Mol Cells 27: 503-513
    • (2009) Mol Cells , vol.27 , pp. 503-513
    • Iozzo, R.V.1    Zoeller, J.J.2    Nyström, A.3
  • 17
    • 67650133662 scopus 로고    scopus 로고
    • Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling
    • Jia J, Maccarana M, Zhang X, Bespalov M, Lindahl U, Li JP (2009) Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling. J Biol Chem 284: 15942-15950
    • (2009) J Biol Chem , vol.284 , pp. 15942-15950
    • Jia, J.1    MacCarana, M.2    Zhang, X.3    Bespalov, M.4    Lindahl, U.5    Li, J.P.6
  • 18
    • 64249151246 scopus 로고    scopus 로고
    • FGFR2-related pathogenesis and FGFR2-targeted therapeutics
    • Katoh Y, Katoh M (2009) FGFR2-related pathogenesis and FGFR2-targeted therapeutics. Int J Mol Med 23: 307-311
    • (2009) Int J Mol Med , vol.23 , pp. 307-311
    • Katoh, Y.1    Katoh, M.2
  • 21
    • 0034707667 scopus 로고    scopus 로고
    • The elusive functions of proteoglycans: In vivo veritas
    • DOI 10.1083/jcb.148.2.227
    • Lander AD, Selleck SB (2000) The elusive functions of proteoglycans: in vivo veritas. J Cell Biol 148: 227-232 (Pubitemid 30078233)
    • (2000) Journal of Cell Biology , vol.148 , Issue.2 , pp. 227-232
    • Lander, A.D.1    Selleck, S.B.2
  • 22
    • 0033019359 scopus 로고    scopus 로고
    • Identification of new tumor suppressor genes based on in vivo functional inactivation of a candidate gene
    • DOI 10.1016/S0014-5793(99)00598-0, PII S0014579399005980
    • Li J, Protopopov AI, Gizatullin RZ, Kiss C, Kashuba VI, Winberg G, Klein G, Zabarovsky ER (1999) Identification of new tumor suppressor genes based on in vivo functional inactivation of a candidate gene. FEBS Lett 451(3): 289-294 (Pubitemid 29243794)
    • (1999) FEBS Letters , vol.451 , Issue.3 , pp. 289-294
    • Li, J.1    Protopopov, A.I.2    Gizatullin, R.Z.3    Kiss, C.4    Kashuba, V.I.5    Winberg, G.6    Klein, G.7    Zabarovsky, E.R.8
  • 23
    • 0035827699 scopus 로고    scopus 로고
    • Characterization of the D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate
    • Li JP, Gong F, El Darwish K, Jalkanen M, Lindahl U (2001) Characterization of the D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate. J Biol Chem 276: 20069-20077
    • (2001) J Biol Chem , vol.276 , pp. 20069-20077
    • Li, J.P.1    Gong, F.2    El Darwish, K.3    Jalkanen, M.4    Lindahl, U.5
  • 24
    • 0043210538 scopus 로고    scopus 로고
    • Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality
    • DOI 10.1074/jbc.C300219200
    • Li JP, Gong F, Hagner-McWhirter A, Forsberg E, Abrink M, Kisilevsky R, Zhang X, Lindahl U (2003) Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality. J Biol Chem 278: 28363-28366 (Pubitemid 36935735)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.31 , pp. 28363-28366
    • Li, J.-P.1    Gong, F.2    Hagner-McWhirter, A.3    Forsberg, E.4    Abrink, M.5    Kisilevsky, R.6    Zhang, X.7    Lindahl, U.8
  • 25
    • 0030736088 scopus 로고    scopus 로고
    • Biosynthesis of heparin/heparan sulfate. cDNA cloning and expression of D-glucuronyl C5-epimerase from bovine lung
    • DOI 10.1074/jbc.272.44.28158
    • Li JP, Hagner-McWhirter A, Kjellén L, Palgi J, Jalkanen M, Lindahl U (1997) Biosynthesis of heparin/heparan sulfate. cDNA cloning and expression of D-glucuronyl C5-epimerase from bovine lung. J Biol Chem 272: 28158-28163 (Pubitemid 27473627)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.44 , pp. 28158-28163
    • Li, J.-P.1    Hagner-McWhirter, A.2    Kjellen, L.3    Palgi, J.4    Jalkanen, M.5    Lindahl, U.6
  • 26
    • 0032500662 scopus 로고    scopus 로고
    • The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate
    • DOI 10.1074/jbc.273.41.26265
    • Lind T, Tufaro F, McCormick C, Lindahl U, Lidholt K (1998) The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate. J Biol Chem 273(41): 26265-26268 (Pubitemid 28471622)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.41 , pp. 26265-26268
    • Lind, T.1    Tufaro, F.2    McCormick, C.3    Lindahl, U.4    Lidholt, K.5
  • 28
    • 15044347694 scopus 로고    scopus 로고
    • Overexpression of vascular endothelial growth factor and its receptors in bronchial dypslasia demonstrated by quantitative RT-PCR analysis
    • DOI 10.1016/j.lungcan.2004.07.049
    • Merrick DT, Haney J, Petrunich S, Sugita M, Miller YE, Keith RL, Kennedy TC, Franklin WA (2005) Overexpression of vascular endothelial growth factor and its receptors in bronchial dypslasia demonstrated by quantitative RT-PCR analysis. Lung Cancer 48: 31-45 (Pubitemid 40380998)
    • (2005) Lung Cancer , vol.48 , Issue.1 , pp. 31-45
    • Merrick, D.T.1    Haney, J.2    Petrunich, S.3    Sugita, M.4    Miller, Y.E.5    Keith, R.L.6    Kennedy, T.C.7    Franklin, W.A.8
  • 32
    • 46849088581 scopus 로고    scopus 로고
    • Heparan sulphate biosynthesis and disease
    • DOI 10.1093/jb/mvn040
    • Nadanaka S, Kitagawa H (2008) Heparan sulphate biosynthesis and disease. J Biochem 144: 7-14 (Pubitemid 351957475)
    • (2008) Journal of Biochemistry , vol.144 , Issue.1 , pp. 7-14
    • Nadanaka, S.1    Kitagawa, H.2
  • 33
    • 72049091524 scopus 로고    scopus 로고
    • Targeting the transforming growth factor-beta signaling pathway in human cancer
    • Nagaraj NS, Datta PK (2010) Targeting the transforming growth factor-beta signaling pathway in human cancer. Expert Opin Investig Drugs 19: 77-91
    • (2010) Expert Opin Investig Drugs , vol.19 , pp. 77-91
    • Nagaraj, N.S.1    Datta, P.K.2
  • 34
    • 33847671384 scopus 로고    scopus 로고
    • Urokinase plasminogen activator and plasminogen activator inhibitor type-1 in nonsmall-cell lung cancer: Relation to prognosis and angiogenesis
    • DOI 10.1016/j.lungcan.2006.11.018, PII S0169500206006222
    • Offersen BV, Pfeiffer P, Andreasen P, Overgaard J (2007) Urokinase plasminogen activator and plasminogen activator inhibitor type-1 in nonsmall-cell lung cancer: relation to prognosis and angiogenesis. Lung Cancer 56: 43-50 (Pubitemid 46356642)
    • (2007) Lung Cancer , vol.56 , Issue.1 , pp. 43-50
    • Offersen, B.V.1    Pfeiffer, P.2    Andreasen, P.3    Overgaard, J.4
  • 36
    • 42649106868 scopus 로고    scopus 로고
    • The heparanome and regulation of cell function: Structures, functions and challenges
    • DOI 10.2741/3007
    • Ori A, Wilkinson MC, Fernig DG (2008) The heparanome and regulation of cell function: structures, functions and challenges. Front Biosci 13: 4309-4338 (Pubitemid 351599686)
    • (2008) Frontiers in Bioscience , vol.13 , Issue.11 , pp. 4309-4338
    • Ori, A.1    Wilkinson, M.C.2    Fernig, D.G.3
  • 37
    • 0036716282 scopus 로고    scopus 로고
    • Strategies for MMP inhibition in cancer: Innovations for the post-trial era
    • DOI 10.1038/nrc884
    • Overall CM, López-Otín C (2002) Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer 2: 657-672 (Pubitemid 37328917)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.9 , pp. 657-672
    • Overall, C.M.1    Lopez-Otin, C.2
  • 38
    • 77953287751 scopus 로고    scopus 로고
    • Lung cancer screening
    • Pastorino U (2010) Lung cancer screening. Br J Cancer 102: 1681-1686
    • (2010) Br J Cancer , vol.102 , pp. 1681-1686
    • Pastorino, U.1
  • 39
    • 0036635757 scopus 로고    scopus 로고
    • Human cell lines engineered for tetracycline-regulated expression of tumor suppressor candidate genes from a frequently affected chromosomal region, 3p21
    • DOI 10.1002/jgm.283
    • Protopopov AI, Li J, Winberg G, Gizatullin RZ, Kashuba VI, Klein G, Zabarovsky ER (2002) Human cell lines engineered for tetracycline-regulated expression of tumor suppressor candidate genes from a frequently affected chromosomal region, 3p21. J Gene Med 4: 397-406 (Pubitemid 40277177)
    • (2002) Journal of Gene Medicine , vol.4 , Issue.4 , pp. 397-406
    • Protopopov, A.I.1    Li, J.2    Winberg, G.3    Gizatullin, R.Z.4    Kashuba, V.I.5    Klein, G.6    Zabarovsky, E.R.7
  • 45
    • 61449111811 scopus 로고    scopus 로고
    • The role of the MTA family and their encoded proteins in human cancers: Molecular functions and clinical implications
    • Toh Y, Nicolson GL (2009) The role of the MTA family and their encoded proteins in human cancers: molecular functions and clinical implications. Clin Exp Metastasis 26: 215-227
    • (2009) Clin Exp Metastasis , vol.26 , pp. 215-227
    • Toh, Y.1    Nicolson, G.L.2
  • 46
    • 54849436630 scopus 로고    scopus 로고
    • Diverse cell signaling events modulated by perlecan
    • Whitelock JM, Melrose J, Iozzo RV (2008) Diverse cell signaling events modulated by perlecan. Biochemistry 47: 11174-11183
    • (2008) Biochemistry , vol.47 , pp. 11174-11183
    • Whitelock, J.M.1    Melrose, J.2    Iozzo, R.V.3
  • 47
    • 67449164585 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 2-positive fibroblasts provide a suitable microenvironment for tumor development and progression in esophageal carcinoma
    • Zhang C, Fu L, Fu J, Hu L, Yang H, Rong TH, Li Y, Liu H, Fu SB, Zeng YX, Guan XY (2009) Fibroblast growth factor receptor 2-positive fibroblasts provide a suitable microenvironment for tumor development and progression in esophageal carcinoma. Clin Cancer Res 15: 4017-4027
    • (2009) Clin Cancer Res , vol.15 , pp. 4017-4027
    • Zhang, C.1    Fu, L.2    Fu, J.3    Hu, L.4    Yang, H.5    Rong, T.H.6    Li, Y.7    Liu, H.8    Fu, S.B.9    Zeng, Y.X.10    Guan, X.Y.11
  • 48
    • 67649367545 scopus 로고    scopus 로고
    • Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis
    • Zoeller JJ, Whitelock JM, Iozzo RV (2009) Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis. Matrix Biol 28: 284-291
    • (2009) Matrix Biol , vol.28 , pp. 284-291
    • Zoeller, J.J.1    Whitelock, J.M.2    Iozzo, R.V.3
  • 49
    • 73349096615 scopus 로고    scopus 로고
    • Effect of syndecan-1 overexpression on mesenchymal tumour cell proliferation with focus on different functional domains
    • Zong F, Fthenou E, Castro J, acute;terfia B, Kovalszky I, lák L, Tzanakakis G, Dobra K (2010) Effect of syndecan-1 overexpression on mesenchymal tumour cell proliferation with focus on different functional domains. Cell Prolif 43: 29-40
    • (2010) Cell Prolif , vol.43 , pp. 29-40
    • Zong F, F.1    Terfia B, K.2
  • 50
    • 70350038068 scopus 로고    scopus 로고
    • Syndecan-1 and FGF-2, but not FGF receptor-1, share a common transport route and co-localize with heparanase in the nuclei of mesenchymal tumor cells
    • Zong F, Fthenou E, Wolmer N, Hollo'si P, Kovalszky I, Szilák L, Mogler C, Nilsonne G, Tzanakakis G, Dobra K (2009) Syndecan-1 and FGF-2, but not FGF receptor-1, share a common transport route and co-localize with heparanase in the nuclei of mesenchymal tumor cells. PLoS One 4(10): e7346
    • (2009) PLoS One , vol.4 , Issue.10
    • Zong F, F.1


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