Testing for synergism over a range of fixed ratio drug combinations: Replacing the isobologram

Life Sciences

Volumn 58, Issue 2, 1995, Pages

  Tallarida, Ronald J ^a,b   Raffa, Robert B ^a,b  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

acetaminophen; drug combination; isobologram; linear regression analysis; synergy; tramadol

Indexed keywords

ACETYLCHOLINE; ANALGESIC AGENT; PARACETAMOL; TRAMADOL;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG POTENTIATION; INTRAPERITONEAL DRUG ADMINISTRATION; ISOBOLOGRAM; MATHEMATICAL MODEL; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; REGRESSION ANALYSIS; STATISTICAL ANALYSIS; TECHNIQUE; WRITHING TEST;

ACETAMINOPHEN; ANALGESICS; ANIMALS; DATA DISPLAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; MICE; MICE, INBRED STRAINS; NOCICEPTORS; PHARMACOLOGY; TRAMADOL;

ANIMALIA;

EID: 0030026024     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/0024-3205(95)02271-6     Document Type: Article

References (10)

1. A simplified method of evaluating dose-effect experiments.