Proof of concept: Pharmacological preconditioning with a Toll-like receptor agonist protects against cerebrovascular injury in a primate model of stroke

Journal of Cerebral Blood Flow and Metabolism

Volumn 31, Issue 5, 2011, Pages 1229-1242

  Bahjat, Frances Rena ^a   Williams Karnesky, Rebecca L ^a   Kohama, Steven G ^b   West, G Alexander ^c   Doyle, Kristian P ^d   Spector, Maxwell D ^a   Hobbs, Theodore R ^b   Stenzel Poore, Mary P ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c SWEDISH MEDICAL CENTER   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CpG ODN; ischemia; neuroprotection; nonhuman primate; stroke; Toll like receptors

Indexed keywords

C REACTIVE PROTEIN; CYTOSINE GUANINE RICH DNA OLIGONUCLEOTIDE; INTERLEUKIN 6; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; CPG ODN 1826; DNA; OLIGODEOXYRIBONUCLEOTIDE; TOLL LIKE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN FUNCTION; BRAIN INFARCTION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DRUG MEGADOSE; LOW DRUG DOSE; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIMATE; PRIORITY JOURNAL; SINGLE DRUG DOSE; STROKE; ANIMAL; C57BL MOUSE; CONVALESCENCE; DISEASE MODEL; DRUG EFFECT; DRUG POTENTIATION; ISCHEMIC PRECONDITIONING; MACACA MULATTA; METHODOLOGY; PATHOLOGY;

ANIMALS; DISEASE MODELS, ANIMAL; DNA; ISCHEMIC PRECONDITIONING; MACACA MULATTA; MALE; MICE; MICE, INBRED C57BL; OLIGODEOXYRIBONUCLEOTIDES; RECOVERY OF FUNCTION; STROKE; TOLL-LIKE RECEPTORS;

EID: 79959602981     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2011.6     Document Type: Article

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