High-throughput scintillation proximity assay for stearoyl-CoA desaturase-1

Journal of Biomolecular Screening

Volumn 16, Issue 5, 2011, Pages 506-517

  Tawa, Paul ^a   Falgueyret, Jean Pierre ^a   Guiral, Sebastien ^a   Isabel, Elise ^a   Powell, David A ^a   Zuck, Paul ^b   Skorey, Kathryn ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

enzyme assays or enzyme kinetics; fluorescence methods; high content screening; lipids or lipid metabolism; protein chemistry; structure activity relationships

Indexed keywords

ACYL COENZYME A DESATURASE 1; ACYL COENZYME A DESATURASE 1 INHIBITOR; BENZIMIDAZOLE DERIVATIVE; OXYGENASE INHIBITOR; RECOMBINANT ENZYME; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HYDROPHOBICITY; IC 50; NONHUMAN; PRIORITY JOURNAL; RADIOASSAY; RAT; SCINTILLATION; SIGNAL NOISE RATIO;

ANIMALS; DRUG DISCOVERY; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIGANDS; MALE; MICROSOMES, LIVER; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SCINTILLATION COUNTING; STEAROYL-COA DESATURASE; TRITIUM;

EID: 79959408813     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057111399436     Document Type: Article

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