Signal transducer and activator of transcription and the risk of rheumatoid arthritis and thyroid autoimmune disorders

Clinical and Experimental Rheumatology

Volumn 29, Issue 2, 2011, Pages 269-274

  Ben Hamad, M ^a   Cornells, F ^b   Mbarek, H ^b   Chabchoub, G ^a   Marzouk, S ^c   Bahloul, Z ^c   Rebai, A ^d   Fakhfakh, F ^a   Ayadi, H ^a   Petit Teixeira, E ^b   Maalej, Abdellatif ^a  

^a UNIVERSITY OF SFAX   (Tunisia)

^b ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^c University Hospital Hedi Choker   (Tunisia)

^d CENTRE DE BIOTECHNOLOGIE DE SFAX   (Tunisia)

Author keywords

Association study; Autoimmune thyroid diseases; Rheumatoid arthritis; STAT4 gene

Indexed keywords

CYCLIC CITRULLINATED PEPTIDE ANTIBODY; STAT4 PROTEIN; STAT4 PROTEIN, HUMAN;

ADULT; ARTICLE; AUTOIMMUNE THYROIDITIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; TUNISIA; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED;

ADULT; ARTHRITIS, RHEUMATOID; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; STAT4 TRANSCRIPTION FACTOR; THYROIDITIS, AUTOIMMUNE; TUNISIA;

EID: 79959505926     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. EDWARDS CJ, COOPER C: Early environmental factors and rheumatoid arthritis. Clin Exp Immunol 2005; 143: 1-5.
2. ANAYA JM, GOMEZ L, CASTIBLANCO J: Is there a common genetic basis for autoimmune diseases? Clin Dev Immunol 2006; 13: 185-95.
3. LEE YH, RHO YH, CHOI SJ et al.: The PTPN22 C1858T functional polymorphism and autoimmune diseases - a meta-analysis. Rheumatology (Oxford) 2007; 46: 49-56.
4. KOCHI Y, YAMADA R, SUZUKI A et al.: A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Nat Genet 2005; 37: 478-85.
5. UEDA H, HOWSON JM, ESPOSITO L et al.: Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003; 423: 506-11.
6. REMMERS EF, PLENGE RM. LEE AT et al.: STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med 2007; 357: 977-86.
7. LEE HS, REMMERS EF, LE JM, KASTNER DL, BAE SC, GREGERSEN PK: Association of STAT4 with rheumatoid arthritis in the Korean population. Mol Med 2007; 13: 455-60.
8. KORMAN BD, ALBA MI, LE JM et al.: Variant form of STAT4 is associated with primary Sjögren's syndrome. Genes Immun 2008; 9: 267-70.
9. MARTINEZ A, VARADE J, MARQUEZ A et al.: Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases. Arthritis Rheum 2008; 58: 2598-602.
10. ZERVOU MI, MAMOULAKIS D, PANIERAKIS C, BOUMPAS DT, GOULIELMOS GN: STAT4: A risk factor for type 1 diabetes? Human Immunology 2008; 69: 647-50.
11. BOWES J, BARTON A: Recent advances in the genetics of RA susceptibility. Rheumatology 2008; 47: 399-402.
12. LEVY DE, DARNELL JE, JR: Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol 2002; 3: 651-62.
13. FRUCHT DM, ARINGER M, GALON J et al.: STAT4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1-mediated inflammation. J Immunol 2000; 164: 4659-64.
14. KAPLAN MH: STAT4 Acritical regulator of inflammation in vivo. Immunol Res 2005; 32: 231-41.
15. AERTS NE, EBO DG, BRIDTS CH, STEVENS WJ, DE CLERCK LS: T cell signal transducer and activator of transcription (STAT) 4 and 6 are affected by adalimumab therapy in rheumatoid arthritis. Clin Exp Rheumatol 2010; 28: 208-14.
16. MATHUR AN, CHANG HC, ZISOULIS DG et al.: Stat3 and Stat4 direct development of IL-17-secreting Th cells. J Immunol 2007; 178: 4901-7.
17. BETTELLI E, OUKKA M, KUCHROO VKT: T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol 2007; 8: 345-50.
18. ARNETT FC, EDWORTHY SM, BLOCH DA et al.: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.
19. LATHROP GM: Estimating genotype relative risks: Tissue Antigens 1983; 22: 160-6.
20. WOOLF B: On estimating the relation between blood group and disease. Ann Hum Genet 1995; 19: 251-3.
21. DEBAKKER PI, YELENSKY R, PE'ER I, GABRIEL SB, DALY MJ, ALTSHULER D: Efficiency and power in genetic association studies. Nat Genet 2005; 37: 1217-23.
22. OROZCO G, ALIZADEH BZ, GADO-VEGA AM et al.: Association of STAT4 with rheumatoid arthritis: a replication study in three European populations. Arthritis Rheum 2008; 58: 1974-80.
23. BARTON A, THOMSON W, KE X et al.: Reevaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Hum Mol Genet 2008; 17: 2274-9.
24. ZERVOU MI, SIDIROPOULOS P, PETRAKI E et al.: Association of a TRAF1 and a STAT4 gene polymorphism with increased risk for rheumatoid arthritis in a genetically homogeneous population. Hum Immunol 2008; 69: 567-71.
25. PALOMINO-MORALES RJ, ROJAS-VILLARRAGA A, GONZALEZ CI, RAMIREZ G, ANAYA JM, MARTIN J: STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians. Genes Immun 2008; 9: 379-82.
26. KOBAYASHI S, IKARI K, KANEKO H et al.: Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population. Arthritis Rheum 2008; 58: 1940-6.
27. LEE YH, WOO JH, CHOI SJ, JI JD, SONG GG: Association between the rs7574865 polymorphism of STAT4 and rheumatoid arthritis: a meta-analysis. Rheumatol Int 2010; 30: 661-6.
28. AMOS CI, CHEN WV, LEE A et al.: High-density SNP analysis of 642 White families with rheumatoid arthritis identifies two new linkage regions on 1 lpt2 and 2q33. Genes Immun 2006; 7: 277-86.
29. DAHA NA, KURREEMAN FA, MARQUES RB et al.: Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis. Arthritis Rheum 2009; 60: 1255-60.
30. PALOMINO-MORALES R, GONZALEZ-JUANATEY C, VAZQUEZ-RODRIGUEZ TR et al.: Lack of association of PTPN22, STAT4 and TRAF1/C5 gene polymorphisms with cardiovascular risk in rheumatoid arthritis. Clin Exp Rheumatol 2010; 28: 695-701.
31. SUAREZ-GESTAL M, CALAZA M, DIEGUEZGONZALEZ R et al.: Rheumatoid Arthritis Does Not Share Most of the Newly Identified Systemic Lupus Erythematosus Genetic Factors. Arthritis Rheum 2009; 60: 2558-64.
32. JI JD, LEE WJ, KONG KA et al.: Association of STAT4 polymorphism with rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis. Mol Biol Rep 2010; 37: 141-7.
33. HAJJEJ A, KÂABI H, SELLAMI MH et al.: The contribution of HLA class I and II alleles and haplotypes to the investigation of the evolutionary history of Tunisians. Tissue Antigens 2006; 68: 153-62.
34. AYED K, AYED-JENDOUBI S, SFAR I, LABONNE MP, GEBUHRER L: HLA class-I and HLA class-II phenotypic, gene and haplotypic frequencies in Tunisians by using molecular typing data. Tissue Antigens 2004; 64: 520-32.
35. MAALEJ A, REBAI A, AYADI A, JOUIDA J, MAKNI H, AYADI H: Allelic structure and distribution of 103 STR loci in a Southern Tunisian population. J Genet 2004; 83: 65-71.