Onconase mediated NFKΒ downregulation in malignant pleural mesothelioma

Oncogene

Volumn 30, Issue 24, 2011, Pages 2767-2777

  Goparaju, C M ^a   Blasberg, J D ^b   Volinia, S ^c   Palatini, J ^c   Ivanov, S ^d   Donington, J S ^a   Croce, C ^c   Carbone, M ^e   Yang, H ^e   Pass, H I ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b Columbia University College of Physicians and Surgeons ^*  (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^e UNIVERSITY OF HAWAII CANCER CENTER   (United States)

Author keywords

mesothelioma; microRNA; multidrug resistance

Indexed keywords

ABC TRANSPORTER; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIGEL; MICRORNA; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN BCL XL; RANPIRNASE; X LINKED INHIBITOR OF APOPTOSIS;

ARTICLE; CELL COUNT; CELL INVASION; CELL PROLIFERATION; CHEMOSENSITIZATION; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; PLEURA MESOTHELIOMA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; UPREGULATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DOWN-REGULATION; HUMANS; MESOTHELIOMA; MICRORNAS; NF-KAPPA B; P-GLYCOPROTEIN; PLEURAL NEOPLASMS; RIBONUCLEASES; TRANSFECTION;

EID: 79958865840     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.643     Document Type: Article

References (57)

1. Ambros V. (2004). The functions of animal microRNAs. Nature 431: 350-355. (Pubitemid 39265675)
2. Ambros V, Lee RC, Lavanway A, Williams PT, Jewell D. (2003). MicroRNAs and other tiny endogenous RNAs in C. elegans. Curr Biol 13: 807-818. (Pubitemid 36573248)
3. Ardelt B, Ardelt W, Darzynkiewicz Z. (2003). Cytotoxic ribonucleases and RNA interference (RNAi). Cell Cycle 2: 22-24.
4. Ardelt B, Juan G, Burfeind P, Salomon T, Wu JM, Hsieh TC et al. (2007). Onconase, an anti-tumor ribonuclease suppresses intracellular oxidative stress. Int J Oncol 31: 663-669.
5. Barnhart BC, Peter ME. (2003). The TNF receptor 1: a split personality complex. Cell 114: 148-150. (Pubitemid 36936906)
6. Bartel DP. (2004). MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
7. Beck AK, Pass HI, Carbone M, Yang H. (2008). Ranpirnase as a potential antitumor ribonuclease treatment for mesothelioma and other malignancies. Future Oncol 4: 341-349. (Pubitemid 351984085)
8. Cao X, Rodarte C, Zhang L, Morgan CD, Littlejohn J, Smythe WR. (2007). Bcl2/bcl-x(L) inhibitor engenders apoptosis and increases chemosensitivity in mesothelioma. Cancer Biol Ther 6: 246-252. (Pubitemid 46641630)
9. Carbone M, Albelda SM, Broaddus VC, Flores RM, Hillerdal G, Jaurand MC et al. (2007). Eighth international mesothelioma interest group. Oncogene 26: 6959-6967. (Pubitemid 350014615)
10. Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT et al. (2005). Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 33: e179.
11. Davidson AL, Dassa E, Orelle C, Chen J. (2008). Structure, function, and evolution of bacterial ATP-binding cassette systems. Microbiol Mol Biol Rev 72: 317-364. (Pubitemid 351822295)
12. Deptala A, Halicka HD, Ardelt B, Ardelt W, Mikulski SM, Shogen K et al. (1998). Potentiation of tumor necrosis factor induced apoptosis by onconase. Int J Oncol 13: 11-16. (Pubitemid 28267489)
13. Dickson KA, Haigis MC, Raines RT. (2005). Ribonuclease inhibitor: structure and function. Prog Nucleic Acid Res Mol Biol 80: 349-374. (Pubitemid 43574893)
14. Gillet JP, Efferth T, Remacle J. (2007). Chemotherapy-induced resistance by ATP-binding cassette transporter genes. Biochim Biophys Acta 1775: 237-262. (Pubitemid 46899341)
15. Gilmore TD. (1999). The Rel/NF-kappaB signal transduction pathway: introduction. Oncogene 18: 6842-6844.
16. Gilmore TD. (2003). The Re1/NF-kappa B/I kappa B signal transduction pathway and cancer. Cancer Treat Res 115: 241-265.
17. Gilmore TD. (2006). Introduction to NF-kappaB: players, pathways, perspectives. Oncogene 25: 6680-6684. (Pubitemid 44657845)
18. Gordon GJ, Mani M, Mukhopadhyay L, Dong L, Yeap BY, Sugarbaker DJ et al. (2007). Inhibitor of apoptosis proteins are regulated by tumour necrosis factor-alpha in malignant pleural mesothelioma. J Pathol 211: 439-446. (Pubitemid 46332555)
19. Halicka DH, Pozarowski P, Ita M, Ardelt WJ, Mikulski SM, Shogen K et al. (2002). Enhancement of activation-induced apoptosis of lymphocytes by the cytotoxic ribonuclease onconase (Ranpirnase). Int J Oncol 21: 1245-1250.
20. Iordanov MS, Ryabinina OP, Wong J, Dinh TH, Newton DL, Rybak SM et al. (2000). Molecular determinants of apoptosis induced by the cytotoxic ribonuclease onconase: evidence for cytotoxic mechanisms different from inhibition of protein synthesis. Cancer Res 60: 1983-1994. (Pubitemid 30207661)
21. Jones PM, George AM. (2004). The ABC transporter structure and mechanism: perspectives on recent research. Cell Mol Life Sci 61: 682-699. (Pubitemid 38446412)
22. Kasashima K, Nakamura Y, Kozu T. (2004). Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells. Biochem Biophys Res Commun 322: 403-410. (Pubitemid 39490318)
23. Kaufman AJ, Pass HI. (2008). Current concepts in malignant pleural mesothelioma. Expert Rev Anticancer Ther 8: 293-303. (Pubitemid 351385919)
24. Khokhar NZ, She Y, Rusch VW, Sirotnak FM. (2001). Experimental therapeutics with a new 10-deazaaminopterin in human mesothe-lioma: further improving efficacy through structural design, pharmacologic modulation at the level of MRP ATPases, and combined therapy with platinums. Clin Cancer Res 7: 3199-3205. (Pubitemid 32963844)
25. Kim DH, Kim EJ, Kalota A, Gewirtz AM, Glickson J, Shogen K et al. (2007). Possible mechanisms of improved radiation response by cytotoxic RNase, Onconase, on A549 human lung cancer xenografts of nude mice. Adv Exp Med Biol 599: 53-59.
26. Kobe B, Deisenhofer J. (1996). Mechanism of ribonuclease inhibition by ribonuclease inhibitor protein based on the crystal structure of its complex with ribonuclease. A J Mol Biol 264: 1028-1043. (Pubitemid 27019490)
27. Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T. (2003). New microRNAs from mouse and human. RNA 9: 175-179. (Pubitemid 36206285)
28. Lee I. (2008). Ranpirnase (Onconase), a cytotoxic amphibian ribonuclease, manipulates tumour physiological parameters as a selective killer and a potential enhancer for chemotherapy and radiation in cancer therapy. Expert Opin Biol Ther 8: 813-827. (Pubitemid 351860211)
29. Lee I, Kim DH, Sunar U, Magnitsky S, Shogen K. (2007). The therapeutic mechanisms of ranpirnase-induced enhancement of radiation response on A549 human lung cancer. In vivo 21s: 721-728. (Pubitemid 350019790)
30. Lee JE, Raines RT. (2008). Ribonucleases as novel chemotherapeutics: the ranpirnase example. BioDrugs 22: 53-58. (Pubitemid 351158535)
31. Littlejohn JE, Cao X, Miller SD, Ozvaran MK, Jupiter D, Zhang L et al. (2008). Bcl-xL antisense oligonucleotide and cisplatin combination therapy extends survival in SCID mice with established mesothelioma xenografts. Int J Cancer 123: 202-208. (Pubitemid 351705210)
32. Micheau O, Tschopp J. (2003). Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114: 181-190. (Pubitemid 36936912)
33. Mikulski SM, Viera A, Darzynkiewicz Z, Shogen K. (1992). Synergism between a novel amphibian oocyte ribonuclease and lovastatin in inducing cytostatic and cytotoxic effects in human lung and pancreatic carcinoma cell lines. Br J Cancer 66: 304-310.
34. O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT. (2005). c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435: 839-843. (Pubitemid 40839736)
35. Pass HI, Liu Z, Wali A, Bueno R, Land S, Lott D et al. (2004). Gene expression profiles predict survival and progression of pleural mesothelioma. Clin Cancer Res 10: 849-859. (Pubitemid 38198883)
36. Pass HI, Stevens EJ, Oie H, Tsokos MG, Abati AD, Fetsch PA et al. (1995). Characteristics of nine newly derived mesothelioma cell lines. Ann Thorac Surg 59: 835-844.
37. Pavlakis N, Vogelzang NJ. (2006). Ranpirnase-an antitumour ribonuclease: its potential role in malignant mesothelioma. Expert Opin Biol Ther 6: 391-399.
38. Porta C, Paglino C, Mutti L. (2008). Ranpirnase and its potential for the treatment of unresectable malignant mesothelioma. Biologics 2: 601-609.
39. Reck M, Krzakowski M, Jastrzebski D et al. (2009). Randomized, multicenter phase III study of ranpirnase plus doxorubicin (DOX) versus DOX in patients with unresectable malignant mesothelioma (MM). J Clin Oncol 27(Suppl.):abstr 7507.
40. Robinson BW, Lake RA. (2005). Advances in malignant mesothelio-ma. N Engl J Med 353: 1591-1603.
41. Robledo R, Mossman B. (1999). Cellular and molecular mechanisms of asbestos-induced fibrosis. J Cell Physiol 180: 158-166. (Pubitemid 29297192)
42. Rybak SM, Pearson JW, Fogler WE, Volker K, Spence SE, Newton DL et al. (1996). Enhancement of vincristine cytotoxicity in drug-resistant cells by simultaneous treatment with onconase, an antitumor ribonuclease. J Natl Cancer Inst 88: 747-753. (Pubitemid 26195922)
43. Saxena SK, Sirdeshmukh R, Ardelt W, Mikulski SM, Shogen K, Youle RJ. (2002). Entry into cells and selective degradation of tRNAs by a cytotoxic member of the RNase A family. J Biol Chem 277: 15142-15146. (Pubitemid 34952593)
44. Shi Z, Parmar S, Peng XX, Shen T, Robey RW, Bates SE et al. (2009). The epidermal growth factor tyrosine kinase inhibitor AG1478 and erlotinib reverse ABCG2-mediated drug resistance. Oncol Rep 21: 483-489.
45. Shi Z, Peng XX, Kim IW, Shukla S, Si QS, Robey RW et al. (2007). Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance. Cancer Res 67: 11012-11020. (Pubitemid 350145931)
46. Shukla S, Robey RW, Bates SE, Ambudkar SV. (2009). Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2. Drug Metab Dispos 37: 359-365.
47. Singh UP, Ardelt W, Saxena SK, Holloway DE, Vidunas E, Lee HS et al. (2007). Enzymatic and structural characterisation of amphi-nase, a novel cytotoxic ribonuclease from Rana pipiens oocytes. J Mol Biol 371: 93-111. (Pubitemid 47030454)
48. Soini Y, Jarvinen K, Kaarteenaho-Wiik R, Kinnula V. (2001). The expression of P-glycoprotein and multidrug resistance proteins 1 and 2 (MRP1 and MRP2) in human malignant mesothelioma. Ann Oncol 12: 1239-1245. (Pubitemid 32994751)
49. Soini Y, Kinnula V, Kaarteenaho-Wiik R, Kurttila E, Linnainmaa K, Paakko P. (1999). Apoptosis and expression of apoptosis regulating proteins bcl-2, mcl-1, bcl-X, and bax in malignant mesothelioma. Clin Cancer Res 5: 3508-3515.
50. Symanowski J, Vogelzang N, Zawel L, Atadja P, Pass H, Sharma S. (2009). A histone deacetylase inhibitor LBH589 downregulates XIAP in mesothelioma cell lines which is likely responsible for increased apoptosis with TRAIL. J Thorac Oncol 4: 149-160.
51. Tsai SY, Ardelt B, Hsieh TC, Darzynkiewicz Z, Shogen K, Wu JM. (2004). Treatment of Jurkat acute T-lymphocytic leukemia cells by onconase (Ranpirnase) is accompanied by an altered nucleocyto-plasmic distribution and reduced expression of transcription factor NF-kappaB. Int J Oncol 25: 1745-1752.
52. Varkonyi-Gasic E, Wu R, Wood M, Walton EF, Hellens RP. (2007). Protocol: a highly sensitive RT-PCR method for detection and quantification of microRNAs. Plant Methods 3: 12.
53. Wang XJ, Reyes JL, Chua NH, Gaasterland T. (2004). Prediction and identification of Arabidopsis thaliana microRNAs and their mRNA targets. Genome Biol 5: R65.
54. Wu Y, Mikulski SM, Ardelt W, Rybak SM, Youle RJ. (1993). A cytotoxic ribonuclease. Study of the mechanism of onconase cytotoxicity. J Biol Chem 268: 10686-10693. (Pubitemid 23150262)
55. Yang H, Bocchetta M, Kroczynska B, Elmishad AG, Chen Y, Liu Z et al. (2006). TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis. Proc Natl Acad Sci USA 103: 10397-10402. (Pubitemid 44051178)
56. Yang H, Testa JR, Carbone M. (2008). Mesothelioma epidemiology, carcinogenesis, and pathogenesis. Curr Treat Options Oncol 9: 147-157.
57. Zhao H, Ardelt B, Ardelt W, Shogen K, Darzynkiewicz Z. (2008). The cytotoxic ribonuclease onconase targets RNA interference (siRNA). Cell Cycle 7: 3258-3261.