-
1
-
-
12344282783
-
Global burden of hypertension: Analysis of worldwide data
-
Kearny PM, Whelton M, Reynolds K, et al. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365:217-223.
-
(2005)
Lancet
, vol.365
, pp. 217-223
-
-
Kearny, P.M.1
Whelton, M.2
Reynolds, K.3
-
2
-
-
33847241207
-
Hypertension. The kidney is the culprit even in the absence of kidney disease
-
Ritz E. Hypertension. The kidney is the culprit even in the absence of kidney disease. Kidney Int. 2007;71:371-372.
-
(2007)
Kidney Int
, vol.71
, pp. 371-372
-
-
Ritz, E.1
-
3
-
-
0037079309
-
Age-specific relevance of usual blood pressure to vascular mortality: A meta-analysis of individual data for one million adults in 61 prospective studies
-
Levington S, Clarke R, Qizilbash N. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360:1903-1913.
-
(2002)
Lancet
, vol.360
, pp. 1903-1913
-
-
Levington, S.1
Clarke, R.2
Qizilbash, N.3
-
4
-
-
79958808460
-
-
United States Renal Data System, Annual Data Report, CD, Chapter 1, Table ei
-
United States Renal Data System 2010 Annual Data Report, CD Vol 1, Chapter 1, Table ei, page 48.
-
(2010)
, vol.1
, pp. 48
-
-
-
5
-
-
79958865409
-
-
United States Renal Data System, Annual Data Report, CD, Chapter 2, Table 19i
-
United States Renal Data System 2010 Annual Data Report, CD Vol 1, Chapter 2, Table 19i, page 61.
-
(2010)
, vol.1
, pp. 61
-
-
-
6
-
-
79958783760
-
-
United States Renal Data System, Annual Data Report, CD, Chapter 2, Table 2 10ii
-
United States Renal Data System 2010 Annual Data Report, CD Vol 2, Chapter 2, Table 2 10ii, page 258.
-
(2010)
, vol.2
, pp. 258
-
-
-
7
-
-
40149083478
-
Slowing nephropathy progression: Focus on proteinuria reduction
-
Bakris GL. Slowing nephropathy progression: focus on proteinuria reduction. Clin J Am Soc Nephrol. 2008;3 Suppl 1:S3-S10.
-
(2008)
Clin J Am Soc Nephrol
, Issue.3 SUPPL. 1
-
-
Bakris, G.L.1
-
8
-
-
0028838569
-
Blood pressure control, proteinuria, and the progression of renal disease. The Modification of Diet in Renal Disease Study
-
Peterson JC, Adler S, Burkart JM, et al. Blood pressure control, proteinuria, and the progression of renal disease. The Modification of Diet in Renal Disease Study. Ann Int Med. 1995;123:754-762.
-
(1995)
Ann Int Med
, vol.123
, pp. 754-762
-
-
Peterson, J.C.1
Adler, S.2
Burkart, J.M.3
-
9
-
-
2442680120
-
Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy:Lessons from RENAAL
-
De Zeew D, Remuzzi G, Parving HH, et al. Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy:Lessons from RENAAL. Kidney Int. 2004;65:2309-2320.
-
(2004)
Kidney Int
, vol.65
, pp. 2309-2320
-
-
de Zeew, D.1
Remuzzi, G.2
Parving, H.H.3
-
10
-
-
0347423198
-
Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure
-
Chobanian AV, Bakris GL, Black HR. Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42:1206-1252.
-
(2003)
Hypertension
, vol.42
, pp. 1206-1252
-
-
Chobanian, A.V.1
Bakris, G.L.2
Black, H.R.3
-
11
-
-
0033852481
-
Preserving renal function in adults with hypertension and diabetes: A consensus approach. National Kidney Foundation Hypertension and Diabetes Executive Committees Working Group
-
Bakris GL, Williams M, Dworkin L. Preserving renal function in adults with hypertension and diabetes: a consensus approach. National Kidney Foundation Hypertension and Diabetes Executive Committees Working Group. Am J Kidney Dis. 2000;36:646-661.
-
(2000)
Am J Kidney Dis
, vol.36
, pp. 646-661
-
-
Bakris, G.L.1
Williams, M.2
Dworkin, L.3
-
12
-
-
4344621497
-
Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy
-
De Zeew D, Remuzzi G, Parving HH, et al. Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy. Circulation. 2004;110:921-927.
-
(2004)
Circulation
, vol.110
, pp. 921-927
-
-
de Zeew, D.1
Remuzzi, G.2
Parving, H.H.3
-
13
-
-
33845760213
-
-
KDOQI clinical practice guidelines and clinical practice recommendations for diabetes and chronic kidney disease
-
KDOQI clinical practice guidelines and clinical practice recommendations for diabetes and chronic kidney disease. Am J Kidney Dis. 2007;49 Suppl 2:S1-S179.
-
(2007)
Am J Kidney Dis
, Issue.49 SUPPL. 2
-
-
-
14
-
-
0035989568
-
Microalbuminuria: Marker of vascular dysfunction, risk factor for cardiovascular disease
-
Garg JP, Bakris GL. Microalbuminuria: marker of vascular dysfunction, risk factor for cardiovascular disease. Vasc Med. 2002;7:35-43.
-
(2002)
Vasc Med
, vol.7
, pp. 35-43
-
-
Garg, J.P.1
Bakris, G.L.2
-
15
-
-
34250350040
-
Guidelines for the management of arterial hypertension: The task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
-
Mancia G, De Backer G, Dominiczak A. 2007 Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2007;25:1105-1187.
-
(2007)
J Hypertens
, vol.25
, pp. 1105-1187
-
-
Mancia, G.1
de Backer, G.2
Dominiczak, A.3
-
16
-
-
40149111007
-
Are two better than one? Angiotensin converting enzyme inhibitors plus angiotensin receptor blockers for reducing blood pressure and proteinuria in kidney disease
-
Linas SL. Are two better than one? Angiotensin converting enzyme inhibitors plus angiotensin receptor blockers for reducing blood pressure and proteinuria in kidney disease. Clin J Am Soc Nephrol. 2008;3 Suppl:S17-S23.
-
(2008)
Clin J Am Soc Nephrol
, Issue.3 SUPPL.
-
-
Linas, S.L.1
-
17
-
-
2642575030
-
Combined blockade of the renin-angiotensin system with angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists
-
Azizi M, Menard J. Combined blockade of the renin-angiotensin system with angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists. Circulation. 2004;109:2492-2499.
-
(2004)
Circulation
, vol.109
, pp. 2492-2499
-
-
Azizi, M.1
Menard, J.2
-
18
-
-
0025073099
-
Reactive hyperreninemia is a major determinant of plasma angiotensin II during ACE inhibition
-
Mooser V, Nussberger J, Jullierat L. Reactive hyperreninemia is a major determinant of plasma angiotensin II during ACE inhibition. J Cardiovasc Pharmacol. 1990;15:276-282.
-
(1990)
J Cardiovasc Pharmacol
, vol.15
, pp. 276-282
-
-
Mooser, V.1
Nussberger, J.2
Jullierat, L.3
-
19
-
-
0031688757
-
Pathways for angiotensin II generation in intact human tissue: Evidence from comparative pharmacological interruption of the renin system
-
Hollenberg NK, Fisher ND, Price DA. Pathways for angiotensin II generation in intact human tissue: evidence from comparative pharmacological interruption of the renin system. Hypertension. 1998;32:387-392.
-
(1998)
Hypertension
, vol.32
, pp. 387-392
-
-
Hollenberg, N.K.1
Fisher, N.D.2
Price, D.A.3
-
20
-
-
0031017144
-
Functional and biochemical analysis of angiotensin II-forming pathways in the human heart
-
Wolny A, Clozel JP, Rein J, et al. Functional and biochemical analysis of angiotensin II-forming pathways in the human heart. Circ Res. 1997;80: 219-227.
-
(1997)
Circ Res
, vol.80
, pp. 219-227
-
-
Wolny, A.1
Clozel, J.P.2
Rein, J.3
-
21
-
-
0028107243
-
Responses of converting enzyme and renin inhibition: Role of angiotensin II in humans
-
Fisher NDL, Allan D, Kifor I, et al. Responses of converting enzyme and renin inhibition: role of angiotensin II in humans. Hypertension. 1994;23:44-51.
-
(1994)
Hypertension
, vol.23
, pp. 44-51
-
-
Fisher, N.D.L.1
Allan, D.2
Kifor, I.3
-
22
-
-
0024462425
-
Plasma angiotensins, renin, and blood pressure during acute renin inhibition by CGP 38 560 A in hypertensive patients
-
Jeunemaitre X, Menard J, Nussberger J, et al. Plasma angiotensins, renin, and blood pressure during acute renin inhibition by CGP 38 560 A in hypertensive patients. Am J Hypertens. 1989;2:819-827.
-
(1989)
Am J Hypertens
, vol.2
, pp. 819-827
-
-
Jeunemaitre, X.1
Menard, J.2
Nussberger, J.3
-
23
-
-
0033941893
-
Structure-based drug design: The discovery of novel non-peptide orally active inhibitors of human renin
-
Rahuel J, Rasetti V, Maibaum J, et al. Structure-based drug design: the discovery of novel non-peptide orally active inhibitors of human renin. Chem Biol. 2000;7:493-504.
-
(2000)
Chem Biol
, vol.7
, pp. 493-504
-
-
Rahuel, J.1
Rasetti, V.2
Maibaum, J.3
-
24
-
-
14844363404
-
Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients
-
Gradman AH, Schimieder RE, Lins RL, et al. Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation. 2005;111:1012-1018.
-
(2005)
Circulation
, vol.111
, pp. 1012-1018
-
-
Gradman, A.H.1
Schimieder, R.E.2
Lins, R.L.3
-
25
-
-
76349121230
-
Aliskiren and the kidney: Beyond hypertension
-
Trimarchi H, Orias M. Aliskiren and the kidney: beyond hypertension. Nephrology Reviews. 2009;1:e1-e4.
-
(2009)
Nephrology Reviews
, vol.1
-
-
Trimarchi, H.1
Orias, M.2
-
26
-
-
0042661157
-
Structure-based design of aliskiren, a novel orally effective renin inhibitor
-
Wood JM, Maibaum J, Rahuel J, et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun. 2003;308:698-705.
-
(2003)
Biochem Biophys Res Commun
, vol.308
, pp. 698-705
-
-
Wood, J.M.1
Maibaum, J.2
Rahuel, J.3
-
27
-
-
0036266596
-
Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
-
Nguyen G, Delarue F, Burckle C, et al. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest. 2002;109:1417-1427.
-
(2002)
J Clin Invest
, vol.109
, pp. 1417-1427
-
-
Nguyen, G.1
Delarue, F.2
Burckle, C.3
-
28
-
-
39749098706
-
Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide
-
Feldt S, Batenburg WW, Mazak I, et al. Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Hypertension. 2008;51:682-688.
-
(2008)
Hypertension
, vol.51
, pp. 682-688
-
-
Feldt, S.1
Batenburg, W.W.2
Mazak, I.3
-
29
-
-
0032787740
-
Increase in serum prorenin precedes onset of microalbuminuria in patients with insulin-dependent diabetes mellitus
-
Deinum J, Ronn B, Mathiesen E, et al. Increase in serum prorenin precedes onset of microalbuminuria in patients with insulin-dependent diabetes mellitus. Diabetologia. 1999;42:1006-1010.
-
(1999)
Diabetologia
, vol.42
, pp. 1006-1010
-
-
Deinum, J.1
Ronn, B.2
Mathiesen, E.3
-
30
-
-
0035144110
-
Plasma prorenin levels may predict persistent microalbuminuria in children with diabetes
-
Chiarelli F, Pomilio M, De Luca FA, et al. Plasma prorenin levels may predict persistent microalbuminuria in children with diabetes. Pediatr Nephrol. 2001;16:116-120.
-
(2001)
Pediatr Nephrol
, vol.16
, pp. 116-120
-
-
Chiarelli, F.1
Pomilio, M.2
de Luca, F.A.3
-
31
-
-
0036266596
-
Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
-
Nguyen G, Delarue F, Burckle C, et al. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest. 2002;109:1417-1427.
-
(2002)
J Clin Invest
, vol.109
, pp. 1417-1427
-
-
Nguyen, G.1
Delarue, F.2
Burckle, C.3
-
32
-
-
30944469631
-
Renin increases mesangial cell transforming growth factor beta and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms
-
Huang Y, Wongamorntham S, Kasting J, et al. Renin increases mesangial cell transforming growth factor beta and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Kidney Int. 2006;69:105-113.
-
(2006)
Kidney Int
, vol.69
, pp. 105-113
-
-
Huang, Y.1
Wongamorntham, S.2
Kasting, J.3
-
33
-
-
0028341425
-
Relation of neurohumoral activation to clinical variables and degree of ventricular dysfunction:A report from the Registry of Studies of Left Ventricular Dysfunction
-
Benedict CR, Johnstone DE, Weiner DH. Relation of neurohumoral activation to clinical variables and degree of ventricular dysfunction:a report from the Registry of Studies of Left Ventricular Dysfunction. J Am Coll Cardiol. 1994;23:1410-1420.
-
(1994)
J Am Coll Cardiol
, vol.23
, pp. 1410-1420
-
-
Benedict, C.R.1
Johnstone, D.E.2
Weiner, D.H.3
-
34
-
-
0022454787
-
Elevated plasma renin activity associated with renal dysfunction
-
Kehoe B, Keeton GR, Hill C. Elevated plasma renin activity associated with renal dysfunction. Nephron. 1986;44:51-57.
-
(1986)
Nephron
, vol.44
, pp. 51-57
-
-
Kehoe, B.1
Keeton, G.R.2
Hill, C.3
-
35
-
-
0015491624
-
Essential hypertension: Renin and aldosterone, heart attack and stroke
-
Brunner HR, Laragh JH, Baer L. Essential hypertension: renin and aldosterone, heart attack and stroke. N Engl J Med. 1972;286:441-449.
-
(1972)
N Engl J Med
, vol.286
, pp. 441-449
-
-
Brunner, H.R.1
Laragh, J.H.2
Baer, L.3
-
36
-
-
79958854961
-
-
Novartis. Tekturna (aliskiren) tablets 150 mg and 300 mg: US prescribing information, Accessed March 4
-
Novartis. Tekturna (aliskiren) tablets 150 mg and 300 mg: US prescribing information. East Hanover (NJ): Novartis Pharmaceuticals Corporation. http://www.pharma.us.novartis.com/product/pi/pdf/tekturna.pdf. Accessed March 4, 2011.
-
(2011)
East Hanover (NJ): Novartis Pharmaceuticals Corporation
-
-
-
38
-
-
9644287897
-
Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption
-
Azizi M, Menard J, Bissery A, et al. Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption. J Am Soc Nephrol. 2004;15:3126-3345.
-
(2004)
J Am Soc Nephrol
, vol.15
, pp. 3126-3345
-
-
Azizi, M.1
Menard, J.2
Bissery, A.3
-
39
-
-
54049086657
-
Pharmacokinetics of the oral direct renin inhibitor aliskiren in combination with digoxin, atorvastatin, and ketoconazole in healthy subjects: The role of P-glycoprotein in the disposition of aliskiren
-
Vaidyanathan S, Camenisch G, Schuetz H, et al. Pharmacokinetics of the oral direct renin inhibitor aliskiren in combination with digoxin, atorvastatin, and ketoconazole in healthy subjects: the role of P-glycoprotein in the disposition of aliskiren. J Clin Pharmacol. 2008;48:1323-1338.
-
(2008)
J Clin Pharmacol
, vol.48
, pp. 1323-1338
-
-
Vaidyanathan, S.1
Camenisch, G.2
Schuetz, H.3
-
41
-
-
77952118055
-
-
European Medicines Agency, Accessed March 4
-
European Medicines Agency. Rasilez: summary of product characteristics. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000780/WC500047010.pdf. Accessed March 4, 2011.
-
(2011)
Rasilez: Summary of Product Characteristics
-
-
-
42
-
-
33750289480
-
Aliskiren exhibits similar pharmacokinetics in healthy volunteers and patients with type 2 diabetes mellitus
-
Zhao C, Vaidyanathan S, Yeh CM, et al. Aliskiren exhibits similar pharmacokinetics in healthy volunteers and patients with type 2 diabetes mellitus. Clin Pharmacokinet. 2006;45:1125-1134.
-
(2006)
Clin Pharmacokinet
, vol.45
, pp. 1125-1134
-
-
Zhao, C.1
Vaidyanathan, S.2
Yeh, C.M.3
-
43
-
-
34547221695
-
Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers
-
Waldmeier F, Glaenzel U, Wirz B, et al. Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers. Drug Metab Dispos. 2007;35:1418-1428.
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1418-1428
-
-
Waldmeier, F.1
Glaenzel, U.2
Wirz, B.3
-
44
-
-
33749861264
-
Pharmacokinetics and safety of the novel oral renin inhibitor aliskiren in patients with type 2 diabetes
-
Vaidyanathan S, Zhao C, Yeh C, et al. Pharmacokinetics and safety of the novel oral renin inhibitor aliskiren in patients with type 2 diabetes. Clin Pharmacol Ther. 2005;79 Suppl:S12.
-
(2005)
Clin Pharmacol Ther
, Issue.79 SUPPL.
-
-
Vaidyanathan, S.1
Zhao, C.2
Yeh, C.3
-
45
-
-
77957739996
-
Multiple dose pharmacokinetics of the direct renin inhibitor aliskiren in healthy Chinese subjects
-
Bartlett M, Vaidyanathan S, Karan RS, et al. Multiple dose pharmacokinetics of the direct renin inhibitor aliskiren in healthy Chinese subjects. Clin Pharmacol Ther. 2008;83 Suppl 1:S61-S62.
-
(2008)
Clin Pharmacol Ther
, Issue.83 SUPPL. 1
-
-
Bartlett, M.1
Vaidyanathan, S.2
Karan, R.S.3
-
46
-
-
33750357566
-
Aliskiren, a novel orally effective renin inhibitor, exhibits similar pharmacokinetics and pharmacodynamics in Japanese and Caucasian subjects
-
Vaidayanathan S, Jermany J, Yeh C, et al. Aliskiren, a novel orally effective renin inhibitor, exhibits similar pharmacokinetics and pharmacodynamics in Japanese and Caucasian subjects. Br J Clin Pharmacol. 2006;62:690-698.
-
(2006)
Br J Clin Pharmacol
, vol.62
, pp. 690-698
-
-
Vaidayanathan, S.1
Jermany, J.2
Yeh, C.3
-
47
-
-
34547907203
-
Assessment of the pharmacokinetic interaction between the oral direct renin inhibitor aliskiren and furosemide: A study in healthy volunteers [abstract no. PIII-78]
-
Dieterich HA, Yeh C, Howard D, et al. Assessment of the pharmacokinetic interaction between the oral direct renin inhibitor aliskiren and furosemide: a study in healthy volunteers [abstract no. PIII-78]. Clin Pharmacol Ther. 2007;81 Suppl 1:S110.
-
(2007)
Clin Pharmacol Ther
, Issue.81 SUPPL. 1
-
-
Dieterich, H.A.1
Yeh, C.2
Howard, D.3
-
48
-
-
77954512988
-
NiemiM. Rifampicin reduces the plasma concentrations and the renin-inhibiting effect of aliskiren
-
Tapaninen T, Neuvonen PJ, NiemiM. Rifampicin reduces the plasma concentrations and the renin-inhibiting effect of aliskiren. Eur J Clin Pharmacol. 2010;66:497-502.
-
(2010)
Eur J Clin Pharmacol
, vol.66
, pp. 497-502
-
-
Tapaninen, T.1
Neuvonen, P.J.2
-
49
-
-
0036266596
-
Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
-
Nguyen G, Delarue F, Burckle C, et al. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest. 2002;109:1417-1427.
-
(2002)
J Clin Invest
, vol.109
, pp. 1417-1427
-
-
Nguyen, G.1
Delarue, F.2
Burckle, C.3
-
50
-
-
37349091464
-
Interpretation of plasma renin concentration in patients receiving aliskiren therapy
-
Campbell DJ. Interpretation of plasma renin concentration in patients receiving aliskiren therapy. Hypertension. 2008;51:15-18.
-
(2008)
Hypertension
, vol.51
, pp. 15-18
-
-
Campbell, D.J.1
-
51
-
-
40049111351
-
Antihypertensive therapy with aliskiren
-
Luft FC, Winberger MH. Antihypertensive therapy with aliskiren. Kidney Int. 2008;73:679-683.
-
(2008)
Kidney Int
, vol.73
, pp. 679-683
-
-
Luft, F.C.1
Winberger, M.H.2
-
52
-
-
34447521458
-
Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: A randomized, double-blind trial
-
Oparil S, Yarows SA, Patel S. Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomized, double-blind trial. Lancet. 2007;370:221-229.
-
(2007)
Lancet
, vol.370
, pp. 221-229
-
-
Oparil, S.1
Yarows, S.A.2
Patel, S.3
-
53
-
-
33846996406
-
The (pro)renin receptor:Pathophysiological roles in cardiovascular and renal pathology
-
Nguyen G. The (pro)renin receptor: pathophysiological roles in cardiovascular and renal pathology. Curr Opin Nephrol Hypertens. 2007;16:129-133.
-
(2007)
Curr Opin Nephrol Hypertens
, vol.16
, pp. 129-133
-
-
Nguyen, G.1
-
54
-
-
34247644329
-
Aliskiren, the first renin inhibitor for treating hypertension: Reactive renin secretion may limit its affectiveness
-
Sealey JE, Laragh JH. Aliskiren, the first renin inhibitor for treating hypertension: reactive renin secretion may limit its affectiveness. Am J Hypertens. 2007;20:587-597.
-
(2007)
Am J Hypertens
, vol.20
, pp. 587-597
-
-
Sealey, J.E.1
Laragh, J.H.2
-
55
-
-
42349086752
-
Renin inhibition by aliskiren prevents atherosclerosis progression. Comparison with irbesartan, atenolol, and amlodipine
-
Nussberger J, Aubert JF, Bouzourene K, et al. Renin inhibition by aliskiren prevents atherosclerosis progression. Comparison with irbesartan, atenolol, and amlodipine. Hypertension. 2008;51: 1306-1311.
-
(2008)
Hypertension
, vol.51
, pp. 1306-1311
-
-
Nussberger, J.1
Aubert, J.F.2
Bouzourene, K.3
-
56
-
-
0028341425
-
Relation of neurohumoral activation to clinical variables and degree of ventricular dysfunction:A report from the Registry of Studies of Left Ventricular Dysfunction
-
Benedict CR, Johnstone DE, Weiner DH. Relation of neurohumoral activation to clinical variables and degree of ventricular dysfunction:a report from the Registry of Studies of Left Ventricular Dysfunction. J Am Coll Cardiol. 1994;23:1410-1420.
-
(1994)
J Am Coll Cardiol
, vol.23
, pp. 1410-1420
-
-
Benedict, C.R.1
Johnstone, D.E.2
Weiner, D.H.3
-
57
-
-
0022454787
-
Elevated plasma renin activity associated with renal dysfunction
-
Kehoe B, Keeton GR, Hill C. Elevated plasma renin activity associated with renal dysfunction. Nephron. 1986;44:51-57.
-
(1986)
Nephron
, vol.44
, pp. 51-57
-
-
Kehoe, B.1
Keeton, G.R.2
Hill, C.3
-
58
-
-
0015491624
-
Essential hypertension: Renin and aldosterone, heart attack and stroke
-
Brunner HR, Laragh JH, Baer L. Essential hypertension: renin and aldosterone, heart attack and stroke. N Engl J Med. 1972;286:441-449.
-
(1972)
N Engl J Med
, vol.286
, pp. 441-449
-
-
Brunner, H.R.1
Laragh, J.H.2
Baer, L.3
-
59
-
-
20544440652
-
Renin inhibition: What are the therapeutic opportunities?
-
Fisher ND, Hollenberg MK. Renin inhibition: what are the therapeutic opportunities? J Am Soc Nephrol. 2005;16:592-599.
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. 592-599
-
-
Fisher, N.D.1
Hollenberg, M.K.2
-
60
-
-
0030005173
-
Distribution of remikiren, a potent orally active inhibotor of human renin, in laboratory animals
-
Richter WF, Whitby BR, Chou RC. Distribution of remikiren, a potent orally active inhibotor of human renin, in laboratory animals. Xenobiotica. 1996;26:243-254.
-
(1996)
Xenobiotica
, vol.26
, pp. 243-254
-
-
Richter, W.F.1
Whitby, B.R.2
Chou, R.C.3
-
61
-
-
33846301971
-
Renal localization of the renin inhibitor aliskiren
-
Feldman DL, Persohn E, Schitz H, et al. Renal localization of the renin inhibitor aliskiren. J Clin Hypertens. 2006;8 Suppl A:A80.
-
(2006)
J Clin Hypertens
, Issue.8 SUPPL. A
-
-
Feldman, D.L.1
Persohn, E.2
Schitz, H.3
-
62
-
-
77957743506
-
Aliskiren. A review of its use as monotherapy and as combination therapy in the management of hypertension
-
2011-1049
-
Duggan ST, Chwieduk CM, Curran MP. Aliskiren. A review of its use as monotherapy and as combination therapy in the management of hypertension. Drugs. 2010;70:2011-1049.
-
(2010)
Drugs
, vol.70
-
-
Duggan, S.T.1
Chwieduk, C.M.2
Curran, M.P.3
-
63
-
-
33947182655
-
Aliskiren, an oral rennin inhibitor, provides dose-dependent efficacy and sustained 24-hour blood pressure control in patients with hypertension
-
Oh BH, Mitchell J, Herron JR, et al. Aliskiren, an oral rennin inhibitor, provides dose-dependent efficacy and sustained 24-hour blood pressure control in patients with hypertension. J Am Coll Cardiol. 2007;49:1157-1163.
-
(2007)
J Am Coll Cardiol
, vol.49
, pp. 1157-1163
-
-
Oh, B.H.1
Mitchell, J.2
Herron, J.R.3
-
64
-
-
34447521458
-
Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: A randomised double-blind trial
-
[published erratum appears in Lancet. 2007;370(9598):1542]
-
Oparil S, Yarows SA, Patel S, et al. Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomised double-blind trial [published erratum appears in Lancet. 2007;370(9598):1542]. Lancet. 2007;370:221-229.
-
(2007)
Lancet
, vol.370
, pp. 221-229
-
-
Oparil, S.1
Yarows, S.A.2
Patel, S.3
-
65
-
-
33845366982
-
Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide
-
Villamil A, Chrysant SG, Calhoun D, et al. Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide. J Hypertens. 2007;25: 217-226.
-
(2007)
J Hypertens
, vol.25
, pp. 217-226
-
-
Villamil, A.1
Chrysant, S.G.2
Calhoun, D.3
-
66
-
-
33846781398
-
Aliskiren, a novel oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in Japanese patients with hypertension
-
Kushiro T, Itakura H, Abo Y, et al. Aliskiren, a novel oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in Japanese patients with hypertension. Hypertens Res. 2006;29:997-1005.
-
(2006)
Hypertens Res
, vol.29
, pp. 997-1005
-
-
Kushiro, T.1
Itakura, H.2
Abo, Y.3
-
67
-
-
14844363404
-
Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients
-
Gradman AH, Schmieder RE, Lins RL, et al. Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation. 2005;111:1012-1018.
-
(2005)
Circulation
, vol.111
, pp. 1012-1018
-
-
Gradman, A.H.1
Schmieder, R.E.2
Lins, R.L.3
-
68
-
-
77957734626
-
Antihypertensive efficacy of the direct renin inhibitor aliskiren in patients with diabetes, metabolic syndrome or obesity: A pooled analysis of 10 randomized trials [abstract no. P888]
-
Weir MR, Prescott MF, Bush C, et al. Antihypertensive efficacy of the direct renin inhibitor aliskiren in patients with diabetes, metabolic syndrome or obesity: a pooled analysis of 10 randomized trials [abstract no. P888]. Circulation. 2008;118:162.
-
(2008)
Circulation
, vol.118
, pp. 162
-
-
Weir, M.R.1
Prescott, M.F.2
Bush, C.3
-
69
-
-
39849089447
-
Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: A 6-month, randomized, double-blind trial
-
Andersen K, Weinberger MH, Egan B, et al. Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: a 6-month, randomized, double-blind trial. J Hypertens. 2008;26:589-599.
-
(2008)
J Hypertens
, vol.26
, pp. 589-599
-
-
Andersen, K.1
Weinberger, M.H.2
Egan, B.3
-
70
-
-
60549087324
-
Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: A 12-month randomized, double-blind comparator trial with hydrochlorothiazide
-
Schmieder RE, Philipp T, Guerediaga J, et al. Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: a 12-month randomized, double-blind comparator trial with hydrochlorothiazide. Circulation. 2009;119:417-425.
-
(2009)
Circulation
, vol.119
, pp. 417-425
-
-
Schmieder, R.E.1
Philipp, T.2
Guerediaga, J.3
-
71
-
-
79951682271
-
Comparative efficacy and safety of aliskiren and irbesartan in patients with hypertension and metabolic syndrome
-
Krone W, Hanefeld M, Meyer H-F, et al. Comparative efficacy and safety of aliskiren and irbesartan in patients with hypertension and metabolic syndrome. J Hum Hypertens. 2011;25:186-195.
-
(2011)
J Hum Hypertens
, vol.25
, pp. 186-195
-
-
Krone, W.1
Hanefeld, M.2
Meyer, H.-F.3
-
72
-
-
33845785350
-
Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan
-
Pool JL, Schmieder RE, Azizi M, et al. Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan. Am J Hypertens. 2007;20:11-20.
-
(2007)
Am J Hypertens
, vol.20
, pp. 11-20
-
-
Pool, J.L.1
Schmieder, R.E.2
Azizi, M.3
-
73
-
-
0347479295
-
Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren
-
Stanton A, Jensen C, Nussberger J, et al. Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren. Hypertension. 2003;42:1137-1143.
-
(2003)
Hypertension
, vol.42
, pp. 1137-1143
-
-
Stanton, A.1
Jensen, C.2
Nussberger, J.3
-
74
-
-
56749085787
-
Effects of the direct renin inhibitor aliskiren and atenolol alone or in combination in patients with hypertension
-
Dietz R, Dechend R, Yu CM, et al. Effects of the direct renin inhibitor aliskiren and atenolol alone or in combination in patients with hypertension. J Renin Angiotensin Aldosterone Syst. 2008;9:163-175.
-
(2008)
J Renin Angiotensin Aldosterone Syst
, vol.9
, pp. 163-175
-
-
Dietz, R.1
Dechend, R.2
Yu, C.M.3
-
75
-
-
77957746219
-
Aliskiren as monotherapy or in combination with hydrochlorothiazide provides effective BP lowering in patients with systolic BP 160 # 180 mm Hg (ACQUIRE study) [abstract no. PO-15]
-
Black HR, Kribben A, Aguirre Palacios F, et al. Aliskiren as monotherapy or in combination with hydrochlorothiazide provides effective BP lowering in patients with systolic BP 160 # 180 mm Hg (ACQUIRE study) [abstract no. PO-15]. J Clin Hypertens. 2010; 12 Suppl 1:A24.
-
(2010)
J Clin Hypertens
, Issue.12 SUPPL.1
-
-
Black, H.R.1
Kribben, A.2
Aguirre, P.F.3
-
76
-
-
42549113198
-
Long-term safety, tolerability and efficacy of aliskiren in combination with valsartan in patients with hypertension: A 6-month interim analysis
-
Chrysant SG, Murray AV, Hoppe UC, et al. Long-term safety, tolerability and efficacy of aliskiren in combination with valsartan in patients with hypertension: a 6-month interim analysis. Curr Med Res Opin. 2008;24:1039-1047.
-
(2008)
Curr Med Res Opin
, vol.24
, pp. 1039-1047
-
-
Chrysant, S.G.1
Murray, A.V.2
Hoppe, U.C.3
-
77
-
-
67649306830
-
Long-term safety, tolerability and efficacy of combination therapy with aliskiren and amlodipine in patients with hypertension
-
Littlejohn TW 3rd, Trenkwalder P, Hollanders G, et al. Long-term safety, tolerability and efficacy of combination therapy with aliskiren and amlodipine in patients with hypertension. Curr Med Res Opin. 2009;25:951-959.
-
(2009)
Curr Med Res Opin
, vol.25
, pp. 951-959
-
-
Littlejohn, T.W.1
Trenkwalder, P.2
Hollanders, G.3
-
78
-
-
67749116073
-
Combination therapy with various combinations of aliskiren, valsartan, and hydrochlorothiazide in hypertensive patients not adequately responsive to hydrochlorothiazide alone
-
Geiger H, Barranco E, Gorostidi M, et al. Combination therapy with various combinations of aliskiren, valsartan, and hydrochlorothiazide in hypertensive patients not adequately responsive to hydrochlorothiazide alone. J Clin Hypertens. 2009;11:324-332.
-
(2009)
J Clin Hypertens
, vol.11
, pp. 324-332
-
-
Geiger, H.1
Barranco, E.2
Gorostidi, M.3
-
79
-
-
34247867955
-
Direct renin inhibition with aliskiren in obese patients with arterial hypertension
-
Jordan J, Engeli S, Boye SW, et al. Direct renin inhibition with aliskiren in obese patients with arterial hypertension. Hypertension. 2007;49:1047-1055.
-
(2007)
Hypertension
, vol.49
, pp. 1047-1055
-
-
Jordan, J.1
Engeli, S.2
Boye, S.W.3
-
80
-
-
77957736098
-
First-line aliskiren/hydrochlorothiazide combination treatment lowers BP more effectively than hydrochlorothiazide alone in older patients with stage 2 hypertension (ACTION study) [abstract no. PO-11]
-
Basile J, Babazadeh S, Lillestol M, et al. First-line aliskiren/hydrochlorothiazide combination treatment lowers BP more effectively than hydrochlorothiazide alone in older patients with stage 2 hypertension (ACTION study) [abstract no. PO-11]. J Clin Hypertens. 2010; 12 Suppl 1:A22.
-
(2010)
J Clin Hypertens
, Issue.12 SUPPL. 1
-
-
Basile, J.1
Babazadeh, S.2
Lillestol, M.3
-
81
-
-
77957733395
-
Responses to aliskiren/HCTZ versus amlodipine on peripheral and central blood pressure in African American patients with stage 2 hypertension
-
A61.E586
-
Ferdinand K, Pool J, Weitzman R. Responses to aliskiren/HCTZ versus amlodipine on peripheral and central blood pressure in African American patients with stage 2 hypertension. J Am Coll Cardiol. 2010;55 (10 Suppl 1):A61.E586.
-
(2010)
J Am Coll Cardiol
, vol.55
, Issue.10 SUPPL. 1
-
-
Ferdinand, K.1
Pool, J.2
Weitzman, R.3
-
82
-
-
77957741504
-
Aliskiren with or without hydrochlorothiazide lowers blood pressure effectively in patients with stage 2 hypertension and metabolic syndrome [abstract no. PP.38.505]
-
Zieve F, Yadao A, Yurkovic C, et al. Aliskiren with or without hydrochlorothiazide lowers blood pressure effectively in patients with stage 2 hypertension and metabolic syndrome [abstract no. PP.38.505]. J Hypertens. 2010;28 Suppl A:e600.
-
(2010)
J Hypertens
, Issue.28 SUPPL. A
-
-
Zieve, F.1
Yadao, A.2
Yurkovic, C.3
-
83
-
-
77957745695
-
Initial combination therapy with aliskiren/hydrochlorothiazide is more effective than amlodipine in patients with stage 2 systolic hypertension and diabetes mellitus [abstract no. LB-PO-03]
-
Townsend RR, Forker A, Rumpelt P, et al. Initial combination therapy with aliskiren/hydrochlorothiazide is more effective than amlodipine in patients with stage 2 systolic hypertension and diabetes mellitus [abstract no. LB-PO-03]. J Clin Hypertens. 2010;12:534.
-
(2010)
J Clin Hypertens
, vol.12
, pp. 534
-
-
Townsend, R.R.1
Forker, A.2
Rumpelt, P.3
-
84
-
-
38649102508
-
Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension
-
Uresin Y, Taylor AA, Kilo C, et al. Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension. J Renin Angiotensin Aldosterone Syst. 2007;8:190-198.
-
(2007)
J Renin Angiotensin Aldosterone Syst
, vol.8
, pp. 190-198
-
-
Uresin, Y.1
Taylor, A.A.2
Kilo, C.3
-
85
-
-
77957739604
-
First line therapy with aliskiren/amlodipine combination provides robust blood pressure reductions in patients with moderate to severe hypertension [abstract no. PO-22]
-
Braun-Dullaeus RC, Zhang J, Hristoskova S, et al. First line therapy with aliskiren/amlodipine combination provides robust blood pressure reductions in patients with moderate to severe hypertension [abstract no. PO-22]. J Clin Hypertens. 2010;12 Suppl 1:A27.
-
(2010)
J Clin Hypertens
, Issue.12 SUPPL. 1
-
-
Braun-Dullaeus, R.C.1
Zhang, J.2
Hristoskova, S.3
-
86
-
-
77957738332
-
Combination aliskiren/ amlodipine is more effective than amlodipine monotherapy in male and female African American subjects with stage 2 hypertension [abstract no. PO-20]
-
Black H, Weinberger M, Purkayastha D, et al. Combination aliskiren/ amlodipine is more effective than amlodipine monotherapy in male and female African American subjects with stage 2 hypertension [abstract no. PO-20]. J Clin Hypertens. 2010;12 Suppl 1:A26.
-
(2010)
J Clin Hypertens
, vol.12
, Issue.SUPPL. 1
-
-
Black, H.1
Weinberger, M.2
Purkayastha, D.3
-
87
-
-
56749085787
-
Effects of the direct renin inhibitor aliskiren and atenolol alone or in combination in patients with hypertension
-
Dietz R, Dechend R, Yu CM, et al. Effects of the direct renin inhibitor aliskiren and atenolol alone or in combination in patients with hypertension. J Renin Angiotensin Aldosterone Syst. 2008;9:163-175.
-
(2008)
J Renin Angiotensin Aldosterone Syst
, vol.9
, pp. 163-175
-
-
Dietz, R.1
Dechend, R.2
Yu, C.M.3
-
88
-
-
44849114597
-
Aliskiren combined with losartan in type 2 diabetes and nephropathy
-
Parving HH, Persson F, Lewis JB, et al. Aliskiren combined with losartan in type 2 diabetes and nephropathy. N Engl J Med. 2008;358:2433-2446.
-
(2008)
N Engl J Med
, vol.358
, pp. 2433-2446
-
-
Parving, H.H.1
Persson, F.2
Lewis, J.B.3
-
89
-
-
61349170589
-
Effect of the direct renin inhibitor aliskiren, the angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy
-
Solomon SD, Appelbaum E, Manning WJ, et al. Effect of the direct renin inhibitor aliskiren, the angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy. Circulation. 2009;119:530-537.
-
(2009)
Circulation
, vol.119
, pp. 530-537
-
-
Solomon, S.D.1
Appelbaum, E.2
Manning, W.J.3
-
90
-
-
79958249630
-
Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure
-
McMurray JJV, Pitt B, Latini R, et al. Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure. Circ Heart Fail. 2008;1:17-24.
-
(2008)
Circ Heart Fail
, vol.1
, pp. 17-24
-
-
McMurray, J.J.V.1
Pitt, B.2
Latini, R.3
-
91
-
-
77955940602
-
Patients with acute coronary syndromes and elevated levels of natriuretic peptides: The results of the AVANT GARDE-TIMI 43 Trial
-
Scirica BM, Morrow DA, Bode C, et al. Patients with acute coronary syndromes and elevated levels of natriuretic peptides: the results of the AVANT GARDE-TIMI 43 Trial. Eur Heart J. 2010;31:1993-2005.
-
(2010)
Eur Heart J
, vol.31
, pp. 1993-2005
-
-
Scirica, B.M.1
Morrow, D.A.2
Bode, C.3
-
92
-
-
77952977869
-
Clinical trials update from the American College of Cardiology meeting 2010: DOSE, ASPIRE, CONNECT, STICH, STOPAF, CABANA, RACE II, EVEREST II, ACCORD, and NAVIGATOR
-
Cleland JGF, Coletta AP, Buga L, et al. Clinical trials update from the American College of Cardiology meeting 2010: DOSE, ASPIRE, CONNECT, STICH, STOPAF, CABANA, RACE II, EVEREST II, ACCORD, and NAVIGATOR. Eur J Heart Fail. 2010;12:623-629.
-
(2010)
Eur J Heart Fail
, vol.12
, pp. 623-629
-
-
Cleland, J.G.F.1
Coletta, A.P.2
Buga, L.3
|