Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 16, 2007, Pages 6846-6851

  Carter, Percy H ^a   Liu, Rui Qin ^a   Foster, William R ^a   Tamasi, Joseph A ^a   Tebben, Andrew J ^a   Favata, Margaret ^a   Staal, Ada ^a   Cvijic, Mary Ellen ^a   French, Michele H ^a   Dell, Vanessa ^a   Apanovitch, Donald ^a   Lei, Ming ^a   Zhao, Qihong ^a   Cunningham, Mark ^a   Decicco, Carl P ^a   Trzaskos, James M ^a   Feyen, Jean H M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Bone; Gene microarray; Homology model; Osteoporosis

Indexed keywords

5 (2 CYCLOPROPYLVINYL) 3 ETHYL 6,7 DIFLUORO 5 (TRIFLUOROMETHYL)BENZO[E][1,4]OXAZEPIN 2(1H,3H,5H) ONE; AZEPINE DERIVATIVE; CYCLIC AMP; DPC AJ1951; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR; PARATHYROID HORMONE RELATED PROTEIN RECEPTOR; PARATHYROID HORMONE[1-34]; PEPTIDE; SW 106; UNCLASSIFIED DRUG; PARATHYROID HORMONE (1 14)AMIDE; PARATHYROID HORMONE (1 34); PARATHYROID HORMONE (1-14)AMIDE; PARATHYROID HORMONE (1-34); PARATHYROID HORMONE RECEPTOR 1; PEPTIDE FRAGMENT;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL STRAIN HEK293; CHEMICAL MODIFICATION; CONTROLLED STUDY; CULTURE MEDIUM; DISEASE MODEL; DRUG EFFECT; DRUG POTENCY; GENETIC TRANSCRIPTION; HIGH THROUGHPUT SCREENING; MALE; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOLYSIS; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; ANIMAL; BINDING COMPETITION; CELL LINE; DRUG ANTAGONISM; DRUG POTENTIATION; DRUG SCREENING; GENETIC PROCEDURES; HUMAN; METABOLISM; MOLECULAR GENETICS; MOLECULAR PROBE; PHYSIOLOGY; PROTEIN BINDING;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CELL LINE; DRUG EVALUATION, PRECLINICAL; HUMANS; MALE; MOLECULAR PROBE TECHNIQUES; MOLECULAR PROBES; MOLECULAR SEQUENCE DATA; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, PARATHYROID HORMONE, TYPE 1;

EID: 34249856432     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0605125104     Document Type: Article

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