Perinatal exposure to low-dose DE-71 increases serum thyroid hormones and gonadal osteopontin gene expression

Experimental Biology and Medicine

Volumn 236, Issue 4, 2011, Pages 445-455

  Blake, Charles A ^a   McCoy, George L ^b   Hui, Yvonne Y ^a   la voie, Holly A ^a  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b BENEDICT COLLEGE   (United States)

Author keywords

DE 71; Osteopontin; Ovary; PBDE; T3; T4; Testis; Thyroid gland; Thyroid hormone

Indexed keywords

DE 71; LIOTHYRONINE; MESSENGER RNA; OSTEOPONTIN; POLYBROMINATED DIPHENYL ETHER; THYROXINE; UNCLASSIFIED DRUG; DIPHENYL ETHER DERIVATIVE; PENTABROMODIPHENYL ETHER; PRIMER DNA; THYROID HORMONE;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIRTH; CONTROLLED STUDY; FEMALE; GENE CONTROL; GENE OVEREXPRESSION; GRANULOSA CELL; IN VITRO STUDY; INGESTION; KIDNEY; LACTATION; LIOTHYRONINE BLOOD LEVEL; LIVER; MALE; NONHUMAN; ORGAN WEIGHT; OVARY; PERINATAL PERIOD; PREGNANCY; PRENATAL EXPOSURE; PROMOTER REGION; RAT; SPLEEN; TESTIS; THYROID FUNCTION; THYROID GLAND; THYROXINE BLOOD LEVEL; WEIGHT REDUCTION; ANIMAL; BLOOD; DOSE RESPONSE; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION; GENETICS; IMMUNOHISTOCHEMISTRY; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; RADIOIMMUNOASSAY;

ANIMALIA; RATTUS; RODENTIA;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION; HALOGENATED DIPHENYL ETHERS; IMMUNOHISTOCHEMISTRY; MALE; MATERNAL EXPOSURE; OSTEOPONTIN; POLYMERASE CHAIN REACTION; RADIOIMMUNOASSAY; RATS; RNA, MESSENGER; THYROID HORMONES;

EID: 79958786756     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1258/ebm.2010.010334     Document Type: Article

References (42)

1. Siddiqi MA, Laessig RH, Reed KD. Polybrominated diphenyl ethers (PBDEs): new pollutants-old diseases. Clin Med Res 2003;1:281-290
2. Darnerud PO. Toxic effects of brominated flame retardants in man and in wildlife. Environ Int 2003;29:841-853
3. Darnerud PO, Eriksen GS, Jóannesson T, Larsen PB, Viluksela M. Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology. Environ Health Perspect 2001;109(Suppl 1):49-68
4. Schecter A, Páke O, Harris TR, Tung KC, Musumba A, Olson J, Birnbaum L. Polybrominated diphenyl ether (PBDE) levels in an expanded market basket survey of U.S. food and estimated PBDE dietary intake by age and sex. Environ Health Perspect 2006;114:1515-1520
5. Schecter A, Páke O, Tung KC, Joseph J, Harris TR, Dahlgren J. Polybrominated diphenyl ether flame retardants in the U.S. population: current levels, temporal trends, and comparison with dioxins, dibenzofurans, and polychlorinated biphenyls. J Occup Environ Med 2005;47:199-211
6. Darnerud PO, Atuma S, Aune M, Bjerselius R, Glynn A, Grawe KP, Becker W. Dietary intake estimations of organohalogen contaminants (dioxins, PCB, PBDE and chlorinated pesticides, e.g. DDT) based on Swedish market basket data. Food Chem Toxicol 2006;44:1597-1606
7. Stapleton HM, Dodder NG, Offenberg JH, Schantz MM, Wise SA. Polybrominated diphenyl ethers in house dust and clothes dryer lint. Environ Sci Technol 2005;39:925-31
8. Schecter A, Johnson-Welch S, Tung KC, Harris TR, Papke O, Rosen R. Polybrominated diphenyl ether (PBDE) levels in livers of U.S. humanfetuses and newborns. J Toxicol Environ Health A 2007;70:1-6
9. Meerts IA, Letcher RJ, Hoving S, Marsh G, Bergman A, Lemmen JG, van der BB, Brouwer A. In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PDBEs, and polybrominated bisphenol A compounds. Environ Health Perspect 2001;109:399-407
10. Stoker TE, Cooper RL, Lambright CS, Wilson VS, Furr J, Gray LE. In vivo and in vitro anti-androgenic effects of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture. Toxicol Appl Pharmacol 2005;207:78-88
11. Mercado-Feliciano M, Bigsby RM. The polybrominated diphenyl ether mixture DE-71 is mildly estrogenic. Environ Health Perspect 2008;116:605-11
12. Gillio-Meina C, Hui YY, LaVoie HA. GATA-4 and GATA-6 transcription factors: expression, immunohistochemical localization, and possible function in the porcine ovary. Biol Reprod 2003;68:412-422
13. LaVoie HA, Garmey JC, Day RN, Veldhuis JD. Concerted regulation of the low density lipoprotein receptor gene expression by FSH and IGF-I in porcine granulosa cells: promoter activation, mRNA stability, and sterol feedback. Endocrinology 1999;140:178-186
14. Ho CK, Strauss JF III. Activation of the control reporter plasmids pRL-TK and pRL-SV40 by multiple GATA transcription factors can leadto aberrant normalization of transfection efficiency. BMC Biotechnol 2004;4:10
15. Ridall AL, Daane EL, Dickinson DP, Butler WT. Characterization of the rat osteopontin gene. Evidence for two vitamin D response elements. Ann N Y Acad Sci 1995;760:59-66
16. Talsness CE, Shakibaei M, Kuriyama SN, Grande SW, Sterner-Kock A, Schnitker P, de Souza C, Grote K, Chahoud I. Ultrastructural changes observed in rat ovaries following in utero and lactational exposure to low doses of a polybrominated flame retardant. Toxicol Lett 2005;157:189-202
17. She J, Petreas M, Winkler J, Visita P, McKinney M, Kopec D. PBDEs in the San Francisco Bay Area: measurements in harbor seal blubber and human breast adipose tissue. Chemosphere 2002;46:697-707
18. Ceccatelli R, Faass O, Schlumpf M, Lichtensteiger W. Gene expression and estrogen sensitivity in rat uterus after developmental exposure to the polybrominated diphenylether PBDE 99 and PCB. Toxicology 2006;220:104-116
19. Kodavanti PR, Coburn CG, Moser VC, MacPhail RC, Fenton SE, Stoker TE, Rayner JL, Kannan K, Birnbaum LS. Developmental exposure to a commercial PBDE mixture, DE-71: neurobehavioral, hormonal, and reproductive effects. Toxicol Sci 2010;116:297-312
20. Lilienthal H, Hack A, Roth-Harer A, Grande SW, Talsness CE. Effects of developmental exposure to 2,2,4,4,5-pentabromodiphenyl ether (PBDE-99) on sex steroids, sexual development, and sexually dimorphic behavior in rats. Environ Health Perspect 2006;114:194-201
21. Stoker TE, Laws SC, Crofton KM, Hedge JM, Ferrell JM, Cooper RL. Assessment of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture, in the EDSP male and female pubertal protocols. Toxicol Sci 2004;78:144-155
22. Korenbrot CC, Huhtaniemi IT, Weiner RI. Preputial separation as an external sign of pubertal development in the male rat. Biol Reprod 1977;17:298-303
23. Kuriyama SN, Talsness CE, Grote K, Chahoud I. Developmental exposure to low dose PBDE 99: effects on male fertility and neurobehavior in rat offspring. Environ Health Perspect 2005;113:149-154
24. van der Ven LTM, van de Kuil T, Verhoef A, Leonards PE, Slob W, Cantó RF, Germer S, Hamers T, Visser TJ, Litens S, Håkansson H, Fery Y, Schrenk D, van den Berg M, Piersma AH, Vos JG. A 28-day oral dose toxicity study enhanced to detect endocrine effects of a purified technical pentabromodiphenyl ether (pentaBDE) mixture in Wistar rats. Toxicology 2008;245:109-122
25. Ellis-Hutchings RG, Cherr GN, Hanna LA, Keen CL. Polybrominated diphenyl ether (PBDE)-induced alterations in vitamin A and thyroid hormone concentrations in the rat during lactation and early postnatal development. Toxicol Appl Pharmacol 2006;215:135-145
26. Skarman E, Darnerud PO, Öhrvik H, Oskarsson A. Reduced thyroxine levels in mice perinatally exposed to polybrominated diphenyl ethers. Environ Toxicol Pharmacol 2005;19:273-281
27. Bondy GS, Gaertner D, Cherry W, Maclellan E, Coady L, Arnold DL, Doucet J, Rowsell PR. Brominated diphenyl ether (BDE) levels in liver, adipose, and milk from adult and juvenile rats exposed by gavage to the DE-71 technical mixture. Environ Toxicol 2010; DOI: 10.1002/tox.20603 (In press)
28. Zhou T, Ross DG, DeVito MJ, Crofton KM. Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats. Toxicol Sci 2001;61:76-82
29. Fowles JR, Fairbrother A, Baecher-Steppan L, Kerkvliet NI. Immunologic and endocrine effects of the flame-retardant pentabromodiphenyl ether (DE-71) in C57BL/6J mice. Toxicology 1994;86:49-61
30. Darnerud PO, Aune M, Larsson L, Hallgren S. Plasma PBDE and thyroxine levels in rats exposed to Bromkal or BDE-47. Chemosphere 2007;67:S386-S92
31. Eriksson P, Jakobsson E, Fredriksson A. Brominated flame retardants: a novel class of developmental neurotoxicants in our environment? Environ Health Perspect 2001;109:903-8
32. Branchi I, Alleva E, Costa LG. Effects of perinatal exposure to a polybrominated diphenyl ether (PBDE 99) on mouse neurobehavioural development. Neurotoxicology 2002;23:375-384
33. Harley KG, Marks AR, Chevrier J, Bradman A, Sjodin A, Eskenazi B. PBDE concentrations in women's serum and fecundability. Environ Health Perspect 2010;118:699-704
34. White FJ, Burghardt RC, Hu J, Joyce MM, Spencer TE, Johnson GA. Secreted phosphoprotein 1 (osteopontin) is expressed by stromal macrophages in cyclic and pregnant endometrium of mice, but is induced by estrogen in luminal epithelium during conceptus attachment for implantation. Reproduction 2006;132:919-929
35. Apparao KB, Illera MJ, Beyler SA, Olson GE, Osteen KG, Corjay MH, Boggess K, Lessey BA. Regulated expression of osteopontin in the peri-implantation rabbit uterus. Biol Reprod 2003;68:1484-1490
36. White FJ, Ross JW, Joyce MM, Geisert RD, Burghardt RC, Johnson GA. Steroid regulation of cell specific secreted phosphoprotein 1 (osteopontin) expression in the pregnant porcine uterus. Biol Reprod 2005;73:1294-1301
37. Denhardt DT, Noda M, O'Regan AW, Pavlin D, Berman JS. Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest 2001;107:1055-61
38. Skinner MK, Schmidt M, Savenkova MI, Sadler-Riggleman I, Nilsson EE. Regulation of granulosa and theca cell transcriptomes during ovarian antral follicle development. Mol Reprod Dev 2008;75:1457-1452
39. Shih I-M, Davidson B. Pathogenesis of ovarian cancer: clues from selected overexpressed genes. Future Oncol 2009;5:1641-1657
40. Schrader M, Muller KM, Carlberg C. Specificity and flexibility of vitamin D signaling. Modulation of the activation of natural vitamin D response elements by thyroid hormone. J Biol Chem 1994;269:5501-5504
41. Vanacker JM, Pettersson K, Gustafsson JA, Laudet V. Transcriptional targets shared by estrogen receptor- related receptors (ERRs) and estrogen receptor (ER) alpha, but not by ERbeta. EMBO J 1999;18:4270-4279
42. Vanacker JM, Delmarre C, Guo X, Laudet V. Activation of the osteopontin promoter by the orphan nuclear receptor estrogen receptor related alpha. Cell Growth Differ 1998;9:1007-114