Carvedilol improves left ventricular function in murine coxsackievirus-induced acute myocarditis: Association with reduced myocardial interleukin-1β and MMP-8 expression and a modulated immune response

European Journal of Heart Failure

Volumn 7, Issue 4, 2005, Pages 444-452

  Pauschinger, Matthias ^a   Rutschow, Susanne ^a   Chandrasekharan, Kumaran ^a   Westermann, Dirk ^a   Weitz, Anneke ^a   Schwimmbeck, Lothar Peter ^a   Zeichhardt, Heinz ^a   Poller, Wolfgang ^a   Noutsias, Michel ^a   Li, Jun ^a   Schultheiss, Heinz Peter ^a   Tschope, Carsten ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Carvedilol; Interleukin 1 ; Matrix metalloproteinase; Metoprolol; Myocarditis; TGF 1

Indexed keywords

CARVEDILOL; GELATINASE B; INTERLEUKIN 10; INTERLEUKIN 15; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; LYMPHOTOXIN; MESSENGER RNA; METOPROLOL; NEUTROPHIL COLLAGENASE; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; COMPARATIVE STUDY; CONTROLLED STUDY; COXSACKIE VIRUS; DRUG EFFECT; GENE EXPRESSION; HEART LEFT VENTRICLE FUNCTION; IMMUNOMODULATION; INFLAMMATORY CELL; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; MYOCARDITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE; UPREGULATION;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CARBAZOLES; COXSACKIEVIRUS INFECTIONS; INTERLEUKIN-1; MALE; MATRIX METALLOPROTEINASE 8; MATRIX METALLOPROTEINASES; METOPROLOL; MICE; MICE, INBRED BALB C; MYOCARDITIS; PROPANOLAMINES; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASES; VENTRICULAR FUNCTION, LEFT;

EID: 19544380184     PISSN: 13889842     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejheart.2004.07.002     Document Type: Article

References (30)

1. M. Pauschinger, A. Doerner, and U. Kuehl Enteroviral RNA replication in the myocardium of patients with left ventricular dysfunction and clinically suspected myocarditis Circulation 99 1999 889 895
2. M. Noutsias, M. Pauschinger, W.C. Poller, H.P. Schultheiss, and U. Kuhl Current insights into the pathogenesis, diagnosis and therapy of inflammatory cardiomyopathy Heart Fail. Monit. 3 2003 127 135
3. P.P. Liu, and J.W. Mason Advances in the understanding of viral myocarditis Circulation 104 2001 1076 1082
4. M.T. Kasaian, M.J. Whitters, and L.L. Carter IL-2 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity Immunity 16 2002 559 569
5. N. Keira, T. Tatsumi, and S. Matoba Lethal effect of cytokine-induced nitric oxide and peroxynitrite on cultured rat cardiac myocytes J. Mol. Cell. Cardiol. 34 2002 583 596
6. K.C. Wollert, and H. Drexler Interleukin-1 beta induces cardiac myocyte growth but inhibits cardiac fibroblast proliferation in culture J. Clin. Invest. 95 1995 2555 2564
7. M.C. Bouluyt, L. O'Neil, and A.L. Mededith Alteration in cardiac gene expression during the transition from stable hypertrophy to heart failure: marked upregulation of genes encoding extracellular components Circ. Res. 75 1994 25 32
8. F.G. Spinale Matrix metalloproteinases: regulation and dysregulation in the failing heart Circ. Res. 90 2002 520 530
9. W. Eichler, U. Friedrichs, and A. Thies Modulation of matrix metalloproteinase and TIMP-1 expression by cytokines in human RPE cells Invest. Ophthalmol. Vis. Sci. 43 2002 2767 2773
10. M. Pauschinger, D. Knopf, and S. Petschauer Dilated cardiomyopathy is associated with significant changes in collagen type I/III ratio Circulation 99 1999 2750 2756
11. S.A. Huber, J. Polgar, and P. Schultheiss Augmentation of pathogenesis of coxsackievirus B3 infections in mice by exogenous administration of interleukin-1 and interleukin-2 J. Virol. 68 1994 195 206
12. B.-K. Lim, S.-C. Choe, and J.-O. Shin Local expression of inteleukin-1 receptor antagonist by plasmid DNA improves mortality and decreases myocardial inflammation in experimental coxsackieviral myocarditis Circulation 105 2002 1278 1281
13. W.H. Frishman Carvedilol N. Engl. J. Med. 339 1998 1759 1765
14. T. Ohtsuka, M. Hamada, and H. Saeki Comparison of effects of carvedilol versus metoprolol on cytokine levels in patients with idiopathic dilated cardiomyopathy Am. J. Cardiol. 89 2002 996 999
15. Y.T. Sia, T.G. Parker, and J.N. Tsoporis Long-term effects of carvedilol on left ventricular function, remodeling, and expression of cardiac cytokines after large myocardial infarction in the rat J. Cardiovasc. Pharmacol. 39 2002 73 87
16. A. Nakano, A. Matsumori, and S. Kawamoto Cytokine gene therapy for myocarditis by in vivo electroporation Hum. Gene Ther. 12 2001 1289 1297
17. J. Li, P.L. Schwimmbeck, and C. Tschöpe Collagen degradation in a murine myocarditis model: relevance of matrix metalloproteinase in association with inflammatory induction Cardiovasc. Res. 56 2002 235 247
18. M.R. Bristow, P. Larrabee, and W. Minobe Receptor pharmacology of carvedilol in the human heart J. Cardiovasc. Pharmacol. 19 Suppl. 1 1992 S68 S80
19. M. Noutsias, M. Pauschinger, and K. Ostermann Digital image analysis system for the quantification of infiltrates and cell adhesion molecules in inflammatory cardiomyopathy Med. Sci. Monit. 8 2002 MT59 MT71
20. S. Mikami, S. Kawashima, and K. Kanazawa Low-dose N-nitro-l-arginine methyl ester treatment improves survival rate and decrease myocardial injury in a murine model of viral myocarditis induced by coxsackievirus B3 Circ. Res. 81 1997 504 511
21. A. Agocha, A.V. Sigel, and M. Eghbali-Webb Characterization of adult human heart fibroblasts in culture: a comparative study of growth, proliferation and collagen production in human and rabbit cardiac fibroblasts and their response to transforming growth factor-beta1 Cell Tissue Res. 288 1 1997 (Apr) 87 93
22. C.V. Thomas, M.L. Coker, and J.L. Zellner Increased matrix metalloproteinase activity and selective upregulation in LV myocardium from patients with end-stage dilated cardiomyopathy Circulation 97 1998 1708 1715
23. W.S. Bradham, G. Moe, and K.A. Wendt TNF-α and myocardial metalloproteinases in heart failure: relationship to LV remodeling Am. J. Physiol., Heart Circ. Physiol. 282 2002 H1288 H1295
24. T.S. Lee, and L.Y. Chau Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice Nat. Med. 8 3 2002 240 246
25. A.D. Santin, P.L. Hermonat, and A. Ravaggi Interleukin-10 increases Th1 cytokine production and cytotoxic potential in human papillomavirus-specific CD8(+) cytotoxic T lymphocytes J. Virol. 74 10 2000 4729 4737
26. C. Stumpf, C. Lehner, A. Yilmaz, W.G. Daniel, and C.D. Garlichs Decrease of serum levels of the anti-inflammatory cytokine interleukin-10 in patients with advanced chronic heart failure Clin. Sci. (Lon) 105 2003 45 50
27. N.P. Weng, K. Liu, M. Catalfamo, Y. Li, and P.A. Henkart IL-15 is a growth factor and an activator of CD8 memory T cells Ann. N.Y. Acad. Sci. 975 2002 46 56
28. D. Körholz, U. Banning, and H. Bönig The role of interleukin-10 (IL-10) in IL-15-mediated T-cell responses Blood 90 11 1997 4513 4521
29. W. Barth, A. Deten, and M. Bauer Differential remodeling of the left and right heart after norepinephrine treatment in rats: studies on cytokines and collagen J. Mol. Cell. Cardiol. 32 2000 273 284
30. D. Grimm, M. Huber, and H.C. Jabusch Extracellular matrix proteins in cardiac fibroblasts derived from rat hearts with chronic pressure overload: effects of beta-receptor blockade J. Mol. Cell. Cardiol. 33 3 2001 487 501