Distribution of remikiren, a potent orally active inhibitor of human renin, in laboratory animals

Xenobiotica

Volumn 26, Issue 3, 1996, Pages 243-254

  Richter, W F ^a   Whitby, B R ^b   Chou, R C ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b Corning Hazleton ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

REMIKIREN; RENIN INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; BILE DUCT; BILIARY EXCRETION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; GALLBLADDER; GUINEA PIG; INTESTINE; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; MALE; NONHUMAN; RAT; SPECIES DIFFERENCE; SQUIRREL MONKEY; WHOLE BODY AUTORADIOGRAPHY;

ANIMALIA; CAVIA PORCELLUS; PRIMATES; SAIMIRI; SCIURIDAE; SUS SCROFA;

EID: 0030005173     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.3109/00498259609046705     Document Type: Article

References (15)

1. BRUNO, G. A., and CHRISTIAN, J. E., 1961, Determination of carbon-14 in aqueous bicarbonate solutions by liquid scintillation counting techniques. Analytical Chemistry, 33, 1216-1218.
2. CLOZEL, J.-P., and FISCHLI, W., 1993, Comparative effects of different potent renin inhibitors in primates. Hypertension, 22, 9-17.
3. COASSOLO, PH., FISCHLI, W., CLOZEL, J.-P., and CHOU, R. C., 1996, Pharmacokinetics of remikiren, a potent orally active inhibitor of human renin in the rat, dog and primate. Xenobiotica, 26, 333-346.
4. DO, T.-S., SHINAGAWA, T., TAM, H., INAGAMI, T., and HSUEH, W. A., 1987, Characterization of pure human renal renin - evidence for a subunit structure. Journal of Biological Chemistry, 262, 1037-1043.
5. ERDÖS, E. G., 1975, Angiotensin I converting enzyme. Circulation Research, 36, 247-255.
6. FISCHLI, W., CLOZEL, J.-P., EL AMRANI, K., WOSTL, W., NEIDHART, W., STADLER, U., and BRANCA, Q., 1991, Ro 42-5892 is a potent orally active renin inhibitor in primates. Hypertension, 18, 22-31.
7. FOUAD-TARAZI, F., BUMPUS, M., and HEALY, B., 1988, The renin-angiotensin system and treatment of heart failure. American Journal of Medicine, 84 (suppl. 3A), 83-86.
8. JAUCH, R., SCHMID, P., FISCHLI, W., MEISTER, W., MAURER, R., and WENDT G., 1996, Excretion and metabolism of remikiren, a potent oral inhibitor of primate renin. Xenobiotica, 26, 285-296.
9. KOBRIN, I., VISKOPER, R. J., LASZT, A., BOCK, J., WEBER, C., and CHARLON, V., 1993, Effects of an orally active renin inhibitor, Ro 42-5892, in patients with essential hypertension. American Journal of Hypertension, 6, 349-356.
10. KOKUBU, T., and HIWADA, K., 1987, Human renin inhibitors. Drugs Today, 23, 101-108.
11. LINDGREN, B. R., and ANDERSSON, R. G. G., 1989, Angiotensin-converting enzyme inhibitors and their influence on inflammation, bronchial reactivity and cough. Medical Toxicology and Adverse Drug Experimentation, 4, 369-380.
12. RONGEN, G. A., LENDERS, J. W. M., KLEINBLOESEM, C. H., WEBER, C., WELKER, H., FAHRNER, E., POZENEL, H., WOITTIEZ, A.-J. J., HAUG, G., BUCHMANN, M. S., HÖGLUND, C. E. K., and THIEN, T., 1993, Efficacy and tolerability of the renin inhibitor Ro 42-5892 in patients with hypertension. Clinical Pharmacology and Therapeutics, 54, 567-577.
13. VAN DEN MEIRACKER, A. H., ADMIRAAL, P. J. J., MAN IN'T FELD, A. J., DERKX, F. H. M., RITSEMA VAN ECK, H. J., MULDER, P., VAN BRUMMELEN, P., and SCHALEKAMP, M. A. D. H., 1990, Prolonged blood pressure reduction by orally active renin inhibitor Ro 42-5892 in essential hypertension. British Medical Journal, 301, 205-210.
14. VÉNIANT, M., CLOZEL, J.-P., HESS, P., and FISCHLI, W., 1992, Effects of renin-angiotensin system blockade in the guinea-pig. Hypertension, 19, 255-262.
15. VISKOPER, R. J., CHARLON, V., LASZT, A., YOSEFY, C., BOCK, J., LAUDAU, M., and KOBRIN, I., 1994, Time dependency of the antihypertensive efficacy of the new renin inhibitor Ro 42-5892. Journal of Human Hypertension, 8, 133-136.