Plk2 Raps up Ras to subdue synapses

Small GTPases

Volumn 2, Issue 3, 2011, Pages 162-166

  Lee, Kea Joo ^a   Hoe, Hyang Sook ^a   Pak, Daniel T S ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

AMPA receptors; Dendritic spines; GAP; GEF; Homeostatic synaptic plasticity; PDZGEF1; Plk2; Rap; Ras; RasGRF1; SNK; SPAR; SynGAP

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; POLO LIKE KINASE 2; RAP PROTEIN; RAS PROTEIN;

ADAPTATION; ARTICLE; BEHAVIOR; DENDRITIC SPINE; ENZYME ACTIVITY; HOMEOSTASIS; LEARNING; NERVE CELL; NERVE CELL PLASTICITY; NONHUMAN; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SYNAPSE; TASK PERFORMANCE;

EID: 79958790100     PISSN: 21541248     EISSN: 21541256     Source Type: Journal    
DOI: 10.4161/sgtp.2.3.16454     Document Type: Article

References (49)

1. Turrigiano GG, Nelson SB. Hebb and homeostasis in neuronal plasticity. Curr Opin Neurobiol 2000; 10:358-64; PMID: 10851171; DOI:10.1016/S0959-4388(00)00091-X.
2. Pozo K, Goda Y. Unraveling mechanisms of homeostatic synaptic plasticity. Neuron 2010; 66:337-51; PMID: 20471348; DOI:10.1016/j.neuron. 2010.04.028.
3. Stornetta RL, Zhu JJ. Ras and rap signaling in synaptic plasticity and mental disorders. Neuroscientist 2011; 17:54-78; PMID: 20431046; DOI:10.1177/1073858410365562.
4. Ye X, Carew TJ. Small G protein signaling in neuronal plasticity and memory formation: the specific role of ras family proteins. Neuron 2010; 68:340-61; PMID: 21040840; DOI:10.1016/j.neuron. 2010.09.013.
5. Cook SJ, Rubinfeld B, Albert I, McCormick F. RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. EMBO J 1993; 12:3475-85; PMID: 8253074.
6. Kitayama H, Sugimoto Y, Matsuzaki T, Ikawa Y, Noda M. A ras-related gene with transformation suppressor activity. Cell 1989; 56:77-84; PMID: 2642744; DOI:10.1016/0092-8674(89)90985-9.
7. Harvey CD, Yasuda R, Zhong H, Svoboda K. The spread of ras activity triggered by activation of a single dendritic spine. Science 2008; 321:136-40; PMID: 18556515; DOI:10.1126/science.1159675.
8. Zhu JJ, Qin Y, Zhao M, Van Aelst L, Malinow R. Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Cell 2002; 110:443-55; PMID: 12202034; DOI:10.1016/S0092-8674(02)00897-8.
9. Kielland A, Bochorishvili G, Corson J, Zhang L, Rosin DL, Heggelund P, et al. Activity patterns govern synapse-specific AMPA receptor trafficking between deliverable and synaptic pools. Neuron 2009; 62:84-101; PMID: 19376069; DOI:10.1016/j. neuron.2009.03.001.
10. McCormack SG, Stornetta RL, Zhu JJ. Synaptic AMPA receptor exchange maintains bidirectional plasticity. Neuron 2006; 50:75-88; PMID: 16600857; DOI:10.1016/j.neuron.2006.02.027.
11. Qin Y, Zhu Y, Baumgart JP, Stornetta RL, Seidenman K, Mack V, et al. State-dependent Ras signaling and AMPA receptor trafficking. Genes Dev 2005; 19:2000-15; PMID: 16107614; DOI:10.1101/gad.342205.
12. Arendt T, Gartner U, Seeger G, Barmashenko G, Palm K, Mittmann T, et al. Neuronal activation of Ras regulates synaptic connectivity. Eur J Neurosci 2004; 19:2953-66; PMID: 15182302; DOI:10.1111/j.0953-816X.2004.03409.x.
13. Wu GY, Deisseroth K, Tsien RW. Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology. Nat Neurosci 2001; 4:151-8; PMID: 11175875; DOI:10.1038/83976.
14. Fu Z, Lee SH, Simonetta A, Hansen J, Sheng M, Pak DT. Differential roles of Rap1 and Rap2 small GTPases in neurite retraction and synapse elimination in hippocampal spiny neurons. J Neurochem 2007; 100:118-31; PMID: 17227435; DOI:10.1111/j.1471-4159.2006.04195.x.
15. Pak DT, Yang S, Rudolph-Correia S, Kim E, Sheng M. Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Neuron 2001; 31:289-303; PMID: 11502259; DOI:10.1016/S0896-6273(01)00355-5.
16. Ryu J, Futai K, Feliu M, Weinberg R, Sheng M. Constitutively active Rap2 transgenic mice display fewer dendritic spines, reduced extracellular signal-regulated kinase signaling, enhanced long-term depression and impaired spatial learning and fear extinction. J Neurosci 2008; 28:8178-88; PMID: 18701680; DOI:10.1523/JNEUROSCI.1944-08.2008.
17. Zhu Y, Pak D, Qin Y, McCormack SG, Kim MJ, Baumgart JP, et al. Rap2-JNK removes synaptic AMPA receptors during depotentiation. Neuron 2005; 46:905-16; PMID: 15953419; DOI:10.1016/j. neuron.2005.04.037.
18. Morozov A, Muzzio IA, Bourtchouladze R, Van-Strien N, Lapidus K, Yin D, et al. Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning and memory. Neuron 2003; 39:309-25; PMID: 12873387; DOI:10.1016/S0896-6273(03)00404-5.
19. Pan BX, Vautier F, Ito W, Bolshakov VY, Morozov A. Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1. J Neurosci 2008; 28:2089-98; PMID: 18305243; DOI:10.1523/JNEUROSCI.5156-07.2008.
20. Manabe T, Aiba A, Yamada A, Ichise T, Sakagami H, Kondo H, et al. Regulation of long-term potentiation by H-Ras through NMDA receptor phosphorylation. J Neurosci 2000; 20:2504-11; PMID: 10729330.
21. Thornton C, Yaka R, Dinh S, Ron D. H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activity. J Biol Chem 2003; 278:23823-9; PMID: 12695509; DOI:10.1074/jbc.M302389200.
22. Mochizuki N, Yamashita S, Kurokawa K, Ohba Y, Nagai T, Miyawaki A, et al. Spatio-temporal images of growth-factor-induced activation of Ras and Rap1. Nature 2001; 411:1065-8; PMID: 11429608; DOI:10.1038/35082594.
23. Bos JL, Rehmann H, Wittinghofer A. GEFs and GAPs: critical elements in the control of small G proteins. Cell 2007; 129:865-77; PMID: 17540168; DOI:10.1016/j.cell.2007.05.018.
24. Thomas GM, Huganir RL. MAPK cascade signalling and synaptic plasticity. Nat Rev Neurosci 2004; 5:173-83; PMID: 14976517; DOI:10.1038/nrn1346.
25. Ye X, Shobe JL, Sharma SK, Marina A, Carew TJ. Small G proteins exhibit pattern sensitivity in MAPK activation during the induction of memory and synaptic facilitation in Aplysia. Proc Natl Acad Sci USA 2008; 105:20511-6; PMID: 19075231; DOI:10.1073/pnas.0808110105.
26. Lee KJ, Lee Y, Rozeboom A, Lee JY, Udagawa N, Hoe HS, et al. Requirement for plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity and memory. Neuron 2011; 69:957-73; PMID: 21382555; DOI:10.1016/j.neuron.2011.02.004.
27. Donohue PJ, Alberts GF, Guo Y, Winkles JA. Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase. J Biol Chem 1995; 270:10351-7; PMID: 7730342; DOI:10.1074/jbc.270.17.10351.
28. Seeburg DP, Pak D, Sheng M. Polo-like kinases in the nervous system. Oncogene 2005; 24:292-8; PMID: 15640845; DOI:10.1038/sj.onc.1208277.
29. Simmons DL, Neel BG, Stevens R, Evett G, Erikson RL. Identification of an early-growth-response gene encoding a novel putative protein kinase. Mol Cell Biol 1992; 12:4164-9; PMID: 1508211.
30. Lowery DM, Lim D, Yaffe MB. Structure and function of Polo-like kinases. Oncogene 2005; 24:248-59; PMID: 15640840; DOI:10.1038/sj.onc.1208280.
31. Kauselmann G, Weiler M, Wulff P, Jessberger S, Konietzko U, Scafidi J, et al. The polo-like protein kinases Fnk and Snk associate with a Ca(2+)-and integrin-binding protein and are regulated dynamically with synaptic plasticity. EMBO J 1999; 18:5528-39; PMID: 10523297; DOI:10.1093/emboj/18.20.5528.
32. Pak DT, Sheng M. Targeted protein degradation and synapse remodeling by an inducible protein kinase. Science 2003; 302:1368-73; PMID: 14576440; DOI:10.1126/science.1082475.
33. Seeburg DP, Feliu-Mojer M, Gaiottino J, Pak DT, Sheng M. Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity. Neuron 2008; 58:571-83; PMID: 18498738; DOI:10.1016/j.neuron.2008.03.021.
34. Seeburg DP, Sheng M. Activity-induced Polo-like kinase 2 is required for homeostatic plasticity of hippocampal neurons during epileptiform activity. J Neurosci 2008; 28:6583-91; PMID: 18579731; DOI:10.1523/JNEUROSCI.1853-08.2008.
35. Vazquez LE, Chen HJ, Sokolova I, Knuesel I, Kennedy MB. SynGAP regulates spine formation. J Neurosci 2004; 24:8862-72; PMID: 15470153; DOI:10.1523/JNEUROSCI.3213-04.2004.
36. Krapivinsky G, Medina I, Krapivinsky L, Gapon S, Clapham DE. SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron 2004; 43:563-74; PMID: 15312654; DOI:10.1016/j.neuron.2004.08.003.
37. Pena V, Hothorn M, Eberth A, Kaschau N, Parret A, Gremer L, et al. The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction. EMBO Rep 2008; 9:350-5; PMID: 18323856; DOI:10.1038/embor.2008.20.
38. Oh JS, Manzerra P, Kennedy MB. Regulation of the neuron-specific Ras GTPase-activating protein, synGAP, by Ca2+/calmodulin-dependent protein kinase II. J Biol Chem 2004; 279:17980-8; PMID: 14970204; DOI:10.1074/jbc.M314109200.
39. Farnsworth CL, Freshney NW, Rosen LB, Ghosh A, Greenberg ME, Feig LA. Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF. Nature 1995; 376:524-7; PMID: 7637786; DOI:10.1038/376524a0.
40. Woolfrey KM, Srivastava DP, Photowala H, Yamashita M, Barbolina MV, Cahill ME, et al. Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines. Nat Neurosci 2009; 12:1275-84; PMID: 19734897; DOI:10.1038/nn.2386.
41. Evers DM, Matta JA, Hoe HS, Zarkowsky D, Lee SH, Isaac JT, et al. Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. Nat Neurosci 2010; 13:1199-207; PMID: 20802490; DOI:10.1038/nn.2624.
42. Brambilla R, Gnesutta N, Minichiello L, White G, Roylance AJ, Herron CE, et al. A role for the Ras signalling pathway in synaptic transmission and long-term memory. Nature 1997; 390:281-6; PMID: 9384379; DOI:10.1038/36849.
43. Shou C, Farnsworth CL, Neel BG, Feig LA. Molecular cloning of cDNAs encoding a guanine-nucleotidereleasing factor for Ras p21. Nature 1992; 358:351-4; PMID: 1379346; DOI:10.1038/358351a0.
44. de Rooij J, Boenink NM, van Triest M, Cool RH, Wittinghofer A, Bos JL. PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2. J Biol Chem 1999; 274:38125-30; PMID: 10608883; DOI:10.1074/jbc.274.53.38125.
45. Liao Y, Kariya K, Hu CD, Shibatohge M, Goshima M, Okada T, et al. RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1Aassociating domain, is conserved between nematode and humans. J Biol Chem 1999; 274:37815-20; PMID: 10608844; DOI:10.1074/jbc.274.53.37815.
46. Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB. A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II. Neuron 1998; 20:895-904; PMID: 9620694; DOI:10.1016/S0896-6273(00)80471-7.
47. Kim JH, Liao D, Lau LF, Huganir RL. SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. Neuron 1998; 20:683-91; PMID: 9581761; DOI:10.1016/S0896-6273(00)81008-9.
48. Krapivinsky G, Krapivinsky L, Manasian Y, Ivanov A, Tyzio R, Pellegrino C, et al. The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Neuron 2003; 40:775-84; PMID: 14622581; DOI:10.1016/S0896-6273(03)00645-7.
49. Ohtsuka T, Hata Y, Ide N, Yasuda T, Inoue E, Inoue T, et al. nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM). Biochem Biophys Res Commun 1999; 265:38-44; PMID: 10548487; DOI:10.1006/bbrc.1999.1619.