Reaction of protein chloramines with DNA and nucleosides: Evidence for the formation of radicals, protein-DNA cross-links and DNA fragmentation

Biochemical Journal

Volumn 365, Issue 3, 2002, Pages 605-615

  Hawkins, Clare L ^a   Pattison, David I ^a   Davies, Michael J ^a  

^a HEART RESEARCH INSTITUTE   (Australia)

Author keywords

DNA damage; Free radicals; Hypochlorite; Myeloperoxidase; Spin trapping

Indexed keywords

DECOMPOSITION; DISEASES; DNA; HYDROGEN PEROXIDE; OXIDATION; PARAMAGNETIC RESONANCE; TISSUE; TUMORS;

NUCLEOSIDES;

PROTEINS;

CHLORAMINE DERIVATIVE; DNA; FREE RADICAL; HYPOCHLORITE; MYELOPEROXIDASE; NUCLEOSIDE;

ARTICLE; DNA CROSS LINKING; DNA DAMAGE; MOLECULAR MODEL; MOLECULAR STABILITY; PRIORITY JOURNAL; PROTEIN DNA BINDING; REACTION ANALYSIS; SPIN TRAPPING;

ANIMALS; ANTIOXIDANTS; CHLORAMINES; DNA; DNA DAMAGE; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICALS; HISTONES; LYSINE; MOLECULAR STRUCTURE; NUCLEOSIDES; NUCLEOSOMES; PLASMIDS; PROTEINS; RNA; SPIN TRAPPING; THYMIDINE;

BACTERIA (MICROORGANISMS); EUKARYOTA; LETHRINIDAE;

EID: 0036682933     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020363     Document Type: Article

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