Engineered heart tissue model of diabetic myocardium

Tissue Engineering - Part A

Volumn 17, Issue 13-14, 2011, Pages 1869-1878

  Song, Hannah ^a   Zandstra, Peter W ^a,b,c,d   Radisic, Milica ^a,b,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d HEART AND STROKE FOUNDATION OF CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG THERAPY; ELECTRIC PROPERTIES; GENE EXPRESSION; GLUCOSE; PEDIATRICS; RATS; TEST FACILITIES; TISSUE;

ANTI-APOPTOTIC EFFECTS; CARDIOMYOCYTES; CELL INTEGRATION; COLLAGEN SCAFFOLDS; DIABETIC CARDIOMYOPATHY; DIABETIC MYOCARDIUM; DRUG SCREENING; GENE EXPRESSION PROFILES; HEART FAILURE; HEART TISSUES; IN-VITRO; IRREVERSIBLE LOSS; ISOFORMS; MODEL SYSTEM; MOLECULAR ASPECTS; MYOCARDIAL INFARCTION; NEONATAL RAT; RAT HEART; TEST CELL; THIAZOLIDINEDIONES; UNDERLYING MECHANISM;

HEART;

RATTUS;

BIOLOGICAL MARKER; GLUCOSE; INSULIN;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CELL COUNT; CELL SURVIVAL; DRUG EFFECT; ELECTROPHYSIOLOGY; EXPERIMENTAL DIABETES MELLITUS; GENE EXPRESSION PROFILING; HEART MUSCLE; HEART MUSCLE CELL; METABOLISM; METHODOLOGY; PATHOLOGY; PATHOPHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; TISSUE ENGINEERING;

ANIMALS; BIOLOGICAL MARKERS; CELL COUNT; CELL SURVIVAL; DIABETES MELLITUS, EXPERIMENTAL; ELECTROPHYSIOLOGICAL PHENOMENA; GENE EXPRESSION PROFILING; GLUCOSE; INSULIN; MODELS, BIOLOGICAL; MYOCARDIUM; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY; TISSUE ENGINEERING;

EID: 79959558716     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2010.0617     Document Type: Article

References (47)

1. Federation ID. Prevalence estimates of diabetes mellitus (DM), 2010. Available at wwwdiabetesatlasorg/content/prevalence-estimates-diabetes-mellitus- dm-2010. Accessed April 2011.
2. Poornima, I. G., Parikh, P., and Shannon, R. P. Diabetic cardiomyopathy: the search for a unifying hypothesis. Circ Res 98, 596, 2006.
3. Rajabi, M., Kassiotis, C., Razeghi, P., and Taegtmeyer, H. Return to the fetal gene program protects the stressed heart: a strong hypothesis. Heart Fail Rev 12, 331, 2007.
4. Radisic, M., Park, H., Gerecht, S., Cannizzaro, C., Langer R., and Vunjak-Novakovic, G. Biomimetic approach to cardiac tissue engineering. Philos Trans R Soc Lond B Biol Sci 362, 1357, 2007.
5. Radisic, M., Park, H., Shing, H., Consi, T., Schoen, F. J., Langer, R., et al. Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds. Proc Natl Acad Sci U S A 101, 18129, 2004.
6. Song, H., Yoon, C., Kattman, S. J., Dengler, J., Masse, S., Thavaratnam, T., et al. Interrogating functional integration between injected pluripotent stem cell-derived cells and surrogate cardiac tissue. Proc Natl Acad Sci U S A 107, 3329, 2010.
7. Au, H. T., Cheng, I., Chowdhury, M. F., and Radisic, M. Interactive effects of surface topography and pulsatile electrical field stimulation on orientation and elongation of fibroblasts and cardiomyocytes. Biomaterials 28, 4277, 2007.
8. Chiu, L. L., Iyer, R. K., King, J. P., and Radisic, M. Biphasic electrical field stimulation aids in tissue engineering of multicell-type cardiac organoids. Tissue Eng Part A 2008 [Epub ahead of print]; DOI: 10.1089/ten. tea.2007.0244.
9. Dengler, J., Song, H., Thavandiran, N., Masse, S., Wood, G. A., Nanthakumar, K., et al. Engineered heart tissue enables study of residual undifferentiated embryonic stem cell activity in a cardiac environment. Biotechnol Bioeng 108, 704, 2011.
10. Song, H., Yoon, C., Kattman, S. J., Dengler, J., Masse, S., Thavaratnam, T., et al. Interrogating functional integration between injected pluripotent stem cell-derived cells and surrogate cardiac tissue. Proc Natl Acad Sci U S A 107, 3329, 2010.
11. Radisic, M., Yang, L., Boublik, J., Cohen, R. J., Langer, R., Freed, L. E., et al. Medium perfusion enables engineering of compact and contractile cardiac tissue. Am J Physiol Heart Circ Physiol 286, H507, 2004.
12. Brown, M. A., Iyer, R. K., and Radisic, M. Pulsatile perfusion bioreactor for cardiac tissue engineering. Biotechnol Prog 24, 907, 2008.
13. Tofovic, S. P., Kusaka, H., Kost, C. K., Jr., and Bastacky, S. Renal function and structure in diabetic, hypertensive, obese ZDFxSHHF-hybrid rats. Ren Fail 22, 387, 2000.
14. Mehrhof, F. B., Muller, F. U., Bergmann, M. W., Li, P., Wang, Y., Schmitz, W., et al. In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH- kinase-dependent and mitogenactivated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein. Circulation 104, 2088, 2001.
15. Boudina, S., and Abel, E. Diabetic cardiomyopathy revisited. Circulation 115, 3213, 2007.
16. Penpargkul, S., Schaible, T., Yipintsoi, T., and Scheuer, J. The effect of diabetes on performance and metabolism of rat hearts. Circ Res 47, 911, 1980.
17. Kajstura, J., Fiordaliso, F., Andreoli, A. M., Li, B., Chimenti, S., Medow, M. S., et al. IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress. Diabetes 50, 1414, 2001.
18. Fredersdorf, S., Thumann, C., Ulucan, C., Griese, D. P., Luchner, A., Riegger, G. A., et al. Myocardial hypertrophy and enhanced left ventricular contractility in Zucker diabetic fatty rats. Cardiovasc Pathol 13, 11, 2004.
19. Greer, J. J., Ware, D. P., and Lefer, D. J. Myocardial infarction and heart failure in the db/db diabetic mouse. Am J Physiol Heart Circ Physiol 290, H146, 2006.
20. Sekine, H., Shimizu, T., Hobo, K., Sekiya, S., Yang, J., Yamato, M., et al. Endothelial cell coculture within tissueengineered cardiomyocyte sheets enhances neovascularization and improves cardiac function of ischemic hearts. Circulation 118, S145, 2008.
21. Vantler, M., Karikkineth, B. C., Naito, H., Tiburcy, M., Didie, M., Nose, M., et al. PDGF-BB protects cardiomyocytes from apoptosis and improves contractile function of engineered heart tissue. J Mol Cell Cardiol 48, 1316, 2010.
22. Radisic, M., Park, H., Shing, H., Consi, T., Schoen, F. J., Langer, R., et al. Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds. Proc Natl Acad Sci U S A 101, 18129, 2004.
23. Dengler, J., Song, H., Thavandiran, N., Masse, S., Wood, G. A., Nanthakumar, K., et al. Engineered heart tissue enables study of residual undifferentiated embryonic stem cell activity in a cardiac environment. Biotechnol Bioeng 108, 704, 2011.
24. McNally, E. M., Kraft, R., Bravo-Zehnder, M., Taylor, D. A., and Leinwand, L. A. Full-length rat alpha and beta cardiac myosin heavy chain sequences. 1. J Mol Biol 210, 665, 1989.
25. Krenz, M., and Robbins, J. Impact of beta-myosin heavy chain expression on cardiac function during stress. J Am Coll Cardiol 44, 2390, 2004.
26. Hoyer, K., Krenz, M., Robbins, J., and Ingwall, J. S. Shifts in the myosin heavy chain isozymes in the mouse heart result in increased energy efficiency. J Mol Cell Cardiol 42, 214, 2007.
27. Shao, C. H., Rozanski, G. J., Nagai, R., Stockdale, F. E., Patel, K. P., Wang, M., et al. Carbonylation of myosin heavy chains in rat heart during diabetes. Biochem Pharmacol 80, 205, 2010.
28. Hang, C. T., Yang, J., Han, P., Cheng, H. L., Shang, C., Ashley, E., et al. Chromatin regulation by Brg1 underlies heart muscle development and disease. Nature 466, 62, 2010.
29. Tardiff, J. C., Hewett, T. E., Factor, S. M., Vikstrom, K. L., Robbins, J., and Leinwand, L. A. Expression of the beta (slow)-isoform of MHC in the adult mouse heart causes dominant-negative functional effects. Am J Physiol Heart Circ Physiol 278, H412, 2000.
30. Krenz, M., Sanbe, A., Bouyer-Dalloz, F., Gulick, J., Klevitsky, R., Hewett, T. E., et al. Analysis of myosin heavy chain functionality in the heart. J Biol Chem 278, 17466, 2003.
31. Feng, B., Chen, S., George, B., Feng, Q., and Chakrabarti, S. miR133a regulates cardiomyocyte hypertrophy in diabetes. Diabetes Metab Res Rev 26, 40, 2010.
32. Wu, C. F., Bishopric, N. H., and Pratt, R. E. Atrial natriuretic peptide induces apoptosis in neonatal rat cardiac myocytes. J Biol Chem 272, 14860, 1997.
33. Horio, T., Nishikimi, T., Yoshihara, F., Matsuo, H., Takishita, S., and Kangawa, K. Inhibitory regulation of hypertrophy by endogenous atrial natriuretic peptide in cultured cardiac myocytes. Hypertension 35, 19, 2000.
34. Wang, Q., Reiter, R. S., Huang, Q. Q., Jin, J. P., and Lin, J. J. Comparative studies on the expression patterns of three troponin T genes during mouse development. Anat Rec 263, 72, 2001.
35. Hershberger, R. E., Norton, N., Morales, A., Li, D., Siegfried, J. D., and Gonzalez-Quintana, J. Coding sequence rare variants identified in MYBPC3, MYH6, TPM1, TNNC1, and TNNI3 from 312 patients with familial or idiopathic dilated cardiomyopathy. Circ Cardiovasc Genet 3, 155, 2010.
36. Toker, A., and Cantley, L. C. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387, 673, 1997.
37. McMullen, J. R., Shioi, T., Huang, W. Y., Zhang, L., Tarnavski, O., Bisping, E., et al. The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase (p110alpha) pathway. J Biol Chem 279, 4782, 2004.
38. McMullen, J. R., Shioi, T., Zhang, L., Tarnavski, O., Sherwood, M. C., Kang, P. M., et al. Phosphoinositide 3-kinase (p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy. Proc Natl Acad Sci U S A 100, 12355, 2003.
39. Lebeche, D., Davidoff, A. J., and Hajjar, R. J. Interplay between impaired calcium regulation and insulin signaling abnormalities in diabetic cardiomyopathy. Nat Clin Pract Cardiovasc Med 5, 715, 2008.
40. Nygren, A., Olson, M. L., Chen, K. Y., Emmett, T., Kargacin, G., and Shimoni, Y. Propagation of the cardiac impulse in the diabetic rat heart: reduced conduction reserve. J Physiol 580, 543, 2007.
41. Kim, B. O., Verma, S., Weisel, R. D., Fazel, S., Jia, Z. Q., Mizuno, T., et al. Preservation of heart function in diabetic rats by the combined effects of muscle cell implantation and insulin therapy. Eur J Heart Fail 10, 14, 2008.
42. Doshi, L. S., Brahma, M. K., Bahirat, U. A., Dixit, A. V., and Nemmani, K. V. Discovery and development of selective PPAR gamma modulators as safe and effective antidiabetic agents. Expert Opin Investig Drugs 19, 489, 2010.
43. Baraka, A., and AbdelGawad, H. Targeting apoptosis in the heart of streptozotocin-induced diabetic rats. J Cardiovasc Pharmacol Ther 15, 175, 2010.
44. Ahren, B. Insulin secretion and insulin sensitivity in relation to fasting glucose in healthy subjects. Diabetes Care 30, 644, 2007.
45. Pfeifer, M. A., Halter, J. B., and Porte, D., Jr. Insulin secretion in diabetes mellitus. Am J Med 70, 579, 1981.
46. Aybar, M. J., Sanchez Riera, A. N., Grau, A., and Sanchez, S. S. Hypoglycemic effect of the water extract of Smallantus sonchifolius (yacon) leaves in normal and diabetic rats. J Ethnopharmacol 74, 125, 2001.
47. Tofovic, S. P., Kusaka, H., Jackson, E. K., and Bastacky, S. I. Renal and metabolic effects of caffeine in obese (fa/fa (cp)), diabetic, hypertensive ZSF1 rats. Ren Fail 23, 159, 2001.