-
2
-
-
15444367989
-
The renin–angiotensin system: peptides and enzymes beyond angiotensin II
-
T.L. Reudelhuber The renin–angiotensin system: peptides and enzymes beyond angiotensin II Curr Opin Nephrol Hypertens 14 2005 155 159
-
(2005)
Curr Opin Nephrol Hypertens
, vol.14
, pp. 155-159
-
-
Reudelhuber, T.L.1
-
3
-
-
0042661157
-
Structure-based design of aliskiren, a novel orally effective renin inhibitor
-
J.M. Wood J. Maibaum J. Rahuel Structure-based design of aliskiren, a novel orally effective renin inhibitor Biochem Biophys Res Commun 308 2003 698 705
-
(2003)
Biochem Biophys Res Commun
, vol.308
, pp. 698-705
-
-
Wood, J.M.1
Maibaum, J.2
Rahuel, J.3
-
4
-
-
14044271546
-
Aliskiren, a novel orally effective renin inhibitor lowers blood pressure in marmosets and spontaneously hypertensive rats
-
J.M. Wood C.R. Schnell F. Cumin J. Menard Aliskiren, a novel orally effective renin inhibitor lowers blood pressure in marmosets and spontaneously hypertensive rats J Hypertens 23 2005 417 426
-
(2005)
J Hypertens
, vol.23
, pp. 417-426
-
-
Wood, J.M.1
Schnell, C.R.2
Cumin, F.3
Menard, J.4
-
5
-
-
26244440599
-
Complement activation in angiotensin II-induced organ damage
-
E. Shagdarsuren M. Wellner J.H. Braesen Complement activation in angiotensin II-induced organ damage Circ Res 97 2005 716 724
-
(2005)
Circ Res
, vol.97
, pp. 716-724
-
-
Shagdarsuren, E.1
Wellner, M.2
Braesen, J.H.3
-
6
-
-
25444454353
-
Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats
-
B. Pilz E. Shagdarsuren M. Wellner Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats Hypertension 46 2005 569 576
-
(2005)
Hypertension
, vol.46
, pp. 569-576
-
-
Pilz, B.1
Shagdarsuren, E.2
Wellner, M.3
-
7
-
-
27444447364
-
Renin, prorenin and the putative (pro)renin receptor
-
A.H. Danser J. Deinum Renin, prorenin and the putative (pro)renin receptor Hypertension 46 2005 1069 1076
-
(2005)
Hypertension
, vol.46
, pp. 1069-1076
-
-
Danser, A.H.1
Deinum, J.2
-
8
-
-
33846996406
-
The (pro)renin receptor: pathophysiological roles in cardiovascular and renal pathology
-
G. Nguyen The (pro)renin receptor: pathophysiological roles in cardiovascular and renal pathology Curr Opin Nephrol Hypertens 16 2007 129 133
-
(2007)
Curr Opin Nephrol Hypertens
, vol.16
, pp. 129-133
-
-
Nguyen, G.1
-
9
-
-
33750723790
-
Imaging the renin–angiotensin system: an important target of anti-hypertensive therapy
-
J.J. Kang I. Toma A. Sipos Imaging the renin–angiotensin system: an important target of anti-hypertensive therapy Adv Drug Deliv Rev 58 2006 824 833
-
(2006)
Adv Drug Deliv Rev
, vol.58
, pp. 824-833
-
-
Kang, J.J.1
Toma, I.2
Sipos, A.3
-
10
-
-
34247644329
-
Aliskiren, the first renin inhibitor for treating hypertension: reactive renin secretion may limit its effectiveness
-
J.E. Sealey J.H. Laragh Aliskiren, the first renin inhibitor for treating hypertension: reactive renin secretion may limit its effectiveness Am J Hypertens 20 2007 587 597
-
(2007)
Am J Hypertens
, vol.20
, pp. 587-597
-
-
Sealey, J.E.1
Laragh, J.H.2
-
11
-
-
34548442794
-
The difficult conception, birth, and delivery of a renin inhibitor: controversies around aliskiren
-
J. Menard M. Azizi The difficult conception, birth, and delivery of a renin inhibitor: controversies around aliskiren J Hypertens 25 2007 1775 17782
-
(2007)
J Hypertens
, vol.25
, pp. 1775-17782
-
-
Menard, J.1
Azizi, M.2
-
12
-
-
34547628374
-
Pharmacokinetics of the oral direct renin inhibitor aliskiren alone and in combination with irbesartan in renal impairment
-
S. Vaidyanathan H. Bigler C. Yeh Pharmacokinetics of the oral direct renin inhibitor aliskiren alone and in combination with irbesartan in renal impairment Clin Pharmacokinet 46 2007 661 675
-
(2007)
Clin Pharmacokinet
, vol.46
, pp. 661-675
-
-
Vaidyanathan, S.1
Bigler, H.2
Yeh, C.3
-
13
-
-
34547221695
-
Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers
-
F. Waldmeier U. Glaenzel B. Wirz Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers Drug Metab Dispos 35 2007 1418 1428
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1418-1428
-
-
Waldmeier, F.1
Glaenzel, U.2
Wirz, B.3
-
14
-
-
33947543780
-
Pharmacokinetics, safety, and tolerability of the novel oral direct renin inhibitor aliskiren in elderly healthy subjects
-
S. Vaidyanathan C. Reynolds C.M. Yeh Pharmacokinetics, safety, and tolerability of the novel oral direct renin inhibitor aliskiren in elderly healthy subjects J Clin Pharmacol 47 2007 453 460
-
(2007)
J Clin Pharmacol
, vol.47
, pp. 453-460
-
-
Vaidyanathan, S.1
Reynolds, C.2
Yeh, C.M.3
-
15
-
-
33846456943
-
Pharmacokinetics, safety, and tolerability of the oral renin inhibitor aliskiren in patients with hepatic impairment
-
S. Vaidyanathan V. Warren C. Yeh Pharmacokinetics, safety, and tolerability of the oral renin inhibitor aliskiren in patients with hepatic impairment J Clin Pharmacol 47 2007 192 200
-
(2007)
J Clin Pharmacol
, vol.47
, pp. 192-200
-
-
Vaidyanathan, S.1
Warren, V.2
Yeh, C.3
-
16
-
-
33750357566
-
Aliskiren, a novel orally effective renin inhibitor, exhibits similar pharmacokinetics and pharmacodynamics in Japanese and Caucasian subjects
-
S. Vaidyanathan J. Jermany C. Yeh Aliskiren, a novel orally effective renin inhibitor, exhibits similar pharmacokinetics and pharmacodynamics in Japanese and Caucasian subjects Br J Clin Pharmacol 62 2006 690 698
-
(2006)
Br J Clin Pharmacol
, vol.62
, pp. 690-698
-
-
Vaidyanathan, S.1
Jermany, J.2
Yeh, C.3
-
17
-
-
33749853955
-
Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers
-
S. Vaidyanathan J. Valencia C. Kemp Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers Int J Clin Pract 60 2006 1343 1356
-
(2006)
Int J Clin Pract
, vol.60
, pp. 1343-1356
-
-
Vaidyanathan, S.1
Valencia, J.2
Kemp, C.3
-
18
-
-
33750289480
-
Aliskiren exhibits similar pharmacokinetics in healthy volunteers and patients with type 2 diabetes mellitus
-
C. Zhao S. Vaidyanathan C.M. Yeh Aliskiren exhibits similar pharmacokinetics in healthy volunteers and patients with type 2 diabetes mellitus Clin Pharmacokinet 45 2006 1125 1134
-
(2006)
Clin Pharmacokinet
, vol.45
, pp. 1125-1134
-
-
Zhao, C.1
Vaidyanathan, S.2
Yeh, C.M.3
-
19
-
-
28044453329
-
Pharmacokinetic interactions of the oral renin inhibitor aliskiren with iovastatin, atenolol, celecoxib and cimetidine
-
W. Dieterle S. Corynen S. Vaidyanathan Pharmacokinetic interactions of the oral renin inhibitor aliskiren with iovastatin, atenolol, celecoxib and cimetidine Int J Clin Pharmacol Ther 43 2005 527 535
-
(2005)
Int J Clin Pharmacol Ther
, vol.43
, pp. 527-535
-
-
Dieterle, W.1
Corynen, S.2
Vaidyanathan, S.3
-
20
-
-
14844363404
-
Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients
-
A.H. Gradman R.E. Schmieder R.L. Lins Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients Circulation 111 2005 1012 1018
-
(2005)
Circulation
, vol.111
, pp. 1012-1018
-
-
Gradman, A.H.1
Schmieder, R.E.2
Lins, R.L.3
-
21
-
-
33947182655
-
Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and sustained 24-hour blood pressure control in patients with hypertension
-
B.H. Oh J. Mitchell J.R. Herron Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and sustained 24-hour blood pressure control in patients with hypertension J Am Coll Cardiol 49 2007 1157 1163
-
(2007)
J Am Coll Cardiol
, vol.49
, pp. 1157-1163
-
-
Oh, B.H.1
Mitchell, J.2
Herron, J.R.3
-
22
-
-
33846781398
-
Aliskiren, a novel oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in Japanese patients with hypertension
-
T. Kushiro H. Itakura Y. Abo Aliskiren, a novel oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in Japanese patients with hypertension Hypertens Res 29 2006 997 1005
-
(2006)
Hypertens Res
, vol.29
, pp. 997-1005
-
-
Kushiro, T.1
Itakura, H.2
Abo, Y.3
-
23
-
-
34447621764
-
Antihypertensive efficacy, safety, and tolerability of the oral direct renin inhibitor aliskeren in patients with hypertension: a pooled analysis
-
M.R. Weir C. Bush D.R. Anderson Antihypertensive efficacy, safety, and tolerability of the oral direct renin inhibitor aliskeren in patients with hypertension: a pooled analysis J Am Soc Hypertension 1 2007 264 277
-
(2007)
J Am Soc Hypertension
, vol.1
, pp. 264-277
-
-
Weir, M.R.1
Bush, C.2
Anderson, D.R.3
-
24
-
-
34247867955
-
Direct renin inhibition with aliskiren in obese patients with arterial hypertension
-
J. Jordan S. Engeli S.W. Boye Direct renin inhibition with aliskiren in obese patients with arterial hypertension Hypertension 49 2007 1047 1055
-
(2007)
Hypertension
, vol.49
, pp. 1047-1055
-
-
Jordan, J.1
Engeli, S.2
Boye, S.W.3
-
25
-
-
33845366982
-
Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide
-
A. Villamil S.G. Chrysant D. Calhoun Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide J Hypertens 25 2007 217 226
-
(2007)
J Hypertens
, vol.25
, pp. 217-226
-
-
Villamil, A.1
Chrysant, S.G.2
Calhoun, D.3
-
26
-
-
34447521458
-
Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomised, double-blind trial
-
S. Oparil S.A. Yarows S. Patel Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomised, double-blind trial Lancet 370 2007 221 229
-
(2007)
Lancet
, vol.370
, pp. 221-229
-
-
Oparil, S.1
Yarows, S.A.2
Patel, S.3
-
27
-
-
34548319203
-
Mechanism of high glucose induced angiotensin II production in rat vascular smooth muscle cells
-
E.N. Lavrentyev A.M. Estes K.U. Malik Mechanism of high glucose induced angiotensin II production in rat vascular smooth muscle cells Circ Res 101 2007 455 464
-
(2007)
Circ Res
, vol.101
, pp. 455-464
-
-
Lavrentyev, E.N.1
Estes, A.M.2
Malik, K.U.3
-
28
-
-
0034573872
-
Angiotensin II-generating enzymes
-
L.A. Belova Angiotensin II-generating enzymes Biochemistry (Mosc) 65 2000 1337 1345
-
(2000)
Biochemistry (Mosc)
, vol.65
, pp. 1337-1345
-
-
Belova, L.A.1
-
29
-
-
0025794059
-
Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension
-
M.H. Alderman S. Madhavan W.L. Ooi Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension N Engl J Med 324 1991 1098 1104
-
(1991)
N Engl J Med
, vol.324
, pp. 1098-1104
-
-
Alderman, M.H.1
Madhavan, S.2
Ooi, W.L.3
-
31
-
-
0021889169
-
Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complications
-
J.A. Luetscher F.B. Kraemer D.M. Wilson Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complications N Engl J Med 312 1985 1412 1417
-
(1985)
N Engl J Med
, vol.312
, pp. 1412-1417
-
-
Luetscher, J.A.1
Kraemer, F.B.2
Wilson, D.M.3
-
32
-
-
0025089160
-
Plasma prorenin activity and complications in children with insulin-dependent diabetes mellitus
-
D.M. Wilson J.A. Luetscher Plasma prorenin activity and complications in children with insulin-dependent diabetes mellitus N Engl J Med 323 1990 1101 1106
-
(1990)
N Engl J Med
, vol.323
, pp. 1101-1106
-
-
Wilson, D.M.1
Luetscher, J.A.2
-
33
-
-
0024495446
-
Renin, prorenin, and immunoreactive renin in vitreous fluid from eyes with and without diabetic retinopathy
-
A.H. Danser M.A. van den Dorpel J. Deinum Renin, prorenin, and immunoreactive renin in vitreous fluid from eyes with and without diabetic retinopathy J Clin Endocrinol Metab 68 1989 160 167
-
(1989)
J Clin Endocrinol Metab
, vol.68
, pp. 160-167
-
-
Danser, A.H.1
van den Dorpel, M.A.2
Deinum, J.3
-
34
-
-
30944469631
-
Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms
-
Y. Huang S. Wongamorntham J. Kasting Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms Kidney Int 69 2006 105 113
-
(2006)
Kidney Int
, vol.69
, pp. 105-113
-
-
Huang, Y.1
Wongamorntham, S.2
Kasting, J.3
-
35
-
-
0029853814
-
Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen
-
G. Nguyen F. Delarue J. Berrou Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen Kidney Int 50 1996 1897 1903
-
(1996)
Kidney Int
, vol.50
, pp. 1897-1903
-
-
Nguyen, G.1
Delarue, F.2
Berrou, J.3
-
36
-
-
33745674108
-
Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin
-
S. Satofuka A. Ichihara N. Nagai Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin Invest Ophthalmol Vis Sci 47 2006 2686 2693
-
(2006)
Invest Ophthalmol Vis Sci
, vol.47
, pp. 2686-2693
-
-
Satofuka, S.1
Ichihara, A.2
Nagai, N.3
-
37
-
-
9644283069
-
Inhibition of diabetic nephropathy by a decoy peptide corresponding to the ‘handle’ region for nonproteolytic activation of prorenin
-
A. Ichihara M. Hayashi Y. Kaneshiro Inhibition of diabetic nephropathy by a decoy peptide corresponding to the ‘handle’ region for nonproteolytic activation of prorenin J Clin Invest 114 2004 1128 1135
-
(2004)
J Clin Invest
, vol.114
, pp. 1128-1135
-
-
Ichihara, A.1
Hayashi, M.2
Kaneshiro, Y.3
-
38
-
-
33646160993
-
Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension
-
A. Ichihara Y. Kaneshiro T. Takemitsu Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension Hypertension 47 2006 894 900
-
(2006)
Hypertension
, vol.47
, pp. 894-900
-
-
Ichihara, A.1
Kaneshiro, Y.2
Takemitsu, T.3
-
39
-
-
33745824649
-
Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice
-
A. Ichihara F. Suzuki T. Nakagawa Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice J Am Soc Nephrol 17 2006 1950 1961
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 1950-1961
-
-
Ichihara, A.1
Suzuki, F.2
Nakagawa, T.3
-
40
-
-
33748044643
-
Contribution of nonproteolytically activated prorenin in glomeruli to hypertensive renal damage
-
A. Ichihara Y. Kaneshiro T. Takemitsu Contribution of nonproteolytically activated prorenin in glomeruli to hypertensive renal damage J Am Soc Nephrol 17 2006 2495 2503
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 2495-2503
-
-
Ichihara, A.1
Kaneshiro, Y.2
Takemitsu, T.3
-
41
-
-
33747060126
-
Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats
-
Y. Kaneshiro A. Ichihara T. Takemitsu Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats Kidney Int 70 2006 641 646
-
(2006)
Kidney Int
, vol.70
, pp. 641-646
-
-
Kaneshiro, Y.1
Ichihara, A.2
Takemitsu, T.3
-
42
-
-
34447272037
-
Regression of nephropathy developed in diabetes by (pro)renin receptor blockade
-
H. Takahashi A. Ichihara Y. Kaneshiro Regression of nephropathy developed in diabetes by (pro)renin receptor blockade J Am Soc Nephrol 18 2007 2054 2061
-
(2007)
J Am Soc Nephrol
, vol.18
, pp. 2054-2061
-
-
Takahashi, H.1
Ichihara, A.2
Kaneshiro, Y.3
-
43
-
-
34447287846
-
Renin and its putative receptor remain enigmas
-
F.C. Luft Renin and its putative receptor remain enigmas J Am Soc Nephrol 18 2007 1989 1992
-
(2007)
J Am Soc Nephrol
, vol.18
, pp. 1989-1992
-
-
Luft, F.C.1
|