Non-invasive product temperature determination during primary drying using tunable diode laser absorption spectroscopy

Journal of Pharmaceutical Sciences

Volumn 98, Issue 9, 2009, Pages 3406-3418

  Schneid, Stefan C ^a   Gieseler, Henning ^a   Kessler, William J ^b   Pikal, Michael J ^c  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b PHYSICAL SCIENCES INC   (United States)

^c UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

End point monitor; Freeze drying; Process analytical technology; Product temperature measurement; Vial heat transfer coefficient

Indexed keywords

GLYCINE; MANNITOL; SUCROSE;

ABSORPTION SPECTROSCOPY; ANALYTIC METHOD; ARTICLE; FLOW RATE; FREEZE DRYING; GRAVIMETRY; HEAT TRANSFER; NON INVASIVE PROCEDURE; SENSOR; STEADY STATE; TEMPERATURE; TUNABLE DIODE LASER ABSORPTION SPECTROSCOPY; WATER VAPOR;

EID: 68949105464     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21522     Document Type: Article

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