Aflatoxin B1 in affecting broiler's performance, immunity, and gastrointestinal tract: A review of history and contemporary issues

Toxins

Volumn 3, Issue 6, 2011, Pages 566-590

  Yunus, Agha W ^a   Razzazi Fazeli, E ^a   Bohm, Josef ^a  

^a UNIVERSITY OF VETERINARY MEDICINE   (Austria)

Author keywords

Aflatoxin; Broiler; Chicken; Hormesis

Indexed keywords

AFLATOXIN B1; AMYLASE; CHYMOTRYPSIN; DEOXYRIBONUCLEASE; RIBONUCLEASE; TRIACYLGLYCEROL LIPASE;

ACTIVE TRANSPORT; ADAPTIVE IMMUNITY; AFLATOXICOSIS; BLOOD CHEMISTRY; BROILER; ENZYME ACTIVITY; GASTROINTESTINAL TRACT FUNCTION; IMMUNITY; INNATE IMMUNITY; INTESTINE FLORA; NONHUMAN; NUTRIENT UPTAKE; REVIEW; SENSITIVITY ANALYSIS; TOXIN ANALYSIS; TOXIN STRUCTURE;

AFLATOXIN B1; ANIMAL FEED; ANIMALS; ASPERGILLUS; CHICKENS; EATING; GASTROINTESTINAL TRACT; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; LETHAL DOSE 50; ORGAN SIZE; ORGAN SPECIFICITY; WEIGHT GAIN;

EID: 79959684795     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins3060566     Document Type: Review

References (128)

1. van Egmond, H.P.; Jonker, M.A. Worldwide regulations on aflatoxins-the situation in 2002. J. Toxicol. Toxin Rev. 2004, 23, 273-293.
2. Bilgrami, K.S.; Choudhary, A.K. Mycotoxins in preharvest contamination of agricultural crops. In Mycotoxins in Agriculture and Food Safety; Sinha, K.K., Bhatnagar, D., Eds.; Marcel Dekker: New York, NY, USA, 1998; pp. 1-43.
3. Galvano, F.; Ritieni, A.; Piva, G.; Pietri, A. Mycotoxins in the human food chain. In The Mycotoxin Blue Book; Diaz, D.E., Ed.; Nottingham University Press: Nottingham, UK, 2005; pp. 187-224.
4. Blount, W.P. Turkey X disease. Turkeys 1961, 9, 52-54.
5. Allcroft, R.; Carnaghan, R.B.A.; Sargeant, K.; O'Kelly, J. A toxic factor in Brazillian groundnut meal. Vet. Rec. 1961, 73, 428-429.
6. Sargeant, K.; Sheridan, A.; O'Kelly, J.; Carnaghan, R.B. Toxicity associated with certain samples of groundnuts. Nature 1961, 192, 1096-1097.
7. Patterson, D.S.P. Aflatoxin and related compounds: Introduction. In Mycotoxic Fungi, Mycotoxins, Mycotoxicoses, an Encyclopaedic Handbook, 1st ed.; Wyllie, T.D., Morehouse, L.G., Eds.; Marcel Dekker Inc.: New York, NY, USA, 1977; Volume 1, pp. 131-135.
8. Van der Zijden, A.S.M.; Koelensmid, W.A.A.B.; Boldingh, J.; Barrett, C.B.; Ord, W.O.; Philp, J. Isolation in crystalline form of a toxin responsible for turkey X disease. Nature 1962, 195, 1060-1062.
9. Nesbitt, B.F.; O'Kelly, J.; Sargeant, K.; Sheridan, A. Toxic metabolites of Aspergillus flavus. Nature 1962, 195, 1062-1063.
10. Asao, T.; Büchi, G.; Abdel-Kadar, M.M.; Chang, S.B.; Wick, E.L.; Wogan, G.N. Structures of aflatoxins B1 and G1. J. Am. Chem. Soc. 1965, 87, 882-886.
11. Butler, W.H. Aflatoxin. In Mycotoxins; Purchase, I.F.H., Ed.; Elsevier Scientific Publishing Company: Amsterdam, The Netherlands, 1974; pp. 1-3.
12. Diaz, D.E. The Mycotoxin Blue Book, 1st ed.; Nottingham University Press: Nottingham, UK, 2005; pp. 25-56.
13. Dersjant-Li, Y.; Verstegen, M.W.A.; Gerrits, W.J.J. The impact of low concentrations of aflatoxin, deoxynivalenol or fumonisin in diets on growing pigs and poultry. Nutr. Res. Rev. 2003, 16, 223-239.
14. Diaz, G.J.; Calabrese, E.; Blain, R. Aflatoxicosis in chickens (Gallus gallus): An example of hormesis? Poult. Sci. 2008, 87, 727-732.
15. Emafo, P.O. Species differences in the metabolism of aflatoxin B1. Afr. J. Med. Med. Sci. 1976, 5, 55-62.
16. Miazzo, R.; Rosa, C.; de Queiroz, C.E.; Magnoli, C.; Chiacchiera, S.; Palacio, G.; Saenz, M.; Kikot, A.; Basaldella, E.; Dalcero, A. Efficacy of synthetic zeolite to reduce the toxicity of aflatoxin in broiler chicks. Poult. Sci. 2000, 79, 1-6.
17. Denli, M.; Blandon, J.C.; Guynot, M.E.; Salado, S.; Perez, J.F. Effects of dietary AflaDetox on performance, serum biochemistry, histopathological changes, and aflatoxin residues in broilers exposed to aflatoxin B1. Poult. Sci. 2009, 88, 1444-1451.
18. Fernández, A.; Ramos, J.J.; Sanz, M.D.C.; Saez, T.; de Luco, D.F. Alterations in the performance, haematology and clinical biochemistry of growing lambs fed with aflatoxin in the diet. J. Appl. Toxicol. 1996, 16, 85-91.
19. Larsson, P.; Busk, L.; Tjälve, H. Hepatic and extrahepatic bioactivation and GSH conjugation of aflatoxin B1 in sheep. Carcinogenesis 1994, 15, 947-955.
20. Hsieh, D.P.H.; Wong, J.J. Pharmacokinetics and excretion of aflatoxins. In The Toxicology of Aflatoxins. Human Health, Veterinary and Agricultural Significance; Eaton, D.L., Groopman, J.D., Eds.; Academic Press: San Diego, CA, USA, 1994; pp. 73-88.
21. Ramos, A.J.; Hernández, E. In situ absorption of aflatoxins in rat small intestine. Mycopathologia 1996, 134, 27-30.
22. Wogan, G.N.; Edwards, G.S.; Shank, R.C. Excretion and tissue distribution of radioactivity from aflatoxin B1-14-C in rats. Cancer Res. 1967, 27, 1729-1736.
23. Coulombe, R.A., Jr.; Sharma, R.P. Clearance and excretion of intratracheally and orally administered aflatoxin B1 in the rat. Food Chem. Toxicol. 1985, 23, 827-830.
24. Eaton, D.L.; Gallagher, E.P. Mechanisms of aflatoxin carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 1994, 34, 135-172.
25. Wong, Z.A.; Hsieh, D.P.H. The comparative metabolism and toxicokinetics of aflatoxin B1 in the monkey, rat, and mouse. Toxicol. Appl. Pharmacol. 1980, 55, 115-125.
26. Sawhney, D.S.; Vadehra, D.V.; Baker, R.C. The metabolism of 14C aflatoxins in laying hens. Poult. Sci. 1973, 52, 1302-1309.
27. Mabee, M.S.; Chipley, J.R. Tissue distribution and metabolism of aflatoxin B 1-14 C in Broiler chickens. Appl. Microbiol. 1973, 25, 763-769.
28. Wolzak, A.; Pearson, A.M.; Coleman, T.H. Aflatoxin carryover and clearance from tissues of laying hens. Food Chem. Toxicol. 1986, 24, 37-41.
29. Hussain, Z.; Khan, M.Z.; Khan, A.; Javed, I.; Saleemi, M.K.; Mahmood, S.; Asi, M.R. Residues of aflatoxin B1 in broiler meat: Effect of age and dietary aflatoxin B1 levels. Food Chem. Toxicol. 2010, 48, 3304-3307.
30. Fernandez, A.; Verde, M.T.; Gascon, M.; Ramos, J.J.; Gomez, J. Aflatoxin and its metabolites in tissues from laying hens and broiler chickens fed a contaminated diet. J. Sci. Food Agric. 1994, 65, 407-414.
31. IARC. IARC Monograph on the Evaluation of Carcinogenic Risk to Humans, Some Naturally Occurring Substances: Food Items and Constituents, Heteroyclic Aromatic Amines and Mycotoxins; The International Agency for Research on Cancer: Lyon, France, 1993; Volume 56.
32. Eaton, D.L.; Gallagher, E.P. Mechanisms of aflatoxin carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 1994, 34, 135-172.
33. Nigam, S.K.; Ghosh, S.K.; Malaviya, R. Aflatoxin, its metabolism and carcinogenesis-A historical review. J. Toxicol. Toxin Rev. 1994, 13, 179-203.
34. IARC. IARC Monograph on the Evaluation of Carcinogenic Risk of Chemicals to Humans, Some Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene; The International Agency for Research on Cancer: Lyon, France, 2002; Volume 82.
35. Do, J.H.; Choi, D.K. Aflatoxins: Detection, toxicity, and biosynthesis. Biotechnol. Bioprocess Eng. 2007, 12, 585-593.
36. Micco, C.; Miraglia, M.; Onori, R.; Brera, C.; Mantovani, A.; Ioppolo, A.; Stasolla, D. Long-term administration of low doses of mycotoxins to poultry. 1. Residues of aflatoxin B1 and its metabolites in broilers and laying hens. Food Addit. Contam. 1988, 5, 303-308.
37. Diaz, G.; Murcia, H.W.; Cepeda, S.M. Cytochrome P450 enzymes involved in the metabolism of aflatoxin B1 in chickens and quail. Poult. Sci. 2010, 89, 2461-2469.
38. Devegowda, G.; Murthy, T.N.K. Mycotoxins: Their effects in poultry and some practical solutions. In The Mycotoxin Blue Book; Diaz, D.E., Ed.; Nottingham University Press: Nottingham, UK, 2005; pp. 25-56.
39. Raju, M.V.L.N.; Devegowda, G. Influence of esterified-glucomannan on performance and organ morphology, serum biochemistry and haematology in broilers exposed to individual and combined mycotoxicosis (aflatoxin, ochratoxin and T-2 toxin). Br. Poult. Sci. 2000, 41, 640-650.
40. Tedesco, D.; Steidler, S.; Galletti, S.; Tameni, M.; Sonzogni, O.; Ravarotto, L. Efficacy of silymarin-phospholipid complex in reducing the toxicity of aflatoxin B1 in broiler chicks. Poult. Sci. 2004, 83, 1839-1843.
41. Zhao, J.; Shirley, R.B.; Dibner, J.D.; Uraizee, F.; Officer, M.; Kitchell, M.; Vazquez-Anon, M.; Knight, C.D. Comparison of hydrated sodium calcium aluminosilicate and yeast cell wall on counteracting aflatoxicosis in broiler chicks. Poult. Sci. 2010, 89, 2147-2156.
42. Valdivia, A.; Martinez, A.; Damian, F.; Quezada, T.; Ortiz, R.; Martinez, C.; Llamas, J.; Rodriguez, M.; Yamamoto, L.; Jaramillo, F. et al. Efficacy of N-acetylcysteine to reduce the effects of aflatoxin B1 intoxication in broiler chickens. Poult. Sci. 2001, 80, 727-734.
43. Edrington, T.; Kubena, L.; Harvey, R.; Rottinghaus, G. Influence of a superactivated charcoal on the toxic effects of aflatoxin or T-2 toxin in growing broilers. Poult. Sci. 1997, 76, 1205-1211.
44. Kubena, L.; Harvey, R.; Buckley, S.; Edrington, T.; Rottinghaus, G. Individual and combined effects of moniliformin present in Fusarium fujikuroi culture material and aflatoxin in broiler chicks. Poult. Sci. 1997, 76, 265-270.
45. Kubena, L.; Harvey, R.; Bailey, R.; Buckley, S.; Rottinghaus, G. Effects of a hydrated sodium calcium aluminosilicate (T-Bind) on mycotoxicosis in young broiler chickens. Poult. Sci. 1998, 77, 1502-1509.
46. Ledoux, D.; Rottinghaus, G.; Bermudez, A.; Alonso-Debolt, M. Efficacy of a hydrated sodium calcium aluminosilicate to ameliorate the toxic effects of aflatoxin in broiler chicks. Poult. Sci. 1999, 78, 204-210.
47. Gowda, N.K.S.; Ledoux, D.R.; Rottinghaus, G.E.; Bermudez, A.J.; Chen, Y.C. Efficacy of turmeric (curcuma longa), containing a known level of curcumin, and a hydrated sodium calcium aluminosilicate to ameliorate the adverse effects of aflatoxin in broiler chicks. Poult. Sci. 2008, 87, 1125-1130.
48. Kana, J.R.; Teguia, A.; Tchoumboue, J. Effect of dietary plant charcoal from Canarium schweinfurthii Engl. and maize cob on aflatoxin B1 toxicosis in broiler chickens. Adv. Anim. Biosci. 2010, 1, 462-463.
49. Çelik, I.; Oguz, H.; Demet, Ö.; Dönmez, H.H.; Boydak, M.; Sur, E. Efficacy of polyvinylpolypyrrolidone in reducing the immunotoxicity of aflatoxin in growing broilers. Br. Poult. Sci. 2000, 41, 430-439.
50. Verma, J.; Johri, T.S.; Swain, B.K.; Ameena, S. Effect of graded levels of aflatoxin, ochratoxin and their combinations on the performance and immune response of broilers. Br. Poult. Sci. 2004, 45, 512-518.
51. Havenstein, G.B.; Ferket, P.R.; Scheideler, S.E.; Larson, B.T. Growth, livability, and feed conversion of 1991 vs. 1957 broilers when fed typical 1957 and 1991 broiler diets. Poult. Sci. 1994, 73, 1785-1794.
52. Havenstein, G.B.; Ferket, P.R.; Qureshi, M.A. Growth, livability, and feed conversion of 1991 vs. 1957 broilers when fed typical 1957 and 2001 broiler diets. Poult. Sci. 2003, 82, 1500-1508.
53. Dozier, W.A., III; Kidd, M.T.; Corzo, A. Dietary amino acid responses of broiler chickens. J. Appl. Poult. Res. 2008, 17, 157-167.
54. Surai, P.F.; Dvorska, J.E. Effects of mycotoxins on antioxidant status and immunity. In The Mycotoxin Blue Book, Diaz, D.E., Ed.; Nottingham University Press: Nottingham, UK, 2005; pp. 93-137.
55. Matur, E.; Ergul, E.; Akyazi, I.; Eraslan, E.; Cirakli, Z.T. The effects of Saccharomyces cerevisiae extract on the weight of some organs, liver, and pancreatic digestive enzyme activity in breeder hens fed diets contaminated with aflatoxins. Poult. Sci. 2010, 89, 2213-2220.
56. Bailey, R.; Kubena, L.; Harvey, R.; Buckley, S.; Rottinghaus, G. Efficacy of various inorganic sorbents to reduce the toxicity of aflatoxin and T-2 toxin in broiler chickens. Poult. Sci. 1998, 77, 1623-1630.
57. Yunus, A.W.; Nasir, M.K.; Farooq, U.; Böhm, J. Prevalence of poultry diseases in district Chakwal and their interactrion with mycotoxicosis: 1. Effects of age and flock size. J. Anim. Plant Sci. 2008, 18, 107-113.
58. Yunus, A.W.; Nasir, M.K.; Aziz, T.; Böhm, J. Prevalence of poultry diseases in district Chakwal and their interactrion with mycotoxicosis: 2. Effects of season and feed. J. Anim. Plant Sci. 2009, 19, 1-5.
59. Giambrone, J.J.; Diener, U.L.; Davis, N.D.; Panangala, V.S.; Hoerr, F.J. Effects of purified aflatoxin on broiler chickens. Poult. Sci. 1985, 64, 852-858.
60. Giambrone, J.J.; Diener, U.L.; Davis, N.D.; Panangala, V.S.; Hoerr, F.J. Effects of aflatoxin on young turkeys and broiler chickens. Poult. Sci. 1985, 64, 1678-1684.
61. Shivachandra, S.B.; Sah, R.L.; Singh, S.D.; Kataria, J.M.; Manimaran, K. Immunosuppression in broiler chicks fed aflatoxin and inoculated with fowl adenovirus serotype-4 (FAV-4) associated with hydropericardium syndrome. Vet. Res. Commum. 2003, 27, 39-51.
62. Ibrahim, I.K.; Shareef, A.M.; Al-Joubory, K.M.T. Ameliorative effects of sodium bentonite on phagocytosis and Newcastle disease antibody formation in broiler chickens during aflatoxicosis. Res. Vet. Sci. 2000, 69, 119-122.
63. Stewart, R.G.; Skeeles, J.K.; Wyatt, R.D.; Brown, J.; Page, R.K.; Russell, I.D.; Lukert, P.D. The effect of aflatoxin on complement activity in broiler chickens. Poult. Sci. 1985, 64, 616-619.
64. Okotie-Eboh, G.O.; Kubena, L.F.; Chinnah, A.D.; Bailey, C.A. Effects of β-Carotene and Canthaxanthin on Aflatoxicosis in Broilers. Poult. Sci. 1997, 76, 1337-1341.
65. Azzam, A.H.; Gabal, M.A. Aflatoxin and immunity in layer hens. Avian Pathol. 1998, 27, 570-577.
66. Giambrone, J.J.; Partadiredja, M.; Eidson, C.S.; Kleven, S.H.; Wyatt, R.D. Interaction of aflatoxin with infectious bursal disease virus infection in young chickens. Avian Dis. 1978, 22, 431-439.
67. Kadian, S.K.; Monga, D.P.; Goel, M.C. Effect of aflatoxin B1 on the delayed type hypersensitivity and phagocytic activity of reticuloendothelial system in chickens. Mycopathologia 1988, 104, 33-36.
68. Corrier, D.E. Mycotoxins: Mechanism of immunosuppression. Vet. Immunol. Immunopathol. 1991, 30, 73-87.
69. Azzam, A.H.; Gabal, M.A. Interaction of aflatoxin in the feed and immunization against selected infectious diseases in poultry. I. Infectious bursal disease. Avian Pathol. 1997, 26, 317-325.
70. Tung, H.-T.; Donaldson, W.E.; Hamilton, P.B. Effects of aflatoxin on some marker enzymes of lysosomes. Biochim. Biophys. Acta Gen. Subj. 1970, 222, 665-667.
71. Yunus, A.W.; Ghareeb, K.; Abd-El-Fattah, A.A.M.; Twaruzek, M.; Böhm, B. Gross intestinal adaptations in relation to broiler performance during a chronic aflatoxin exposure. Poult. Sci. 2011, 90, in press.
72. Kumar, R.; Balachandran, C. Histopathological changes in broiler chickens fed aflatoxin and cyclopiazonic acid. Vet. Arhiv. 2009, 79, 31-40.
73. Warren, M.F.; Hamilton, P.B. Intestinal fragility during ochratoxicosis and aflatoxicosis in broiler chickens. Appl. Environ. Microbiol. 1980, 40, 641-645.
74. Applegate, T.J.; Schatzmayr, G.; Pricket, K.; Troche, C.; Jiang, Z. Effect of aflatoxin culture on intestinal function and nutrient loss in laying hens. Poult. Sci. 2009, 88, 1235-1241.
75. Ruff, M.D.; Wyatt, R.D. Intestinal absorption of L-methionine and glucose in chickens with aflatoxicosis. Toxicol. Appl. Pharmacol. 1976, 37, 257-262.
76. Carrillo, M.C.; Monti, J.A.; Grosman, M.E.; Rodriguez Garay, E.A. Effect of pH on aflatoxin B1 transfer in the everted rat jejunum. Toxicol. Lett. 1985, 27, 35-44.
77. Chotinski, D.; Profirov, I.; Voǐnova, R.; Borisova, L. SH group content and hydrolase activity of the small intestine mucosa in chickens fed a mixture containing aflatoxin B1. Vet. Med. Nauki 1987, 24, 48-51.
78. Gursoy, N.; Sarac, B.; Durmus, N.; Parlak, A.; Yildirim, S.; Kaya, T.; Bagcivan, I. Changes in spontaneous contractions of rat ileum by aflatoxin in vitro. Food Chem. Toxicol. 2008, 46, 2124-2127.
79. Winding, B.; Winding, H.; Bindslev, N. Second messengers and ion channels in acetylcholine-induced chloride secretion. Comp. Biochem. Physiol. C-Pharmacol. Toxicol. Endocrinol. 1992, 103, 195-205.
80. Yunus, A.W.; Awad, W.A.; Kröger, A.; Zentek, J.; Böhm, J. In vitro aflatoxin B1 exposure decreases response to carbamycholine in the hehunal epithelium of broilers. Poult. Sci. 2010, 89, 1372-1378.
81. Nelson, T.S.; Johnson, Z.B.; Kirby, L.K.; Beasley, J.N. Digestion of dry matter and amino acids and energy utilization by chicks fed molded corn containing mycotoxins. Poult. Sci. 1982, 61, 584-585.
82. Richardson, K.E.; Hamilton, P.B. Enhanced production of pancreatic digestive enzymes during aflatoxicosis in egg-type chickens. Poult. Sci. 1987, 66, 640-644.
83. Osborne, D.J.; Hamilton, P.B. Decreased pancreatic digestive enzymes during aflatoxicosis. Poult. Sci. 1981, 60, 1818-1821.
84. Verma, J.; Swain, B.K.; Johri, T.S. Effect of various levels of aflatoxin and ochratoxin A and combinations thereof on protein and energy utilisation in broilers. J. Sci. Food Agric. 2002, 82, 1412-1417.
85. Verma, J.; Johri, T.S.; Swain, B.K. Effect of aflatoxin, ochratoxin and their combination on protein and energy utilisation in white leghorn laying hens. J. Sci. Food Agric. 2007, 87, 760-764.
86. Müller, C.C.; Autenrieth, I.B.; Peschel, A. Innate defences of the intestinal epithelial barrier. Cell. Mol. Life Sci. 2005, 52, 1297-1307.
87. Gaikwad, S.S.; Pillai, M.M. Effect of aflatoxin B1 in gastrointestine of mice. J. Ecophys. Occup. Health 2004, 4, 153-159.
88. Fleming, S.E.; Youngman, L.D.; Ames, B.N. Intestinal cell proliferation is influenced by intakes of protein and energy, aflatoxin, and Whole-body radiation. Nutr. Cancer 1994, 22, 11-30.
89. Watzl, B.; Neudecker, C.; Hänsch, G.M.; Rechkemmer, G.; Pool-Zobel, B.L. Short-term moderate aflatoxin B1 exposure has only minor effects on the gut-associated lymphoid tissue of Brown Norway rats. Toxicology 1999, 138, 93-102.
90. García, J.C.D.R.; Ramos, C.M.; Pinton, P.; Elvira, S.M.; Oswald, I.P. Evaluation of the cytotoxicity of AFB1, FB1 and AFB1/FB1 in intestinal cell. Revista Iberoamericana de Micologia 2007, 24, 136-141.
91. Rao, J.R.; Sharma, N.N.; Iyer, P.K.; Sharma, A.K. Interaction between Eimeria uzura infection and aflatoxicosis in Japanese quail (Coturnix coturnix japonica). Vet. Parasitol. 1990, 35, 259-267.
92. Rao, J.R.; Sharma, N.N.; Johri, T.S. Influence of dietary aflatoxin on Eimeria uzura infection in Japanese quail (Coturnix coturnix japonica). Vet. Parasitol. 1995, 56, 17-22.
93. Ruff, M.D. Influence of dietary aflatoxin on the severity of Eimeria acervulina infection in broiler chickens. Avian Dis. 1978, 22, 471-480.
94. Geiger, W.B.; Conn, J.E. The mechanism of the antibiotic action of clavacin and penicillic acid 1,2. J. Am. Chem. Soc. 1945, 67, 112-116.
95. Rinderknecht, H.; Ward, J.L.; Bergel, F.; Morrison, A.L. Studies on antibiotics: 2. Bacteriological activity and possible mode of action of certain non-nitrogenous natural and synthetic antibiotics. Biochem. J. 1947, 41, 463-469.
96. Brian, P.W.; Dawkins, A.W.; Grove, J.F.; Hemming, H.G.; Lowe, D.; Norris, G.L.F. Phytotoxic compounds produced by Fusarium equiseti. J. Exp. Bot. 1961, 12, 1-12.
97. Ciegler, A. Patulin. In Mycotoxins in Human and Animal Health; Rodricks, J.V.C., Hesseltine, W., Mehlman, M.A., Eds.; Pathotox Publishers Inc.: Park Forest South, IL, USA, 1977; pp. 609-624.
98. Wehner, F.C.; Thiel, P.G.; Van Rensburg, S.J.; Demasius, I.P.C. Mutagenicity to Salmonella typhimurium of some Aspergillus and Penicillium mycotoxins. Mutat. Res. 1978, 58, 193-203.
99. Burmeister, H.R.; Hesseltine, C.W. Survey of the sensitivity of microorganisms to aflatoxin. Appl. Microbiol. 1966, 14, 403-404.
100. Burmeister, H.R.; Hesseltine, C.W. Aflatoxin sensitivities of an L form and Bacillus megaterium. Bacteriol. Proc. 1967, 17, A97.
101. Lillehoj, E.B.; Ciegler, A. Aflatoxin B1 binding and toxic effects on Bacillus megaterium. J. Gen. Microbiol. 1968, 54, 185-194.
102. Beuchat, L.R.; Lechowich, R.V. Morphological alterations in Bacillus megaterium as produced by aflatoxin B1. Appl. Microbiol. 1971, 21, 124-131.
103. Lillehoj, E.B.; Ciegler, A.; Hall, H.H. Fungistatic action of aflatoxin B1. Experientia 1967, 23, 187-188.
104. Reiss, J. Untersuchungen über den Einfluss von Aflatoxin B1 auf die Morphologie und die cytochemisch fassbare Aktivität einiger Enzyme von Mucor hiemalis (Mucorales). Mycopathol. Mycol. Appl. 1970, 42, 225-231.
105. Ong, T.M. Mutagenicity of aflatoxins in Neurospora crassa. Mutat. Res. 1970, 9, 615-618.
106. Ong, T.M. Mutagenic activities of aflatoxin B1 and G1 in Neurospora crassa. Mol. Gen. Genet. 1971, 111, 159-170.
107. Reiss, J. Inhibition of fungal sporulation by aflatoxin. Arch. Mikrobiol. 1971, 76, 219-222.
108. Reiss, J. Hypha abnormalities in Thamnidium elegans Link due to aflatoxin B1. Z. Allg. Mikrobiol. 1971, 11, 637-638.
109. Reiss, J. Effects of mycotoxins on higher plants, algae, fungi, and bacteria. In Mycotoxic Fungi Mycotoxins Mycotoxicoses. Mycotoxicoses of Man and Plants: Mycotoxin Control and Regulatory Practices, 1st ed.; Wyllie, T.D., Morehouse, L.G., Eds.; Marcel Dekker, Inc.: New York, NY, USA, 1978; Volume 3, pp. 125-126.
110. Ali-Vehmas, T.; Rizzo, A.; Westermarck, T.; Atroshi, F. Measurement of antibacterial activities of T-2 toxin, deoxynivalenol, ochratoxin A, aflatoxin B1 and fumonisin B1 Using microtitration tray-based turbidimetric techiques. Zentralbl. Veterinarmed. A 1998, 45, 453-458.
111. Watson, D.H.; Lindsay, D.G. A critical review of biological methods for the detection of fungal toxins in foods and foodstuffs. J. Sci. Food Agric. 1982, 33, 59-67.
112. Kranendonk, M.; Pintado, F.; Mesquita, P.; Laires, A.; Vermeulen, N.P.; Rueff, J. MX100, a new Escherichia coli tester strain for use in genotoxicity studies. Mutagenesis 1996, 11, 327-333.
113. Mejia, G.E.; Ramos-Gomez, M.; Loarca-Pina, G. Antimutagenic activity of natural xanthophylls against aflatoxin B1 in Salmonella typhimurium. Environ. Mol. Mutagen. 1997, 30, 346-353.
114. Miyazawa, M.; Okuno, Y.; Oshiro, K.; Kasahara, H.; Shimamura, H.; Nakamura, S.I.; Kameoka, H. Suppression of the SOS-inducing activity of Trp-P-1 and aflatoxin B1 by meso-dihydroguaiaretic acid from Machilus thunbergii in the Salmonella typhimurium TA1535/pSK1002 umu test. Biosci. Biotechnol. Biochem. 1998, 62, 1425-1427.
115. Engler, K.H.; Coker, R.D.; Evans, I.H. Uptake of aflatoxin B1 and T-2 toxin by two mycotoxin bioassay microorganisms: Kluyveromyces marxianus and Bacillus megaterium. Arch. Microbiol. 2000, 174, 381-385.
116. Gomes-Carneiro, M.R.; Dias, D.M.; Paumgartten, F.J. Study on the mutagenicity and antimutagenicity of beta-ionone in the Salmonella/microsome assay. Food Chem. Toxicol. 2006, 44, 522-527.
117. Uwaifo, O.A. Reversion by vitamin K of aflatoxin B1 (AFB)-induced inhibition of oxygen uptake in three AFB-susceptible bacteria. Toxicol. Lett. 1983, 15, 57-60.
118. Tiwari, R.P.; Dham, C.K.; Bhalla, T.C. Mechanism of action of aflatoxin B1 in Bacillus megaterium. Appl. Environ. Microbiol. 1985, 49, 904-907.
119. Atroshi, F.; Rizzo, A.; Westermarck, T.; Ali-Vehmas, T. Effects of tamoxifen, melatonin, coenzyme Q10, and L-carnitine supplementation on bacterial growth in the presence of mycotoxins. Pharmacol. Res. 1998, 38, 289-295.
120. Moricz, A.M.; Ott, P.G.; Szilagyi, M.; Otta, K.H.; Tyihak, E. Opposite effect of Cu(II) and Se(IV) ions on the antibacterial-toxic action of mycotoxins. Acta Biol. Hung. 2007, 58, 301-310.
121. Tiwari, R.P.; Singh, G.; Vadehra, D.V. Drug resistance patterns and susceptibility to aflatoxin B1 of strains of Escherichia coli and Staphylococcus aureus. J. Med. Microbiol. 1986, 22, 115-118.
122. Weekley, L.B.; Sherertz, P.C.; Kimbrough, T.D.; Llewellyn, G.C. Altered bacterial culture density following exposure to aflatoxins. J. Ind. Microbiol. Biotechnol. 1989, 4, 275-278.
123. Kubena, L.F.; Bailey, R.H.; Byrd, J.A.; Young, C.R.; Corrier, D.E.; Stanker, L.H.; Rottinghaust, G.E. Cecal volatile fatty acids and broiler chick susceptibility to Salmonella typhimurium colonization as affected by aflatoxins and T-2 toxin. Poult. Sci. 2001, 80, 411-417.
124. Larsen, A.B.; Cysewski, S.J.; Miller, J.M. Effect of aflatoxin on susceptibility of hamsters to Mycobacterium paratuberculosis. Am. J. Vet. Res. 1975, 36, 1545-1547.
125. Abdelhamid, A.M.; El-Ayouty, S.A.; El-Saadany, H.H. The influence of contamination with separate mycotoxins (aflatoxins, ochratoxin A, citrinin, patulin, penicillic acid or sterigmatocystin) on the in vitro dry matter and organic matter digestibilities of some roughages (berseem hay and wheat straw). Arch. Anim. Nutr. 1992, 42, 179-185.
126. Reiss, J. Influence of the mycotoxins aflatoxin B1, rubratoxin B, patulin and diacetoxyscirpenol on the fermentation activity of baker's yeast. Mycopathologia 1973, 51, 337-345.
127. Mohran, M.A.; Megalla, S.E.; Said, M.R. Effect of aflatoxin B-1 on the proteolytic activity of some lactic-acid bacteria. Mycopathologia 1984, 86, 99-101.
128. Sutic, M.; Banina, A. Influence of aflatoxin B1 on gas production by lactic acid bacteria. J. Environ. Pathol. Toxicol. Oncol. 1990, 10, 149-153.