Bacterial infections in Wegener's granulomatosis: Mechanisms potentially involved in autoimmune pathogenesis

Current Opinion in Rheumatology

Volumn 23, Issue 4, 2011, Pages 366-371

  Tadema, Henko ^a   Heeringa, Peter ^a   Kallenberg, Cees G M ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

infection; Pr3 ANCA; Staphylococcus aureus; Toll like receptors; Wegener's granulomatosis

Indexed keywords

BACTERIAL PROTEIN; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; FIMH PROTEIN; GLOMERULUS BASEMENT MEMBRANE ANTIBODY; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MYELOBLASTIN; MYELOPEROXIDASE ANTIBODY; NEUTROPHIL CYTOPLASMIC ANTIBODY; SUPERANTIGEN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TOXIC SHOCK SYNDROME TOXIN 1; UNCLASSIFIED DRUG;

ANCA ASSOCIATED VASCULITIS; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; BACTERIAL INFECTION; DISEASE ASSOCIATION; GLOMERULONEPHRITIS; HELICOBACTER PYLORI; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; MOLECULAR MIMICRY; NONHUMAN; PATHOPHYSIOLOGY; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; T LYMPHOCYTE; WEGENER GRANULOMATOSIS;

BACTERIAL INFECTIONS; HUMANS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; WEGENER GRANULOMATOSIS;

EID: 79958789044     PISSN: 10408711     EISSN: 15316963     Source Type: Journal    
DOI: 10.1097/BOR.0b013e328346c332     Document Type: Article

References (56)

1. Jennette JC, Falk RJ, Andrassy K, et al. Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum 1994; 37:187-192. (Pubitemid 24065492)
2. Heeringa P, Tervaert JW. Pathophysiology of ANCA-associated vasculitides: are ANCA really pathogenic? Kidney Int 2004; 65:1564-1567. (Pubitemid 38591002)
3. Kallenberg CG. Pathogenesis of PR3-ANCA associated vasculitis. J Auto-immun 2008; 30:29-36.
4. Falk RJ, Terrell RS, Charles LA, Jennette JC. Antineutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci USA 1990; 87:4115-4119. (Pubitemid 20217992)
5. Swain SD, Rohn TT, Quinn MT. Neutrophil priming in host defense: role of oxidants as priming agents. Antioxid Redox Signal 2002; 4:69-83. (Pubitemid 34260688)
6. Van der Veen BS, Chen M, Muller R, et al. Effects of p38 mitogen-activated protein kinase inhibition on antineutrophil cytoplasmic autoantibody patho-genicity in vitro and in vivo. Ann Rheum Dis 2011; 70:356-365.
7. Lamprecht P, Wieczorek S, Epplen JT, et al. Granuloma formation in ANCA-associated vasculitides. APMIS Suppl 2009; 32-36.
8. Wegener F. Uber eine eigenartige rhinogene Granulomatose mit besonderer Beteiligung des Arteriensystems under Nieren. Beitr Pathol 1939; 102:36-68.
9. Pinching AJ, Rees AJ, Pussell BA, et al. Relapses in Wegener's granuloma-tosis: the role of infection. Br Med J 1980; 281:836-838. (Pubitemid 10059945)
10. Dowell SF, Ho MS. Seasonality of infectious diseases and severe acute respiratory syndrome: what we don't know can hurt us. Lancet Infect Dis 2004; 4:704-708. (Pubitemid 39452524)
11. Aries PM, Herlyn K, Reinhold-Keller E, Latza U. No seasonal variation in the onset of symptoms of 445 patients with Wegener's granulomatosis. Arthritis Rheum 2008; 59:904. (Pubitemid 351847576)
12. Stegeman CA, Tervaert JW, Sluiter WJ, et al. Association of chronic nasal carriage of Staphylococcus aureus and higher relapse rates in Wegener's granulomatosis. Ann Intern Med 1994; 120:12-17. (Pubitemid 24011495)
13. Zycinska K, Wardyn KA, Zielonka TM, et al. Chronic crusting, nasal carriage of Staphylococcus aureus and relapse rate in pulmonary Wegener's granulomatosis. J Physiol Pharmacol 2008; 59 (Suppl 6):825-831.
14. Laudien M, Gadola SD, Podschun R, et al. Nasal carriage of Staphylococcus aureus and endonasal activity in Wegener's granulomatosis as compared to rheumatoid arthritis and chronic rhinosinusitis with nasal polyps. Clin Exp Rheumatol 2010; 28:51-55.
15. Richter AG, Stockley RA, Harper L, Thickett DR. Pulmonary infection in Wegener's granulomatosis and idiopathic pulmonary fibrosis. Thorax 2009; 64:692-697.
16. Stegeman CA, Tervaert JW, de Jong PE, Kallenberg CG. Trimethoprim- sulfamethoxazole (co-trimoxazole) forthe prevention of relapses of Wegener's granulomatosis. Dutch Co-Trimoxazole Wegener Study Group. N Engl J Med 1996; 335:16-20. (Pubitemid 26230808)
17. Zycinska K, Wardyn KA, Zielonka TM, et al. Co-trimoxazole and prevention of relapses of PR3-ANCA positive vasculitis with pulmonary involvement. Eur J Med Res 2009; 14 (Suppl 4):265-267.
18. Lidar M, Lipschitz N, Langevitz P, et al. Infectious serologies and autoantibodies in Wegener's granulomatosis and other vasculitides: novel associations disclosed using the Rad Bio Plex 2200. Ann N YAcad Sci 2009; 1173:649-657.
19. Zycinska K, Wardyn KA, Zycinski Z, Smolarczyk R. Correlation between Helicobacter pylori infection and pulmonary Wegener's granulomatosis activity. J Physiol Pharmacol 2008; 59 (Suppl 6):845-851.
20. Blank M, Barzilai O, Shoenfeld Y. Molecular mimicry and auto-immunity. Clin Rev Allergy Immunol 2007; 32:111-118. (Pubitemid 46594581)
21. Hughes RA, Cornblath DR. Guillain-Barre syndrome. Lancet 2005; 366: 1653-1666.
22. Carapetis JR, McDonald M, Wilson NJ. Acute rheumatic fever. Lancet 2005; 366:155-168. (Pubitemid 40991218)
23. Wegner N, Wait R, Sroka A, et al. Peptidylarginine deiminase from Porphyr-omonas gingivalis citrullinates human fibrinogen and alpha-enolase: implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum 2010; 62:2662-2672.
24. Mikuls TR, Payne JB, Reinhardt RA, et al. Antibody responses to Porphyr-omonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. Int Immunopharmacol 2009; 9:38-42.
25. Pendergraft WF III, Preston GA, Shah RR, et al. Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen protei-nase-3. Nat Med 2004; 10:72-79. (Pubitemid 38524701)
26. Kain R, Exner M, Brandes R, et al. Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis. Nat Med 2008; 14:1088-1096.
27. Popa ER, Stegeman CA, Abdulahad WH, et al. Staphylococcal toxic-shock-syndrome-toxin-1 as a risk factor for disease relapse in Wegener's granulomatosis. Rheumatology (Oxford) 2007; 46:1029-1033. (Pubitemid 47062516)
28. Abdulahad WH, Stegeman CA, Kallenberg CG. Review article: the role of CD4(+)T cells in ANCA-associated systemic vasculitis. Nephrology (Carlton) 2009; 14:26-32.
29. Popa ER, Stegeman CA, Bos NA, et al. Staphylococcal superantigens and T cell expansions in Wegener's granulomatosis. Clin Exp Immunol 2003; 132:496-504. (Pubitemid 36713957)
30. Abdulahad WH, Stegeman CA, Limburg PC, Kallenberg CG. Skewed distribution of Th17 lymphocytes in patients with Wegener's granulomatosis in remission. Arthritis Rheum 2008; 58:2196-2205. (Pubitemid 351988114)
31. Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 2010; 11:373-384.
32. Takeuchi O, Hoshino K, Akira S. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol 2000; 165:5392-5396.
33. Stenzel W, Soltek S, Sanchez-Ruiz M, et al. Both TLR2 and TLR4 are required forthe effective immune response in Staphylococcus aureus-induced experimental murine brain abscess. Am J Pathol 2008; 172:132-145. (Pubitemid 351186375)
34. Capolunghi F, Rosado MM, Cascioli S, et al. Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients. Oxford: Rheumatology; 2010.
35. Hurtado PR, Jeffs L, Nitschke J, et al. CpG oligodeoxynucleotide stimulates production of antineutrophil cytoplasmic antibodies in ANCA associated vasculitis. BMC Immunol 2008; 9:34.
36. Tadema H, Abdulahad WH, Lepse N, et al. Bacterial DNA motifs trigger ANCA production in ANCA-associated vasculitis in remission. Oxford: Rheu matology; 2010.
37. Xiao H, Heeringa P, Hu P, et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest 2002; 110:955-963.
38. Huugen D, Xiao H, van Esch A, et al. Aggravation of antimyeloperoxidase antibody-induced glomerulonephritis by bacterial lipopolysaccharide: role of tumor necrosis factor-alpha. Am J Pathol 2005; 167:47-58. (Pubitemid 40884769)
39. Summers SA, van der Veen BS, O'Sullivan KM, et al. Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis. Kidney Int 2010; 78:1263-1274.
40. Summers SA, Steinmetz OM, Gan PY, et al. TLR2 induces Th17 myeloper-oxidase autoimmunity, while TLR9 drives Th1 autoimmunity. Arthritis Rheum 2011; 63:1124-1135.
41. Deng J, Ma-Krupa W, Gewirtz AT, et al. Toll-like receptors 4 and 5 induce distinct types of vasculitis. Circ Res 2009; 104:488-495.
42. Okamoto Yoshida Y, Umemura M, Yahagi A, et al. Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung. J Immunol 2010; 184:4414-4422.
43. Niebuhr M, Gathmann M, Scharonow H, et al. Staphylococcal a-toxin is a strong inducerof interleukin (IL)-17 in humans. Infect Immun 2011; 79:1615-1622.
44. Cho JS, Pietras EM, Garcia NC, et al. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest 2010; 120:1762-1773.
45. Horton CG, Pan ZJ, Farris AD. Targeting Toll-like receptors for treatment of SLE. Mediators Inflamm 2010.
46. McCormack WJ, Parker AE, O'Neill LA. Toll-like receptors and NOD-like receptors in rheumatic diseases. Arthritis Res Ther 2009; 11:243.
47. Tadema H, Abdulahad WH, Stegeman CA, et al. Expression of Toll-like receptors 2, 4 and 9 by peripheral blood leukocytes in patients with ANCA-associated vasculitis [abstract]. Arthritis Rheum 2010; 62 (Suppl 10):2023.
48. Batsford S, Duermueller U, Seemayer C, et al. Protein level expression of Tolllike receptors 2, 4 and 9 in renal disease. Nephrol Dial Transplant 2011.
49. Schilder AM. Wegener's granulomatosis vasculitis and granuloma. Autoim-mun Rev 2010; 9:483-487.
50. Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria. Science 2004; 303:1532-1535. (Pubitemid 38314426)
51. Kessenbrock K, Krumbholz M, Schonermarck U, et al. Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med 2009; 15:623-625.
52. Pilsczek FH, Salina D, Poon KK, et al. A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus. J Immunol 2010; 185:7413-7425.
53. Leadbetter EA, Rifkin IR, Hohlbaum AM, et al. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 2002; 416:603-607. (Pubitemid 34406754)
54. Tuon FF, Fernandes ER, Pagliari C, et al. The expression of TLR9 in human cutaneous leishmaniasis is associated with granuloma. Parasite Immunol 2010; 32:769-772.
55. Velayudham A, Hritz I, Dolganiuc A, et al. Critical role of Toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury. J Hepatol 2006; 45:813-824. (Pubitemid 44646677)
56. Ito T, Schaller M, Hogaboam CM, et al. TLR9 regulates the mycobacteria-elicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4. J Clin Invest 2009; 119:33-46.