High-cell-density cultivation of microorganisms

Applied Microbiology and Biotechnology

Volumn 51, Issue 4, 1999, Pages 422-430

  Riesenberg, D ^a   Guthke, R ^a  

^a HANS KNÖLL INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARCHAEBACTERIUM; ARTIFICIAL NEURAL NETWORK; BACTERIUM CULTURE; BIOREACTOR; CELL DENSITY; CYCLONE SEPARATOR; DIALYSIS MEMBRANE; EXPERT SYSTEM; FERMENTATION; FUNGUS CULTURE; MEMBRANE REACTOR; NONHUMAN; SHORT SURVEY; YEAST;

ARCHAEA; BACTERIA; BIOMASS; BIOREACTORS; BIOTECHNOLOGY; FERMENTATION; YEASTS;

ARCHAEA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA; FUNGI;

EID: 0032922829     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002530051412     Document Type: Short Survey

References (85)

1. Andersson L, Strandberg L, Enfors S-O (1996) Cell differentiation and lysis have a profound effect on the growth of E. coli in high cell density fed batch cultures. Biotechnol Prog 12: 190-195
2. Aynsley M, Hofland A, Morris AJ, Montague G, Di Massimo C (1993) Artificial intelligence and the supervision of bioprocesses (real-time knowledge-based systems and neural networks). Advances in Biochemical Engineering Biotechnology 48: 1-27
3. Bermejo LL, Welker NE, Papoutsakis ET (1998) Expression of Clostridium acetobutylicum ATCC824 genes in Escherichia coli for acetone production and acetate detoxification. Appl Environ Microbiol 64: 1079-1085
4. Bittner C, Wehnert G, Scheper T (1998) In situ microscopy for on-line determination of biomass. Biotechnol Bioeng 60: 24-35
5. Brandt J, Hitzmann B (1994) Knowledge-based fault detection and diagnosis in flow-injection analysis. Anal Chim Acta 291: 29-40
6. Chang HN, Lee WG, Kim BS (1993) Cell retention culture with an internal filter module: continuous ethanol fermentation. Biotechnol Bioeng 41: 677-681
7. Chang CC, Ryu DDY, Park CS, Kim J-Y (1998) Improvement of heterologous protein productivity using recombinant Yarrowia lipolytica and cyclic fed-batch process strategy. Biotechnol Bioeng 59: 379-385
8. Curless C, Baclaski J, Sachdev R (1996) Phosphate glass as a phosphate source in high cell density Escherichia coli fermentations. Biotechnol Prog 12: 22-25
9. Dekkers RM, Voetter M (1985) Adaptive control of a fed-batch bakers's yeast fermentation. IFAC modelling and control of biotechnological processes, Noordwijkerhout
10. Dubach AC, Märkl H (1992) Applications of extended Kalman filter method for monitoring high density cultivation of Escherichia coli. J Ferment Bioeng 73: 396-402
11. Filev PD, Kishimoto M, Sengupta S, Yoshida T, Taguchi H (1985) Application of the fuzzy theory to simulation of batch fermentation. J Ferment Technol 63: 545-553
12. Fowler GL, Higgs RE, Clapp DL, Alford JS, Huber FM (1992) Development of real time expert system applications for the on-line analysis of fermentation respiration data. In: Karim MN, Stephanopoulos G (eds) IFAC Modeling and Control of Biotechnological Processes, Colorado. USA. Pergamon Press, Oxford pp 173-178
13. Garn M, Gisin M, Thommen C, Cevey P (1989) A flow injection analysis system for fermentation monitoring and control. Biotechnol Bioeng 34: 423-428
14. George S, Larsson G, Enfors S-O (1993) A scale-down two-compartment reactor with controlled substrate oscillations: metabolic response of Saccaromyces cerevisiae. Bioprocess Eng 9: 249-257
15. Gomersall R, Hitzmann B, Guthke R (1997) Fermentation fault management and on-line state estimation using methods of cluster analysis. Bioprocess Eng 17: 69-73
16. Guthke R, Ludwig B (1994) Generation of rules for expert systems by statistical methods of fermentation data analysis. Acta Biotechnol 14: 13-26
17. Guthke R, Schmidt-Heck W, Pfaff M (1998) Knowledge aquisition and knowledge base control in bioprocess engineering. J Biotechnol 65: 37-46
18. Hartbrich A, Weuster-Botz D, Wandrey C (1995) Verfahren und Anordnung zur Durchführung biotechnologischer Prozesse unter Kultivierung aerober Organismen in hoher Zelldichte. DE 195 07 456 A1
19. Hartbrich A, Schmitz G, Weuster-Botz D, De Graaf AA, Wandrey C (1996) Development and application of a membrane cyclone reactor for in vivo NMR spectroscopy with high microbial densities. Biotechnol Bioeng 51: 624-635
20. Hartnett M, Diamond D, Barker PG (1993) Neural network based recognition of flow-injection patterns. Analyst 118: 347-354
21. Hitzmann B, Lübbert A, Schügerl K (1992) An expert system approach for the control of a bioprocess. I. Knowledge representation and processing. Biotechnol Bioeng 39: 33-43
22. Hitzmann B, Marose S, Lindemann C, Scheper T (1998) New sensor application in European industries for detailed bioprocess monitoring. In: Yoshida T, Shioya S (eds) Proceedings of the 7th International Conference on Computer Applications in Biotechnology, Osaka. Elsevier Science, Oxford pp 231-236
23. Holst O, Manelius A, Krahe M, Märkl H, Raven N, Sharp R (1997) Thermophiles and Fermentation technology. Comp Biochem Physiol 118 A: 415-422
24. Horiuchi J, Hiraga K (1998) Industrial application of fuzzy control to large-scale recombinant vitamin B2 production. In: Yoshida T, Shioya S (eds) Proceedings of the 7th International Conference on Computer Applications in Biotechnology, Osaka. Elsevier Science, Oxford pp 281-286
25. Horn U, Strittmatter W, Krebber A, Knüpfer U, Kujau M, Wenderoth R, Müller K, Matzku S, Plückthun A, Riesenberg D (1996) High volumetric yields of functional dimeric mini-antibodies in Escherichia coli, using an optimized expression vector and high-cell-density fermentation under non-limited growth conditions. Appl Microbiol Biotechnol 46: 524-532
26. Kamimura R, Konstantinov K, Stephanopoulos G (1996) Knowledge-based systems, artificial neural networks and pattern recognition: applications to biotechnological processes. Curr Opin Biotechnol 7: 231-234
27. Karim MN, Rivera SL (1992) Artificial neural networks in process state estimation. In: Fiechter A (ed) Adv Biochem Eng Biotechnol 46: 2-33
28. Kim GJ, Lee IY, Choi DK, Yoon SC, Park YH (1996) High cell density cultivation of Pseudomonas putida BM01 using glucose. J Microbiol Biotechnol 6: 221-224
29. King R (1992) Plant and sensor failure detection by multiple nonlinear filters. In: Karim MN, Stephanopoulos G (eds) IFAC Modelling and Control of Biotechnology Processes, Colorado, USA. Pergamon Press, Oxford pp 129-134
30. Kishimoto M, Suzuki H (1995) Application of an expert system to high cell density cultivation of Escherichia coli. J Ferment Bioeng 80: 58-62
31. Kitsuta Y, Kishimoto M (1994) Fuzzy supervisory control of glutamic acid production. Biotechnol Bioeng 44: 87-94
32. Kleman GL, Strohl WR (1994) Developments in high cell density and high productivity microbial fermentation. Curr Opin Biotechnol 5: 180-186
33. Knorre WA, Deckwer W-D, Korz D, Pohl H-D, Riesenberg D, Roß A, Sanders E, Schulz V (1990) Hochzelldichte-Fermentationen von E. coli für rDNA-Produkte. BioEng 5: 28-33
34. Konstantinov KB, Yoshida T (1989) Physiological state control of fermentation processes. Biotechnol Bioeng 33: 1145-1156
35. Konstantinov KB, Yoshida T (1992) Knowledge-based control of fermentation process. Biotechnol Bioeng 39: 479-486
36. Korz DJ, Rinas U, Hellmuth K, Sanders EA, Deckwer W-D (1995) Simple fed-batch technique for high cell density cultivation of Escherichia coli. J Biotechnol 39: 59-65
37. Krahe M, Antranikian G, Märkl H (1996) Fermentation of extremophilic microorganisms. FEMS Microbiol Rev 18: 271-285
38. Kresta JV, MacGregor JF, Marlin TE (1991) Multivariate statistical monitoring of process operating performance. Can J Chem Eng 69: 35-47
39. Lee CW, Gu MB, Chang HN (1989) High-density culture of Escherichia coli carrying recombinant plasmid in a membrane cell recycle fermenter. Enzyme Microb Technol 11: 49-54
40. Lee IY, Choi ES, Kim GJ, Nam SW, Shin YC, Chang HN, Park YH (1994) Optimization of fed-batch fermentation for production of poly-ß-hydroxybutyrate in Alcaligenes eutrophus. J Microbiol Biotechnol 4: 146-150
41. Lee SS, Mohler RD (1988) Controlled growth rate fermentation. EP 0 315 944 A2
42. Lee SY (1996) High cell-density culture of Escherichia coli. Trends Biotechnol 14: 98-105
43. Lee SY, Chang HN (1995) Production of poly(hydroxyalkanoic acid). Adv Biochem Eng Biotechnol 52: 27-58
44. Lee WG, Lee Y-S, Chang HN, Chang YK (1994) A cell retention internal filter reactor for ethanol production using tapioca hydrolysates. Biotechnol Tech 8: 817-820
45. Linko P, Zhu Y-H (1992) Neural networks modelling for real-time variable estimation and prediction in the control of glycoamylase fermentation. Process Biochem 27: 75-283
46. Locher G, Sonnleitner B, Fiechter A (1990) Pattern recognition: a useful tool in technological processes. Bioprocess Eng 5: 181-187
47. Luttmann R, Munack A, Thoma M (1985) Mathematical modelling, parameter identification and adaptive control of single cell protein processes in tower loop bioreactors. Adv Biochem Eng Biotechnol 32: 95-205
48. Macaloney G, Draper I, Preston J, Anderson KB, Rollins MJ, Thompson BG, Hall JW, McNeil B (1996) At-line control and fault analysis in an industrial high cell density Escherichia coli fermentation, using NIR spectroscopy. Trans Inst Chem Eng 74: 212-220
49. Macaloney G, Hall JW, Rollins MJ, Draper I, Anderson K, Preston J, Thompson BG, McNeil B (1997) The utility and performance of near-infra red spectroscopy in simultaneous monitoring of multiple components in a high cell density recombinant Escherichia coli production process. Process Eng 17: 157-167
50. MacDonald HL, Neway JO (1990) Effects of medium quality on the expression of human interleukin-2 at high cell density in fermentor cultures of Escherichia coli K-12. Appl Environ Microbiol 56: 640-645
51. Makrides SC (1996) Strategies for achieving high-level expression of genes in Escherichia coli. Microbiol Rev 60: 512-538
52. Märkl H, Lechner M, Götz F (1990) A new dialysis fermentor for the production of high concentrations of extracellular enzymes. J Ferment Bioeng 69: 244-249
53. Montague G, Morris AJ (1994) Neural-network contributions in biotechnology. Trends Biotechnol 12: 312-324
54. Montague GA, Hiden HG, Kornfeld G (1998) Multivariate statistical monitoring procedures for fermentation supervision: an industrial case study. In: Yoshida T, Shioya S (eds) Proceedings of the 7th International Conference on Computer Applications in Biotechnology, Osaka. Elsevier Science, Oxford pp 423-428
55. Nakano K, Rischke M, Sato S, Märkl H (1997) Influence of acetic acid on the growth of Escherichia coli K12 during high-cell-density cultivation in a dialysis reactor. Appl Microbiol Biotechnol 48: 597-601
56. Neubauer P, Häggström L, Enfors S-O (1995) Influence of substrate oscillations on acetate formation and growth yield in Escherichia coli glucose limited fed-batch cultivations. Biotechnol Bioeng 47: 139-146
57. Park YS, Kai K, Iijima S, Kobayashi T (1992) Enhanced ß-galactosidas production by high cell-density culture of recombinant Bacillus subtilis with glucose concentration control. Biotechnol Bioeng 40: 686-696
58. Park YS, Shi ZP, Shiba S, Chantal C, Iijima S, Kobayashi T (1993) Application of fuzzy reasoning to control of glucose and ethanol concentrations in baker's yeast culture. Appl Microbiol Biotechnol 38: 649-655
59. Pfaff M, Wagner E, Wenderoth R, Knüpfer U, Guthke R, Riesenberg D (1995) Model-aided on-line glucose monitoring for computer-controlled high cell density fermentations. In: Munack A, Schügerl K (eds) Proceedings of the 6th International Conference on Comparative Applied Biotechnology. Garmisch-Partenkirchen, Elsevier Science, Oxford pp 6-11
60. Phelps MR, Hobbs JB, Kilburn DG, Turner RFB (1995) An autoclavable glucose biosensor for microbial fermentation monitoring and control. Biotechnol Bioeng 46: 514-524
61. Preusting H, Houten R van, Hoefs A, Langenberghe EK van, Favre-Bulle O, Witholt B (1993) High cell density cultivation of Pseudomonas oleovorans: growth and production of poly(3-hydroxyalkanoates) in two-liquid phase batch and fed-batch systems. Biotechnol Bioeng 41: 550-556
62. Riesenberg D (1991) High-cell-density cultivation of Escherichia coli. Curr Opin Biotechnol 2: 380-384
63. Riesenberg D, Menzel K, Schulz V, Schumann K, Veith G, Zuber G, Knorre WA (1990) High cell density fermentation of recombinant Escherichia coli expressing human Interferon alpha 1. Appl Microbiol Biotechnol 34: 77-82
64. Schmidt-Heck W, Guthke R (1995) Wissensbasierte Störfalldiagnose bei der Hochzelldichte-Fermentation. In: Bense H, Bodrow W (eds) Objektorientierte und regelbasierte Wissensverarbeitung. Spektrum A, Heidelberg Berlin Oxford, pp 407-444
65. Schroeckh V, Kujau M, Knüpfer U, Wenderoth R, Mörbe J, Riesenberg D (1996) Formation of recombinant proteins in Escherichia coli under control of a nitrogen regulated promotor at low and high cell densities. J Biotechnol 49: 45-58
66. Schubert J, Simutis R, Dors M, Havlik I, Lübbert A (1994) Bioprocess optimization and control: Application of hybrid modelling. J Biotechnol 35: 51-68
67. Steinbüchel A, Schmack G (1995) Large-scale production of poly(3-hydroxyvaleric acid) by fermentation of Chromobacterium violaceum, processing, and characterization of the homo-polyester. J Environ Polym Degrad 3: 243-258
68. Stratton J, Chiruvolu V, Meagher M (1998) High cell-density fermentation. In: Higgins DR, Cregg JM (eds) Methods in molecular biology, vol 103. Pichia protocols. Humana P, Totowa NJ, pp 107-120
69. Suzuki T (1996) A dense cell culture system for microorganisms using a stirred ceramic membrane reactor incorporating asymmetric porous ceramic filters. J Ferment Bioeng 82: 264-271
70. Suzuki T, Yamane T, Shimizu S (1986) Mass production of poly-ß-hydroxybutyric acid by fed-batch culture with controlled carbon/nitrogen feeding. Appl Microbiol Biotechnol 24: 370-374
71. Suzuki T, Yamane T, Shimizu S (1987) Mass production of thiostrepton by fed-batch culture of Streptomyces laurentii with pH-stat modal feeding of multi-substrate. Appl Microbiol Biotechnol 25: 526-531
72. Suzuki T, Sato T, Kominami M (1994) A dense cell retention culture system using a stirred ceramic membrane reactor. Biotechnol Bioeng 44: 1186-1192
73. Suzuki T, Kamoshita Y, Ochashi R (1997) A dense cell culture system for microorganisms using a shake flask incorporating a porous ceramic filter. J Ferment Bioeng 84: 133-137
74. Turner C, Gregory ME, Thornhill NF (1994) Closed-loop control of fed-batch cultures of recombinant Escherichia coli using on-line HPLC. Biotechnol Bioeng 44: 819-829
75. Van de Walle M, Shiloach J (1998) Proposed mechanism of acetate accumulation in two recombinant Escherichia coli strains during high cell density fermentation. Biotechnol Bioeng 57: 71-78
76. Wandrey C, Wichmann R, Groeger U, Kircher M, Leuchtenberger W, Brenker E (1986) Verfahren zur fermentativen Herstellung von L-Aminosäuren aus ∝-Ketocarbonsäuren. DE 3614586 A1
77. Wang F, Lee AY (1998) High cell density culture of metabolically engineered Escherichia coli for the production of poly(3-hydroxybutyrate) in a defined medium. Biotechnol Bioeng 58: 325-328
78. Wang NS, Stephanopoulos G (1983) Application of macroscopic balances to the identification of gross measurement errors. Biotechnol Bioeng 25: 2177-2208
79. Weikert C, Sauer U, Bailey JF (1997) Use of a glycerol-limited, long-term chemostat for isolation of Escherichia coli mutants with improved physiological properties. Microbiol 143: 1567-1574
80. Winter J, Neubauer P (1999) Successful production of recombinant proteins in Escherichia coli. In: Recent research development, vol 2. Research signpost. Trivandrum India (in press)
81. Wu X, Bellgardt K-H (1998) Fast on-line data evaluation of flow-injection analysis signals based on parameter estimation by an extended Kalman filter. J Biotechnol 62: 1-28
82. Yano T, Kobayashi T, Shimizu S (1985) High concentration cultivation of Candida brassicae in a fed-batch system. J Ferment Technol 63: 415-418
83. Ye K, Jin S, Shimizu K (1994) Fuzzy Neural Network for the control of high cell density cultivation of recombinant Escherichia coli. J Ferment Bioeng 77: 663-673
84. Zabriskie DW, Humphrey AE (1978) Estimation of fermentation biomass concentration by measuring culture fluorescence. Appl Eur Microbiol 35: 337-343
85. Zhang J, Greasham R (1999) Chemically-defined media for commercial fermentations. Appl Microbiol Biotechnol (in press)