Triglyceride-based microemulsion for intravenous administration of sparingly soluble substances

Journal of Pharmaceutical Sciences

Volumn 87, Issue 2, 1998, Pages 200-208

  Von Corswant, Christian ^a   Thorén, Peter ^b   Engström, Sven ^c  

^a ASTRAZENECA R AND D   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

EPICURON 200; INTRALIPID; MACROGOL 400; MEDIUM CHAIN TRIACYLGLYCEROL; MIGLYOL; MIGLYOL 810N; SOYBEAN OIL EMULSION; SURFACTANT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ACID BASE BALANCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD GAS; CONTROLLED STUDY; DRUG SAFETY; DRUG SOLUBILITY; HEART DEPOLARIZATION; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MICROEMULSION; MOLECULAR DYNAMICS; NONHUMAN; PARTICLE SIZE; RAT;

EID: 0031891234     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js970258w     Document Type: Article

References (27)

1. Yalkowsky, S. H. Techniques of solubilization of drugs; Marcel Dekker: New York, 1981.
2. Lorenz, W.; Reimann, H.-J.; Schmal, A.; Dormann, P.; Schwartz, B.; Neugebauer, E. Histamine release in dogs by Cremophor EL and its derivatives: oxethylated oleic acid is the most effective constituent. Agents Actions 1977, 7, 63-67.
3. Clarke, R. S. J.; Dundee, J. W.; Garrett, R. T.; Mcardle, G. K.; Sutton, J. A. Adverse reactions to intravenous anaesthetics. A survey of 100 reports. Br. J. Anaesth. 1975, 47, 575-585.
4. Danielsson, I.; Lindman, B. The definition of microemulsion. Colloids Surf. 1981, 3, 391-2.
5. Attwood, D. Microemulsions. In Colloidal Drug Delivery Systems; Kreuter, J., Ed.; Marcel Dekker: New York, 1994; Vol. 66; pp 31-71.
6. Lawrence, M. J. Microemulsions as drug delivery vehicles. Current Opinion in Colloid & Interface Science 1996, 1, 826-832.
7. Constantinides, P. P. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm. Res. 1995, 12, 1561-1572.
8. Thevenin, M. A.; Grossiord, J. L.; Poelman, M. C. Sucrose esters/cosurfactant microemulsion systems for transdermal delivery: assessment of bicontinuous structures. Int. J. Pharm. 1996, 137, 177-186.
9. Kriwet, K.; Muller-Goymann, C. C. Diclofenac release from phospholipid drug systems and permeation through excised human stratum corneum. Int. J. Pharm. 1995, 125, 231-242.
10. Satra, C.; Thomas, M.; Lawrence, M. J. "Formulating oil-in-water microemulsions for pulmonary drug delivery"; Drug delivery to the lungs IV, London; The Aerosol Society (Bristol); 1995; pp 40-43.
11. von Corswant, C.; Engström, S.; Söderman, O. Microemulsions based on soybean phosphatidylcholine and triglycerides - phase behavior and microstructure. Langmuir 1997, 13, 5061-5070.
12. Leser, M. E.; Vanevert, W. C.; Agterof, W. G. M. Phase behaviour of lecithin-water-alcohol-triacylglycerol mixtures. Colloids Surf., A 1996, 116, 293-308.
13. Aboofazeli, R.; Patel, N.; Thomas, M.; Lawrence, M. J. Investigations into the formation and characterization of phospholipid microemulsions. IV. Pseudo-ternary phase diagrams of systems containing water-lecithin-alcohol and oil; the influence of oil. Int. J. Pharm. 1995, 125, 107-16.
14. Davis, S. S.; Hadgraft, J.; Palin, K. J. Medical and pharmaceutical applications of emulsions. In Encyclopedia of emulsion technology; Becher, P., Ed.; Marcel Dekker: New York/ Basel, 1983; Vol. 2; pp 159-238.
15. Shinoda, K.; Araki, M.; Sadaghiani, A.; Khan, A.; Lindman, B. Lecithin-based microemulsions: phase behavior and microstructure. J. Phys. Chem. 1991, 55, 989-93.
16. Stilbs, P.; Moseley, M. E. Multicomponent self-diffusion measurement by the pulsed-gradient spin-echo method on standard Fourier transform NMR spectrometers. Chem. Scr. 1980, 15, 176.
17. Stilbs, P. Fourier transform pulsed-gradient spinn-echo studies of molecular diffusion. Prog. Nucl. Magn. Reson. Spectrosc. 1987, 19, 1-45.
18. Gibbs, S. J.; Johnsson, C. S., Jr. A PFG NMR experiment for accurate diffusion and flow studies in the presence of eddy currents. J. Magn. Reson. 1991, 93, 391.
19. Stejskal, E. O.; Tanner, J. E. Spin diffusion measurements: spin-echoes in the presence of a time-dependent field gradient. J. Chem. Phys. 1965, 42, 288-292.
20. Axenborg, J.; Hirsch, I. A PC-based on-line system for physiological in vivo and in vitro experiments. Comput. Meth. Prog. Biomed. 1993, 41, 55-67.
21. Gerlsma, S. Y. Reversible denaturation of ribonuclease in aqueous solutions as influenced by polyhydric alcohols and some other additives. J. Biol. Chem. 1968, 243, 957.
22. Jonströmer, M.; Jönsson, B.; Lindman, B. Self-diffusion in nonionic surfactant-water systems. J. Phys. Chem. 1991, 95, 3293.
23. 1H and less-common nuclei. J. Magn. Reson. 1991, 92, 115-125.
24. Strey, R. Microemulsion microstructure and interfacial curvature. Colloid Polym. Sci. 1994, 272, 1005-1019.
25. Shinoda, K.; Kunieda, H.; Arai, T.; Saijo, H. Principles of attaining very large solubilization (microemulsion): inclusive understanding of the solubilization of oil and water in aqueous and hydrocarbon media. J. Phys. Chem. 1984, 88, 5126-9.
26. Anderson, D. M.; Wennerström, H. Self-diffusion in bicontinuous cubic phases, L3 phases, and microemulsions. J. Phys. Chem. 1990, 94, 8683-94.
27. Lundin, S.; Ricksten, S.-E.; Thorén, P. Interaction between "mental stress" and baroreceptor reflexes concerning effects on heart rate, mean arterial pressure and renal symphathetic activity in conscious spontaneously hypertensive rats. Acta Physiol. Scand. 1984, 120, 273-281.