Inhibition of NADPH-cytochrome P450 reductase by tannic acid in rat liver microsomes and primary hepatocytes: Methodological artifacts and application to ischemia-reperfusion injury

Journal of Pharmaceutical Sciences

Volumn 100, Issue 8, 2011, Pages 3495-3505

  Pillai, Venkateswaran C ^a   Mehvar, Reza ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Cell culture; Drug metabolizing enzymes; Hepatocytes; Inhibition; Microsomes; NADPH Cytochrome P450 reductase; Protein binding; Simulated ischemia reperfusion injury; Tannic acid

Indexed keywords

CYTOCHROME C; CYTOCHROME P450 REDUCTASE; REACTIVE OXYGEN METABOLITE; RECOMBINANT ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TANNIN;

ANIMAL CELL; ARTICLE; ARTIFACT; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ASSAY; ENZYME INHIBITION; IC 50; LIVER CELL; LIVER INJURY; LIVER ISCHEMIA; LIVER MICROSOME; MALE; NONHUMAN; RAT; REDUCTION;

EID: 79958803717     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22531     Document Type: Article

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