Myeloperoxidase: The yin and yang in tumour progression

Journal of Experimental Therapeutics and Oncology

Volumn 9, Issue 2, 2011, Pages 93-100

  Mika, Denish ^a   Guruvayoorappan, C ^a  

^a KARUNYA UNIVERSITY   (India)

Author keywords

Hypochlorous acid; Myeloperoxidase; Natural products; Tumour; Ulcer

Indexed keywords

ANTIOXIDANT; BETANIN; CARCINOGEN; CHLORIDE; DNA; GELATINASE A; HERBACEOUS AGENT; HYDROGEN PEROXIDE; HYPOCHLOROUS ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDICAXANTHIN; INTERLEUKIN 8; MANGIFERA INDICA EXTRACT; MATRILYSIN; MATRIX METALLOPROTEINASE; MAYTENUS SILICIFOLIA EXTACT; MYELOPEROXIDASE; NATURAL PRODUCT; NEUTROPHIL COLLAGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLANT EXTRACT; PROTEIN BCL 2; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; RESVERATROL; SCAVENGER; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; CATALYSIS; CHEMICAL INTERACTION; CHEMICAL MUTAGENESIS; CHRONIC INFLAMMATION; DNA DAMAGE; DNA POLYMORPHISM; DNA REPAIR; DRUG SCREENING; EXCISION REPAIR; EXTRACELLULAR MATRIX; GENETIC RISK; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; MEDICINAL PLANT; METABOLIC ACTIVATION; METASTASIS POTENTIAL; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REVIEW; STOMACH ULCER; TUMOR GROWTH; ULCEROGENESIS;

DISEASE PROGRESSION; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; NEOPLASMS; PEROXIDASE; POLYMORPHISM, GENETIC; STOMACH ULCER;

EID: 79959201922     PISSN: 13594117     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (113)

1. Weitzman SA, Gordon LI. Inflammation and cancer: role of phagocyte generated oxidants in carcinogenesis. Blood 76: 655-663, 1990. (Pubitemid 20253278)
2. Engels EA. Inflammation in the development of lung cancer: epidemiological evidence. Expert Rev Anticancer Ther. 8: 605-615, 2008. (Pubitemid 351818355)
3. Haqqani AS, Sandhu JK, Birnboim HC. Expression of interleukin-8 promotes neutrophil infiltration and genetic instability in mutatecttumors. Neoplasia 2: 561-568, 2000. (Pubitemid 32098691)
4. Kawakami N, Takemasa H, Yamaguchi T, et al. Indication of a protein kinase C-independent pathway for NADPH oxidase activation in human neutrophils. Arch Biochem Biophys 349: 89-94, 1998. (Pubitemid 28368394)
5. Rosen H, Crowley JR, Heinecke JW. Human neutrophils use the myeloperoxidase-hydrogen peroxide-chloride system to chlorinate but not nitrate bacterial proteins during phagocytosis. J BiolChem 277: 30463-30468, 2002. (Pubitemid 34970737)
6. Gerber CE, Bruchelt G, Falk UB, et al. Reconstitution of bactericidal activity in chronic granulomatous disease cells by glucose oxidase- containing liposomes. Blood 98: 3097-3105, 2001.
7. Bainton DF, Ullyot JL, Farquhar MG. The development of neutrophilicpolymorphonuclear leukocytes in human bone marrow. J. Exp. Med 134: 907-934, 1971.
8. Klebanoff SJ. Myeloperoxidase: occurrence and biological function, Johannes E. E. Kathleen B. G. Mathaw (ed.), Peroxidase in chemistry and biology. Boca Raton: CRC Press IncFla. 1991. pp 1-35
9. Winterbourn CC, Kettle AJ. Biomarkers of myeloperoxidase-derived hypochlorous acid. Free Radic. Biol. Med 29: 403-409, 2000.
10. Jesaitis AJ, Dratz EA. The molecular basis of oxidative damage by leukocytes. Boca Raton: CRC Press; 1992. pp 350.
11. Whiteman M, Jenner A, Halliwell B. Hypochlorous acid-induced base modifications in isolated calf thymus DNA. Chem. Res. Toxicol 10: 1240-1246, 1997.
12. Arnhold J, Hammerschmidt S, Wagner M, Mueller S, Arnold K, Grimm E. On the action of hypochlorite on human serum albumin. Biomed. Biochim. Acta 49: 991-997, 1990.
13. Hawkins CL, Davies MJ. Hypochlorite-induced damage to proteins: Formation of nitrogen-centred radicals from lysine residues and their role in protein fragmentation. Biochem. J 332: 617-625, 1998. (Pubitemid 28306685)
14. Hawkins CL, Davies MJ. Hypochlorite-induced oxidation of proteins in plasma: Formation of chloramines and nitrogen-centred radicals and their role in protein Fragmentation. Biochem. J 340: 539-548, 1999. (Pubitemid 29286577)
15. Carr AC, Vissers MC, Domigan NM, Winterbourn CC. Modification of red cell membrane lipids by hypochlorous acid and haemolysis by preformed lipid chlorohydrins. Redox Rep 3: 263-271, 1997. (Pubitemid 28421136)
16. Arnhold J, Panasenko OM, Schiller J, Vladimirov Yu A, Arnold K. The action of hypochlorous acid on phosphatidylcholine liposomes in dependence on the content of double bonds. Stoichiometry and NMR analysis. Chem. Phys. Lipids 78: 55-64, 1995.
17. Carr AC, Van den Berg JJM, Winterbourn CC. Chlorination of cholesterol in cell membranes by hypochlorous acid. Arch. Biochem Biophys 332: 63-69, 1996.
18. Panasenko OM, Arnhold J. Mechanism of hypochlorite-induced peroxidation in phospholipid liposomes. Membr. Cell Biol 10: 93-104, 1996. (Pubitemid 26245224)
19. Winterbourn CC. Comparative reactivities of various biological compounds with myeloperoxidase-hydrogen peroxide-chloride, and similarity of the oxidant to hypochlorite. Biochim. Biophys. Acta 840: 204-210, 1985.
20. Ohnishi S, Murata M, Kawanishi S. DNA damage induced by hypochlorite and hypobromite with reference to inflammation-associated carcinogenesis. Cancer Lett 178: 37-42, 2002. (Pubitemid 34159239)
21. Whiteman M, Spencer JP, Jenner A, Halliwell B. Hypochlorous acid-induced DNA base modification: potentiation bynitrite: biomarkers of DNA damage by reactive oxygen species. Biochem. Biophys. Res. Commun 257: 572-576, 1999.
22. Trush MA, Seed JL, Kensler TW. Oxidant-dependent metabolic activation of polycyclic aromatic hydrocarbons by phorbol ester-stimulated human polymorphonuclear leukocytes: possible link between inflammation and cancer. Proc. Natl. Acad Sci. USA 82: 5194-5198, 1985.
23. Van Rensburg CE, Van Staden AM, Anderson R, Van Rensburg E J. Hypochlorous acid potentiates hydrogen peroxide-mediated DNA-strand breaks in human mononuclear Leucocytes. Mutat Res 265: 255-261, 1992.
24. Trush MA, Kensler T. An overview of the relationship between oxidative stress and chemical carcinogenesis. Free Radical Biol. Med 10: 201-209, 1991. (Pubitemid 121003229)
25. Petruska JM, Mosebrook DR, Jakab GJ, Trush MA. Myeloperoxidase- enhanced formation of (6)-trans-7,8-dihydroxy-7,8-dihydrobenzo- [a] pyrene-DNA adducts in lung tissue in vitro: a role of pulmonary inflammation in the bioactivation of a procarcinogen. Carcinogenesis (Lond.) 13: 1075-1081, 1992.
26. Tsuruta Y, Subrahmanyam VV, Marshall W, O'Brien PJ. Peroxidase- mediated irreversible binding of arylamine carcinogens to DNA in intact polymorphonuclear leukocytes activated by a tumor promoter. Chem. Biol. Interact 53: 254-235, 1985.
27. Pero RW, Sheng Y, Olsson A, Bryngelsson C, Lund-Pero M. Hypochlorous acid/N-chloramines are naturally produced DNA repair inhibitors. Carcinogenesis (Lond.) 17: 13-18, 1996. (Pubitemid 26091264)
28. Jackson AL, Loeb LA. The contribution of endogenous sources of DNA damage to the multiple mutations in cancer. Mutat. Res 477: 7-21, 2001. (Pubitemid 32480184)
29. Prutz WA. Hypochlorous acid interactions with thiols, nucleotides, DNA, and other biological substrates. Arch. Biochem. Biophys 332: 110-120, 1996.
30. Prutz WA. Interactions of hypochlorous acid with pyrimidine nucleotides, and secondary reactions of chlorinated pyrimidines with GSH, NADH, and other substrates. Arch. Biochem. Biophys 349: 183-191, 1998. (Pubitemid 28368405)
31. Prutz WA. Consecutive halogen transfer between various functional groups induced by reaction of hypohalous acids: NADH oxidation by halogenated amide groups. Arch. Biochem. Biophys 371: 107-114, 1999.
32. Prutz WA, Kissner R, Koppenol WH, Ruegger H. On the irreversible destruction of reduced nicotinamide nucleotides by hypohalous acids. Arch. Biochem. Biophys 380: 181-191, 2000.
33. Hayatsu H, Pan S-K, Ukita T. Reaction of sodium hypochlorite with nucleic acids and their constituents. Chem. Pharm. Bull 19: 2189-2192, 1971.
34. Patton W, Bacon V, Duffield AM, Halpern B, Hoyano Y, Pereira W, Lederberg J. Chlorination studies. I. The reaction of aqueous hypochlorous acid with cytosine. Biochem. Biophys. Res. Comm. 48: 880-884, 1972.
35. Gould JP, Richards JT, Miles MG. The kinetics and primary products of uracil Chlorination. Water Res 18: 205-212, 1984. (Pubitemid 14192617)
36. Gould JP, Richards JT, Miles MG. The formation of stable organic chloramines during the aqueous chlorination of cytosine and 5-methylcytosine. Water Res 18: 991-999, 1984.
37. Hawkins CL, Davies MJ. Hypochlorite-induced damage to nucleosides: Formation of chloramines and nitrogen-centered radicals. Chem. Res. Toxicol. 14: 1071-1081, 2001.
38. Wolffe A. Chromatin : Structure and function, Academic Press San Diego; 1998.
39. Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine, Oxford University Press Oxford; 1999.
40. Kulcharyk, PA, Heinecke JW. Hypochlorous acid produced by the myeloperoxidase system of human phagocytes induces covalent cross-links between DNA and protein. Biochemistry 40: 3648-3656, 2001. (Pubitemid 32242822)
41. Hawkins CL, Pattison DI, Davies MJ. Reaction of protein chloramines with DNA and nucleosides : evidence for the formation of radicals, protein-DNA cross-links and DNA fragmentation. Biochem. J 365: 605-615, 2002. (Pubitemid 34864442)
42. Thomas EL, Grisham MB, Jefferson MM. Cytotoxicity of chloramines. Methods Enzymol 132: 585-593, 1986.
43. Suzuki H, Seto K, Mori M, Suzuki M, Miura S, Ishii H. Monochloramine induced DNA fragmentation in gastric cell line MKN45. Am. J. Physiol. 275: G712-G716, 1998.
44. Weiss SJ. Tissue destruction by neutrophils. N Engl J Med 320: 365-376, 1989. (Pubitemid 19106873)
45. Stossel TP, Mason RJ, Smith AL. Lipid peroxidation by human blood phagocytes, J Clin Invest 54: 638-645, 1974.
46. Carlin G, Djursater R. Peroxidation of phospholipids promoted by myeloperoxidase, Free Radic Res Commun 4: 251-257, 1988. (Pubitemid 18073061)
47. Esterbauer H. Lipid peroxidation products: formation, chemical properties and biological activities. Free Radical in Liver Injury, ed. C.K. Pli G, Dianzani MU, Slater TF. Oxford: IRL Press; 1985 pp: 29-47.
48. Seto H, Seto T, Takesue T, Ikemura T. Reaction of malonaldehyde with nucleic acid. III. Studies of the fluorescent substances released by enzymatic digestion of nucleic acids modified with malonaldehyde. Chem Pharm Bull (Tokyo) 34: 5079-5085, 1986.
49. Benamira M, Johnson K, Chaudhary A, Bruner K, Tibbetts C, Marnett LJ. Induction of mutations by replication of malondialdehyde-modified M13 DNA in Escherichia coli: determination of the extent of DNA modification, genetic requirements for mutagenesis, and types of mutations induced. Carcinogenesis 16: 93-99, 1995.
50. Hunninghake GW, Crystal RG. Cigarette smoking and lung destruction.Accumulation of neutrophils in the lungs of cigarette smokers. Am. Rev. Respir. Dis 128: 833-838, 1983.
51. Schmekel B, Venge P. The distribution of myeloperoxidase, eosinophil cationic protein, albumin and urea in sequential bronchoalveolar lavage. Eur.Respir. J 4: 517-523, 1991.
52. Schmekel B, Karlsson SE, Linden M, Sundstrom C, Tegner H, Venge P. Myeloperoxidase in human lung lavage. I. A marker of local neutrophil activity. Inflammation 14: 447-454, 1990.
53. Schabath MB, Spitz MR, Zhang X, Delcos GL and Wu X. Genetic variants of myeloperoxidase and lung cancer risk. Carcinogenesis 21 : 1163-1166, 2000. (Pubitemid 30389342)
54. Van Schooten FJ, Boots AW, Knaapen AM, Godschalk RW, Maas LM, Borm PJ, Drent M, Jacobs JA. Myeloperoxidase (MPO) -463G→A reduces MPO activity and DNA adduct levels in bronchoalveolar lavages of smokers. Cancer Epidemiol. Biomarkers Prev 13: 828-833, 2004. (Pubitemid 38737873)
55. Arlt VM, Henderson CJ, Wolf CR, Schmeiser HH, Phillips DH, Stiborova M. Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidises. Cancer Lett 234: 220-231, 2006.
56. Mallet WG, Mosebrook DR, Trush MA. Activation of (1-)-trans- 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to diolepoxides by human polymorphonuclear leukocytes or myeloperoxidase. Carcinogenesis 12: 521-524, 1991.
57. Borm PJ, Knaapen AM, Schins RP, Godschalk RW, Schooten FJ. Neutrophils amplify the formation of DNA adducts by benzo[a]pyrene in lung target cells. Environ. Health Perspect 105: 1089-1093, 1997.
58. Van Schooten FJ, Boots AW, Knaapen AM, Godschalk RWL, Maas LM, Borm PJA, Drent M, Jacobs JA. Myeloperoxidase (MPO) - 463G→A Reduces MPO Activity and DNA Adduct Levels in Bronchoalveolar Lavages of Smokers. Cancer Epidemiol Biomarkers Prev 13: 828-833, 2004. (Pubitemid 38737873)
59. Denissenko MF, Pao A, Tang M, Pfeifer GP. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53. Science 274 : 430-432, 1996. (Pubitemid 26353359)
60. Gelboin HV. Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. Physiol. Rev 60: 1107-1166, 1980.
61. Phillips DH. Fifty years of benzo[a]pyrene. Nature 303: 468-472, 1983.
62. Xue W, Warshawsky D. Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review. Toxicol. Appl. Pharmacol 206: 73-93, 2005.
63. Luch A. Nature and nurture-lessons from chemical carcinogenesis. Nat. Rev. Cancer 5: 113-125, 2005.
64. Hussain SP, Amstad P, Raja K, Sawyer M, Hofseth L, Shields PG, Hewer A, Phillips DH, Ryberg D, Haugen A, Harris CC. Mutability of p53 hotspot codons to benzo(a)pyrenediol epoxide (BPDE) and the frequency of p53 mutations in non tumorous human lung. Cancer Res 61: 6350-6355, 2001. (Pubitemid 32783236)
65. Hoeijimakers JHJ, Bootsma D. Molecular genetics of the eukaryotic DNA excision repair. Cancer cell 2: 311-320, 1990. (Pubitemid 20354910)
66. Hoeijmakers JHJ. Nucleotide excision repair, II: from yeast to mammals. Trends Genet. 9: 211-217, 1993.
67. Lehmann AR. Nucleotide excision repair and the link with transcription. Trends Biochem. Sci 20: 402-405, 1995.
68. Friedberg EC, Walker GC, Siede W. DNA repair and Mutagenesis. American Society for microbiology press, Washington, DC, 1995.
69. Wood RD. DNA repair in eukaryotes, Annu Rev. Biochem 65: 135-167,1996. (Pubitemid 26250607)
70. Cleaver JE, Kraemer KH. Xerodermapigmentosum and Cockayne syndrome. In Scriver CR., Beaudet AL., Sly WS and Valle D. (eds) The Metabolic and Molecular Basis of Inherited Disease. McGraw Hill, New York, NY, 1995. Vol. III, pp. 4393-4419.
71. Lindahl T, Wood RD. Quality control by DNA repair. Science 286: 1897-1905, 1999.
72. Gillet LC, Scharer OD. Molecular mechanisms of mammalian global genome nucleotide excision repair. Chem. Rev. 106: 253-276, 2006.
73. Gungor N, Godschalk RW, Pachen DM, Van Schooten FJ, Knaapen AM. Activated neutrophils inhibit nucleotide excision repair in human pulmonary epithelial cells: role of myeloperoxidase. FASEB J 21: 2359-2367, 2007. (Pubitemid 47230666)
74. Van Rensburg CE, Van Staden AM, Anderson R. Inactivation of poly (ADP-ribose) polymerase by hypochlorous acid. Free Radic Biol Med 11: 285-291, 1991. (Pubitemid 121003925)
75. Winterbourn CC, Kettle AJ. Reactions of superoxide with myeloperoxidase and its products. Jpn J Infect Dis. 57: S31 - 33, 2004.
76. De Larco JE, Wuertz BRK, Furcht LT. The Potential Role of Neutrophils in Promoting the Metastatic Phenotype of Tumors Releasing Interleukin-8. Clin Cancer Res. 10: 4895-4900, 2004. (Pubitemid 39099762)
77. Vissers MC, Thomas C. Hypochlorous acid disrupts the adhesive properties of subendothelial matrix. Free Radic Biol Med 23: 401-411, 1997. (Pubitemid 27276776)
78. Nelson ARB, Fingleton, ML Rothenberg, LM Matrisian. Matrix metalloproteinases: biologic activity and clinical implications. J Clin Oncol. 18: 1135-1149, 2000. (Pubitemid 30123793)
79. D'Angio CT, Finkelstein JN. Oxygen regulation of gene expression: a study in opposites. Mol Genet Metabol. 71: 371-380, 2000.
80. Li N, M Karin: Is NF-kappaB the sensor of oxidative stress? FASEB J 13: 1137-1143, 1999.
81. Saile B, Matthes N, El Armouche H, Neubauer K, Ramadori G. The bcl, NFkappaB and p53/p21WAF1 systems are involved in spontaneous apoptosis and in the anti-apoptotic effect of TGFbeta or TNF-alpha on activated hepatic stellate cells. Eur J Cell Biol 80: 554-561, 2001. (Pubitemid 32821626)
82. Ernst PB, Gold BD. The disease spectrum of Heliobacterpyroli: the immunopathogenesis of gastroduodenal ulcer and gastric cancer. Annu Rev Microbiol 54: 615-640, 2000.
83. Blaser MJ. Hypotheses on the pathogenesis and natural history of Helicobacter pylori-induced inflammation. Gastroenterol 102: 720-727, 1992.
84. Yamaoka Y, Kita M, Kodama T, Sawai N, Kashima K, Imanishi I Expression of cytokine mRNA in gastric mucosa with Helicobacter pylori infection. Scand. J. Gastroenterol 30: 1153-1159, 1995.
85. Mizuki I, Shimoyama T, Fukuda S, Liu Q, Nakaji S, Munakata A. Association of gastric epithelial apoptosis with the ability of Helicobacter pylori to induce a neutrophil oxidative burst. J Med Microbiol 49: 521-524, 2000. (Pubitemid 30347589)
86. Wallace JL. Possible mechanisms and mediators of gastritis associated with Helicobacter pylori infection. Scand. J. Gastroenterol 187: 65-70, 1991.
87. Roe I, Nam S, Kim J, Shin J, Bang W, Yang M. Association of the myeloperoxidase -463G→A polymorphism with development of atrophy in Helicobacter pylori-infected Gastritis. Am J Gastroenterol 97: 1629-1634, 2002. (Pubitemid 34761381)
88. Cascorbi I, Henning S, Brockmoller J, Gephart J, Meisel C, Muller JM, Loddenkemper R, Roots I. Substantially reduced risk of cancer of the aerodigestive tract in subjects with variant-463A of the myeloperoxidase gene. Cancer Res. 60: 644-649, 2000. (Pubitemid 30094562)
89. Bhattacharjee M, Bhattacharjee S, Gupta A, Banerjee RK. Critical role of an endogenous gastric peroxidase in controlling oxidative damage in H. pylori-mediated and nonmediated gastric ulcer. Free Radic Biol Med 32: 731-743, 2002. (Pubitemid 34286594)
90. Karmeli F, Okon E, Rachmilewitz D. Sulphydryl blocker induced gastric damage is ameliorated by scavenging of free radicals. Gut 38: 826-831, 1996. (Pubitemid 26231764)
91. Matsuo K, Hamajima N, Suzuki R, Nakamura S, Seto M, Morishima Y, Tajima K. No substantial difference in genotype frequencies of interleukin and myeloperoxidase polymorphisms between malignant lymphoma patients and non-cancer controls. Haematologica 86: 602-608, 2001. (Pubitemid 32601103)
92. Tran CD, Huynh H, van den Berg M, van der Pas M, Campbell MA, Philcox JC, Coyle P, Rofe AM, Butler RN. Helicobacter induced gastritis in mice not expressing metallothionein-I and II. Helicobacter 8: 533-541, 2003.
93. Foster CB, Lehrnbecher T, Mol F, Steinberg SM, Venzon DJ, Walsh TJ, Noack D, Rae J, Winkelstein JA, Curnutte JT, Chanock SJ. Host defense molecule polymorphisms influence the risk for immune-mediated complications in chronic granulomatous disease. J Clin Invest 102: 2146-2155, 1998. (Pubitemid 29018821)
94. Rutgers A, Heeringa P, Giesen JE, Theunissen RT, Jacobs H, Tervaert JW. Neutrophil myeloperoxidase activity and the influence of two single-nucleotide promoter polymorphisms. Br J Haematol 123: 536-538, 2003. (Pubitemid 37363501)
95. Le Marchand L, Seifried A, Lum A, Wilkens LR. Association of the myeloperoxidase - 463 A polymorphism with lung cancer risk. Cancer Epidemiol Biomarkers Prev 9: 181-184, 2000. (Pubitemid 30111941)
96. Austin GE, Lam L, Zaki SR, Chan WC, Hodge T, Hou J, Swan D, Zhang W, Racine M, Whitsett C et al. Sequence comparison of putative regulatory DNA of the 5' flanking of the myeloperoxidase gene in normal and leukemic bone marrow cells. Leukemia 7: 1445-1450, 1993. (Pubitemid 23291089)
97. Piedrafita FJ, Molander RB, Vansant G, Orlova EA, Pfahl M, Reynolds WF. An Alu element in the myeloperoxidase promoter contains a composite SP1-thyroid hormone-retinoid acid response element. J Biol Chem 271: 14412-14420, 1996.
98. Hansson M, Olsson I, Nauseef WM. Biosynthesis, processing, and sorting of human myeloperoxidase. Arch Biochem Biophys 445: 214-224, 2006.
99. Feyler A, Voho A, Bouchardy C, Kuokkanen K, Dayer P, Hirvonen A, Benhamou S. Point: myeloperoxidase -463G -a polymorphism and lung cancer risk. Cancer Epidemiol. Biomarkers Prev. 11: 1550-1554, 2002.
100. Schabath MB, Spitz MR, Hong WK, Delclos GL, Reynolds WF, Gunn GB, Whitehead LW, Wu X. A myeloperoxidase polymorphism associated with reduced risk of lung cancer. Lung Cancer 37: 35-40, 2002. (Pubitemid 34621456)
101. Larsen JE, Colosimo ML, Yang IA, Bowman R, Zimmerman PV, Fong KM. CYP1A1 IIe462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung. Carcinogenesis 27: 525-532, 2006. (Pubitemid 43372882)
102. Olson SH, Carlson MD, Ostrer H, Harlap S, Stone A, Winters M, Ambrosone CB. Genetic variants in SOD2, MPO, and NQO1, and risk of ovarian cancer.Gynecol. Oncol. 93: 615-620, 2004.
103. Hung RJ, Boffetta P, Brennan P, Malaveille C, Gelatti U, Placidi D, Carta A, Hautefeuille A, Porru S. Genetic polymorphisms of MPO, COMT, MnSOD, NQO1, interactions with environmental exposures and bladder cancer risk. Carcinogenesis 25: 973-978, 2004. (Pubitemid 38886083)
104. Pakakasama S, Chen TT, Frawley W, Muller C, Douglass EC, Tomlinson GE. Myeloperoxidase promotor polymorphism and risk of hepatoblastoma. Int. J. Cancer 106: 205-207, 2003. (Pubitemid 36835172)
105. Hamajima N, Matsuo K, Suzuki T, Nakamura T, Matsuura A, Tajima K, Tominaga S. Low expression myeloperoxidase genotype negatively associated with Helicobacter pylori Infection. Jpn J Cancer Res 92: 488-493, 2001. (Pubitemid 32515088)
106. Katsuda N, Hamajima N, Tamakoshi A, Wakai K, Matsuo K, Saito T, Tajima K, Tominaga S. Helicobacter pylori seropositivity and the myeloperoxidase G-463A polymorphism in combination with interleukin-1B C-31T in Japanese health checkup examinees. Jpn J Clin Oncol 33: 192-197, 2003. (Pubitemid 43102863)
107. Allegra M, Furtmuller PG, Jantschko W, Zederbauer M, Tesoriere L, Livrea MA, Obinger C. Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid. Biochem. Biophys. Res. Commun 332: 837-844, 2005.
108. Vellosa JCR, Khalil OAK, Khalil NM, Santos VAFFM, Hakime-Silva RA, Furlan M, Brunetti IL, Oliveira OMMF. Maytenusilicifoliaas source of antioxidants and antiradicals agents and its action on neutrophils peroxidase (myeloperoxidase).African Journal of Biochemistry Research 2: 232-239, 2008.
109. Jang M, Pezzuto JM. Cancer chemopreventive activity of resveratrol. Drugs Exp Clin Res 25: 65-77, 1999. (Pubitemid 29257597)
110. Pereira DA, Koelzer J, Dalmarco JB, Pizzolatti MG, Frode TS. Evaluation of the antiinflammatory efficacy of Lotus pedunculatus. International Journal of Green Pharmacy, 2: 105-111, 2009.
111. Cabrini DA, Moresco HH, Imazu P, Silva CD, Pietrovski EF, Mendes DAGB, Prudente AS, Pizzolatti MG, Brighente IMC, Otuki MF, Analysis of the Potential Topical Anti-inflammatory Activity of Averrhoa carambola L. in Mice, Evidence-based Compl. and Alt. Medicine,10:1093, 2010.
112. Cestari SH, Bastos JK, Stasi LCD, Intestinal Antiinflammatory Activity of Baccharis dracunculifolia in the Trinitrobenzenesulphonic Acid Model of Rat Colitis. Evidence-based Compl. and Alt. Medicine, 10: 1093, 2009.
113. Magina MDA, Pietrovski EF, Gomig G, Falkenberg DDBF, Cabrini DA, Otuki MF; Pizzollati MG, Brighente IMC, Topical antiinflammatory activity and chemical composition of the epicuticular wax from the leaves of Eugenia beaurepaireana (Myrtaceae). Braz. J. Pharm. Sci., 45 1 2009.