Genetically modified mouse models used for studying the role of the AT 2 receptor in cardiac hypertrophy and heart failure

Journal of Biomedicine and Biotechnology

Volumn 2011, Issue , 2011, Pages

  Yan, Xinhua ^a   Avila, Maria D ^a   Morgan, James P ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANGIOTENSIN II; MYOSIN HEAVY CHAIN ALPHA;

AORTA STENOSIS; APOPTOSIS; BODY WEIGHT; CARDIOVASCULAR SYSTEM; CELL PROLIFERATION; DNA MODIFICATION; ECHOCARDIOGRAPHY; ENDOTHELIUM CELL; FIBROBLAST; GENE DELETION; GENE OVEREXPRESSION; HEART FAILURE; HEART INFARCTION; HEART LEFT VENTRICLE MASS; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; HUMAN; HYPERTENSION; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SMOOTH MUSCLE FIBER; SYSTOLIC BLOOD PRESSURE; TRANSGENIC MOUSE; X CHROMOSOME; ANIMAL; CARDIOMEGALY; DISEASE MODEL; METABOLISM; MOUSE;

ANIMALS; CARDIOMEGALY; DISEASE MODELS, ANIMAL; HEART FAILURE; MICE; MICE, TRANSGENIC; RECEPTOR, ANGIOTENSIN, TYPE 2;

EID: 79959370726     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/141039     Document Type: Review

References (33)

1. Lorell B. H., Role of angiotensin AT 1 and AT 2 receptors in cardiac hypertrophy and disease American Journal of Cardiology 1999 83 12A 48H 52H (Pubitemid 29330928)
2. Matsubara H., Renin-angiotensin system in human failing hearts: message from nonmyocyte cells to myocytes Circulation Research 2001 88 9 861 863 (Pubitemid 32441463)
3. Grady E. F., Sechi L. A., Griffin C. A., Schambelan M., Kalinyak J. E., Expression of AT 2 receptors in the developing rat fetus Journal of Clinical Investigation 1991 88 3 921 933
4. Wang Z. Q., Moore A. F., Ozono R., Siragy H. M., Carey R. M., Immunolocalization of subtype 2 angiotensin II (AT 2) receptor protein in rat heart Hypertension 1998 32 1 78 83 (Pubitemid 28324128)
5. Booz G. W., Baker K. M., Role of type 1 and type 2 angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophy Hypertension 1996 28 4 635 640 (Pubitemid 26327961)
6. Schneider M. D., Lorell B. H., AT 2, judgment day: which angiotensin receptor is the culprit in cardiac hypertrophy? Circulation 2001 104 3 247 248 (Pubitemid 32666941)
7. Booz G. W., Cardiac angiotensin AT 2 receptor. What exactly does it do? Hypertension 2004 43 6 1162 1163 (Pubitemid 38691731)
8. Horiuchi M., Akishita M., Dzau V. J., Recent progress in angiotensin II type 2 receptor research in the cardiovascular system Hypertension 1999 33 2 613 621 (Pubitemid 29091636)
9. Opie L. H., Sack M. N., Enhanced angiotensin II activity in heart failure: reevaluation of the counterregulatory hypothesis of receptor subtypes Circulation Research 2001 88 7 654 658 (Pubitemid 32378133)
10. Asano K., Dutcher D. L., Port J. D., Minobe W. A., Tremmel K. D., Roden R. L., Bohlmeyer T. J., Bush E. W., Jenkin M. J., Abraham W. T., Raynolds M. V., Zisman L. S., Perryman M. B., Bristow M. R., Selective downregulation of the angiotensin II AT 1 -receptor subtype in failing human ventricular myocardium Circulation 1997 95 5 1193 1200 (Pubitemid 27097830)
11. Regitz-Zagrosek V., Friedel N., Heymann A., Bauer P., Neuss M., Rolfs A., Steffen C., Hildebrandt A., Hetzer R., Fleck E., Regulation, chamber localization, and subtype distribution of angiotensin II receptors in human hearts Circulation 1995 91 5 1461 1471
12. Senbonmatsu T., Saito T., Landon E. J., Watanabe O., Price E., Roberts R. L., Imboden H., Fitzgerald T. G., Gaffney F. A., Inagami T., A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy The EMBO Journal 2003 22 24 6471 6482 (Pubitemid 38009595)
13. Izumo S., Shioi T., Cardiac transgenic and gene-targeted mice as models of cardiac hypertrophy and failure: a problem of (new) riches Journal of Cardiac Failure 1998 4 4 263 270 (Pubitemid 29042612)
14. Yan X., Price R. L., Nakayama M., Ito K., Schuldt A. J. T., Manning W. J., Sanbe A., Borg T. K., Robbins J., Lorell B. H., Ventricular-specific expression of angiotensin II type 2 receptors causes dilated cardiomyopathy and heart failure in transgenic mice American Journal of Physiology 2003 285 5 H2179 H2187
15. Masaki H., Kurihara T., Yamaki A., Inomata N., Nozawa Y., Mori Y., Murasawa S., Kizima K., Maruyama K., Horiuchi M., Dzau V. J., Takahashi H., Iwasaka T., Inada M., Matsubara H., Cardiac-specific overexpression of angiotensin II AT 2 receptor causes attenuated response to AT 1 receptor-mediated pressor and chronotropic effects Journal of Clinical Investigation 1998 101 3 527 535 (Pubitemid 28084234)
16. Ichiki T., Labosky P. A., Shiota C., Okuyama S., Imagawa Y., Fogo A., Niimura F., Ichikawa I., Hogan B. L. M., Inagami T., Effects on blood pressure exploratory behaviour of mice lacking angiotensin II type 2 receptor Nature 1995 377 6551 748 750
17. Hein L., Barsh G. S., Pratt R. E., Dzau V. J., Kobilka B. K., Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice Nature 1995 377 6551 744 747
18. Yang Z., Bove C. M., French B. A., Epstein F. H., Berr S. S., DiMaria J. M., Gibson J. J., Carey R. M., Kramer C. M., Angiotensin II type 2 receptor overexpression preserves left ventricular function after myocardial infarction Circulation 2002 106 1 106 111 (Pubitemid 34747449)
19. Sugino H., Ozono R., Kurisu S., Matsuura H., Ishida M., Oshima T., Kambe M., Teranishi Y., Masaki H., Matsubara H., Apoptosis is not increased in myocardium overexpressing type 2 angiotensin II receptor in transgenic mice Hypertension 2001 37 6 1394 1398 (Pubitemid 34225380)
20. Nakayama M., Yan X., Price R. L., Borg T. K., Ito K., Sanbe A., Robbins J., Lorell B. H., Chronic ventricular myocyte-specific overexpression of angiotensin II type 2 receptor results in intrinsic myocyte contractile dysfunction American Journal of Physiology 2005 288 1 H317 H327
21. Yan X., Schuldt A. J. T., Price R. L., Amende I., Liu F. F., Okoshi K., Ho K. K. L., Pope A. J., Borg T. K., Lorell B. H., Morgan J. P., Pressure overload-induced hypertrophy in transgenic mice selectively overexpressing AT 2 receptors in ventricular myocytes American Journal of Physiology 2008 294 3 H1274 H1281
22. Senbonmatsu T., Ichihara S., Price E., Gaffney F. A., Inagami T., Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload Journal of Clinical Investigation 2000 106 3 R25 R29
23. Ichihara S., Senbonmatsu T., Price E., Ichiki T., Gaffney F. A., Inagami T., Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension Circulation 2001 104 3 346 351 (Pubitemid 32666959)
24. Akishita M., Iwai M., Wu L., Zhang L., Ouchi Y., Dzau V. J., Horiuchi M., Inhibitory effect of angiotensin II type 2 receptor on coronary arterial remodeling after aortic banding in mice Circulation 2000 102 14 1684 1689
25. Adachi Y., Saito Y., Kishimoto I., Harada M., Kuwahara K., Takahashi N., Kawakami R., Nakanishi M., Nakagawa Y., Tanimoto K., Saitoh Y., Yasuno S., Usami S., Iwai M., Horiuchi M., Nakao K., Angiotensin II type 2 receptor deficiency exacerbates heart failure and reduces survival after acute myocardial infarction in mice Circulation 2003 107 19 2406 2408 (Pubitemid 36605220)
26. Tsutsumi Y., Matsubara H., Ohkubo N., Mori Y., Nozawa Y., Murasawa S., Kijima K., Maruyama K., Masaki H., Moriguchi Y., Shibasaki Y., Kamihata H., Inada M., Iwasaka T., Angiotensin II type 2 receptor is upregulated in human heart with interstitial fibrosis, and cardiac fibroblasts are the major cell type for its expression Circulation Research 1998 83 10 1035 1046 (Pubitemid 28520933)
27. Stoll M., Steckelings U. M., Paul M., Bottari S. P., Metzger R., Unger T., The angiotensin AT 2 -receptor mediates inhibition of cell proliferation in coronary endothelial cells Journal of Clinical Investigation 1995 95 2 651 657
28. Van Kesteren C. A. M., Van Heugten H. A. A., Lamers J. M. J., Saxena P. R., Schalekamp M. A. D. H., Danser A. H. J., Angiotensin II-mediated growth and antigrowth effects in cultured neonatal rat cardiac myocytes and fibroblasts Journal of Molecular and Cellular Cardiology 1997 29 8 2147 2157 (Pubitemid 27348525)
29. Nakajima M., Hutchinson H. G., Fujinaga M., Hayashida W., Morishita R., Zhang L., Horiuchi M., Pratt R. E., Dzau V. J., The angiotensin II type 2 (AT 2) receptor antagonizes the growth effects of the AT 1 receptor: gain-of-function study using gene transfer Proceedings of the National Academy of Sciences of the United States of America 1995 92 23 10663 10667
30. D'Amore A., Black M. J., Thomas W. G., The angiotensin II type 2 receptor causes constitutive growth of cardiomyocytes and does not antagonize angiotensin II type 1 receptor-mediated hypertrophy Hypertension 2005 46 6 1347 1354 (Pubitemid 43189734)
31. Widdop R. E., Jones E. S., Hannan R. E., Gaspari T. A., Angiotensin AT 2 receptors: cardiovascular hope or hype? British Journal of Pharmacology 2003 140 5 809 824 (Pubitemid 37464062)
32. Ohkubo N., Matsubara H., Nozawa Y., Mori Y., Murasawa S., Kijima K., Maruyama K., Masaki H., Tsutumi Y., Shibazaki Y., Iwasaka T., Inada M., Angiotensin type 2 receptors are reexpressed by cardiac fibroblasts from failing myopathic hamster hearts and inhibit cell growth and fibrillar collagen metabolism Circulation 1997 96 11 3954 3962
33. Wharton J., Morgan K., Rutherford R. A. D., Catravas J. D., Chester A., Whitehead B. F., De Leval M. R., Yacoub M. H., Polak J. M., Differential distribution of angiotensin AT 2 receptors in the normal and failing human heart Journal of Pharmacology and Experimental Therapeutics 1998 284 1 323 336 (Pubitemid 28109563)