Regulation of focal adhesions by flightless i involves inhibition of paxillin phosphorylation via a rac1-dependent pathway

Journal of Investigative Dermatology

Volumn 131, Issue 7, 2011, Pages 1450-1459

  Kopecki, Zlatko ^a   O'Neill, Geraldine M ^b   Arkell, Ruth M ^c   Cowin, Allison J ^a,d  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^d UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ALPHA ACTININ; FIBRONECTIN; FLIGHTLESS I; GUANOSINE TRIPHOSPHATASE; PAXILLIN; PROTEIN; PROTEIN P30; RAC1 PROTEIN; RHO FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CELL LEVEL; CELL MOTILITY; CONTROLLED STUDY; FIBROBLAST; FOCAL ADHESION; IN VIVO STUDY; MEMBRANE STABILIZATION; MOUSE; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SUPPRESSION SUBTRACTIVE HYBRIDIZATION; UPREGULATION; WILD TYPE; WOUND; WOUND HEALING;

EID: 79958825428     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2011.69     Document Type: Article

References (36)

1. Adams DH, Ruzehaji N, Strudwick XL et al. (2009) Attenuation of Flightless I, an actin-remodelling protein, improves burn injury repair via modulation of transforming growth factor (TGF)-b1 and TGF-b3. Br J Dermatol 161:326-36
2. Adams DH, Strudwick XL, Kopecki Z et al. (2008) Gender specific effects on the actin-remodelling protein Flightless I and TGF-beta1 contribute to impaired wound healing in aged skin. Int J Biochem Cell Biol 40:1555-69
3. Alon R, Feigelson SW, Manevich E et al. (2005) Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain. J Cell Biol 171:1073-84 (Pubitemid 41815838)
4. Arnaout MA, Goodman SL, Xiong JP (2007) Structure and mechanics of integrin-based cell adhesion. Curr Opin Cell Biol 19:495-507 (Pubitemid 350019555)
5. Arthur WT, Petch LA, Burridge K (2000) Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism. Curr Biol 10: 719-22 (Pubitemid 30437944)
6. Bach CT, Creed S, Zhong J et al. (2009) Tropomyosin isoform expression regulates the transition of adhesions to determine cell speed and direction. Mol Cell Biol 29:1506-14
7. Bargon SD, Gunning PW, O'Neill GM (2005) The Cas family docking protein, HEF1, promotes the formation of neurite-like membrane extensions. Biochim Biophys Acta 1746:143-54 (Pubitemid 41774289)
8. Ben-Ze'ev A (1997) Cytoskeletal and adhesion proteins as tumour suppressors. Curr Opin Cell Biol 9:99-108
9. Berrier AL, Yamada KM (2007) Cell-matrix adhesion. J Cell Physiol 213:565-73 (Pubitemid 350058247)
10. Bershadsky AD, Ballestrem C, Carramusa L et al. (2006) Assembly and mechanosensory function of focal adhesions: experiments and models. Eur J Cell Biol 85:165-73
11. Brown MC, Turner CE (2004) Paxillin: adapting to change. Physiol Rev 84:1315-39 (Pubitemid 39287952)
12. Campbell HD, Fountain S, McLennan IS et al. (2002) Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development. Mol Cell Biol 22:3518-26 (Pubitemid 34453990)
13. Campbell HD, Fountain S, Young IG et al. (1997) Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL. Genomics 42:46-54 (Pubitemid 27215125)
14. Clark EA, King WG, Brugge JS et al. (1998) Integrin-mediated signals regulated by members of the rho family of GTPases. J Cell Biol 142:573-86 (Pubitemid 28361561)
15. Cowell LN, Graham JD, Bouton AH et al. (2006) Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway. Oncogene 25:7597-607 (Pubitemid 44924473)
16. Cowin A, Adams D, Strudwick X et al. (2007) Flightless I deficiency enhances wound repair by increasing cell migration and proliferation. J Pathol 211:572-81 (Pubitemid 46502434)
17. Cowin AJ, Adams D, Geary SM et al. (2006) Wound healing is defective in mice lacking tetraspanin CD151. J Invest Dermatol 126:680-9 (Pubitemid 43255660)
18. Davy DA, Ball EE, Matthaei KI et al. (2000) The flightless I protein localizes to actin-based structures during embryonic development. Immunol Cell Biol 78:423-9 (Pubitemid 30655568)
19. Davy DA, Campbell HD, Fountain S et al. (2001) The flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts: evidence for the involvement of PI 3-kinase and Ras-related small GTPases. J Cell Sci 114:549-62 (Pubitemid 32186112)
20. Geary SM, Cowin AJ, Copeland B et al. (2008) The role of the tetraspanin CD151 in primary keratinocyte and fibroblast functions: implications for wound healing. Exp Cell Res 314:2165-75
21. Geiger B, Bershadsky A (2001) Assembly and mechanosensory function of focal contacts. Curr Opin Cell Biol 13:584-92 (Pubitemid 32817017)
22. Goetz JG (2009) Bidirectional control of the inner dynamics of focal adhesions promotes cell migration. Cell Adh Migr 3:185-90
23. Higashi T, Ikeda T, Murakami T et al. (2010) Flightless-I (Fli-I) regulates the actin assembly activity of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperation with active Rho GTPase. J Biol Chem 285:16231-8
24. Kaibuchi K, Kuroda S, Amano M (1999) Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. Annu Rev Biochem 68:459-86 (Pubitemid 29449200)
25. Kligys K, Jones JC (2009) Flii control: balancing migration and adhesion. J Invest Dermatol 129:1856-8
26. Kopecki Z, Arkell R, Powell BC et al. (2009) Flightless I regulates hemidesmosome formation and integrin-mediated cellular adhesion and migration during wound repair. J Invest Dermatol 129:2031-45
27. Kopecki Z, Cowin AJ (2008) Flightless I: an actin-remodelling protein and an important negative regulator of wound repair. Int J Biochem Cell Biol 40:1415-9 (Pubitemid 351626699)
28. Lunn JA, Rozengurt E (2004) Hyperosmotic stress induces rapid focal adhesion kinase phosphorylation at tyrosines 397 and 577. Role of Src family kinases and Rho family GTPases. J Biol Chem 279:45266-78 (Pubitemid 39430942)
29. Moser M, Legate KR, Zent R et al. (2009) The tail of integrins, talin, and kindlins. Science 324:895-9
30. Panetti TS (2002) Tyrosine phosphorylation of paxillin, FAK, and p130CAS: effects on cell spreading and migration. Front Biosci 7:143-50
31. Shah M, Foreman DM, Ferguson MW (1995) Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring. J Cell Sci 108:985-1002
32. Sharma A, Mayer BJ (2008) Phosphorylation of p130Cas initiates Rac activation and membrane ruffling. BMC Cell Biol 9:50-65
33. Tominaga T, Sahai E, Chardin P et al. (2000) Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling. Mol Cell 5:13-25 (Pubitemid 30105432)
34. Turner CE (1998) Paxillin. Int J Biochem Cell Biol 30:955-9
35. Webb DJ, Donais K, Whitmore LA et al. (2004) FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol 6:154-61 (Pubitemid 38425715)
36. Zaidel-Bar R, Milo R, Kam Z et al. (2007) A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions. J Cell Sci 120:137-48 (Pubitemid 46206656)