Pregnancy-associated plasma protein-A accounts for the insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) proteolytic activity in human pregnancy serum and enhances the mitogenic activity of IGF by degrading IGFBP-4 in vitro

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 2, 2001, Pages 847-854

  Byun, Dongwon ^a   Mohan, Subburaman ^a   Yoo, Myunghi ^b   Sexton, Christopher ^a   Baylink, David J ^a   Qin, Xuezhong ^a,c  

^a LOMA LINDA UNIVERSITY   (United States)

^b Soonchunhyang University College of Medicine   (South Korea)

^c Jerry L Pettis Memorial VA Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH PROMOTOR; NEUTRALIZING ANTIBODY; PREGNANCY ASSOCIATED PLASMA PROTEIN A; PROTEINASE; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 4;

ARTICLE; CELL PROLIFERATION; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MITOGENESIS; OSTEOSARCOMA CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PREGNANCY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DETERMINATION; STATISTICAL ANALYSIS; WESTERN BLOTTING;

CELL DIVISION; CELL LINE; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 4; INSULIN-LIKE GROWTH FACTOR II; METALLOENDOPEPTIDASES; OSTEOBLASTS; PREGNANCY; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; REFERENCE VALUES;

EID: 0035093065     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.86.2.847     Document Type: Article

References (38)

1. Insulin-like growth factors and the local regulation of bone formation
2. Insulin-like growth factors and bone: The osteoporosis connection
3. Insulin-like growth factor binding proteins and their role in controlling IGF actions
4. IGF system components and their role in bone metabolism
5. Role of insulin-like growth factors in embryonic and postnatal development
6. Insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and proteolyzed IGFBP-3 in embryonic cavities in early human pregnancy: Their potential relevance to maternal-embryonic and fetal interactions
7. Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth
8. Profiles of insulin-like growth factor binding proteins and protease activity in the maternal circulation and its local regulation between placenta and decidua
9. Structure of the Mr 140,000 growth hormone-dependent insulin-like growth factor binding protein complex: Determination by redistribution and affinity labeling
10. A major portion of the 150-kilodalton insulin-like growth factor binding protein (IGFBP) complex in adult rat serum contains unoccupied, proteolytically nicked IGFBP-3 that bind to IGF-II preferentially
11. Characterization of the high molecular weight insulin- like growth factor complex in term pregnancy serum
12. Insulin-like growth factor binding protein-3 is functionally altered in pregnancy plasma
13. Evidence that human bone cells in culture produce insulin-like growth factor-binding protein-4 and -5 proteases
14. Evidence of enzymatic degradation of insulin-like growth factor-binding proteins in the 150K complex during pregnancy
15. Insulin-like growth factor binding proteins in maternal serum throughout gestation and in the puerperium: Effects of a pregnancy-associated serum protease activity
16. Chromatographic characterization of insulin-like growth factor- binding proteins in human pregnancy serum
17. Proteolysis of insulin-like growth factor binding protein-5 by pregnancy serum and amniotic fluid
18. Proteolysis of insulin-like growth factor binding proteins by a novel 50-kilodalton metalloproteinase in human pregnancy serum
19. The free form of insulin-like growth factor I increases in circulation during normal human pregnancy
20. The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy associated plasma protein-A
21. Evidence that the insulin-like growth factor binding protein-4 protease in human ovarian follicular fluid is pregnancy associated plasma protein-A
22. Identification of angiotensinogen and coplement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma
23. Pregnancy-associated plasma protein A: Circulating levels during normal pregnancy
24. Serum PAPP-A in normal pregnancy: Relationship to fetal and maternal characteristics
25. First trimester biochemical markers for Down's syndrome
26. Second-trimester pregnancy associated plasma protein-A levels are reduced in Cornelia de Lange syndrome pregnancies
27. Pregnancy-associated plasma protein-A: A possible maker in the classification and prenatal diagnosis of Cornelia de Lange syndrome
28. Studies on the human pregnancy-induced insulin-like growth factor binding protein (IGFBP)- 4 poetesses in serum: Determination of IGF-II dependency and localization of cleavage site
29. Structure-function analysis of the human insulin-like growth factor (IGF) binding protein (hIGFBP)-4
30. Studies on the role of human insulin-like growth factor-II (IGF-II) dependent IGF binding protein (hIGFBP)-4 protease in human osteoblasts using protease resistant IGFBP-4 analogs
31. 3 differentially regulates the production of insulin-like growth factor I (IGF-I) and IGF-binding protein-4 in mouse osteoblasts
32. Proteolysis of insulin-like growth factor binding protein-3 during rat pregnancy: A role for matrix metalloproteases
33. Proteolysis of insulin-like growth factor binding protein-3 in serum from pregnant, non-pregnant and fetal rats by matrix metalloproteases and serine proteases
34. Human pregnancy serum contains at least two distinct proteolytic activities with the ability to degrade insulin-like growth factor binding protein-3
35. Human placental trophoblasts secrete a disintegrin metalloproteinase very similar to the insulin-like growth factor binding protein-3 protease in human pregnancy serum
36. ADAM 12, a disintegrin metalloprotease, interacts with insulin-like growth factor-binding protein-3
37. In vivo proteolysis of serum insulin-like growth factor (IGF) binding protein-3 results in increased availability of IGF to target cells
38. Evidence that the interaction between insulin-like growth factor (IGF)-II and IGF binding protein (IGFBP)-4 is essential for the action of the IGF-II dependent IGFBP-4 protease