Role of angiotensin AT1 and AT2 receptors in cardiac hypertrophy and disease

American Journal of Cardiology

Volumn 83, Issue 12 A, 1999, Pages 48-52

  Lorell, Beverly H ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; RECEPTOR SUBTYPE; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA STENOSIS; CELL GROWTH; CELL PROLIFERATION; CONFERENCE PAPER; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; ANIMAL; AORTA VALVE STENOSIS; CARDIOMEGALY; CELL DIVISION; DRUG EFFECT; HEART MUSCLE; HUMAN; METABOLISM; PATHOLOGY; PHYSIOLOGY; REVIEW;

ANGIOTENSIN II; ANIMALS; AORTIC VALVE STENOSIS; CARDIOMEGALY; CELL DIVISION; HUMANS; HYPERTENSION; MYOCARDIUM; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RECEPTORS, ANGIOTENSIN; SIGNAL TRANSDUCTION;

EID: 0033577915     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(99)00258-1     Document Type: Conference Paper

References (64)

1. Morgan H.E., Baker K.M. Cardiac hypertrophy mechanical, neural, and endocrine dependence . Circulation. 83:1991;13-25.
2. Sadoshima J.I., Izumo S. Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Circ Res. 73:1993;413-423.
3. Baker K.M., Aceto J.F. Angiotensin II stimulation of protein synthesis and cell growth in chick hearts cells. Am J Physiol. 258:1990;H610-H618.
4. Schunkert H., Sadoshima J., Corneliuus T., Kagaya Y., Weinberg E.O., Izumo S., Riegger G., Lorell B.H. Angiotensin II-induced growth responses in isolated adult rat hearts evidence for load-independent induction of cardiac protein synthesis by angiotensin II . Circ Res. 76:1995;489-497.
5. Schunkert H., Weinberg E.O., Bruckschlegel G., Rigger A.J.G., Lorell B.H. Alteration of growth responses in established cardiac pressure overload hypertrophy in rats with aortic banding. J Clin Invest. 96:1995;2768-2774.
6. 1 receptor . Am J Hypertens. 5:1992;276-280.
7. Shubeita H.E., McDonough P.M., Harris A.N., Knowlton K.U., Glembotski C.C., Brown J.H., Chien K.R. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy. J Biol Chem. 265:1990;20555-20562.
8. +-H+ exchange is impaired in cardiac hypertrophy. J Clin Invest. 99:1997;125-135.
9. Kem D.C., Johnson E.I., Capponi A.M., Chardonnens D., Lang U., Blondel B., Koshida H., Vallotton M.B. Effects of angiotensin II on cytosolic free calcium in neonatal rat cardiomyocytes. Am J Physiol. 261:1991;C77-C85.
10. Barry W.H., Matsui H., Bridge J.H.B., Spitzer K.W. Excitation-contraction coupling in ventricular myocytes effects of angiotensin II . Adv Exp Med Biol. 382:1995;31-39.
11. Pan J., Fukuda K., Kodama H., Makino S., Takahashi T., Sano M., Hori S., Ogawa S. Role of angiotensin II in activation of the JAK/STAT pathway induced by acute pressure overload in the rat heart. Circ Res. 81:1997;611-617.
12. 2-terminal kinase in cultured cardiac myocytes of neonatal rats. Circ Res. 80:1997;139-146.
13. Booz G.W., Dostal D.E., Baker K.M. Paracrine actions of cardiac fibroblasts on cardiomyocytes implications for the cardiac renin-angiotensin system . Am J Cardiol. 83:1999;44H-47H.
14. Schunkert H., Dzau H.J., Tang S.S., Hirsch A.T., Apstein C.S., Lorell B.H. Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy effects on coronary resistance, contractility and relaxation . J Clin Invest. 86:1990;1913-1920.
15. Schunkert H., Jackson B., Tang S.S., Schoen F.J., Smits J.F.M., Apstein C.S., Lorell B.H. Distribution and functional significance of cardiac ACE in hypertrophied rat hearts. Circulation. 87:1993;1328-1339.
16. Struder R., Reinecke H., Muller B., Holtz J., Just H. Increased angiotensin-I converting enzyme gene expression in the failing human heart quantification by competitive RNA polymerase chain reaction . J Clin Invest. 94:1994;301-310.
17. Kromer E.P., Elsner D., Riegger G.A.J. Role of neurohumoral systems for pressure induced left ventricular hypertrophy in experimental supravalvular aortic stenosis in rats. Am J Hypertens. 4:1991;521-524.
18. Baker K.M., Chernin M.I., Wixson S.K., Aceto J.F. Renin-angiotensin system involvement in pressure-overload cardiac hypertrophy in rats. Am J Physiol. 259:1990;H324-H332.
19. Dahlof B., Pennert K., Hansson L. Regression of left ventricular hypertrophy a meta-analysis . Clin Exp Hypertens. A14:1992;173-180.
20. Sadoshima J., Xu Y., Slayter H.S., Izumo S. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell. 75:1993;413-423.
21. Kojima K., Shiohima I., Yamasaki T., Komuro I., Yunzeng Z., Ying W., Mizuno T., Ueki K., Tobe K., Kadowaki T., Nagai R., Yazaki Y. Angiotensin II receptor antagonist TCV-116 induces regression of hypertensive left ventricular hypertrophy in vivo and inhibits the intracellular signaling pathway of stretch-mediated cardiomyocyte hypertrophy in vitro. Circulation. 89:1994;2204-2211.
22. Harada K., Komuro I., Shiojima I., Hayashi D., Kudoh S., Mizuno T., Kijima K., Matsubara H., Sugaya T., Murakami K., Yazaki Y. Pressure overload induces cardiac hypertrophy in angiotensin II type 1A receptor knockout mice. Circulation. 97:1998;1952-1959.
23. 1A receptors. Am J Physiol. 274:1998;H868-H873.
24. 1B receptors in blood pressure regulation . Am J Physiol. 272:1997;F515-F520.
25. Tsuchida S., Matsusaka T., Chen X., Okubo S., Niimura F., Nisimura H., Fogo A., Utsunomiya H., Inagami T., Ichikawa I. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicated severe abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest. 101:1998;755-760.
26. 1 receptor . Circulation. 95:1997;2677-2683.
27. 1 receptor inhibition. Effects on hypertrophic remodeling and ACE expression in rats with pressure-overload hypertrophy due to ascending aortic stenosis. Circulation. 95:1997;1592-1600.
28. Weinberg E.O., Schoen F.S., George D., Kagaya Y., Douglas P.S., Litwin S.E., Schunkert H., Benedict C.R., Lorell B.H. Angiotensin-converting enzyme inhibition prolongs survival and modifies the transition to heart failure in rats with pressure overload hypertrophy due to ascending aortic stenosis. Circulation. 90:1994;1410-1422.
29. Raya T.E., Fonken S.J., Lee R.W., Daugherty S., Goldman S., Wong P.C., Timmermans P., Morkin E. Hemodynamic effects of direct angiotensin II blockade compared to converting enzyme inhibition in rat model of heart failure. Am J Hypertens. 4:1991;334S-340S.
30. Schieffer B., Wirger A., Meybrunn M., Steiz S., Holtz J., Riede U.N., Drexler H. Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodeling after myocardial infarction in the rat. Circulation. 89:1994;2273-2282.
31. Ruzicka M., Yuan B., Harmsen E., Leenen F.H.H. The renin-angiotensin system and volume overload-induced cardiac hypertrophy in rats effects of angiotensin converting enzyme inhibitor versus angiotensin II receptor blocker . Circulation. 87:1993;921-930.
32. McDonald K.M., Garr M., Carlyle P.F., Francis G.S., Hauer K., Hunter D.W., Parish T., Stillman A., Cohn J.N. Relative effects of α1-adrenoreceptor blockade, converting enzyme inhibitor therapy, and angiotensin II subtype 1 receptor blockade on ventricular remodeling in the dog. Circulation. 90:1994;3034-3046.
33. 1 angiotensin II receptor blockade on LV and myocyte function and structure with dilated cardiomyopathy. Circulation. 90:1994;I-111. (Abstr.).
34. Liu Y.H., Yang X.P., Sharov V.G., Nass O., Sabbah H.N., Peterson E., Carretero O.A. Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1-receptor antagonists in rats with heart failure. Role of kinins and angiotensin II type 2 receptors. J Clin Invest. 99:1997;1926-1935.
35. Minshall R.D., Tan F., Nakamura F., Rabito S.F., Becher R.P., Marcic B., Erdos E.G. Potentiation of the actions of bradykinin by angiotensin I-converting enzyme inhibitors. Circ Res. 81:1997;848-856.
36. 2 receptor . J Hum Hypertens. 12:1998;311-318.
37. 2) receptor protein in rat heart. Hypertension. 32:1998;78-83.
38. Price R.L., Carver W., Simpson D.G., Fu L., Zhao J. The effects of angiotensin II and specific angiotensin receptor blockers on embryonic cardiac development and looping patterns. Dev Biol. 192:1997;5672-5684.
39. + current in neurons by an angiotensin II type 2-receptor fragment. Am J Physiol. 268:1995;C278-C282.
40. Murad F. What are the molecular mechanisms for the antiproliferative effects of nitric oxide and cGMP in vascular smooth muscle? Circulation. 95:1997;1101-1103.
41. Hayashida W., Horiuchi M., Dzau V.J. Intracellular third loop domain of angiotensin II type 2 receptor. Role in mediating signal transduction and cellular function. J Biol Chem. 271:1996;21985-21992.
42. Bedecs K., Elbaz N., Sutren M., Masson M., Susini C., Strosberg A.D., Nahmias C. Angiotensin II type receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase. Biochem J. 325:1997;449-454.
43. 2 receptor coupled signal transduction. J Mol Med. 76:1998;202-207.
44. 2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J Clin Invest. 95:1995;651-657.
45. Yamada T., Horiuchi M., Dzau V.J. Angiotensin II type 2 receptor mediates programmed cell death. Proc Natl Acad Sci USA. 93:1996;156-160.
46. Tanaka M. Characterization of angiotensin II receptor type 2 during differentiation and apoptosis of rat ovarian cultured granulosa cells. Biochem Biophys Res Commun. 207:1995;593-598.
47. Horiuchi M., Yanada T., Hayashida W., Dzau V.J. Interferon regulatory factor-1 up-regulates angiotensin II type 2 receptor and induces apoptosis. J Biol Chem. 272:1997;11952-11958.
48. Siragy H.M., Carey R.M. The subtype 2 angiotensin receptor regulates renal prostaglandin F2 alpha formation in conscious rats. Am J Physiol. 273:1997;R1103-R1107.
49. 1 receptor-mediated prostaglandin E2 production in conscious rats. J Clin Invest. 97:1996;1978-1982.
50. 2) angiotensin receptor mediates renal production of nitric oxide in conscious rats. J Clin Invest. 100:1997;264-269.
51. Hein L., Barsh G.S., Pratt R.E., Dzau V.J., Kobilka B.K. Behavioral and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice. Nature. 377:1995;744-747.
52. Ichiki T., Labosky P.A., Hiota C., Okuyama S., Imagawa Y., Fogo A., Niimura F., Ichikawa I., Hogan B.L.M., Inagami R. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature. 377:1995;748-750.
53. 2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism. Hypertension. 31:1998;349-355.
54. 1 receptor gain of function study using gene transfer . Proc Natl Acad Sci USA. 92:1995;10663-10667.
55. 2 receptor subtypes in hypertrophied rat hearts. Am J Physiol. 267:1994;H844-H852.
56. Suzuki J., Matsubara H., Urakami M., Inada M. Rat angiotensin II (type 1A) receptor mRNA regulation and subtype expression in myocardial growth and hypertrophy. Circ Res. 73:1993;439-447.
57. 1-receptor subtype in failing human myocardium. Circulation. 95:1997;1193-2000.
58. 2 angiotensin receptor gene expression in human heart failure. Circulation. 95:1997;1201-1206.
59. Kurabayashi M., Yazaki Y. Downregulation of angiotensin II receptor type 1 in heart failure. A process of adaptation or deterioration? Circulation. 95:1997;1104-1107.
60. 1 receptor-mediated pressor and chronotropic effects. J Clin Invest. 101:1998;527-535.
61. Ohkubo N., Matsubara H., Nozawa Y., Mori Y., Murasawa S., Kijima K., Maruyama K., Masaki H., Tsutumi Y., Shibasaki Y., Iwasaka T., Inada M. Angiotensin type 2 receptors are reexpressed by cardiac fibroblasts from failing myopathic hamster hearts and inhibit cell growth and fibrillar collagen metabolism. Circulation. 11:1997;3954-3962.
62. van Kesteren C.A., van Heugten H.A., Lamers J.M., Saxena P.R., Schalekamp M.A., Danser A.H. Angiotensin II-mediated growth and antigrowth effects in cultured neonatal rat cardiac myocytes and fibroblasts. J Mol Cell Cardiol. 29:1997;2147-2157.
63. Booz G.W., Baker K.M. Role of type 1 and type 2 angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophy. Hypertension. 28:1996;635-640.
64. Bartunek J., Weinberg E.O., Tajima M., Rohrbach S., Lorell B.H. Angiotensin II type 2 receptor blockade amplifies the early signals of cardiac growth response to angiotensin II in hypertrophied hearts. Circulation. 99:1999;22-25.