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Volumn 6, Issue 6, 2011, Pages

Intestinal activation of notch signaling induces rapid onset hepatic steatosis and insulin resistance

Author keywords

[No Author keywords available]

Indexed keywords

INTRACELLULAR DOMAIN OF NOTCH1; MUTANT PROTEIN; NOTCH RECEPTOR; RIBOSOME PROTEIN; RIBOSOME PROTEIN L29; UNCLASSIFIED DRUG; RPL29 PROTEIN, MOUSE;

EID: 79959208664     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020767     Document Type: Article
Times cited : (14)

References (59)
  • 1
    • 60449094498 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, et al. (2009) Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 119: 480-486.
    • (2009) Circulation , vol.119 , pp. 480-486
    • Lloyd-Jones, D.1    Adams, R.2    Carnethon, M.3    De Simone, G.4    Ferguson, T.B.5
  • 3
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
    • Feldstein AE, Canbay A, Angulo P, Taniai M, Burgart LJ, et al. (2003) Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 125: 437-443.
    • (2003) Gastroenterology , vol.125 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3    Taniai, M.4    Burgart, L.J.5
  • 4
    • 70350241227 scopus 로고    scopus 로고
    • The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years
    • Feldstein AE, Charatcharoenwitthaya P, Treeprasertsuk S, Benson JT, Enders FB, et al. (2009) The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut 58: 1538-1544.
    • (2009) Gut , vol.58 , pp. 1538-1544
    • Feldstein, A.E.1    Charatcharoenwitthaya, P.2    Treeprasertsuk, S.3    Benson, J.T.4    Enders, F.B.5
  • 5
    • 11144351102 scopus 로고    scopus 로고
    • The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies
    • Adams LA, Sanderson S, Lindor KD, Angulo P, (2005) The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. J Hepatol 42: 132-138.
    • (2005) J Hepatol , vol.42 , pp. 132-138
    • Adams, L.A.1    Sanderson, S.2    Lindor, K.D.3    Angulo, P.4
  • 6
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, et al. (2005) Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 115: 1343-1351.
    • (2005) J Clin Invest , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5
  • 7
    • 77954956697 scopus 로고    scopus 로고
    • Recent insights into fatty liver, metabolic dyslipidaemia and their links to insulin resistance
    • Savage DB, Semple RK, (2010) Recent insights into fatty liver, metabolic dyslipidaemia and their links to insulin resistance. Curr Opin Lipidol 21: 329-336.
    • (2010) Curr Opin Lipidol , vol.21 , pp. 329-336
    • Savage, D.B.1    Semple, R.K.2
  • 8
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, et al. (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444: 1027-1031.
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5
  • 10
    • 43549107065 scopus 로고    scopus 로고
    • Energy intake is associated with endotoxemia in apparently healthy men
    • Amar J, Burcelin R, Ruidavets JB, Cani PD, Fauvel J, et al. (2008) Energy intake is associated with endotoxemia in apparently healthy men. Am J Clin Nutr 87: 1219-1223.
    • (2008) Am J Clin Nutr , vol.87 , pp. 1219-1223
    • Amar, J.1    Burcelin, R.2    Ruidavets, J.B.3    Cani, P.D.4    Fauvel, J.5
  • 11
    • 68949148889 scopus 로고    scopus 로고
    • Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
    • Miele L, Valenza V, La Torre G, Montalto M, Cammarota G, et al. (2009) Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 49: 1877-1887.
    • (2009) Hepatology , vol.49 , pp. 1877-1887
    • Miele, L.1    Valenza, V.2    La Torre, G.3    Montalto, M.4    Cammarota, G.5
  • 12
    • 34347399563 scopus 로고    scopus 로고
    • Metabolic endotoxemia initiates obesity and insulin resistance
    • Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, et al. (2007) Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56: 1761-1772.
    • (2007) Diabetes , vol.56 , pp. 1761-1772
    • Cani, P.D.1    Amar, J.2    Iglesias, M.A.3    Poggi, M.4    Knauf, C.5
  • 13
    • 34748851341 scopus 로고    scopus 로고
    • Cell and molecular biology of Notch
    • Fiuza UM, Arias AM, (2007) Cell and molecular biology of Notch. J Endocrinol 194: 459-474.
    • (2007) J Endocrinol , vol.194 , pp. 459-474
    • Fiuza, U.M.1    Arias, A.M.2
  • 14
    • 33747623018 scopus 로고    scopus 로고
    • Notch signalling: a simple pathway becomes complex
    • Bray SJ, (2006) Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7: 678-689.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 678-689
    • Bray, S.J.1
  • 17
    • 0035177388 scopus 로고    scopus 로고
    • A model Notch response element detects Suppressor of Hairless-dependent molecular switch
    • Furriols M, Bray S, (2001) A model Notch response element detects Suppressor of Hairless-dependent molecular switch. Curr Biol 11: 60-64.
    • (2001) Curr Biol , vol.11 , pp. 60-64
    • Furriols, M.1    Bray, S.2
  • 18
    • 20544447734 scopus 로고    scopus 로고
    • Notch signals control the fate of immature progenitor cells in the intestine
    • Fre S, Huyghe M, Mourikis P, Robine S, Louvard D, et al. (2005) Notch signals control the fate of immature progenitor cells in the intestine. Nature 435: 964-968.
    • (2005) Nature , vol.435 , pp. 964-968
    • Fre, S.1    Huyghe, M.2    Mourikis, P.3    Robine, S.4    Louvard, D.5
  • 19
    • 20544460148 scopus 로고    scopus 로고
    • Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
    • van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, et al. (2005) Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435: 959-963.
    • (2005) Nature , vol.435 , pp. 959-963
    • van Es, J.H.1    van Gijn, M.E.2    Riccio, O.3    van den Born, M.4    Vooijs, M.5
  • 20
    • 23044452747 scopus 로고    scopus 로고
    • Notch signaling regulates the differentiation of post-mitotic intestinal epithelial cells
    • Zecchini V, Domaschenz R, Winton D, Jones P, (2005) Notch signaling regulates the differentiation of post-mitotic intestinal epithelial cells. Genes Dev 19: 1686-1691.
    • (2005) Genes Dev , vol.19 , pp. 1686-1691
    • Zecchini, V.1    Domaschenz, R.2    Winton, D.3    Jones, P.4
  • 22
    • 68549115658 scopus 로고    scopus 로고
    • Notch signaling controls liver development by regulating biliary differentiation
    • Zong Y, Panikkar A, Xu J, Antoniou A, Raynaud P, et al. (2009) Notch signaling controls liver development by regulating biliary differentiation. Development 136: 1727-1739.
    • (2009) Development , vol.136 , pp. 1727-1739
    • Zong, Y.1    Panikkar, A.2    Xu, J.3    Antoniou, A.4    Raynaud, P.5
  • 23
    • 77950609317 scopus 로고    scopus 로고
    • Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice
    • Sparks EE, Huppert KA, Brown MA, Washington MK, Huppert SS, (2010) Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice. Hepatology 51: 1391-1400.
    • (2010) Hepatology , vol.51 , pp. 1391-1400
    • Sparks, E.E.1    Huppert, K.A.2    Brown, M.A.3    Washington, M.K.4    Huppert, S.S.5
  • 24
    • 9644307844 scopus 로고    scopus 로고
    • The role of notch signaling in the development of intrahepatic bile ducts
    • Kodama Y, Hijikata M, Kageyama R, Shimotohno K, Chiba T, (2004) The role of notch signaling in the development of intrahepatic bile ducts. Gastroenterology 127: 1775-1786.
    • (2004) Gastroenterology , vol.127 , pp. 1775-1786
    • Kodama, Y.1    Hijikata, M.2    Kageyama, R.3    Shimotohno, K.4    Chiba, T.5
  • 25
    • 0036339631 scopus 로고    scopus 로고
    • A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency
    • McCright B, Lozier J, Gridley T, (2002) A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency. Development 129: 1075-1082.
    • (2002) Development , vol.129 , pp. 1075-1082
    • McCright, B.1    Lozier, J.2    Gridley, T.3
  • 26
    • 49649111405 scopus 로고    scopus 로고
    • Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice
    • Geisler F, Nagl F, Mazur PK, Lee M, Zimber-Strobl U, et al. (2008) Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice. Hepatology 48: 607-616.
    • (2008) Hepatology , vol.48 , pp. 607-616
    • Geisler, F.1    Nagl, F.2    Mazur, P.K.3    Lee, M.4    Zimber-Strobl, U.5
  • 27
    • 2142709556 scopus 로고    scopus 로고
    • Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin
    • Ireland H, Kemp R, Houghton C, Howard L, Clarke AR, et al. (2004) Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Gastroenterology 126: 1236-1246.
    • (2004) Gastroenterology , vol.126 , pp. 1236-1246
    • Ireland, H.1    Kemp, R.2    Houghton, C.3    Howard, L.4    Clarke, A.R.5
  • 28
    • 77955488532 scopus 로고    scopus 로고
    • A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis
    • Lee JH, Wada T, Febbraio M, He J, Matsubara T, et al. (2010) A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis. Gastroenterology 139: 653-663.
    • (2010) Gastroenterology , vol.139 , pp. 653-663
    • Lee, J.H.1    Wada, T.2    Febbraio, M.3    He, J.4    Matsubara, T.5
  • 29
    • 3042856262 scopus 로고    scopus 로고
    • Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
    • Srinivas S, Watanabe T, Lin CS, William CM, Tanabe Y, et al. (2001) Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol 1: 4.
    • (2001) BMC Dev Biol , vol.1 , pp. 4
    • Srinivas, S.1    Watanabe, T.2    Lin, C.S.3    William, C.M.4    Tanabe, Y.5
  • 30
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, et al. (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41: 1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    van Natta, M.3    Behling, C.4    Contos, M.J.5
  • 32
    • 77951228960 scopus 로고    scopus 로고
    • Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion
    • Sundaram M, Yao Z, (2010) Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion. Nutr Metab (Lond) 7: 35.
    • (2010) Nutr Metab (Lond) , vol.7 , pp. 35
    • Sundaram, M.1    Yao, Z.2
  • 33
    • 33645828659 scopus 로고    scopus 로고
    • Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation
    • Reddy JK, Rao MS, (2006) Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. Am J Physiol Gastrointest Liver Physiol 290: G852-858.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290 , pp. 852-858
    • Reddy, J.K.1    Rao, M.S.2
  • 34
    • 7244221588 scopus 로고    scopus 로고
    • Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis
    • Inoue Y, Inoue J, Lambert G, Yim SH, Gonzalez FJ, (2004) Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis. J Biol Chem 279: 44740-44748.
    • (2004) J Biol Chem , vol.279 , pp. 44740-44748
    • Inoue, Y.1    Inoue, J.2    Lambert, G.3    Yim, S.H.4    Gonzalez, F.J.5
  • 35
    • 70449927254 scopus 로고    scopus 로고
    • Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein
    • Erion DM, Ignatova ID, Yonemitsu S, Nagai Y, Chatterjee P, et al. (2009) Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein. Cell Metab 10: 499-506.
    • (2009) Cell Metab , vol.10 , pp. 499-506
    • Erion, D.M.1    Ignatova, I.D.2    Yonemitsu, S.3    Nagai, Y.4    Chatterjee, P.5
  • 37
    • 28744450445 scopus 로고    scopus 로고
    • Inactivation of the peroxisomal ABCD2 transporter in the mouse leads to late-onset ataxia involving mitochondria, Golgi and endoplasmic reticulum damage
    • Ferrer I, Kapfhammer JP, Hindelang C, Kemp S, Troffer-Charlier N, et al. (2005) Inactivation of the peroxisomal ABCD2 transporter in the mouse leads to late-onset ataxia involving mitochondria, Golgi and endoplasmic reticulum damage. Hum Mol Genet 14: 3565-3577.
    • (2005) Hum Mol Genet , vol.14 , pp. 3565-3577
    • Ferrer, I.1    Kapfhammer, J.P.2    Hindelang, C.3    Kemp, S.4    Troffer-Charlier, N.5
  • 38
    • 33845593356 scopus 로고    scopus 로고
    • Upregulation of liver VLDL receptor and FAT/CD36 expression in LDLR-/- apoB100/100 mice fed trans-10,cis-12 conjugated linoleic acid
    • Degrace P, Moindrot B, Mohamed I, Gresti J, Du ZY, et al. (2006) Upregulation of liver VLDL receptor and FAT/CD36 expression in LDLR-/- apoB100/100 mice fed trans-10,cis-12 conjugated linoleic acid. J Lipid Res 47: 2647-2655.
    • (2006) J Lipid Res , vol.47 , pp. 2647-2655
    • Degrace, P.1    Moindrot, B.2    Mohamed, I.3    Gresti, J.4    Du, Z.Y.5
  • 40
    • 22344436360 scopus 로고    scopus 로고
    • p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation
    • Devgan V, Mammucari C, Millar SE, Brisken C, Dotto GP, (2005) p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev 19: 1485-1495.
    • (2005) Genes Dev , vol.19 , pp. 1485-1495
    • Devgan, V.1    Mammucari, C.2    Millar, S.E.3    Brisken, C.4    Dotto, G.P.5
  • 42
    • 34547922380 scopus 로고    scopus 로고
    • Delta-Notch-and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors
    • Fischer A, Gessler M, (2007) Delta-Notch-and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Nucleic Acids Res 35: 4583-4596.
    • (2007) Nucleic Acids Res , vol.35 , pp. 4583-4596
    • Fischer, A.1    Gessler, M.2
  • 43
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P, (2002) Nonalcoholic fatty liver disease. N Engl J Med 346: 1221-1231.
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 45
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: human gut microbes associated with obesity
    • Ley RE, Turnbaugh PJ, Klein S, Gordon JI, (2006) Microbial ecology: human gut microbes associated with obesity. Nature 444: 1022-1023.
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 47
    • 46749083373 scopus 로고    scopus 로고
    • Identification of heparin/heparan sulfate interacting protein as a major broad-spectrum antimicrobial protein in lung and small intestine
    • Meyer-Hoffert U, Hornef M, Henriques-Normark B, Normark S, Andersson M, et al. (2008) Identification of heparin/heparan sulfate interacting protein as a major broad-spectrum antimicrobial protein in lung and small intestine. FASEB J 22: 2427-2434.
    • (2008) FASEB J , vol.22 , pp. 2427-2434
    • Meyer-Hoffert, U.1    Hornef, M.2    Henriques-Normark, B.3    Normark, S.4    Andersson, M.5
  • 48
    • 58149289684 scopus 로고    scopus 로고
    • Alpha/beta hydrolase 1 is upregulated in D5 dopamine receptor knockout mice and reduces O2- production of NADPH oxidase
    • Stoelting M, Geyer M, Reuter S, Reichelt R, Bek MJ, et al. (2009) Alpha/beta hydrolase 1 is upregulated in D5 dopamine receptor knockout mice and reduces O2- production of NADPH oxidase. Biochem Biophys Res Commun 379: 81-85.
    • (2009) Biochem Biophys Res Commun , vol.379 , pp. 81-85
    • Stoelting, M.1    Geyer, M.2    Reuter, S.3    Reichelt, R.4    Bek, M.J.5
  • 49
    • 33845574569 scopus 로고    scopus 로고
    • Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1
    • Rizki G, Arnaboldi L, Gabrielli B, Yan J, Lee GS, et al. (2006) Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1. J Lipid Res 47: 2280-2290.
    • (2006) J Lipid Res , vol.47 , pp. 2280-2290
    • Rizki, G.1    Arnaboldi, L.2    Gabrielli, B.3    Yan, J.4    Lee, G.S.5
  • 50
    • 33644955272 scopus 로고    scopus 로고
    • Mouse models in non-alcoholic fatty liver disease and steatohepatitis research
    • Anstee QM, Goldin RD, (2006) Mouse models in non-alcoholic fatty liver disease and steatohepatitis research. Int J Exp Pathol 87: 1-16.
    • (2006) Int J Exp Pathol , vol.87 , pp. 1-16
    • Anstee, Q.M.1    Goldin, R.D.2
  • 51
    • 33847729533 scopus 로고    scopus 로고
    • Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage
    • Loomes KM, Russo P, Ryan M, Nelson A, Underkoffler L, et al. (2007) Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage. Hepatology 45: 323-330.
    • (2007) Hepatology , vol.45 , pp. 323-330
    • Loomes, K.M.1    Russo, P.2    Ryan, M.3    Nelson, A.4    Underkoffler, L.5
  • 52
    • 0014601949 scopus 로고
    • A semiquantitative screening test and quantitative assay for total fecal fat
    • Nelson WR, O'Hopp SJ, (1969) A semiquantitative screening test and quantitative assay for total fecal fat. Clin Chem 15: 1062-1071.
    • (1969) Clin Chem , vol.15 , pp. 1062-1071
    • Nelson, W.R.1    O'Hopp, S.J.2
  • 53
    • 65549150087 scopus 로고    scopus 로고
    • Comparative assessment of human and farm animal faecal microbiota using real-time quantitative PCR
    • Furet JP, Firmesse O, Gourmelon M, Bridonneau C, Tap J, et al. (2009) Comparative assessment of human and farm animal faecal microbiota using real-time quantitative PCR. FEMS Microbiol Ecol 68: 351-362.
    • (2009) FEMS Microbiol Ecol , vol.68 , pp. 351-362
    • Furet, J.P.1    Firmesse, O.2    Gourmelon, M.3    Bridonneau, C.4    Tap, J.5
  • 54
    • 70349116543 scopus 로고    scopus 로고
    • Targeted deletion of Dicer disrupts lens morphogenesis, corneal epithelium stratification, and whole eye development
    • Li Y, Piatigorsky J, (2009) Targeted deletion of Dicer disrupts lens morphogenesis, corneal epithelium stratification, and whole eye development. Dev Dyn 238: 2388-2400.
    • (2009) Dev Dyn , vol.238 , pp. 2388-2400
    • Li, Y.1    Piatigorsky, J.2
  • 55
    • 61349170312 scopus 로고    scopus 로고
    • Comparative microarray analysis and pulmonary changes in Brown Norway rats exposed to ovalbumin and concentrated air particulates
    • Heidenfelder BL, Reif DM, Harkema JR, Cohen Hubal EA, Hudgens EE, et al. (2009) Comparative microarray analysis and pulmonary changes in Brown Norway rats exposed to ovalbumin and concentrated air particulates. Toxicol Sci 108: 207-221.
    • (2009) Toxicol Sci , vol.108 , pp. 207-221
    • Heidenfelder, B.L.1    Reif, D.M.2    Harkema, J.R.3    Cohen Hubal, E.A.4    Hudgens, E.E.5
  • 56
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical bayes methods for assessing differential expression in microarray experiments
    • PMID: 16646809
    • Smyth GK, (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: Article3 PMID: 16646809.
    • (2004) Stat Appl Genet Mol Biol , vol.3
    • Smyth, G.K.1
  • 57
    • 0027979778 scopus 로고
    • Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha
    • Wu JC, Merlino G, Fausto N, (1994) Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha. Proc Natl Acad Sci U S A 91: 674-678.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 674-678
    • Wu, J.C.1    Merlino, G.2    Fausto, N.3
  • 59
    • 2642594045 scopus 로고    scopus 로고
    • Both Epstein-Barr viral nuclear antigen 2 (EBNA2) and activated Notch1 transactivate genes by interacting with the cellular protein RBP-J kappa
    • Strobl LJ, Hofelmayr H, Stein C, Marschall G, Brielmeier M, et al. (1997) Both Epstein-Barr viral nuclear antigen 2 (EBNA2) and activated Notch1 transactivate genes by interacting with the cellular protein RBP-J kappa. Immunobiology 198: 299-306.
    • (1997) Immunobiology , vol.198 , pp. 299-306
    • Strobl, L.J.1    Hofelmayr, H.2    Stein, C.3    Marschall, G.4    Brielmeier, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.