α1-Antitrypsin Inhibits the Lethal Response to TNF in Mice

Journal of Immunology

Volumn 157, Issue 11, 1996, Pages 5126-5129

  Libert, Claude ^a   Van Molle, Wim ^a   Brouckaert, Peter ^a   Fiers, Walter ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA 1 ANTITRYPSIN; ASPARTATE AMINOTRANSFERASE; GALACTOSAMINE; THROMBOCYTE ACTIVATING FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; BLOOD; BLOOD CLOTTING; BODY TEMPERATURE; C57BL MOUSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG INTERACTION; ENZYMOLOGY; FEMALE; LIVER; MOUSE; PHYSIOLOGY; SECRETION;

ALANINE TRANSAMINASE; ALPHA 1-ANTITRYPSIN; ANIMALS; ASPARTATE AMINOTRANSFERASES; BLOOD COAGULATION; BODY TEMPERATURE; DRUG INTERACTIONS; FEMALE; GALACTOSAMINE; LIVER; MICE; MICE, INBRED C57BL; PLATELET ACTIVATING FACTOR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030442778     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Fiers, W. 1995. Biologic therapy with TNF: preclinical studies. In Biologic Therapy of Cancer, 2nd Ed. V. T. DeVita, Jr., S. Hellman, and S. A. Rosenberg, eds. J. B. Lippincott, Philadelphia, PA, p. 295.
2. Lejeune, F., D. Liénard, A. Eggermont, H. Schraffordt Koops, B. Kroon, J. Gérain, F. Rosenkaimer, and P. Schmitz. 1994. Clinical experience with high-dose tumor necrosis factor alpha in regional therapy of advanced melanoma. Circ. Shock 43:191.
3. Brouckaert, P., P. Ameloot, A. Cauwels, B. Everaerdt, C. Libert, N. Takahashl, W. Van Molle, and W. Fiers. 1994. Receptor-selective mutants of tumour necrosis factor in the therapy of cancer: preclinical studies. Circ. Shock 43:185.
4. Vassalli, P. 1992. The pathophysiology of tumor necrosis factors. Annu. Rev. Immunol. 10:411.
5. 1-acid glycoprotein against tumor necrosis factor-induced lethality. J. Exp. Med 180:1571.
6. Travis, J., and G. S. Salvesen. 1983. Human plasma proteinase inhibitors. Annu. Rev. Biochem. 52:655.
7. 1-antitrypsin in human mononuclear phagocytes and in human hepatoma cells. J. Clin. Invest. 84:138.
8. Perlmutter, D. H., C. A. Dinarello, P. I. Punsal, and H. R. Colten. 1986. Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression. J. Clin. Invest. 78:1349.
9. Libert, C., P. Brouckaert, A. Shaw, and W. Fiers. 1990. Induction of interleukin 6 by human and murine recombinant interleukin 1 in mice. Eur. J. Immunol. 20:691.
10. 1-antitrypsin. Lung 168:S530.
11. Reutelingsperger, C. P. M., G. Hornstra, and H. C. Hemker. 1985. Isolation and partial purification of a novel anticoagulant from arteries of human umbilical cord. Eur. J. Biochem. 151:625.
12. Brouckaert, P., C. Libert, B. Everaerdt, and W. Fiers. 1992. Selective species specificity of tumor necrosis factor for toxicity in the mouse. Lymphokine Cytokine Res. 11:193.
13. Decker, K., and D. Keppler. 1974. Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death. Rev. Physiol. Biochem. Pharmacol. 71:77.
14. Galanos, C., M. Freudenberg, and W. Reutter. 1979. Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc. Natl. Acad. Sci. USA 76:5939.
15. Lehmann, V., M. A. Freudenberg, and C. Galanos. 1987. Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice. J. Exp. Med. 165:657.
16. Libert, C., S. Van Bladel, P. Brouckaert, A. Shaw, and W. Fiers. 1991. Involvement of the liver, but not of IL-6, in IL-1-induced desensitization to the lethal effects of tumor necrosis factor. J. Immunol. 146:2625.
17. Baumann, H., and J. Gauldie. 1994. The acute-phase response. Immunol. Today 15:74.
18. Xia, D., C. Lin, J. Yun, T. Wagner, T. Magnuson, and D. Samols. 1991. Transgenic mice expressing rabbit C-reactive protein (CRP) resist endotoxemia. FASEB J. 5:1628.
19. Heuertz, R. M., C. A. Piquette, and R. O. Webster. 1993. Rabbits with elevated serum C-reactive protein exhibit diminished neutrophil infiltration and vascular permeability in C5a-induced alveolitis. Am. J. Pathol. 142:319.
20. 2 in mice. Scand. J. Immunol. 34:179.
21. Szalai, A. J., D. E. Briles, and J. E. Volanakis. 1995. Human C-reactive protein is protective against fatal Streptococcus pneumoniae infection in transgenic mice. J. Immunol. 155:2557.
22. Niehörster, M., G. Tiegs, U. F. Schade, and A. Wendel. 1990. In vivo evidence for protease-catalysed mechanism providing bioactive tumor necrosis factor α. Biochem. Pharmacol. 40:1601.
23. Scuderi, P., R. T. Dorr, J. D. Liddil, P. R. Finley, P. Meltzer, A. B. Raitano, and J. Rybski. 1989. Alpha-globulins suppress human leukocyte tumor necrosis factor secretion. Eur. J. Immunol. 19:939.
24. Libert, C., W. Van Molle, P. Brouckaert, and W. Fiers. 1996. Platelet-activating factor is a mediator in tumor necrosis factor/galactosamine-induced lethality. J. Inflamm. 46:139.
25. Camussi, G., F. Bussolino, G. Salvidio, and C. Baglioni. 1987. Tumor necrosis factor/cachectin stimulates peritoneal macrophages, polymorphonuclear neutrophils, and vascular endothelial cells to synthesize and release platelet-activating factor. J. Exp. Med. 166:1390.
26. 1-antichymotrypsin and is stimulated by proteinases. J. Exp. Med. 168:1293.
27. Bussolino, F., M. Arese, L. Silvestro, R. Soldi, E. Benfenati, F. Sanavio, M. Aglietta, A. Bosia, and G. Camussi. 1994. Involvement of a serine protease in the synthesis of platelet-activating factor by endothelial cells stimulated by tumor necrosis factor-α or interleukin-1α. Eur. J. Immunol. 24:3131.
28. 1 antitrypsin. Biochim. Biophys. Acta 1224:433.
29. Harbrecht, B. G., T. R. Billiar, R. D. Curran, J. Stadler, and R. L. Simmons 1993. Hepatocyte injury by activated neutrophils in vitro is mediated by proteases. Ann. Surg. 218:120.
30. Oka, Y., A. Murata, J. Mishijima, M. Ogawa, and T. Mori. 1993. The mechanism of hepatic cellular injury in sepsis: an in vitro study of the implications of cytokines and neutrophils in its pathogenesis. J. Surg. Res. 55:1.
31. Tilg, H., E. Vannier, G. Vachino, C. A. Dinarello, and J. W. Mier. 1993. Antiinflammatory properties of hepatic acute-phase proteins: preferential induction of interleukin 1 (IL-1) receptor antagonist over IL-1β synthesis by human peripheral blood mononuclear cells. J. Exp. Med, 178:1629.
32. Everaerdt, B., P. Brouckaert, and W. Fiers. 1994. Recombinant IL-1 receptor antagonist protects against TNF-induced lethality in mice. J. Immunol. 152:5041.
33. 1-protease inhibitor is not an acute-phase reactant. Arch. Biochem. Biophys. 246:488.