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Volumn 60, Issue 5, 2011, Pages 1582-1589

Increased GABAergic output in the ventromedial hypothalamus contributes to impaired hypoglycemic counterregulation in diabetic rats

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR; ADRENALIN; BICUCULLINE METHIODIDE; CATECHOLAMINE; GLUCAGON; GLUTAMATE DECARBOXYLASE 65; INSULIN; ISOPHANE INSULIN; STREPTOZOCIN;

EID: 79959410500     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-1579     Document Type: Article
Times cited : (46)

References (44)
  • 1
    • 57249098943 scopus 로고    scopus 로고
    • The barrier of hypoglycemia in diabetes
    • Cryer PE. The barrier of hypoglycemia in diabetes. Diabetes 2008;57:3169-3176
    • (2008) Diabetes , vol.57 , pp. 3169-3176
    • Cryer, P.E.1
  • 2
    • 64749110344 scopus 로고    scopus 로고
    • Hypoglycemia: Still the limiting factor in the glycemic management of diabetes
    • Cryer PE. Hypoglycemia: still the limiting factor in the glycemic management of diabetes. Endocr Pract 2008;14:750-756
    • (2008) Endocr Pract , vol.14 , pp. 750-756
    • Cryer, P.E.1
  • 4
    • 0031038124 scopus 로고    scopus 로고
    • Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats
    • Borg MA, Sherwin RS, Borg WP, Tamborlane WV, Shulman GI. Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. J Clin Invest 1997;99:361-365 (Pubitemid 27053991)
    • (1997) Journal of Clinical Investigation , vol.99 , Issue.2 , pp. 361-365
    • Borg, M.A.1    Sherwin, R.S.2    Borg, W.P.3    Tamborlane, W.V.4    Shulman, G.I.5
  • 6
    • 0028931891 scopus 로고
    • Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release
    • Borg WP, Sherwin RS, During MJ, Borg MA, Shulman GI. Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release. Diabetes 1995;44:180-184
    • (1995) Diabetes , vol.44 , pp. 180-184
    • Borg, W.P.1    Sherwin, R.S.2    During, M.J.3    Borg, M.A.4    Shulman, G.I.5
  • 7
    • 0030913976 scopus 로고    scopus 로고
    • Hierarchy of physiological responses to hypoglycemia: Relevance to clinical hypoglycemia in type I (insulin dependent) diabetes mellitus
    • Cryer PE. Hierarchy of physiological responses to hypoglycemia: relevance to clinical hypoglycemia in type I (insulin dependent) diabetes mellitus. Horm Metab Res 1997;29:92-96 (Pubitemid 27209909)
    • (1997) Hormone and Metabolic Research , vol.29 , Issue.3 , pp. 92-96
    • Cryer, P.E.1
  • 8
    • 33644664033 scopus 로고    scopus 로고
    • Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes
    • DOI 10.2337/diabetes.54.12.3592
    • Cryer PE. Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes. Diabetes 2005;54:3592-3601 (Pubitemid 43334356)
    • (2005) Diabetes , vol.54 , Issue.12 , pp. 3592-3601
    • Cryer, P.E.1
  • 9
    • 0015901935 scopus 로고
    • Lack of glucagon response to hypoglycemia in diabetes: Evidence for an intrinsic pancreatic alpha cell defect
    • Gerich JE, Langlois M, Noacco C, Karam JH, Forsham PH. Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect. Science 1973;182:171-173
    • (1973) Science , vol.182 , pp. 171-173
    • Gerich, J.E.1    Langlois, M.2    Noacco, C.3    Karam, J.H.4    Forsham, P.H.5
  • 10
    • 0023855186 scopus 로고
    • Correlation between minimal secretory capacity of pancreatic beta-cells and stability of diabetic control
    • Fukuda M, Tanaka A, Tahara Y, et al. Correlation between minimal secretory capacity of pancreatic beta-cells and stability of diabetic control. Diabetes 1988;37:81-88 (Pubitemid 18036462)
    • (1988) Diabetes , vol.37 , Issue.1 , pp. 81-88
    • Fukuda, M.1    Tanaka, A.2    Tahara, Y.3    Ikegami, H.4    Yamamoto, Y.5    Kumahara, Y.6    Shima, K.7
  • 11
    • 78049300087 scopus 로고    scopus 로고
    • Insulin reciprocally regulates glucagon secretion in humans
    • Cooperberg BA, Cryer PE. Insulin reciprocally regulates glucagon secretion in humans. Diabetes 2010;59:2936-2940
    • (2010) Diabetes , vol.59 , pp. 2936-2940
    • Cooperberg, B.A.1    Cryer, P.E.2
  • 12
    • 77953183468 scopus 로고    scopus 로고
    • Influence of insulin in the ventromedial hypothalamus on pancreatic glucagon secretion in vivo
    • Paranjape SA, Chan O, Zhu W, et al. Influence of insulin in the ventromedial hypothalamus on pancreatic glucagon secretion in vivo. Diabetes 2010;59:1521-1527
    • (2010) Diabetes , vol.59 , pp. 1521-1527
    • Paranjape, S.A.1    Chan, O.2    Zhu, W.3
  • 14
    • 34047099750 scopus 로고    scopus 로고
    • Zinc, not insulin, regulates the rat a-cell response to hypoglycemia in vivo
    • DOI 10.2337/db06-1454
    • Zhou H, Zhang T, Harmon JS, Bryan J, Robertson RP. Zinc, not insulin, regulates the rat a-cell response to hypoglycemia in vivo. Diabetes 2007;56:1107-1112 (Pubitemid 46525066)
    • (2007) Diabetes , vol.56 , Issue.4 , pp. 1107-1112
    • Zhou, H.1    Zhang, T.2    Harmon, J.S.3    Bryan, J.4    Robertson, R.P.5
  • 15
    • 33645051453 scopus 로고    scopus 로고
    • Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system
    • Xu E, Kumar M, Zhang Y, et al. Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system. Cell Metab 2006;3:47-58
    • (2006) Cell Metab , vol.3 , pp. 47-58
    • Xu, E.1    Kumar, M.2    Zhang, Y.3
  • 16
    • 0027324924 scopus 로고
    • Alterations in brain glucose transporter proteins, GLUT1 and GLUT3, in streptozotocin diabetic rats
    • Maher F, Simpson IA, Vannucci SJ. Alterations in brain glucose transporter proteins, GLUT1 and GLUT3, in streptozotocin diabetic rats. Adv Exp Med Biol 1993;331:9-12 (Pubitemid 23180882)
    • (1993) Advances in Experimental Medicine and Biology , vol.331 , pp. 9-12
    • Maher, F.1    Simpson, I.A.2    Vannucci, S.J.3
  • 17
    • 0032557956 scopus 로고    scopus 로고
    • GLUT4 glucose transporter expression in rodent brain: Effect of diabetes
    • DOI 10.1016/S0006-8993(98)00103-6, PII S0006899398001036
    • Vannucci SJ, Koehler-Stec EM, Li K, Reynolds TH, Clark R, Simpson IA. GLUT4 glucose transporter expression in rodent brain: effect of diabetes. Brain Res 1998;797:1-11 (Pubitemid 28331484)
    • (1998) Brain Research , vol.797 , Issue.1 , pp. 1-11
    • Vannucci, S.J.1    Koehler-Stec, E.M.2    Li, K.3    Reynolds, T.H.4    Clark, R.5    Simpson, I.A.6
  • 18
    • 0026683654 scopus 로고
    • The impact of diabetes on the CNS
    • McCall AL. The impact of diabetes on the CNS. Diabetes 1992;41:557-570
    • (1992) Diabetes , vol.41 , pp. 557-570
    • McCall, A.L.1
  • 19
    • 1842684425 scopus 로고    scopus 로고
    • Cerebral glucose metabolism in diabetes mellitus
    • DOI 10.1016/j.ejphar.2004.02.052, PII S0014299904002092
    • McCall AL. Cerebral glucose metabolism in diabetes mellitus. Eur J Pharmacol 2004;490:147-158 (Pubitemid 38482168)
    • (2004) European Journal of Pharmacology , vol.490 , Issue.1-3 , pp. 147-158
    • McCall, A.L.1
  • 21
  • 22
    • 0015950390 scopus 로고
    • Regulation of glucose and ketone-body metabolism in brain of anaesthetized rats
    • Ruderman NB, Ross PS, Berger M, Goodman MN. Regulation of glucose and ketone-body metabolism in brain of anaesthetized rats. Biochem J 1974;138:1-10
    • (1974) Biochem J , vol.138 , pp. 1-10
    • Ruderman, N.B.1    Ross, P.S.2    Berger, M.3    Goodman, M.N.4
  • 23
    • 33745216834 scopus 로고    scopus 로고
    • Increased brain monocarboxylic acid transport and utilization in type 1 diabetes
    • DOI 10.2337/diabetes.55.04.06.db05-1325
    • Mason GF, Petersen KF, Lebon V, Rothman DL, Shulman GI. Increased brain monocarboxylic acid transport and utilization in type 1 diabetes. Diabetes 2006;55:929-934 (Pubitemid 44100166)
    • (2006) Diabetes , vol.55 , Issue.4 , pp. 929-934
    • Mason, G.F.1    Petersen, K.F.2    Lebon, V.3    Rothman, D.L.4    Shulman, G.I.5
  • 24
    • 0028951455 scopus 로고
    • Glucose modulates rat substantia nigra GABA release in vivo via ATP-sensitive potassium channels
    • During MJ, Leone P, Davis KE, Kerr D, Sherwin RS. Glucose modulates rat substantia nigra GABA release in vivo via ATP-sensitive potassium channels. J Clin Invest 1995;95:2403-2408
    • (1995) J Clin Invest , vol.95 , pp. 2403-2408
    • During, M.J.1    Leone, P.2    Davis, K.E.3    Kerr, D.4    Sherwin, R.S.5
  • 27
    • 34047114378 scopus 로고    scopus 로고
    • + channels regulate the release of GABA in the ventromedial hypothalamus during hypoglycemia
    • DOI 10.2337/db06-1102
    • Chan O, Lawson M, Zhu W, Beverly JL, Sherwin RS. ATP-sensitive K(+) channels regulate the release of GABA in the ventromedial hypothalamus during hypoglycemia. Diabetes 2007;56:1120-1126 (Pubitemid 46525084)
    • (2007) Diabetes , vol.56 , Issue.4 , pp. 1120-1126
    • Chan, O.1    Lawson, M.2    Zhu, W.3    Beverly, J.L.4    Sherwin, R.S.5
  • 28
    • 33745327159 scopus 로고    scopus 로고
    • A receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo- Pituitary-adrenal response to hypoglycemia
    • DOI 10.2337/diabetes.55.04.06.db05-0958
    • Chan O, Zhu W, Ding Y, McCrimmon RJ, Sherwin RS. Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia. Diabetes 2006;55:1080-1087 (Pubitemid 44100185)
    • (2006) Diabetes , vol.55 , Issue.4 , pp. 1080-1087
    • Chan, O.1    Zhu, W.2    Ding, Y.3    McCrimmon, R.J.4    Sherwin, R.S.5
  • 29
    • 48449083962 scopus 로고    scopus 로고
    • Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemia
    • Chan O, Cheng H, Herzog R, et al. Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemia. Diabetes 2008;57:1363-1370
    • (2008) Diabetes , vol.57 , pp. 1363-1370
    • Chan, O.1    Cheng, H.2    Herzog, R.3
  • 30
    • 77951148698 scopus 로고    scopus 로고
    • Effects of antecedent GABAA activation with alprazolam on counterregulatory responses to hypoglycemia in healthy humans
    • Hedrington MS, Farmerie S, Ertl AC, Wang Z, Tate DB, Davis SN. Effects of antecedent GABAA activation with alprazolam on counterregulatory responses to hypoglycemia in healthy humans. Diabetes 2010;59:1074-1081
    • (2010) Diabetes , vol.59 , pp. 1074-1081
    • Hedrington, M.S.1    Farmerie, S.2    Ertl, A.C.3    Wang, Z.4    Tate, D.B.5    Davis, S.N.6
  • 32
    • 0030947806 scopus 로고    scopus 로고
    • Hypoglycemia-induced inhibition of LH and stimulation of ACTH secretion in the rhesus monkey is blocked by alprazolam
    • Van Vugt DA, Washburn DL, Farley AE, Reid RL. Hypoglycemia-induced inhibition of LH and stimulation of ACTH secretion in the rhesus monkey is blocked by alprazolam. Neuroendocrinology 1997;65:344-352 (Pubitemid 27174060)
    • (1997) Neuroendocrinology , vol.65 , Issue.5 , pp. 344-352
    • Van Vugt, D.A.1    Washburn, D.L.S.2    Farley, A.E.3    Reid, R.L.4
  • 35
    • 40749132626 scopus 로고    scopus 로고
    • Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia
    • McCrimmon RJ, Shaw M, Fan X, et al. Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia. Diabetes 2008;57:444-450
    • (2008) Diabetes , vol.57 , pp. 444-450
    • McCrimmon, R.J.1    Shaw, M.2    Fan, X.3
  • 36
    • 13844275313 scopus 로고    scopus 로고
    • Assays for measuring extracellular GABA levels and cell migration rate in acute slices
    • DOI 10.1016/j.brainresprot.2004.12.005
    • Bolteus AJ, Garganta C, Bordey A. Assays for measuring extracellular GABA levels and cell migration rate in acute slices. Brain Res Brain Res Protoc 2005;14:126-134 (Pubitemid 40249953)
    • (2005) Brain Research Protocols , vol.14 , Issue.2 , pp. 126-134
    • Bolteus, A.J.1    Garganta, C.2    Bordey, A.3
  • 37
    • 0024383110 scopus 로고
    • Increased GABA shunt activity in VMN of three hyperphagic rat models
    • Beverly JL, Martin RJ. Increased GABA shunt activity in VMN of three hyperphagic rat models. Am J Physiol 1989;256:R1225-R1231
    • (1989) Am J Physiol , vol.256
    • Beverly, J.L.1    Martin, R.J.2
  • 38
    • 0026340609 scopus 로고
    • Dietary fat, hypothalamic glutamate decarboxylase, and food intake of streptozotocin-diabetic rats
    • Beverly JL, Oster MH, Castonguay TW, Stern JS. Dietary fat, hypothalamic glutamate decarboxylase, and food intake of streptozotocin-diabetic rats. Am J Physiol 1991;261:R1554-R1559
    • (1991) Am J Physiol , vol.261
    • Beverly, J.L.1    Oster, M.H.2    Castonguay, T.W.3    Stern, J.S.4
  • 39
    • 0030967891 scopus 로고    scopus 로고
    • Microdialysis study of modification of hypothalamic neurotransmitters in streptozotocin-diabetic rats
    • Ohtani N, Ohta M, Sugano T. Microdialysis study of modification of hypothalamic neurotransmitters in streptozotocin-diabetic rats. J Neurochem 1997;69:1622-1628 (Pubitemid 27406963)
    • (1997) Journal of Neurochemistry , vol.69 , Issue.4 , pp. 1622-1628
    • Ohtani, N.1    Ohta, M.2    Sugano, T.3
  • 41
    • 78349279184 scopus 로고    scopus 로고
    • Astrocytes are GABAergic cells that modulate microglial activity
    • Lee M, Schwab C, McGeer PL. Astrocytes are GABAergic cells that modulate microglial activity. Glia 2011;59:152-165
    • (2011) Glia , vol.59 , pp. 152-165
    • Lee, M.1    Schwab, C.2    McGeer, P.L.3
  • 42
    • 77950805120 scopus 로고    scopus 로고
    • Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia
    • Zhu W, Czyzyk D, Paranjape SA, et al. Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia. Am J Physiol Endocrinol Metab 2010;298:E971-E977
    • (2010) Am J Physiol Endocrinol Metab , vol.298
    • Zhu, W.1    Czyzyk, D.2    Paranjape, S.A.3
  • 43
    • 63449087896 scopus 로고    scopus 로고
    • Insulin signaling in alpha cells modulates glucagon secretion in vivo
    • Kawamori D, Kurpad AJ, Hu J, et al. Insulin signaling in alpha cells modulates glucagon secretion in vivo. Cell Metab 2009;9:350-361
    • (2009) Cell Metab , vol.9 , pp. 350-361
    • Kawamori, D.1    Kurpad, A.J.2    Hu, J.3
  • 44
    • 67049146814 scopus 로고    scopus 로고
    • Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes
    • Fan X, Ding Y, Brown S, et al. Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes. Am J Physiol Regul Integr Comp Physiol 2009;296:R1702-R1708
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.296
    • Fan, X.1    Ding, Y.2    Brown, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.