Homozygous missense N629D hERG (KCNH2) potassium channel mutation causes developmental defects in the right ventricle and its outflow tract and embryonic lethality

Circulation Research

Volumn 103, Issue 12, 2008, Pages 1483-1491

  Teng, Guo Qi ^a   Zhao, Xian ^a   Lees Miller, James P ^a   Quinn, F Russell ^a   Li, Pin ^a   Rancourt, Derrick E ^a   London, Barry ^b   Cross, James C ^a   Duff, Henry J ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Embryo developmental defect; KCNH2 (hERG); Knock in mouse

Indexed keywords

POTASSIUM CHANNEL HERG; PROTEIN; PROTEIN HAND2; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; TRANSCRIPTION FACTOR ERG; UNCLASSIFIED DRUG; ASPARAGINE; ASPARTIC ACID; ERG1 POTASSIUM CHANNEL; KCNH1 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRANCHIAL ARCH; CALCIUM SIGNALING; CELL MEMBRANE; CONTROLLED STUDY; CRANIOFACIAL MORPHOLOGY; EMBRYO; EMBRYONIC STEM CELL; FEMALE; HEART ARRHYTHMIA; HEART BEAT; HEART DEPOLARIZATION; HEART DISEASE; HEART MUSCLE CELL; HEART OUTPUT; HEART REPOLARIZATION; HEART VENTRICLE SEPTUM; LETHALITY; MEMBRANE STEADY POTENTIAL; MISSENSE MUTATION; MOUSE; MUSCLE ACTION POTENTIAL; NONHUMAN; OSCILLATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; AMINO ACID SUBSTITUTION; ANIMAL; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENETICS; HEART RIGHT VENTRICLE FUNCTION; HEART VENTRICLE; HOMOZYGOTE; LONG QT SYNDROME; METABOLISM; MORTALITY; MOUSE MUTANT; PREGNANCY; PRENATAL DEVELOPMENT;

AMINO ACID SUBSTITUTION; ANIMALS; ASPARAGINE; ASPARTIC ACID; CARDIAC OUTPUT; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART VENTRICLES; HOMOZYGOTE; LONG QT SYNDROME; MICE; MICE, MUTANT STRAINS; MUTATION, MISSENSE; PREGNANCY; VENTRICULAR DYSFUNCTION, RIGHT;

EID: 58149389212     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.177055     Document Type: Article

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