Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality

Journal of Biological Chemistry

Volumn 278, Issue 31, 2003, Pages 28363-28366

  Li, Jin Ping ^a   Gong, Feng ^a,d   Hagner McWhirter, Åsa ^a   Forsberg, Erik ^a   Åbrink, Magnus ^a,e   Kisilevsky, Robert ^b   Zhang, Xiao ^c   Lindahl, Ulf ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b QUEEN S UNIVERSITY   (Canada)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d Beijing Institute of Blood Transfusion   (China)

^e SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GENETIC ENGINEERING; NEONATAL MONITORING; PROTEINS;

SKELETAL MALFORMATIONS;

GENES;

EPIMERASE; GLUCURONYL C5 EPIMERASE; GLYCOSAMINOGLYCAN; HEPARAN SULFATE; IDURONIC ACID; LEVO IDURONIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; EMBRYO; EMBRYO DEVELOPMENT; GENE DISRUPTION; KIDNEY AGENESIS; KIDNEY DEVELOPMENT; LETHAL MUTANT; LETHALITY; LUNG DEVELOPMENT; LUNG MALFORMATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SKELETON MALFORMATION; SULFATION;

ANIMALS; BONE AND BONES; CARBOHYDRATE EPIMERASES; FEMALE; GENE TARGETING; HEPARITIN SULFATE; IDURONIC ACID; KIDNEY; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; MAMMALIA; MURINAE;

EID: 0043210538     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C300219200     Document Type: Article

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