Distinct actions of endothelin A-selective versus combined endothelin A/B receptor antagonists in early diabetic kidney disease

Journal of Pharmacology and Experimental Therapeutics

Volumn 338, Issue 1, 2011, Pages 263-270

  Saleh, Mohamed A ^a   Pollock, Jennifer S ^a   Pollock, David M ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (BENZO[D][1,3]DIOXOL 5 YL) 2 (3 FLUORO 4 METHOXYPHENYL) 1 [2 (N PROPYLPENTYLSULFONAMIDO)ETHYL]PYRROLIDINE 3 CARBOXYLIC ACID; A 182086; ALBUMIN; ATRASENTAN; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; ENDOTHELIN B RECEPTOR ANTAGONIST; INTERCELLULAR ADHESION MOLECULE 1; MATRIX METALLOPROTEINASE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NEPHRIN; PODOCIN; PROTEIN ZO1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFIBROTIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE COURSE; DRUG ACTIVITY; DRUG EFFICACY; DRUG PREFERENCE; DRUG SELECTIVITY; ENZYME ACTIVITY; GLOMERULUS FILTRATION; HYPERGLYCEMIA; KIDNEY FUNCTION; MALE; NEPHRINURIA; NEPHRITIS; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEINURIA; RAT; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; TREATMENT DURATION; URINARY TRACT DISEASE;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; MALE; PYRROLIDINES; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; STEREOISOMERISM; SULFONAMIDES;

EID: 79959526176     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.178988     Document Type: Article

References (42)

1. Adler S (1992) Characterization of glomerular epithelial cell matrix receptors. Am J Pathol 141:571-578.
2. Benigni A and Remuzzi G (1995) Endothelin in the progressive renal disease of glomerulopathies. Miner Electrolyte Metab 21:283-291.
3. Chen HC, Chen CA, Guh JY, Chang JM, Shin SJ, and Lai YH (2000) Altering expression of α3β1 integrin on podocytes of human and rats with diabetes. Life Sci 67:2345-2353.
4. Chen S, Jim B, and Ziyadeh FN (2003) Diabetic nephropathy and transforming growth factor-β: transforming our view of glomerulosclerosis and fibrosis build-up. Semin Nephrol 23:532-543.
5. Collino F, Bussolati B, Gerbaudo E, Marozio L, Pelissetto S, Benedetto C, and Camussi G (2008) Preeclamptic sera induce nephrin shedding from podocytes through endothelin-1 release by endothelial glomerular cells. Am J Physiol Renal Physiol 294:F1185-F1194.
6. Dessapt C, Baradez MO, Hayward A, Dei Cas A, Thomas SM, Viberti G, and Gnudi L (2009) Mechanical forces and TGFβ1 reduce podocyte adhesion through α3β1 integrin downregulation. Nephrol Dial Transplant 24:2645-2655.
7. Dhaun N, Macintyre IM, Melville V, Lilitkarntakul P, Johnston NR, Goddard J, and Webb DJ (2009) Blood pressure-independent reduction in proteinuria and arterial stiffness after acute endothelin-a receptor antagonism in chronic kidney disease. Hypertension 54:113-119.
8. Dreieicher E, Beck KF, Lazaroski S, Boosen M, Tsalastra-Greul W, Beck M, Fleming I, Schaefer L, and Pfeilschifter J (2009) Nitric oxide inhibits glomerular TGF-β signaling via SMOC-1. J Am Soc Nephrol 20:1963-1974.
9. Dubey RK, Boegehold MA, Gillespie DG, and Rosselli M (1996) Increased nitric oxide activity in early renovascular hypertension. Am J Physiol Regul Integr Comp Physiol 270:R118-R124.
10. Foster JM, Carmines PK, and Pollock JS (2009) PP2B-dependent NO production in the medullary thick ascending limb during diabetes. Am J Physiol Renal Physiol 297:F471-F480.
11. Fukui M, Nakamura T, Ebihara I, Osada S, Tomino Y, Masaki T, Goto K, Furuichi Y, and Koide H (1993) Gene expression for endothelins and their receptors in glomeruli of diabetic rats. J Lab Clin Med 122:149-156.
12. B receptors in rats. Biochem Biophys Res Commun 199:1461-1465.
13. Gagliardini E, Corna D, Zoja C, Sangalli F, Carrara F, Rossi M, Conti S, Rottoli D, Longaretti L, Remuzzi A, et al. (2009) Unlike each drug alone, lisinopril if combined with avosentan promotes regression of renal lesions in experimental diabetes. Am J Physiol Renal Physiol 297:F1448-F1456.
14. Gómez-Garre D, Ruiz-Ortega M, Ortego M, Largo R, López-Armada MJ, Plaza JJ, González E, and Egido J (1996) Effects and interactions of endothelin-1 and angiotensin II on matrix protein expression and synthesis and mesangial cell growth. Hypertension 27:885-892.
15. Gross ML, El-Shakmak A, Szábó A, Koch A, Kuhlmann A, Münter K, Ritz E, and Amann K (2003) ACE-inhibitors but not endothelin receptor blockers prevent podocyte loss in early diabetic nephropathy. Diabetologia 46:856-868.
16. Heeringa P, van Goor H, Itoh-Lindstrom Y, Maeda N, Falk RJ, Assmann KJ, Kallenberg CG, and Jennette JC (2000) Lack of endothelial nitric oxide synthase aggravates murine accelerated anti-glomerular basement membrane glomerulonephritis. Am J Pathol 156:879-888.
17. Hocher B, Lun A, Priem F, Neumayer HH, and Raschack M (1998) Renal endothelin system in diabetes: comparison of angiotensin-converting enzyme inhibition and endothelin-A antagonism. J Cardiovasc Pharmacol 31:S492-S495.
18. Hocher B, Schwarz A, Reinbacher D, Jacobi J, Lun A, Priem F, Bauer C, Neumayer HH, and Raschack M (2001) Effects of endothelin receptor antagonists on the progression of diabetic nephropathy. Nephron 87:161-169.
19. Hocher B, Thöne-Reineke C, Bauer C, Raschack M, and Neumayer HH (1997) The paracrine endothelin system: pathophysiology and implications in clinical medicine. Eur J Clin Chem Clin Biochem 35:175-189.
20. Hu RM, Levin ER, Pedram A, and Frank HJ (1993) Insulin stimulates production and secretion of endothelin from bovine endothelial cells. Diabetes 42:351-358.
21. Kohan DE, Hughes AK, and Perkins SL (1992) Characterization of endothelin receptors in the inner medullary collecting duct of the rat. J Biol Chem 267:12336-12340.
22. Korhonen M, Ylänne J, Laitinen L, and Virtanen I (1990) Distribution of β1 and β3 integrins in human fetal and adult kidney. Lab Invest 62:616-625.
23. Krag S, Nyengaard JR, and Wogensen L (2007) Combined effects of moderately elevated blood glucose and locally produced TGF-β1 on glomerular morphology and renal collagen production. Nephrol Dial Transplant 22:2485-2496.
24. Nakamura T, Ebihara I, Fukui M, Tomino Y, and Koide H (1995) Effect of a specific endothelin receptor A antagonist on mRNA levels for extracellular matrix components and growth factors in diabetic glomeruli. Diabetes 44:895-899.
25. Namiki A, Hirata Y, Ishikawa M, Moroi M, Aikawa J, and Machii K (1992) Endothelin-1- and endothelin-3-induced vasorelaxation via common generation of endothelium-derived nitric oxide. Life Sci 50:677-682.
26. Petermann AT, Krofft R, Blonski M, Hiromura K, Vaughn M, Pichler R, Griffin S, Wada T, Pippin J, Durvasula R, et al. (2003) Podocytes that detach in experimental membranous nephropathy are viable. Kidney Int 64:1222-1231.
27. Pollock DM and Pollock JS (2001) Evidence for endothelin involvement in the response to high salt. Am J Physiol Renal Physiol 281:F144-F150.
28. Rosenstock J and Raskin P (1986) Early diabetic nephropathy: assessment and potential therapeutic interventions. Diabetes Care 9:529-545.
29. Saetre T, Hovig T, Røger M, Gundersen Y, and Aasen AO (2001) Hepatocellular damage in porcine endotoxemia: beneficial effects of selective versus non-selective nitric oxide synthase inhibition? Scand J Clin Lab Invest 61:503-512.
30. Saleh MA, Boesen EI, Pollock JS, Savin VJ, and Pollock DM (2010) Endothelin-1 increases glomerular permeability and inflammation independent of blood pressure in the rat. Hypertension 56:942-949.
31. Saleh MA, Boesen EI, Pollock JS, Savin VJ, and Pollock DM (2011) Endothelin receptor A-specific stimulation of glomerular inflammation and injury in a streptozotocin-induced rat model of diabetes. Diabetologia 54:979-988.
32. Sasser JM, Sullivan JC, Hobbs JL, Yamamoto T, Pollock DM, Carmines PK, and Pollock JS (2007) Endothelin A receptor blockade reduces diabetic renal injury via an anti-inflammatory mechanism. J Am Soc Nephrol 18:143-154.
33. Shankland SJ (2006) The podocyte's response to injury: role in proteinuria and glomerulosclerosis. Kidney Int 69:2131-2147.
34. Sharma K, Jin Y, Guo J, and Ziyadeh FN (1996) Neutralization of TGF-β by anti-TGF-β antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. Diabetes 45:522-530.
35. Shin SJ, Lee YJ, Lin SR, Tan MS, Lai YH, and Tsai JH (1995) Decrease of renal endothelin 1 content and gene expression in diabetic rats with moderate hyperglycemia. Nephron 70:486-493.
36. Suzuki Y, Lopez-Franco O, Gomez-Garre D, Tejera N, Gomez-Guerrero C, Sugaya T, Bernal R, Blanco J, Ortega L, and Egido J (2001) Renal tubulointerstitial damage caused by persistent proteinuria is attenuated in AT1-deficient mice: role of endothelin-1. Am J Pathol 159:1895-1904.
37. Tack I, Marin Castano E, Pêcher C, Praddaude F, Bascands JL, Bompart G, Ader JL, and Girolami JP (1997) Endothelin increases NO-dependent cGMP production in isolated glomeruli but not in mesangial cells. Am J Physiol Renal Physiol 272:F31-F39.
38. Takahashi K, Suda K, Lam HC, Ghatei MA, and Bloom SR (1991) Endothelin-like immunoreactivity in rat models of diabetes mellitus. J Endocrinol 130:123-127.
39. Wessale JL, Adler AL, Novosad EI, Calzadilla SV, Dayton BD, Marsh KC, Winn M, Jae HS, von Geldern TW, Opgenorth TJ, et al. (2002) Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: ex vivo and in vivo studies. Clin Sci (Lond) 103 (Suppl 48):112S-117S.
40. Wu Y, Wu G, Qi X, Lin H, Qian H, Shen J, and Lin S (2006) Protein kinase Cβ inhibitor LY333531 attenuates intercellular adhesion molecule-1 and monocyte chemotactic protein-1 expression in the kidney in diabetic rats. J Pharmacol Sci 101:335-343.
41. Wu-Wong JR, Dixon DB, Chiou WJ, Sorensen BK, Liu G, Jae HS, Tasker A, von Geldern TW, Winn M, and Opgenorth TJ (2002) Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: in vitro studies. Clin Sci (Lond) 103 (Suppl 48):107S-111S.
42. Yamauchi T, Ohnaka K, Takayanagi R, Umeda F, and Nawata H (1990) Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells. FEBS Lett 267:16-18.