Comparative effects of sildenafil, phentolamine, yohimbine and L-arginine on the rabbit corpus cavernosum

Fundamental and Clinical Pharmacology

Volumn 18, Issue 2, 2004, Pages 187-194

  Sharabi, F M ^a   Daabees, T T ^a   El Metwally, M A ^a   Senbel, A M ^a  

^a Alexandria University Faculty of Pharmacy   (Egypt)

Author keywords

Erectile dysfunction; Phentolamine; Rabbit corpus cavernosum; Sildenafil; Yohimbine

Indexed keywords

ARGININE; NITRIC OXIDE SYNTHASE; PHENTOLAMINE; SILDENAFIL; YOHIMBINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG EFFECT; DRUG POTENCY; DRUG POTENTIATION; ELECTRIC FIELD; ELECTROSTIMULATION; ENZYME INHIBITION; ERECTILE DYSFUNCTION; INTERMETHOD COMPARISON; MALE; MAXIMUM ALLOWABLE CONCENTRATION; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; SMOOTH MUSCLE RELAXATION; SMOOTH MUSCLE TONE;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; ARGININE; ATROPINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; ELECTRIC STIMULATION; GUANETHIDINE; IMPOTENCE; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NITROARGININE; PENILE ERECTION; PENIS; PHENTOLAMINE; PHENYLEPHRINE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PIPERAZINES; RABBITS; YOHIMBINE;

EID: 1842866302     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2003.00229.x     Document Type: Article

References (31)

1. Burnett A.L., Lowernstein C.J., Bredt D.S., Chang T.S.K., Snyder S.H. Nitric oxide: a physiological mediator of penile erection. Science (1992) 257 401-403.
2. Burnett A.L. Nitric oxide in the penis: physiology and pathology. J. Urol. (1997) 157 320-324.
3. Holmquist F., Andersson K.E., Hedlund H. Characterization of inhibitory neurotransmission in the isolated corpus cavernosum from rabbit and man. J. Physiol. Lond. (1992) 449 295-311.
4. Stief C.G., Noack T., Andersson K.E. Signal transduction in cavernous smooth muscle. World J. Urol. (1997) 15 27-31.
5. Boolell M., Gepi-Attee S., Gingell J.C., Allen M.J. Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br. J. Urol. (1996) 78 257-261.
6. Goldstein I., Lue T.F., Padma-Nathan H. Oral sildenafil in the treatment of erectile dysfunction. N. Engl. J. Med. (1998) 338 1397-1404.
7. Rajfer J., Aronson W.J., Bush P.A., Dorey F.J., Ignarro L.J. Nitric oxide as a mediator of relaxation of the corpus cavernosum on response to nonadrenergic noncholinergic neurotransmission. N. Engl. J. Med. (1992) 326 90-94.
8. Tralsh A., Kim N.N., Moreland R.D., Goldstein I. Role of alpha adrenergic receptors in erectile function. Int. J. Impot. Res. (2000) 12 (Suppl. 1) S48-S63.
9. Montorsi F., Guazzoni G., Rigatti P., Pozza G. Pharmacological management of erectile dysfunction. Drugs (1995) 50 465-479.
10. Reid K., Morales A., Harris C. et al. Double blind trial of yohimbine in treatment of pychogenic impotence. Lancet (1987) 1 421-423.
11. Morales A., Condra M., Owen J.A., Surridge D.H., Fenemore J., Harris C. Is yohimbine effective in treatment of organic impotence? Results of a controlled trial. J. Urol. (1987) 137 1169-1172.
12. 2-adrenoceptors. Pharmacol. Rev. (1983) 35 143-156.
13. Zorgniotti A.W., Lizza E.F. Effect of large doses of the nitric oxide precursor, L-arginine, on erectile dysfunction. Int. J. Impot. Res. (1994) 6 33-36.
14. Sparwasser C., Drescher P., Will J.A., Madsen P.O. Smooth muscle tone regulation in rabbit cavernosal and spongiosal tissue by cyclic AMP, and cyclic GMP dependent mechanisms. J. Urol. (1994) 152 2159-2163.
15. Kaya T., Sarioglu Y., Goksu O.C., Yildirim S., Yildirim K. Effect of additional testosterone on purinergic responses in isolated rabbit corpus cavernosum strips. Pharmacol. Res. (1998) 37 227-282.
16. Chen X., Tony J., Lee F. Ginsenosides induced nitric oxide-mediated relaxation of the rabbit corpus cavernosum. Br. J. Pharmacol. (1995) 115 15-18.
17. Bush P.A., Aronson W.J., Rajfer J., Ignarro L.J. The L-arginine-nitric oxide-cyclic GMP pathway mediates inhibitory nonadrenergic noncholinerglc neurotransmission in the corpus cavernosum of human and rabbit. Circulation (1993) 87 (Suppl. 5) V30-V32.
18. Ballard S.A., Gingell J.C., Tang K., Teirner L.A., Price M.E., Naylor A.M. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J. Urol. (1998) 159 2164-2171.
19. Saenz De Tejada T., Blanco R., Goldstein T. Cholinergic neurotransmission in human corpus cavernosum. I. Responses of isolated tissue. Am. J. Physiol. (1988) 254 H459-H467.
20. Kim N.N., Goldstein I., Krane R.J., Saenz De Tejada I. Neurogenic relaxation of penile smooth muscle. J. Urol. (1990) 143 224A-228A.
21. Brindley G.S. Cavernosal alpha-blockade a new technique for investigating and treating impotence. Br. J. Psychiatry (1983) 143 332-337.
22. Padma-Nathan H., Goldstein I., Payton T., Krane R.J. Intracavernosal pharmacotherapy: the pharmacologic erection program. World J. Urol. (1987) 5 160-165.
23. Laurant P., Domolombe B., Berthelot A. Dietary L-arginine attenuates blood pressure in mineralocorticoid-salt hypertension rats. Clin. Exp. Hypertens. (1995) 17 1009-1024.
24. G-substituted analogues of L-arginine on NANC relaxation of the rat anococcygeus and bovine retractor penis muscle and the bovine penile artery. Br. J. Pharmacol. (1991) 104 53-58.
25. Li C.G., Rand M.J. Nitric oxide and vasoactive intestinal polypeptide mediate nonadrenergic noncholinergic inhibitory transmission to smooth muscle of the rat gastric fundus. Eur. J. Pharmacol. (1990) 191 303-309.
26. Toda N., Okamura T. Role of nitric oxide in nonadrenergic noncholinergic nerve mediated relaxation in dog duodenal mesenteric and cerebral arteries. Jpn. J. Pharmacol. (1990) 52 170-173.
27. Yildirim S., Ayan S., Sarioglu Y., Gultekin Y., Butuner C. The effects of long term oral administration of L-arginine on the erectile response of rabbits with alloxan-induced diabetes. BJU Int. (1999) 83 679-685.
28. Chetlin M.D. Use of sildenafil in patients with cardiovascular disease. Circulation (1999) 99 168-177.
29. Favoeus M., Andersson K.E., Hedlund H. Effects of some calcium channel blockers on isolated human penile erectile tissues. J. Urol. (1984) 138 1267-1272.
30. Saenz De Tejada I., Kim N., Lagan I., Krane R.J., Goldstein I. Regulation of adrenergic activity in penile corpus cavernosum. J. Urol. (1989) 142 1117-1121.
31. Stief C.G., Uckert S., Becker A.J., Truss M.C., Jonas U. The effect of the specific phosphodisterase (PDE) inhibitors on human and rabbit cavernous tissue in vitro and in vivo. J. Urol. (1998) 159 1390-1393.