Effects of tirilazad mesylate on vasospasm and phospholipid hydroperoxides in a primate model of subarachnoid hemorrhage

Stroke

Volumn 30, Issue 2, 1999, Pages 450-456

  Suzuki, Hidenori ^a   Kanamaru, Kenji ^a   Kuroki, Minoru ^a   Sun, Hong ^a   Waga, Shiro ^a   Miyazawa, Teruo ^b  

^a MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Cerebral ischemia; Lipid peroxidation; Monkeys; Phospholipids; Subarachnoid hemorrhage; Transient

Indexed keywords

LIPID HYDROPEROXIDE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PLACEBO; TIRILAZAD;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN VASOSPASM; CONTROLLED STUDY; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; LIPID PEROXIDATION; MACACA; MALE; NONHUMAN; PRIORITY JOURNAL; SUBARACHNOID HEMORRHAGE;

EID: 0032955165     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.30.2.450     Document Type: Article

References (48)

1. Kanamaru K, Weir BKA, Findlay JM, Grace M, Macdonald RL. A dosage study of the effect of the 21-aminosteroid U-74006F on chronic cerebral vasospasm in a primate model. Neurosurgery, 1990;27:29-38.
2. Kanamaru K, Weir BKA, Simpson I, Witbeck T, Grace M. Effect of 21-aminosteroid U-74006F on lipid peroxidation in subarachnoid clot. J Neurosurg. 1991;74:454-459.
3. Matsui T, Asano T. Effects of new 21-aminosteroid tirilazad mesylate (U74006F) on chronic cerebral vasospasm in a "two-hemorrhage" model of beagle dogs. Neurosurgery. 1994;34:1035-1039.
4. Steinke DE, Weir BKA, Findlay JM, Tanabe T, Grace M, Krushelnycky BW. A trial of the 21-aminosteroid U74006F in a primate model of chronic cerebral vasospasm. Neurosurgery. 1989;24:179-186.
5. Vollmer DG, Kassell NF, Hongo K, Ogawa H, Tsukahara T. Effect of the non-glucocorticoid U74006F in experimental cerebral vasospasm. Surg Neurol. 1989;31:190-194.
6. Zuccarello M, Anderson DK. Protective effect of a 21-aminosteroid on the blood-brain barrier following subarachnoid hemorrhage in rats. Stroke. 1989;20:367-371.
7. Zuccarello M, Marsch JT, Schmitt G, Woodward J, Anderson DK. Effect of the 21-aminosteroid U-74006F on cerebral vasospasm following subarachnoid hemorrhage. J Neurosurg. 1989;71:98-104.
8. Macdonald RL, Bassiouny M, Johns L, Sajdak M, Marton LS, Weir BK, Hall ED, Andrus PK. U74389G prevents vasospasm after subarachnoid hemorrhage in dogs. Neurosurgery. 1998;42:1339-1346.
9. Haley EC, Kassell NF, Alves WM, Weir BKA, Apperson-Hansen C. Phase II trial of tirilazad in aneurysmal subarachnoid hemorrhage. J Neurosurg. 1995;82:786-790.
10. Kassell NF, Haley EC, Apperson-Hansen C, Alves WM. Randomized, double-blind, vehicle-controlled trial of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage: a cooperative study in Europe, Australia, and New Zealand. J Neurosurg. 1996;84:221-228.
11. Haley EC, Kassell NF, Apperson-Hansen C, Maile MH, Alves WM. A randomized, double-blind, vehicle-controlled trial of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage: a cooperative study in North America. J Neurosurg. 1997;86:467-474.
12. Hall ED, McCall JM, Means ED. Therapeutic potential of the lazaroids (21-aminosteroids) in CNS trauma, ischemia and subarachnoid hemorrhage. Adv Pharmacol. 1994;28:221-268.
13. Miyazawa T, Suzuki T, Fujimoto K, Kaneda T. Phospholipid hydroperoxide accumulation in liver of rats intoxicated with carbon tetrachloride and its inhibition by dietary α-tocopherol. J Biochem. 1990; 107:689-693.
14. Miyazawa T, Yasuda K, Fujimoto K. Chemiluminescence-high performance liquid chromatography of phosphatidylcholine hydroperoxide. Anal Lett. 1987;20:915-925.
15. Miyazawa T, Suzuki T, Fujimoto K, Yasuda K. Chemiluminescent simultaneous determination of phosphatidylcholine hydroperoxide and phosphatidylethanolamine hydroperoxide in the liver and brain of the rat. J Lipid Res. 1992;33:1051-1058.
16. Farrar JK. Hydrogen clearance technique. In: Wood JM, ed. Cerebral Blood Flow. New York, NY: McGraw-Hill Publishing Co; 1987: 275-287.
17. Pasztor E, Symon L, Dorsch NWC, Branston NM. The hydrogen clearance method in assessment of blood flow in cortex, white matter and deep nuclei of baboons. Stroke. 1973;4:556-567.
18. 2 clearance. J Cereb Blood Flow Metab. 1992;12:230-237.
19. Miyazawa T, Suzuki T, Fujimoto K, Yasuda K. Determination of phospholipid hydroperoxides using luminol chemiluminescence-high-performance liquid chromatography. Methods Enzymol. 1994;233:324-332.
20. Bartlett GR. Phosphorus assay in column chromatography. J Biol Chem. 1959;234:466-468.
21. Gaetani P, Marzatico F, Rodriguez y Baena R, Pacchiarini L, Viganò T, Grignani G, Crivellari MT, Benzi G. Arachidonic acid metabolism and pathophysiologic aspects of subarachnoid hemorrhage in rats. Stroke. 1990;21:328-332.
22. Villa RF, Gorini A. Pharmacology of lazaroids and brain energy metabolism: a review. Pharmacol Rev. 1997;49:99-136.
23. Chehrazi BB, Giri S, Joy RM. Prostaglandins and vasoactive amines in cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Stroke. 1989;20:217-224.
24. Sakaki S, Kuwabara H, Ohta S. Biological defense mechanism in the pathogenesis of prolonged vasospasm in the patients with ruptured intracranial aneurysm. Stroke. 1986;17:196-202.
25. Sakaki S, Ohta S, Nakamura H, Takeda S. Free radical reaction and biological defense mechanism in the pathogenesis in experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab. 1988;8:1-8.
26. Nakao K, Murata H, Kanamaru K, Waga S. Effects of nitroglycerin on vasospasm and cyclic nucleotides in a primate model of subarachnoid hemorrhage. Stroke. 1996;27:1882-1888.
27. Handa Y, Hayashi M, Takeuchi H, Kubota T, Kobayashi H, Kawano H. Time course of the impairment of cerebral autoregulation during chronic cerebral vasospasm after subarachnoid hemorrhage in primates. J Neurosurg. 1992;76:493-501.
28. Yoshino H, Hattori N, Urabe T, Uchida K, Tanaka M, Mizuno Y. Postischemic accumulation of lipid peroxidation products in the rat brain: immunohistochemical detection of 4-hydroxy-2-nonenal modified protein. Brain Res. 1997;767:81-86.
29. Takuwa Y, Matsui T, Abe Y, Nagafuji T, Yamashita K, Asano T. Alterations in protein kinase C activity and membrane lipid metabolism in cerebral vasospasm after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 1993;13:409-415.
30. Itabe H, Kobayashi T, Inoue K. Generation of toxic phospholipid(s) during oxyhemoglobin-induced peroxidation of phosphatidylcholines. Biochim Biophys Acta. 1988;961:13-21.
31. Eizawa H, Yui Y, Inoue R, Kosuga K, Hattori R, Aoyama T, Sasayama S. Lysophosphatidylcholine inhibits endothelium-dependent hyperpolarization and N-nitro-L-arginine/indomethacin resistant endothelium-dependent relaxation in the porcine coronary artery. Circulation. 1995; 92:3520-3526.
32. Yokoyama M, Hirata K, Miyake R, Akita H, Ishikawa Y, Fukazaki H. Lysophosphatidylcholine: essential role in the inhibition of endothelium-dependent vasorelaxation by oxidized low density lipoprotein. Biochem Biophys Res Commun. 1990;168:301-308.
33. Fujiwara S, Kassell NF, Sasaki T, Nakagomi T, Lehman RM. Selective hemoglobin inhibition of endothelium-dependent vasodilation of rabbit basilar artery. J Neurosurg. 1986;64:445-452.
34. Kanamaru K, Waga S, Kojima T, Fujimoto K, Niwa S. Endothelium-dependent relaxation of canine basilar artery, part 2: inhibition by hemoglobin and cerebrospinal fluid from patients with subarachnoid hemorrhage. Stroke. 1987;18:938-943.
35. Kanamaru K, Weir BKA, Findlay JM, Krueger CA, Cook DA. Pharmacological studies on relaxation of spastic primate cerebral arteries in subarachnoid hemorrhage. J Neurosurg. 1989;71:909-915.
36. Kim P, Sundt TM, Vanhoutte PM. Alterations in endothelium-dependent responsiveness of the canine basilar artery after subarachnoid hemorrhage. J Neurosurg. 1988;69:239-246.
37. Kim P, Lorenz RR, Sundt TM, Vanhoutte PM. Release of endothelium-derived relaxing factor after subarachnoid hemorrhage. J Neurosurg. 1989;70:108-114.
38. Oishi K, Raynor RL, Charp PA, Kuo JF. Regulation of protein kinase C by lysophospholipids: potential role in signal transduction. J Biol Chem. 1988;263:6865-6871.
39. Asano T, Matsui T, Takuwa Y. Lipid peroxidation, protein kinase C, and cerebral vasospasm. Crit Rev Neurosurg. 1991;1:361-379.
40. Matsui T, Takuwa Y, Johshita H, Yamashita K, Asano T. Possible role of protein kinase C-dependent smooth muscle contraction in the pathogenesis of chronic cerebral vasospasm. J Cereb Blood Flow Metab. 1991;11:143-149.
41. Nishizawa S, Nezu N, Uemura K. Direct evidence for a key role of protein kinase C in the development of vasospasm after subarachnoid hemorrhage. J Neurosurg. 1992;76:635-639.
42. Sako M, Nishihara J, Ohta S, Wang J, Sakaki S. Role of protein kinase C in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage. J Cereb Blood Flow Metb. 1993;13:247-254.
43. Nakashima T, Takenaka K, Nishimura Y, Andoh T, Sakai N, Yamada H, Banno Y, Okano Y, Nozawa Y. Phospholipase C activity in cerebrospinal fluid following subarachnoid hemorrhage related to brain damage. J Cereb Blood Flow Metab. 1993;13:255-259.
44. Schinitti ML, Sbarbati R, Scarlettini M. Superoxide production by human umbilical vein endothelial cells in an anoxia re-oxygenation model. Cardiovasc Res. 1989;23:76-80.
45. Terada LS, Willigham IR, Rosandich ME, Leff JA, Kindt GW, Repine JE. Generation of Superoxide anion by brain endothelial cell xanthine oxidase. J Cell Physiol. 1991;148:191-196.
46. Kinnula VL, Whorton AR, Chang LY, Crapo JD. Regulation of hydrogen peroxide generation in cultured endothelial cells. Am J Respir Dis. 1992; 6:175-182.
47. Audus KL, Guillot FL, Braughler JM. Evidence for 21-aminosteroid association with the hydrophobic domains of brain microvessel endothelial cells. Free Radie Biol Med. 1991;11:361-371.
48. Bracken MB, Shepard MJ, Holford TR, Leo-Summers L, Aldrich EF, Fazl M, Fehlings M, Herr DL, Hitchon PW, Marshall LF, Nockels RP, Pascale V, Perot PL, Piepmeier J, Sonntag VKH, Wagner F, Wilberger JE, Winn HR. Young W. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. JAMA. 1997;277:1597-1604.