Biomimetic screening of class-B G protein-coupled receptors

Journal of the American Chemical Society

Volumn 133, Issue 23, 2011, Pages 8927-8933

  Devigny, Christian ^a   Perez Balderas, Francisco ^a,c   Hoogeland, Bastiaan ^a   Cuboni, Serena ^a   Wachtel, Rudolf ^a   Mauch, Christoph P ^a   Webb, Katharine J ^a,b   Deussing, Jan M ^a,b   Hausch, Felix ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION DOMAIN; C-TERMINUS; CELL-BASED ASSAYS; CORTICOTROPIN-RELEASING FACTORS; DIPOLAR CYCLOADDITIONS; ENDOGENOUS RECEPTORS; G PROTEIN COUPLED RECEPTORS; HIGH POTENCY; HIGH-THROUGHPUT; IN-SITU; IN-VIVO; MOOD DISORDERS; NATIVE ENVIRONMENT; NATURAL ACTIVATION; ORDERS OF MAGNITUDE; PEPTIDE LIBRARY; RECEPTOR ACTIVATION; SEQUENCE MOTIFS; STRESS RESPONSE; STRUCTURE ACTIVITY RELATIONSHIPS; TRANS-MEMBRANE DOMAINS;

ACETYLENE; ACTIVATION ANALYSIS; AMINO ACIDS; BIOMIMETICS; CHROMATOGRAPHY; CYCLOADDITION; FUNCTIONAL GROUPS; MAMMALS; PROBES;

PEPTIDES;

ACETYLENE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR CLASS B; PEPTIDE LIBRARY; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOMIMETICS; CHROMATOGRAPHY; CONJUGATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BIOMIMETICS; CELL MEMBRANE; CLICK CHEMISTRY; CORTICOTROPIN-RELEASING HORMONE; DRUG EVALUATION, PRECLINICAL; LIGANDS; MICE; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP; UROCORTINS;

EID: 79958849896     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja200160s     Document Type: Article

References (27)

1. Foord, S. M.; Jupe, S.; Holbrook J. Biochem. Soc. Trans. 2002, 30, 473
2. Hoare, S. R. Drug Discov. Today 2005, 10, 417
3. Holsboer, F. Neuropsychopharmacology 2000, 23, 477
4. Bale, T. L.; Vale, W. W. Annu. Rev. Pharmacol. Toxicol. 2004, 44, 525
5. Grigoriadis, D. E. Expert Opin. Ther. Targets 2005, 9, 651
6. Holsboer, F.; Ising, M. Annu. Rev. Psychol. 2010, 61, 81
7. Koob, G. F.; Zorrilla, E. P. Curr. Opin. Invest. Drugs 2010, 11, 63
8. Parthier, C.; Reedtz-Runge, S.; Rudolph, R.; Stubbs, M. T. Trends Biochem. Sci. 2009, 34, 303
9. The juxtamembrane domain is defined as the extracellular loops and the extracellular facing parts of the transmembrane helices of GPCRs.
10. Beyermann, M.; Rothemund, S.; Heinrich, N.; Fechner, K.; Furkert, J.; Dathe, M.; Winter, R.; Krause, E.; Bienert, M. J. Biol. Chem. 2000, 275, 5702
11. Yamada, Y.; Mizutani, K.; Mizusawa, Y.; Hantani, Y.; Tanaka, M.; Tanaka, Y.; Tomimoto, M.; Sugawara, M.; Imai, N.; Yamada, H.; Okajima, N.; Haruta, J. J. Med. Chem. 2004, 47, 1075
12. Jensen, J. A.; Songster, M. F.; Vágner, J.; Albericio, F.; Barany, G. J. Am. Chem. Soc. 1998, 120, 5441
13. Springer, J.; Kimberly, R. d. C.; Sandrine, C. V.; Jan, A. J. G.; Pedro, H. H. H.; Henk, H.; Jan, H. v. M. Eur. J. Org. Chem. 2008, 15) 2592
14. 1R with equal potency compared to their corresponding correct isomers.
15. Gulyas, J.; Rivier, C.; Perrin, M.; Koerbe, S. C.; Sutton, S.; Corrigan, A.; Lahrichi, S. L.; Craig, A. G.; Vale, W. W.; Rivier, J. E. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 10575
16. Kornreich, W. D.; Galyean, R.; Hernandez, J. F.; Craig, A. G.; Donaldson, C. J.; Yamamoto, G.; Rivier, C.; Vale, W. W.; Rivier, J. E. J. Med. Chem. 1992, 35, 1870
17. Beyermann, M.; Fechner, K.; Furkert, J.; Krause, E.; Bienert, M. J. Med. Chem. 1996, 39, 3324
18. Murray, C. W.; Verdonk, M. L. J. Comput. Aided Mol. Des. 2002, 16, 751
19. He, L.; Gilligan, P. J.; Zaczek, R.; Fitzgerald, L. W.; McElroy, J.; Shen, H. S.; Saye, J. A.; Kalin, N. H.; Shelton, S.; Christ, D.; Trainor, G.; Hartig, P. J. Med. Chem. 2000, 43, 449
20. Golub, Y.; Mauch, C. P.; Dahlhoff, M.; Wotjak, C. T. Behav. Brain Res. 2009, 205, 544
21. Dong, M.; Pinon, D. I.; Asmann, Y. W.; Miller, L. J. Mol. Pharmacol. 2006, 70, 206
22. Dong., M.; Gao, F. D.; Pinon, D. I.; Miller, L. J. Mol. Endocrinol. 2008, 22, 1489
23. Shimizu, M.; Potts, J. T., Jr.; Gardella, T. J. J. Biol. Chem. 2000, 275, 21836
24. Carter, P. H. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 6846
25. Fortin, J.-P.; Zhu, Y.; Choi, C.; Beinborn, M.; Nitabach, M. N.; Kopin, A. S. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 8049
26. Müller, M. B. Nat. Neurosci. 2003, 6, 1100
27. Timpl, P.; Spanagel, R.; Sillaber, I.; Kresse, A.; Reul, J. H. M.; Stalla, G. K.; Blanquet, V.; Steckler, T.; Holsboer, F.; Wurst, W. Nat. Genet. 1998, 19, 162