TTBK2 kinase substrate specificity and the impact of spinocerebellar- ataxia-causing mutations on expression, activity, localization and development

Biochemical Journal

Volumn 437, Issue 1, 2011, Pages 157-167

  Bouskila, Michale ^a,c   Esoof, Noor ^a   Gay, Laurie ^a,d   Fang, Emily H ^a   Deak, Maria ^a   Begley, Michael J ^b   Cantley, Lewis C ^b   Prescott, Alan ^a   Storey, Kate G ^a   Alessi, Dario R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Dando Weiss and Colucci   (United Kingdom)

^d Trends in Molecular Medicine   (United States)

Author keywords

Movement disorder; Neurodegeneration; Protein kinase; Signal transduction; Tau tubulin kinase peptide substrate (TTBKtide)

Indexed keywords

PHOSPHOTRANSFERASE; TAU TUBULIN KINASE 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE ACTIVITY; GENE LOCATION; GENE MUTATION; HOMOZYGOSITY; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY; SPINOCEREBELLAR DEGENERATION;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN-SERINE-THREONINE KINASES; SPINOCEREBELLAR ATAXIAS; SPINOCEREBELLAR DEGENERATIONS; SUBSTRATE SPECIFICITY;

EID: 79958826704     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20110276     Document Type: Article

References (22)

1. Houlden, H., Johnson, J., Gardner-Thorpe, C., Lashley, T., Hernandez, D., Worth, P., Singleton, A. B., Hilton, D. A., Holton, J., Revesz, T. et al. (2007) Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11. Nat. Genet. 39, 1434-1436
2. Bauer, P., Stevanin, G., Beetz, C., Synofzik, M., Schmitz-Hubsch, T., Wullner, U., Berthier, E., Ollagnon-Roman, E., Riess, O., Forlani, S. et al. (2010) Spinocerebellar ataxia type 11 (SCA11) is an uncommon cause of dominant ataxia among French and German kindreds. J. Neurol. Neurosurg. Psychiatry 81, 1229-1232
3. Houlden, H. (2008) Spinocerebellar ataxia type 11. GeneReviews (Pagon, R. A., Bird, T. D., Dolan, C. R. and Stephens, K, eds), PMID 20301723, University of Washington, Seattle
4. Takahashi, M., Tomizawa, K., Sato, K., Ohtake, A. and Omori, A. (1995) A novel tau-tubulin kinase from bovine brain. FEBS Lett. 372, 59-64
5. Manning, G., Whyte, D. B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science 298, 1912-1934 (Pubitemid 35425239)
6. Hanks, S. K. and Hunter, T. (1995) Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J. 9, 576-596
7. Manning, G., Plowman, G. D., Hunter, T. and Sudarsanam, S. (2002) Evolution of protein kinase signaling from yeast to man. Trends Biochem. Sci. 27, 514-520
8. Sato, S., Cerny, R. L., Buescher, J. L. and Ikezu, T. (2006) Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. J. Neurochem. 98, 1573-1584 (Pubitemid 44200447)
9. Takahashi, M., Tomizawa, K., Ishiguro, K., Takamatsu, M., Fujita, S. C. and Imahori, K. (1995) Involvement of tau protein kinase I in paired helical filament-like phosphorylation of the juvenile tau in rat brain. J. Neurochem. 64, 1759-1768
10. Tomizawa, K., Omori, A., Ohtake, A., Sato, K. and Takahashi, M. (2001) Tau-tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites found in paired helical filament-tau. FEBS Lett. 492, 221-227 (Pubitemid 32217832)
11. Noble, W., Planel, E., Zehr, C., Olm, V., Meyerson, J., Suleman, F., Gaynor, K., Wang, L., LaFrancois, J., Feinstein, B. et al. (2005) Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proc. Natl. Acad. Sci. U.S.A. 102, 6990-6995
12. Xu, J., Sato, S., Okuyama, S., Swan, R. J., Jacobsen, M. T., Strunk, E. and Ikezu, T. (2010) Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice. FASEB J. 24, 2904-2915
13. Vazquez-Higuera, J. L., Martinez-Garcia, A., Sanchez-Juan, P., Rodriguez-Rodriguez, E., Mateo, I., Pozueta, A., Frank, A., Valdivieso, F., Berciano, J., Bullido, M. J. and Combarros, O. (2011) Genetic variations in tau-tubulin kinase-1 are linked to Alzheimer's disease in a Spanish case-control cohort. Neurobiol. Aging 32, e555-e559
14. Yu, N. N., Yu, J. T., Xiao, J. T., Zhang, H. W., Lu, R. C., Jiang, H., Xing, Z. H. and Tan, L. (2011) Tau-tubulin kinase-1 gene variants are associated with Alzheimer's disease in Han Chinese. Neurosci. Lett. 491, 83-86
15. Hutti, J. E., Jarrell, E. T., Chang, J. D., Abbott, D. W., Storz, P., Toker, A., Cantley, L. C. and Turk, B. E. (2004) A rapid method for determining protein kinase phosphorylation specificity. Nat. Methods 1, 27-29
16. Turk, B. E., Hutti, J. E. and Cantley, L. C. (2006) Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates. Nat. Protoc. 1, 375-379
17. Marin, O., Meggio, F. and Pinna, L. A. (1994) Design and synthesis of two new peptide substrates for the specific and sensitive monitoring of casein kinases-1 and -2. Biochem. Biophys. Res. Commun. 198, 898-905
18. Flotow, H., Graves, P. R., Wang, A. Q., Fiol, C. J., Roeske, R. W. and Roach, P. J. (1990) Phosphate groups as substrate determinants for casein kinase I action. J. Biol. Chem. 265, 14264-14269
19. Flotow, H. and Roach, P. J. (1989) Synergistic phosphorylation of rabbit muscle glycogen synthase by cyclic AMP-dependent protein kinase and casein kinase I. Implications for hormonal regulation of glycogen synthase. J. Biol. Chem. 264, 9126-9128
20. Nakielny, S., Campbell, D. G. and Cohen, P. (1991) The molecular mechanism by which adrenalin inhibits glycogen synthesis. Eur. J. Biochem. 199, 713-722
21. Xu, R. M., Carmel, G., Sweet, R. M., Kuret, J. and Cheng, X. (1995) Crystal structure of casein kinase-1, a phosphate-directed protein kinase. EMBO J. 14, 1015-1023
22. Longenecker, K. L., Roach, P. J. and Hurley, T. D. (1996) Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition. J. Mol. Biol. 257, 618-631