Rapid-onset sildenafil nasal spray carried by microemulsion systems: In vitro evaluation and in vivo pharmacokinetic studies in rabbits

Xenobiotica

Volumn 41, Issue 7, 2011, Pages 567-577

  Lu, Hsien Tsung ^a   Chen, Ray Neng ^b   Sheu, Ming Thau ^c   Chang, Chung Chiao ^c   Chou, Po Yu ^c   Ho, Hsiu O ^c  

^a TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b NURSING AND MANAGEMENT COLLEGE   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

intranasal absorption; Microemulsion; oleic acid; sildenafil; Tween

Indexed keywords

2 PROPANOL; ALCOHOL; CASTOR OIL; CREMOPHOR; DEOXYCHOLATE SODIUM; MACROGOL 200; MACROGOL 400; METHANOL; NOSE SPRAY; OLEIC ACID; OLIVE OIL; POLYSORBATE 20; POLYSORBATE 40; POLYSORBATE 80; PROPANOL; PROPYLENE GLYCOL; SAFFLOWER OIL; SILDENAFIL; SODIUM CHLORIDE; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG HALF LIFE; DRUG SCREENING; DRUG SOLUBILITY; ERECTILE DYSFUNCTION; EXCIPIENT COMPATIBILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MAXIMUM PLASMA CONCENTRATION; MICROEMULSION; NASAL CILIOTOXICITY; NONHUMAN; NOSE MUCOSA; RABBIT; RAT; SCANNING ELECTRON MICROSCOPY; TIME TO MAXIMUM PLASMA CONCENTRATION; TREATMENT DURATION; VISCOSITY;

ABSORPTION; ADMINISTRATION, INTRANASAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CILIA; EMULSIONS; NASAL SPRAYS; PHASE TRANSITION; PIPERAZINES; PURINES; RABBITS; RATS; SOLUBILITY; SULFONES;

ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 79958853399     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2011.563877     Document Type: Article

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