Overexpression of microRNA-16-2 contributes to the abnormal erythropoiesis in polycythemia vera

Blood

Volumn 117, Issue 25, 2011, Pages 6923-6927

  Guglielmelli, Paola ^a   Tozzi, Lorenzo ^a   Bogani, Costanza ^a   Iacobucci, Ilaria ^b   Ponziani, Vanessa ^a   Martinelli, Giovanni ^b   Bosi, Alberto ^a   Vannucchi, Alessandro M ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; ERYTHROPOIETIN; JANUS KINASE 2; MICRORNA; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL MATURATION; CELL PROLIFERATION; CHROMOSOME 13; CHROMOSOME 3; CONTROLLED STUDY; DYSERYTHROPOIESIS; ERYTHROID CELL; GENE LOCUS; GENE OVEREXPRESSION; GENE SILENCING; MOUSE; NONHUMAN; POLYCYTHEMIA VERA; PRIORITY JOURNAL; REGULATORY MECHANISM;

EID: 79959531320     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-09-306506     Document Type: Article

References (25)

1. Ambros V. The functions of animal microRNAs. Nature. 2004;431(7006):350- 355. (Pubitemid 39265675)
2. Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2002;99(24):15524-15529. (Pubitemid 35403967)
3. Lujambio A, Calin GA, Villanueva A, et al. A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci U S A. 2008;105(36):13556-13561.
4. Esquela-Kerscher A, Slack FJ. Oncomirs: microRNAs with a role in cancer. Nat Rev Cancer. 2006;6(4):259-269.
5. Hammond SM. MicroRNAs as tumor suppressors. Nat Genet. 2007;39(5):582-583. (Pubitemid 46676097)
6. Cimmino A, Calin GA, Fabbri M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A. 2005;102(39):13944-13949. (Pubitemid 41377683)
7. Vannucchi AM, Guglielmelli P, Tefferi A. Advances in understanding and management of myeloproliferative neoplasms. CA Cancer J Clin. 2009;59:171-191.
8. Vannucchi AM, Antonioli E, Guglielmelli P, Pardanani A, Tefferi A. Clinical correlates of JAK2V617F presence or allele burden in myeloproliferative neoplasms: a critical reappraisal. Leukemia. 2008;22(7):1299-1307.
9. Jamieson CH, Gotlib J, Durocher JA, et al. The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation. Proc Natl Acad Sci U S A. 2006;103(16):6224-6229.
10. Chen CZ, Li L, Lodish HF, Bartel DP. MicroRNAs modulate hematopoietic lineage differentiation. Science. 2004;303(5654):83-86. (Pubitemid 38055775)
11. Garzon R, Croce CM. MicroRNAs in normal and malignant hematopoiesis. Curr Opin Hematol. 2008;15(4):352-358.
12. Choong ML, Yang HH, McNiece I. MicroRNA expression profiling during human cord blood-derived CD34 cell erythropoiesis. Exp Hematol. 2007;35(4):551-564. (Pubitemid 46427958)
13. Felli N, Fontana L, Pelosi E, et al. MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation. Proc Natl Acad Sci U S A. 2005;102(50):18081-18086. (Pubitemid 41798505)
14. Lu J, Guo S, Ebert BL, et al. MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Dev Cell. 2008;14(6):843-853. (Pubitemid 351757199)
15. Dore LC, Amigo JD, Dos Santos CO, et al. A GATA-1-regulated microRNA locus essential for erythropoiesis. Proc Natl Acad Sci U S A. 2008;105(9):3333-3338. (Pubitemid 351723553)
16. Bruchova H, Merkerova M, Prchal JT. Aberrant expression of microRNA in polycythemia vera. Haematologica. 2008;93(7):1009-1016. (Pubitemid 351957018)
17. Bruchova H, Yoon D, Agarwal AM, Mendell J, Prchal JT. Regulated expression of microRNAs in normal and polycythemia vera erythropoiesis. Exp Hematol. 2007;35(11):1657-1667. (Pubitemid 47633777)
18. Tefferi A, Thiele J, Orazi A, et al. Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel. Blood. 2007;110(4):1092-1097.
19. Corcoran DL, Pandit KV, Gordon B, Bhattacharjee A, Kaminski N, Benos PV. Features of mammalian microRNA promoters emerge from polymerase II chromatin immunoprecipitation data. PLoS ONE. 2009;4(4):e5279.
20. Brueckner B, Stresemann C, Kuner R, et al. The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function. Cancer Res. 2007;67(4):1419-1423. (Pubitemid 46383365)
21. Ozsolak F, Poling LL, Wang Z, et al. Chromatin structure analyses identify miRNA promoters. Genes Dev. 2008;22(22):3172-3183.
22. low mice). Blood. 2001;97(10):3040-3050.
23. Krutzfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with "antagomirs." Nature. 2005;438(7068):685-689.
24. Care A, Catalucci D, Felicetti F, et al. MicroRNA-133 controls cardiac hypertrophy. Nat Med. 2007;13(5):613-618. (Pubitemid 46828487)
25. Sankaran VG, Menne TF, Šćepanović D, et al. MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proc Natl Acad Sci U S A. 2011;108(4):1519-1524.