MyD88 signaling is required for efficient innate and adaptive immune responses to Paracoccidioides brasiliensis infection

Infection and Immunity

Volumn 79, Issue 6, 2011, Pages 2470-2480

  Loures, Flávio V ^a   Pina, Adriana ^a   Felonato, Maíra ^a   Feriotti, Claudia ^a   de Araújo, Eliseu F ^a   Calich, Vera L G ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOID DIFFERENTIATION FACTOR 88; NITRIC OXIDE;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FUNGAL CELL; FUNGUS GROWTH; GRANULOMA; HISTOPATHOLOGY; IMMUNE RESPONSE; INFLAMMATION; INNATE IMMUNITY; LIVER; LUNG INFECTION; LYMPHOCYTE PROLIFERATION; MACROPHAGE; NEUTROPHIL; NONHUMAN; PARACOCCIDIOIDES BRASILIENSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SOUTH AMERICAN BLASTOMYCOSIS; SPLEEN; T LYMPHOCYTE; TH1 CELL; TH17 CELL; TH2 CELL;

ADAPTIVE IMMUNITY; ANIMALS; IMMUNITY, INNATE; INTERLEUKIN-18; LEUKOCYTES; MICE; MICE, INBRED C57BL; MYELOID DIFFERENTIATION FACTOR 88; PARACOCCIDIOIDES; PARACOCCIDIOIDOMYCOSIS; PHAGOCYTOSIS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 79959397918     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00375-10     Document Type: Article

References (40)

1. Adachi, O., et al. 1998. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9:143-150.
2. Biondo, C., et al. 2005. MyD88 and TLR2, but not TLR4, are required for host defense against Cryptococcus neoformans. Eur. J. Immunol. 35:870-878.
3. Bonfim, C. V., R. L. Mamoni, and M. H. Blotta. 2009. TLR-2, TLR-4 and dectin-1 expression in human monocytes and neutrophils stimulated by Paracoccidioides brasiliensis. Med. Mycol. 47:722-733.
4. Bonifazi, P., et al. 2009. Balancing inflammation and tolerance in vivo through dendritic cells by the commensal Candida albicans. Mucosal Immunol. 2:362-374.
5. Bretz, C., et al. 2008. MyD88 signaling contributes to early pulmonary responses to Aspergillus fumigatus. Infect. Immun. 76:952-958.
6. Brummer, E. 1994. Interaction of Paracoccidioides brasiliensis with host defense cells, p. 213-223. In M. Franco, C. S. Lacaz, A. Restrepo, and G. Del Negro (ed.), Paracaccidioidomycosis. CRC Press, Boca Raton, FL.
7. Cai, S., S. Batra, L. Shen, N. Wakamatsu, and S. Jeyaseelan. 2009. Both TRIF- and MyD88-dependent signaling contribute to host defense against pulmonary Klebsiella infection. J. Immunol. 183:6629-6638.
8. Calich, V. L., et al. 2008. Innate immunity to Paracoccidioides brasiliensis infection. Mycopathologia 165:223-236.
9. Calich, V. L. G., et al. 2008. Toll-like receptors and fungal infections: the role of TLR2, TLR4 and MyD88 in paracoccidioidomycosis. FEMS Immunol. Med. Microbiol. 53:1-7.
10. Cano, L. E., L. M. Singer-Vermes, C. A. C. Vaz, M. Russo, and V. L. G. Calich. 1995. Pulmonary paracoccidioidomycosis in resistant and susceptible mice: relationship among progression of infection, bronchoalveolar cell activation, cellular immune response, and specific isotype patterns. Infect. Immun. 63:1777-1783.
11. Casanova, J. L., L. Abel, and L. Quintana-Murci. 2011. Human TLRs and IL-1Rs in host defense: natural insights from evolutionary, epidemiological, and clinical genetics. Annu. Rev. Immunol. 29:447-491.
12. De Luca, A., et al. 2007. Functional yet balanced reactivity to Candida albicans requires TRIF, MyD88, and IDO-dependent inhibition of Rorc. J. Immunol. 179:5999-6008.
13. Ding, A. H., C. F. Nathan, and D. J. Stuehr. 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. J. Immunol. 141:2407-2412.
14. Edelson, B. T., and E. R. Unanue. 2002. MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity. J. Immunol. 169:3869-3875.
15. Felonato, M., et al. 2010. CD28 exerts protective and detrimental effects in a pulmonary model of paracoccidioidomycosis. Infect. Immun. 78:4922- 4935.
16. Franco, M. 1987. Host-parasite relationships in paracoccidioidomycosis. J. Med. Vet. Mycol. 25:5-18.
17. González, A., A. Yáñez, D. Gozalbo, and M. L. Gil. 2008. MyD88 is dispensable for resistance to Paracoccidioides brasiliensis in a murine model of blood-borne disseminated infection. FEMS Immunol. Med. Microbiol. 54: 365-374.
18. Kashino, S. S., et al. 2000. Resistance to Paracoccidioides brasiliensis infection is linked to a preferential Th1 immune response, whereas susceptibility is associated with absence of IFN-gamma production. J. Interferon Cytokine Res. 20:89-97.
19. Kawai, T., and S. Akira. 2007. TLR signaling. Semin. Immunol. 19:24-32.
20. Ley, K., E. Smith, and M. A. Stark. 2006. IL-17A-producing neutrophilregulatory T lymphocytes. Immunol. Res. 34:229-242.
21. Liang, S. C., et al. 2007. An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment. J. Immunol. 179:7791-7799.
22. Loures, F. V., A. Pina, M. Felonato, E. F. Araújo, and V. L. G. Calich. 2010. TLR4 signaling leads to a more severe fungal infection associated with enhanced proinflammatory immunity and impaired expansion of regulatory T cells. Infect. Immun. 78:1078-1088.
23. Loures, F. V., A. Pina, M. Felonato, and V. L. G. Calich. 2009. TLR2 is a negative regulator of Th17 cells and tissue pathology in a pulmonary model of fungal infection. J. Immunol. 183:1279-1290.
24. Muraille, E., et al. 2003. Genetically resistant mice lacking MyD88-adapter protein display a high susceptibility to Leishmania major infection associated with a polarized Th2 response. J. Immunol. 170:4237-4241.
25. Nascimento, F. R., V. L. Calich, D. Rodríguez, and M. Russo. 2002. Dual role for nitric oxide in paracoccidioidomycosis: essential for resistance, but overproduction associated with susceptibility. J. Immunol. 168:4593-4600.
26. Netea, M. G., et al. 2010. IL-1beta processing in host defense: beyond the inflammasomes. PLoS Pathog. 6:e1000661.
27. O'Neill, L. A. J., and A. G. Bowie. 2007. The family of five: TIR-domaincontaining adaptors in Toll-like receptor signaling. Nat. Rev. Immunol. 7:353-364.
28. Reid, D. M., N. A. Gow, and G. D. Brown. 2009. Pattern recognition: recent insights from Dectin-1. Curr. Opin. Immunol. 21:30-37.
29. Saijo, S., et al. 2010. Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity 32:681-691.
30. Scanga, C. A., et al. 2002. Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J. Immunol. 168:5997-6001.
31. Singer-Vermes, L. M., M. C. Ciavaglia, S. S. Kashino, E. Burguer, and V. L. G. Calich. 1992. The source of the growth-promoting factor(s) affects the plating efficiency of Paracoccidioides brasiliensis. J. Med. Vet. Mycol. 30:261-264.
32. Sun, D., and A. Ding. 2006. MyD88-mediated stabilization of interferongamma-induced cytokine and chemokine mRNA. Nat. Immunol. 7:375-381.
33. Sutmuller, R. P., et al. 2006. Toll-like receptor 2 controls expansion and function of regulatory T cells. J. Clin. Invest. 116:485-494.
34. Takeda, K., T. Kaisho, and S. Akira. 2003. Toll-like receptors. Annu. Rev. Immunol. 21:335-376.
35. Takeuchi, O., K. Hoshino, and S. Akira. 2000. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J. Immunol. 165:5392-5396.
36. van de Veerdonk, F. L., et al. 2009. The macrophage mannose receptor induces IL-17 in response to Candida albicans. Cell Host Microbe 5:329-340.
37. Wiersinga, W. J., C. W. Wieland, J. J. Roelofs, and T. van der Poll. 2008. MyD88 dependent signaling contributes to protective host defense against Burkholderia pseudomallei. PLoS One 3:e3494.
38. Wu, Q., et al. 2007. IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection. Microbes Infect. 9:78-86.
39. Xu, L., A. Kitani, I. Fuss, and W. Strober. 2007. Cutting edge: regulatory T cells induce CD4 CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J. Immunol. 178:6725-6729.
40. Yang, X. O., et al. 2008. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29:44-56.