Extracellular matrix-associated cytokines regulate CD4+ effector T-cell responses in the human intestinal mucosa

Mucosal Immunology

Volumn 4, Issue 4, 2011, Pages 420-427

  Huff, K R ^a   Akhtar, L N ^b   Fox, A L ^a   Cannon, J A ^c   Smith, P D ^a,d   Smythies, L E ^a  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c Kentucky   (United States)

^d BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; STAT3 PROTEIN; TRANSCRIPTION FACTOR T BET; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CD4 LYMPHOCYTE COUNT; CELL PROLIFERATION; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWN REGULATION; EFFECTOR CELL; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOMODULATION; INNATE IMMUNITY; INTESTINE MUCOSA; MUCOSAL IMMUNITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STROMA CELL; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH17 CELL;

EID: 79959431703     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2010.86     Document Type: Article

References (39)

1. Smith, P. D. et al. Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS-and IgA-mediated activities. J. Immunol. 167, 2651-2656 (2001). (Pubitemid 32768894)
2. Smythies, L. E. et al. Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity J. Clin. Invest. 115, 66-75 (2005) (Pubitemid 40385506)
3. Smythies, L. E. et al. Mucosal IL-8 and TGF-beta recruit blood monocytes: evidence for cross-talk between the lamina propria stroma and myeloid cells. J. Leukoc. Biol. 80, 492-499 (2006) (Pubitemid 44835782)
4. Smythies, L. E. et al. Inflammation anergy in human intestinal macrophages is due to Smad-induced IκBα expression and NF-?B inactivation. J. Biol. Chem. 285, 19593-19604 (2010).
5. Targan, S. R., Deem, R. L., Liu, M., Wang, S. & Nel, A. Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway J. Immunol. 154, 664-675 (1995).
6. Di Sabatino, A. et al. Blockade of transforming growth factor-ß upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa. Gut 57, 605-612 (2008) (Pubitemid 351579972)
7. Zeitz, M., Quinn, T. C., Graeff, A. S. & James, S. P. Mucosal T cells provide helper function but do not proliferate when stimulated by specific antigen in lymphogranuloma venereum proctitis in nonhuman primates. Gastroenterology 94, 353-366 (1988). (Pubitemid 18054770)
8. Sartor, R. B. Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat. Clin. Pract. Gastroenterol. Hepatol. 3, 390-407 (2006). (Pubitemid 44018812)
9. Monteleone, G., Kumberova, A., Croft, N. M., McKenzie, C., Steer, H. W. & MacDonald, T. T Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease. J. Clin. Invest. 108, 601-609 (2001). (Pubitemid 32777740)
10. Dominitzki, S. et al. Cutting edge: Trans-signaling via the soluble L-6R abrogates the induction of FoxP3 in naive CD4 + CD25-T cells. J. Immunol. 179, 2041-2045 (2007)
11. Bauge, C. et al. Interleukin-1beta impairment of transforming growth factor beta1 signaling by down-regulation of transforming growth factor beta receptor type II and up-regulation of Smad7 in human articular chondrocytes. Arthritis. Rheum. 56, 3020-3032 (2007) (Pubitemid 47502749)
12. Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T. & Akira, S. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J. Immunol. 161, 4652-4660 (1998). (Pubitemid 28492039)
13. + effector T cells. J. Immunol. 176, 7278-7287 (2006). (Pubitemid 43849028)
14. Sutton, C., Brereton, C., Keogh, B., Mills, K. H. & Lavelle, E. C. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 203, 1685-1691 (2006). (Pubitemid 44036274)
15. Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M. & Stockinger, B. TGFß in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24, 179-189 (2006) (Pubitemid 43214587)
16. Mangan, P. R. et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441, 231-234 (2006).
17. Blobe, G. C., Schiemann, W. P. & Lodish, H. F. Role of transforming growth factor ß in human disease. N. Engl. J. Med. 342, 1350-1358 (2000) (Pubitemid 30408720)
18. Mummery R. S. & Rider, C. C. Characterization of the heparin-binding properties of IL-6. J. Immunol. 165, 5671-5679 (2000)
19. Ramsden, L. & Rider, C. C. Selective and differential binding of interleukin (IL)-1 α, IL-1 ß, IL-2 and IL-6 to glycosaminoglycans. Eur. J. Immunol. 22, 3027-3031 (1992).
20. Maloy, K. J. The interleukin-23/Interleukin-17 axis in intestinal Inflammation. J. Intern. Med. 263, 584-590 (2008). (Pubitemid 351678587)
21. Sellon, R. K. et al. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect. Immun. 66, 5224-5231 (1998). (Pubitemid 29044613)
22. van Beelen, A. J. et al. Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity 27, 660-669 (2007).
23. Young, H. A. & Bream, J. H. IFN-γ: recent advances in understanding regulation of expression, biological functions, and clinical applications. Curr. Top. Microbiol. Immunol. 316, 97-117 (2007).
24. Volpe, E. et al. Multiparametric analysis of cytokine-driven human Th17 differentiation reveals a differential regulation of IL-17 and IL-22 production. Blood 114, 3610-3614 (2009).
25. Yang, L. et al. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature 454, 350-352 (2008).
26. Liu, H. & Rohowsky-Kochan, C. Regulation of IL-17 in human CCR6+ effector memory T cells. J. Immunol. 180, 7948-7957 (2008).
27. Iliev, I. D., Mileti, E., Matteoli, G., Chieppa, M. & Rescigno, M. Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning. Mucosal Immunol. 2, 340-350 (2009).
28. Iliev, I. D. et al. Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells. Gut 58, 1481-1489 (2009).
29. + dendritic cells display unique functional properties that are conserved between mice and humans. J. Exp. Med. 205, 2139-2149 (2008)
30. Denning, T. L., Wang, Y. C., Patel, S. R., Williams, I. R. & Pulendran, B. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat. Immunol. 8, 1086-1094 (2007) (Pubitemid 47423756)
31. Suffia, I., Reckling, S. K., Salay G. & Belkaid, Y A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection J. Immunol. 174, 5444-5455 (2005) (Pubitemid 40593184)
32. Coombes, J. L. et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J. Exp. Med. 204, 1757-1764 (2007). (Pubitemid 47236314)
33. Harrington, L. E. et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6, 1123-1132 (2005) (Pubitemid 41541790)
34. Alten, R. et al. The human anti-IL-1 ßmonoclonal antibody ACZ885 is effective in joint Inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis. Arthritis Res. Ther. 10, R67 (2008).
35. Casini-Raggi, V, Kam, L., Chong, Y. J., Fiocchi, C., Pizarro, T. T. & Cominelli, F. Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal Inflammation. J. Immunol. 154, 2434-2440 (1995)
36. Cominelli, F., Nast, C. C., Duchini, A. & Lee, M. Recombinant interleukin-1 receptor antagonist blocks the proinflammatory activity of endogenous interleukin-1 in rabbit immune colitis. Gastroenterology 103, 65-71 (1992).
37. Cominelli, F. et al. Interleukin 1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis. J. Clin. Invest. 86, 972-980 (1990). (Pubitemid 20327390)
38. Arai, Y., Takanashi, H., Kitagawa, H. & Okayasu, I. Involvement of interleukin-1 in the development of ulcerative colitis induced by dextran sulfate sodium in mice. Cytokine 10, 890-896 (1998). (Pubitemid 29002742)
39. Smith, P. D. et al. Isolation and purifi cation of CD14-negative mucosal macrophages from normal human small intestine. J. Immunol. Methods 202, 1-11 (1997). (Pubitemid 27104262)