1,3-dipolar cycloaddition on baylis-hillman adducts: Novel synthesis of pyrrolidines, spiropyrrolidines, and spiropyrrolizidines

Synthesis

Volumn , Issue 13, 2011, Pages 2136-2146

  Bakthadoss, Manickam ^a   Sivakumar, Nagappan ^a   Devaraj, Anthonisamy ^a   Sharada, Duddu S ^b  

^a UNIVERSITY OF MADRAS   (India)

^b CENTRAL LEATHER RESEARCH INSTITUTE   (India)

Author keywords

1,3 dipolar cycloaddition; azomethine ylides; Baylis Hillman reaction; intermolecular 3+2 cycloaddition; pyrrolidines; spiro compounds

Indexed keywords

1 ,3-DIPOLARCYCLOADDITION; AZOMETHINE YLIDES; BAYLIS-HILLMAN REACTIONS; INTERMOLECULAR [3+2] CYCLOADDITION; PYRROLIDINES; SPIRO COMPOUNDS;

CYCLOADDITION; STEREOCHEMISTRY; STEREOSELECTIVITY;

SYNTHESIS (CHEMICAL);

(1 METHYL 3 NITRO 4 PHENYLPYRROLIDIN 3 YL)METHANOL; 2 NITRO 3 (2 TOLYL)PROP 2 EN 1 OL; 2 NITRO 3 (4 TOLYL)PROP 2 EN 1 OL; 2 NITRO 3 (THIOPHEN 2 YL)PROP 2 EN 1 OL; 2 NITRO 3 PHENYLPROP 2 EN 1 OL; 3 (2 CHLOROPHENYL) 2 NITROPROP 2 EN 1 OL; 3 (2 METHOXYPHENYL) 2 NITROPROP 2 EN 1 OL; 3 (3 CHLOROPHENYL) 2 NITROPROP 2 EN 1 OL; 3 (3,4 DIMETHOXYPHENYL) 2 NITROPROP 2 EN 1 OL; 3 (4 CHLOROPHENYL) 2 NITROPROP 2 EN 1 OL; 3 (4 ETHYLPHENYL) 2 NITROPROP 2 EN 1 OL; 3 (4 FLUOROPHENYL) 2 NITROPROP 2 EN 1 OL; 3 (4 ISOPROPYLPHENYL) 2 NITROPROP 2 EN 1 OL; 3 (4 METHOXYPHENYL) 2 NITROPROP 2 EN 1 OL; 3 (NAPHTHALEN 2 YL) 2 NITROPROP 2 EN 1 OL; 3 [3,4 (METHYLENEDIOXY)PHENYL] 2 NITROPROP 2 EN 1 OL; 3' (HYDROXYMETHYL) 1' METHYL 3' NITRO 4' (2 TOLYL)SPIRO(INDOLE 3,2' PYRROLIDIN) 2(1H) ONE; 3' (HYDROXYMETHYL) 1' METHYL 3' NITRO 4' (4 TOLYL)SPIRO(INDOLE 3,2' PYRROLIDIN) 2(1H) ONE; 3' (HYDROXYMETHYL) 1' METHYL 3' NITRO 4' PHENYLSPIRO(INDOLE 3,2' PYRROLIDIN) 2(1H) ONE; [1 METHYL 3 NITRO 4 (4 TOLYL)PYRROLIDIN 3 YL]METHANOL; [1 METHYL 3 NITRO 4 (THIOPHEN 2 YL)PYRROLIDIN 3 YL]METHANOL; [1 METHYL 4 (NAPHTHALEN 2 YL) 3 NITROPYRROLIDIN 3 YL]METHANOL; [4 (3,4 DIMETHOXYPHENYL) 1 METHYL 3 NITROPYRROLIDIN 3 YL]METHANOL; [4 (4 ETHYLPHENYL) 1 METHYL 3 NITROPYRROLIDIN 3 YL]METHANOL; [4 (4 METHOXYPHENYL) 1 METHYL 3 NITROPYRROLIDIN 3 YL]METHANOL; PYRROLIDINE DERIVATIVE; PYRROLIZIDINE DERIVATIVE; SPIROPYRROLIDINE DERIVATIVE; SPIROPYRROLIZIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BAYLIS HILLMAN REACTION; CHEMICAL REACTION KINETICS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CYCLOADDITION; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; SOLVENT EFFECT; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY;

EID: 79959374758     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0030-1260053     Document Type: Article

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