Enhancing the mechanical stability of proteins through a cocktail approach

Biophysical Journal

Volumn 100, Issue 7, 2011, Pages 1794-1799

  Cao, Yi ^a,b   Li, Yongnan Devin ^a   Li, Hongbin ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79959673671     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2011.02.030     Document Type: Article

References (27)

1. Tatham, A. S., and P. R. Shewry. 2000. Elastomeric proteins: biological roles, structures and mechanisms. Trends Biochem. Sci. 25:567-571.
2. Li, H., and Y. Cao. 2010. Protein mechanics: from single molecules to functional biomaterials. Acc. Chem. Res. 43:1331-1341.
3. Sharma, D., O. Perisic,..., H. Li. 2007. Single-molecule force spectroscopy reveals a mechanically stable protein fold and the rational tuning of its mechanical stability. Proc. Natl. Acad. Sci. USA. 104:9278-9283. (Pubitemid 47185770)
4. Ng, S. P., K. S. Billings,..., J. Clarke. 2007. Designing an extracellular matrix protein with enhanced mechanical stability. Proc. Natl. Acad. Sci. USA. 104:9633-9637. (Pubitemid 47175318)
5. Sadler, D. P., E. Petrik,..., D. J. Brockwell. 2009. Identification of a mechanical rheostat in the hydrophobic core of protein L. J. Mol. Biol. 393:237-248.
6. Borgia, A., A. Steward, and J. Clarke. 2008. An effective strategy for the design of proteins with enhanced mechanical stability. Angew. Chem. Int. Ed. Engl. 47:6900-6903.
7. Sharma, D., Y. Cao, and H. Li. 2006. Engineering proteins with novel mechanical properties by recombination of protein fragments. Angew. Chem. Int. Ed. Engl. 45:5633-5638. (Pubitemid 44366765)
8. Ainavarapu, S. R., L. Li,..., J. M. Fernandez. 2005. Ligand binding modulates the mechanical stability of dihydrofolate reductase. Biophys. J. 89:3337-3344. (Pubitemid 41636089)
9. Bertz, M., and M. Rief. 2008. Mechanical unfoldons as building blocks of maltose-βinding protein. J. Mol. Biol. 378:447-458.
10. Cao, Y., M. M. Balamurali,..., H. Li. 2007. A functional single-molecule binding assay via force spectroscopy. Proc. Natl. Acad. Sci. USA. 104:15677-15681. (Pubitemid 350035359)
11. Cao, Y., T. Yoo,..., H. Li. 2008. Protein-protein interaction regulates proteins' mechanical stability. J. Mol. Biol. 378:1132-1141.
12. Cao, Y., T. Yoo, and H. Li. 2008. Single molecule force spectroscopy reveals engineered metal chelation is a general approach to enhance mechanical stability of proteins. Proc. Natl. Acad. Sci. USA. 105:11152-11157.
13. Zhuang, S., Q. Peng,..., H. Li. 2009. Modulating the mechanical stability of extracellular matrix protein tenascin-C in a controlled and reversible fashion. J. Mol. Biol. 390:820-829.
14. Arnold, F. H., and J. H. Zhang. 1994. metal-mediated protein stabilization. Trends Biotechnol. 12:189-192. (Pubitemid 24160426)
15. Eijsink, V. G., A. Bjørk,..., G. Vriend. 2004. Rational engineering of enzyme stability. J. Biotechnol. 113:105-120. (Pubitemid 39237074)
16. van den Burg, B., and V. G. Eijsink. 2002. Selection of mutations for increased protein stability. Curr. Opin. Biotechnol. 13:333-337. (Pubitemid 35254091)
17. Zhou, H., Z. Tong, and J. F. McLeod. 2004. "Cocktail" approaches and strategies in drug development: valuable tool or flawed science? J. Clin. Pharmacol. 44:120-134. (Pubitemid 38114310)
18. Cao, Y., and H. Li. 2007. Polyprotein of GB1 is an ideal artificial elastomeric protein. Nat. Mater. 6:109-114. (Pubitemid 46197646)
19. Kato, K., L. Y. Lian,..., G. C. K. Roberts. 1995. Model for the complex between protein G and an antibody Fc fragment in solution. Structure. 3:79-85.
20. Minor, Jr., D. L., and P. S. Kim. 1994. Measurement of the βsheetforming propensities of amino acids. Nature. 367:660-663.
21. Klimov, D. K., and D. Thirumalai. 2000. Native topology determines force-induced unfolding pathways in globular proteins. Proc. Natl. Acad. Sci. USA. 97:7254-7259. (Pubitemid 30431450)
22. Li, P. C., and D. E. Makarov. 2004. Ubiquitin-like protein domains show high resistance to mechanical unfolding similar to that of the 127 domain in titin: evidence from simulations. J. Phys. Chem. B. 108:745-749.
23. Sułkowska, J. I., and M. Cieplak. 2008. Mechanical stretching of proteins-a theoretical survey of the Protein Data Bank. J. Phys. Condens. Matter. 19:1-60.
24. Valbuena, A., J. Oroz,..., M. Carrión-Vázquez. 2009. On the remarkable mechanostability of scaffoldins and the mechanical clamp motif. Proc. Natl. Acad. Sci. USA. 106:13791-13796.
25. Bertz, M., M. Wilmanns, and M. Rief. 2009. The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk. Proc. Natl. Acad. Sci. USA. 106:13307-13310.
26. Grandbois, M., M. Beyer,..., H. E. Gaub. 1999. How strong is a covalent bond? Science. 283:1727-1730. (Pubitemid 129502058)
27. Alam, M. T., T. Yamada,..., A. Ikai. 2002. The importance of being knotted: effects of the C-terminal knot structure on enzymatic and mechanical properties of bovine carbonic anhydrase II. FEBS Lett. 519:35-40. (Pubitemid 34521988)