Pharmacokinetics of Extended-Release Versus Conventional Tramadol/Acetaminophen Fixed-Dose Combination Tablets: An Open-Label, 2-Treatment, Multiple-Dose, Randomized-Sequence Crossover Study in Healthy Korean Male Volunteers

Clinical Therapeutics

Volumn 33, Issue 6, 2011, Pages 728-737

  Yi, SoJeong ^a   Chung, Yong ju ^a   Kim, Tae Eun ^a   Shin, Hyun Suk ^b   Yoon, Seo Hyun ^a   Cho, Joo Youn ^a   Jang, In Jin ^a   Shin, Sang Goo ^a   Yu, Kyung Sang ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University Hospital   (South Korea)

Author keywords

Acetaminophen; Extended release formulation; Fixed dose combination; Pharmacokinetics; Tramadol

Indexed keywords

PARACETAMOL PLUS TRAMADOL; PHENACETIN;

ADULT; ANALGESIA; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIZZINESS; DRUG EXPOSURE; DYSURIA; ELECTROCARDIOGRAPHY; HEADACHE; HUMAN; HUMAN EXPERIMENT; INTERVIEW; KOREA; LABORATORY TEST; LETHARGY; LIQUID CHROMATOGRAPHY; LISTLESSNESS; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; MULTIPLE DRUG DOSE; NORMAL HUMAN; OPEN STUDY; PHASE 1 CLINICAL TRIAL; PHYSICAL EXAMINATION; RANDOMIZED CONTROLLED TRIAL; TABLET; TIME TO MAXIMUM PLASMA CONCENTRATION; VITAL SIGN;

ACETAMINOPHEN; ADULT; ANALGESICS, NON-NARCOTIC; ANALGESICS, OPIOID; AREA UNDER CURVE; CHROMATOGRAPHY, LIQUID; CROSS-OVER STUDIES; DELAYED-ACTION PREPARATIONS; DRUG COMBINATIONS; HUMANS; MALE; REPUBLIC OF KOREA; TANDEM MASS SPECTROMETRY; TRAMADOL; YOUNG ADULT;

EID: 79959436540     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2011.04.023     Document Type: Article

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