Vitamin C and E suppress mitogen-stimulated peripheral blood mononuclear cells in vitro

International Archives of Allergy and Immunology

Volumn 142, Issue 2, 2007, Pages 127-132

  Winkler, C ^a   Schroecksnadel, K ^a   Schennach, H ^b   Fuchs, D ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

Author keywords

Indoleamine (2,3) dioxygenase; Kynurenine; Neopterin; Tryptophan; Vitamin C; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CONCANAVALIN A; NEOPTERIN; PHYTOHEMAGGLUTININ; TRYPTOPHAN;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; HUMAN; IMMUNOBIOLOGY; IMMUNOSTIMULATION; IN VITRO STUDY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; VITAMIN SUPPLEMENTATION;

ANTIOXIDANTS; ASCORBIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LEUKOCYTES, MONONUCLEAR; MITOGENS; NEOPTERIN; TRYPTOPHAN; VITAMIN E;

EID: 33846207779     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000096438     Document Type: Article

References (23)

1. McCall MR, Frei B: Can antioxidant vitamins materially reduce oxidative damage in humans? Free Radic Biol Med 1999;26:1034-1053.
2. Winklhofer-Roob BM, Rock E, Ribalta J, Shmerling DH, Roob JM: Effects of vitamin E and carotenoid status on oxidative stress in health and disease: evidence obtained from human intervention studies. Mol Aspects Med 2003;24:391-402.
3. Terentis AC, Thomas SR, Burr JA, Liebler DC, Stocker R: Vitamin E oxidation in human atherosclerotic lesions. Circ Res 2002;90:333-339.
4. Flader D, Brandsch C, Hirche F, Eder K: Effects of megadoses of dietary vitamin E on the antioxidant status of rats fed lard or salmon oil. Int J Vitam Nutr Res 2003;73:275-283.
5. Fuchs D, Weiss G, Wachter H: Neopterin, biochemistry and clinical use as a marker for cellular immune reactions. Int Arch Allergy Immunol 1993;101:1-6.
6. Murr C, Widner B, Wirleitner B, Fuchs D: Neopterin as a marker for immune system activation. Curr Drug Metab 2002;3:175-187.
7. Huber C, Batchelor JR, Fuchs D, et al: Immune response-associated production of neopterin - release from macrophages primarily under control of interferon-γ. J Exp Med 1984;160:310-316.
8. Wirleitner B, Rudzite V, Neurauter G, et al: Immune activation and degradation of tryptophan in coronary heart disease. Eur J Clin Invest 2003;33:550-554.
9. Wirleitner B, Neurauter G, Schroecksnadel K, Frick B, Fuchs D: Interferon-γ-induced conversion of tryptophan: immunologic and neuropsychiatric aspects. Curr Med Chem 2003;16:1581-1591.
10. Weiss G, Murr C, Zoller H, et al: Modulation of neopterin formation and tryptophan degradation by Th1- and Th2-derived cytokines in human monocytic cell. Clin Exp Immunol 1999;116:435-440.
11. Zvetkova E, Wirleitner B, Tram NT, Schennach H, Fuchs D: Aqueous extracts of Crinum latifolium (L.) and Camellia sinensis show immunomodulatory properties in human peripheral blood mononuclear cells. Int Immunopharmacol 2001;1:2143-1250.
12. Neurauter G, Wirleitner B, Schroecksnadel K, Schennach H, Fuchs D: Wine and grape juice modulate interferon-γ-induced neopterin production and tryptophan degradation in human PBMC. Pteridines 2004;15:1-9.
13. Winkler C, Wirleitner B, Schroecksnadel K, Schennach H, Fuchs D: Beer down-regulates activated peripheral blood mononuclear cells in vitro. Int Immunopharmacol 2006;6:390-395.
14. Wirleitner B, Schroecksnadel K, Winkler C, Schennach H, Fuchs D: Resveratrol suppresses interferon-γ-induced biochemical pathways in human peripheral blood mononuclear cells in vitro. Immunol Lett 2005;100:159-163.
15. Widner B, Werner ER, Schennach H, Wachter H, Fuchs D: Simultaneous measurement of serum tryptophan and kynurenine by HPLC. Clin Chem 1997;43:2424-2326.
16. Winkler C, Wirleitner B, Schroecksnadel K, Schennach H, Fuchs D: St. John's wort (Hypericum perforatum) counteracts cytokine-induced tryptophan catabolism in vitro. Biol Chem 2004;385:1197-1202.
17. Tan PH, Sagoo P, Chan C, et al: Inhibition of NF-κB and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells. J Immunol 2005;174:7633-7644.
18. Nathan CF, Murray HW, Wiebe ME, Rubin BY: Identification of interferon-γ as the lymphokine that activates human macrophage oxidative metabolism and antimircrobial activity. J Exp Med 1983;158:203-209.
19. Karin M, Greten FR: NF-κB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005;5:749-759.
20. Li Q, Withoff S, Verma IM: Inflammation-associated cancer: NF-κB is the lynchpin. Trends Immunol 2005;26:318-325.
21. Halliwell B, Whiteman M: Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Br J Pharmacol 2004;142:231-255.
22. Gutteridge JM, Halliwell B: Free radicals and antioxidants in the year 2000: a historical look to the future. Ann NY Acad Sci 2000;899:136-147.
23. Murr C, Schroecksnadel K, Winkler C, Ledochowski M, Fuchs D: Antioxidants may increase the probability of developing allergic diseases and asthma. Med Hypotheses 2005;64:973-977.