Inhibition of alanine aminotransferase in Silico and in vivo promotes mitochondrial metabolism to impair malignant growth

Journal of Biological Chemistry

Volumn 286, Issue 25, 2011, Pages 22323-22330

  Beuster, Gregor ^a   Zarse, Kim ^a   Kaleta, Christoph ^a   Thierbach, René ^b   Kiehntopf, Michael ^a   Steinberg, Pablo ^b   Schuster, Stefan ^a   Ristow, Michael ^a,c  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^c GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINOTRANSFERASE; AMP-ACTIVATED PROTEIN KINASE; ATP CONTENT; CANCER CELLS; CANCER GROWTH; CYCLIN-DEPENDENT KINASE; D-GLUCOSE; ELEMENTARY MODE; EXTRACELLULAR- SIGNAL-REGULATED KINASE 1/2; IN-SILICO; IN-VIVO; INITIAL ENERGY; L-ALANINE; LEWIS LUNG CARCINOMATA; MITOCHONDRIAL METABOLISM; MITOCHONDRIAL PRODUCTION; MITOGEN ACTIVATED PROTEIN KINASE; NON-OXIDATIVE; P38 MAPK; REACTIVE OXYGEN SPECIES; RESPIRATION RATE; RETINOBLASTOMA;

AMINO ACIDS; ANCHORAGES (FOUNDATIONS); DISEASES; ENZYME ACTIVITY; GLUCOSE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEINS;

MITOCHONDRIA;

3 CHLOROALANINE; ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; CYCLIN DEPENDENT KINASE 4; CYCLOSERINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN TYROSINE PHOSPHATASE; REACTIVE OXYGEN METABOLITE; RETINOBLASTOMA PROTEIN;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL GROWTH; COMPUTER MODEL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GLUCOSE TRANSPORT; GROWTH RATE; IN VIVO STUDY; LEWIS CARCINOMA; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING;

ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; ALANINE; ALANINE TRANSAMINASE; ANIMALS; BINDING, COMPETITIVE; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL RESPIRATION; COMPUTATIONAL BIOLOGY; ENERGY METABOLISM; ENZYME ACTIVATION; ENZYME INHIBITORS; GLUCOSE; GLUTAMINE; LUNG NEOPLASMS; MICE; MITOCHONDRIA; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 79959364013     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.205229     Document Type: Article

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