The cyclic-AMP receptor protein (CRP) regulon in Aggregatibacter actinomycetemcomitans includes leukotoxin

Microbial Pathogenesis

Volumn 51, Issue 3, 2011, Pages 133-141

  Feuerbacher, Leigh A ^a   Burgum, Alex ^a   Kolodrubetz, David ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Aggregatibacter actinomycetemcomitans; CRP regulon; Cyclic AMP receptor protein; Leukotoxin

Indexed keywords

BACTERIAL RNA; BINDING PROTEIN; CARRIER PROTEIN; CYCLIC AMP BINDING PROTEIN; LEUKOTOXIN;

AGGREGATIBACTER ACTINOMYCETEMCOMITANS; ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL STRAIN; BINDING SITE; CONTROLLED STUDY; CYCLIC AMP RECEPTOR PROTEIN GENE; ENERGY METABOLISM; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REPRESSION; MICROARRAY ANALYSIS; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE ANALYSIS; REGULATOR GENE; REGULON; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SYNTHESIS; TOXIN SYNTHESIS; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

CYCLIC AMP RECEPTOR PROTEIN; EXOTOXINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; MICROARRAY ANALYSIS; PASTEURELLACEAE; REGULON; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 79959349020     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2011.04.009     Document Type: Article

References (52)

1. Nørskov-Lauritsen N., Kilian M. Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter aphrophilus to include V factor-dependent and V factor-independent isolates. Int J Syst Evol Microbiol 2005, 56:2135-2146.
2. Slots J., Ting M. Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in human periodontal disease: occurrence and treatment. Periodontol 2000 1999, 20:82-121.
3. van Winkelhoff A.J., Slots J. Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in nonoral infections. Periodontol 2000 1999, 20:122-135.
4. Mitchell R.G., Gillespie W.A. Bacterial Endocarditis due to an actinobacillus. J Clin Pathol 1964, 17:511-512.
5. Slots J. The predominant cultivable organisms in juvenile periodontitis. Scand J Dent Res 1976, 84:1-10.
6. Zambon J.J. Actinobacillus actinomycetemcomitans in human periodontal disease. J Clin Periodontol 1985, 12:1-20.
7. Henderson B., Ward J.M., Ready D. Aggregatibacter (Actinobacillus) actinomycetemcomitans: a triple A periodontopathogen?. Periodontol 2000 2010, 54:78-105.
8. Fine D.H., Kaplan J.B., Kachlany S.C., Schreiner H.C. How we got attached to Actinobacillus actinomycetemcomitans: a model for infectious diseases. Periodontol 2000 2006, 42:114-157.
9. Kinane D.F., Mooney J., Ebersole J.L. Humoral immune response to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in periodontal disease. Periodontol 2000 1999, 20:289-340.
10. Fives-Taylor P.M., Meyer D.H., Mintz K.P., Brissette C. Virulence factors of Actinobacillus actinomycetemcomitans. Periodontol 2000 1999, 20:136-167.
11. Henderson B., Nair S.P., Ward J.M., Wilson M. Molecular pathogenicity of the oral opportunistic pathogen Actinobacillus actinomycetemcomitans. Annu Rev Microbiol 2003, 57:29-55.
12. Tsai C.C., McArthur W.P., Baehni P.C., Hammond B.F., Taichman N.S. Extraction and partial characterization of a leukotoxin from a plaque-derived gram-negative microorganism. Infect Immun 1979, 25:427-439.
13. Kachlany S.C. Aggregatibacter actinomycetemcomitans leukotoxin: from threat to therapy. J Dent Res 2010, 89:561-570.
14. Haubek D. The highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans: evolutionary aspects, epidemiology and etiological role in aggressive periodontitis. Acta Pathol Microbiol Immunol Scand 2010, 118(Suppl. 130):1-53.
15. Taichman N.S., Wilton J.M. Leukotoxicity of an extract from Actinobacillus actinomycetemcomitans for human gingival polymorphonuclear leukocytes. Inflammation 1981, 5:1-12.
16. Lally E.T., Kieba I.R., Sato A., Green C.L., Rosenbloom J., Korostoff J., et al. RTX toxins recognize a β2 integrin on the surface of human target cells. J Biol Chem 1997, 272:30463-30469.
17. Johansson A., Sandström G., Claesson R., Hänström L., Kalfas S. Anaerobic neutrophil-dependent killing of Actinobacillus actinomycetemcomitans in relation to the bacterial leukotoxicity. Eur J Oral Sci 2000, 108:136-146.
18. Venketaraman V., Lin A.K., Le A., Kachlany S.C., Connell N.D., Kaplan J.B. Both leukotoxin and poly-N-acetylglucosamine surface polysaccharide protect Aggregatibacter actinomycetemcomitans cells from macrophage killing. Microb Pathog 2008, 45:173-180.
19. Balashova N.V., Crosby J.A., Al Ghofaily L., Kachlany S.C. Leukotoxin confers beta-hemolytic activity to Actinobacillus actinomycetemcomitans. Infect Immun 2006, 74:2015-2021.
20. Korostoff J., Wang J.F., Kieba I., Miller M., Shenker B.J., Lally E.T. Actinobacillus actinomycetemcomitans leukotoxin induces apoptosis in HL-60 cells. Infect Immun 1998, 66:4474-4483.
21. Kelk P., Claesson R., Chen C., Sjöstedt A., Johansson A. IL-1β secretion induced by Aggregatibacter (Actinobacillus) actinomycetemcomitans is mainly caused by the leukotoxin. Int J Med Microbiol 2008, 298:529-541.
22. Kelk P., Abd H., Claesson R., Sandström G., Sjöstedt A., Johansson A. Cellular and molecular response of human macrophages exposed to Aggregatibacter actinomycetemcomitans leukotoxin. Cell Death Dis 2011, 2:e126.
23. Tsai C.C., Shenker B.J., DiRienzo J.M., Malamud D., Taichman N.S. Extraction and isolation of a leukotoxin from Actinobacillus actinomycetemcomitans with polymyxin B. Infect Immun 1984, 43:700-705.
24. Brogan J.M., Lally E.T., Poulsen K., Kilian M., Demuth D.R. Regulation of Actinobacillus actinomycetemcomitans leukotoxin expression: analysis of the promoter regions of leukotoxic and minimally leukotoxic strains. Infect Immun 1994, 62:501-508.
25. Kolodrubetz D., Spitznagel J., Wang B., Phillips L.H., Jacobs C., Kraig E. cis elements and trans factors are both important in strain-specific regulation of the leukotoxin gene in Actinobacillus actinomycetemcomitans. Infect Immun 1996, 64:3451-3460.
26. Spitznagel J., Kraig E., Kolodrubetz D. The regulation of leukotoxin production in Actinobacillus actinomycetemcomitans strain JP2. Adv Dent Res 1995, 9:48-54.
27. Kolodrubetz D., Phillips L., Jacobs C., Burgum A., Kraig E. Anaerobic regulation of Actinobacillus actinomycetemcomitans leukotoxin transcription is ArcA/FnrA-independent and requires a novel promoter element. Res Microbiol 2003, 154:645-653.
28. Fong K.P., Chung W.O., Lamont R.J., Demuth D.R. Intra- and interspecies regulation of gene expression by Actinobacillus actinomycetemcomitans LuxS. Infect Immun 2001, 69:7625-7634.
29. Balashova N.V., Diaz R., Balashov S.V., Crosby J.A., Kachlany S.C. Regulation of Aggregatibacter (Actinobacillus) actinomycetemcomitans leukotoxin secretion by iron. J Bacteriol 2006, 188:8658-8661.
30. Isaza M.P., Duncan M.S., Kaplan J.B., Kachlany S.C. Screen for leukotoxin mutants in Aggregatibacter actinomycetemcomitans: genes of the phosphotransferase system are required for leukotoxin biosynthesis. Infect Immun 2008, 76:3561-3568.
31. Mizoguchi K., Ohta H., Miyagi A., Kurihara H., Takashiba S., Kato K., et al. The regulatory effect of fermentable sugar levels on the production of leukotoxin by Actinobacillus actinomycetemcomitans. FEMS Microbiol Lett 1997, 146:161-166.
32. Inoue T., Tanimoto I., Tada T., Ohashi T., Fukui K., Ohta H. Fermentable-sugar-level-dependent regulation of leukotoxin synthesis in a variably toxic strain of Actinobacillus actinomycetemcomitans. Microbiology 2001, 147:2749-2756.
33. Kolb A., Busby S., Buc H., Garges S., Adhya S. Transcriptional regulation by cAMP and its receptor protein. Annu Rev Biochem 1993, 62:749-795.
34. Gosset G., Zhang Z., Nayyar S., Cuevas W.A., Saier M.H. Transcriptome analysis of Crp-dependent catabolite control of gene expression in Escherichia coli. J Bacteriol 2004, 186:3516-3524.
35. Zheng D., Constantinidou C., Hobman J.L., Minchin S.D. Identification of the CRP regulon using in vitro and in vivo transcriptional profiling. Nucleic Acids Res 2004, 32:5874-5893.
36. Hollands K., Busby S.J., Lloyd G.S. New targets for the cyclic AMP receptor protein in the Escherichia coli K-12 genome. FEMS Microbiol Lett 2007, 274:89-94.
37. Liang W., Pascual-Montano A., Silva A.J., Benitez J.A. The cyclic AMP receptor protein modulates quorum sensing, motility and multiple genes that affect intestinal colonization in Vibrio cholerae. Microbiology 2007, 153:2964-2975.
38. Zhan L., Han Y., Yang L., Geng J., Li Y., Gao H., et al. The cyclic AMP receptor protein, CRP, is required for both virulence and expression of the minimal CRP regulon in Yersinia pestis biovar microtus. Infect Immun 2008, 76:5028-5037.
39. Spitznagel J., Kraig E., Kolodrubetz D. Regulation of leukotoxin in leukotoxic and nonleukotoxic strains of Actinobacillus actinomycetemcomitans. Infect Immun 1991, 59:1394-1401.
40. Görke B., Stülke J. Carbon catabolite repression in bacteria: many ways to make the most out of nutrients. Nat Rev Microbiol 2008, 6:613-624.
41. Gama-Castro S., Jiménez-Jacinto V., Peralta-Gil M., Santos-Zavaleta A., Peñaloza-Spinola M.I., Contreras-Moreira B., et al. RegulonDB (version 6.0): gene regulation model of Escherichia coli K-12 beyond transcription, active (experimental) annotated promoters and Textpresso navigation. Nucleic Acids Res 2008, 36:D120-D124.
42. Saddi-Ortega L., Carvalho M.A., Cisalpino P.S., Moreira E.S. Actinobacillus actinomycetemcomitans genetic heterogeneity: amplification of JP2-like ltx promoter pattern correlated with specific arbitrarily primed polymerase chain reaction (AP-PCR) genotypes from human but not marmoset Brazilian isolates. Can J Microbiol 2002, 48:602-610.
43. Chen C., Kittichotirat W., Si Y., Bumgarner R. Genome sequence of Aggregatibacter actinomycetemcomitans serotype c strain D11S-1. J Bacteriol 2009, 191:7378-7379.
44. Jansen C., Gronenborn A.M., Clore G.M. The binding of the cyclic AMP receptor protein to synthetic DNA sites containing permutations in the consensus sequence TGTGA. Biochem J 1987, 246:227-232.
45. Deutscher J., Francke C., Postma P.W. How phosphotransferase system-related protein phosphorylation regulates carbohydrate metabolism in bacteria. Microbiol Mol Biol Rev 2006, 70:939-1031.
46. Seidman C.E., Struhl K., Sheen J., Jessen T. Introduction of plasmid DNA into cells. Curr Protoc Mol Biol 1997, 37:1.8.1-1.8.10.
47. LeBlanc D.J., Lee L.N., Inamine J.M. Cloning and nucleotide base sequence analysis of a spectinomycin adenyltransferase AAD(9) determinant from Enterococcus faecalis. Antimicrob Agents Chemother 1991, 35:1804-1810.
48. Reyrat J.M., Pelicic V., Gicquel B., Rappuoli R. Counterselectable markers: untapped tools for bacterial genetics and pathogenesis. Infect Immun 1998, 66:4011-4017.
49. Ferrari E., Hoch J.A. Genetics. Bacillus 1989, 57-72. Plenum Press, New York, NY. C.R. Harwood (Ed.).
50. Irizarry R.A., Hobbs B., Collin F., Beazer-Barclay Y.D., Antonellis K.J., Scherf U., et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003, 4:249-264.
51. Bolstad B.M., Irizarry R.A., Åstrand M., Speed T.P. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 2003, 19:185-193.
52. Saeed A.I., Bhagabati N.K., Braisted J.C., Liang W., Sharov V., Howe E.A., et al. TM4 microarray software suite. Methods Enzymol 2006, 411:134-193.