DL-α-lipoic acid ameliorates cyclophosphamide induced cardiac mitochondrial injury

Toxicology

Volumn 215, Issue 1-2, 2005, Pages 108-114

  Mythili, Y ^a   Sudharsan, P T ^a   Varalakshmi, P ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Cyclophosphamide; Heart; Lipoic acid; Mitochondrial enzymes; Ultrastructure

Indexed keywords

CYCLOPHOSPHAMIDE; ISOCITRATE DEHYDROGENASE; MALATE DEHYDROGENASE; MITOCHONDRIAL ENZYME; SUCCINATE DEHYDROGENASE; THIOCTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL FUNCTION; CITRIC ACID CYCLE; CONTROLLED STUDY; CYTOTOXICITY; ELECTRON TRANSPORT; ENZYME ACTIVITY; HEART INJURY; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART MUSCLE INJURY; MALE; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; RAT; ULTRASTRUCTURE;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CYCLOPHOSPHAMIDE; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA, HEART; MITOCHONDRIAL DISEASES; RATS; RATS, WISTAR; THIOCTIC ACID;

EID: 26444605469     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2005.07.001     Document Type: Article

References (43)

1. 2+ dependent damage of rat heart and liver mitochondria by cyclosporin A Comp. Biochem. Physiol. A Mol. Integr. Physiol. 121 1998 209 214
2. C. Antozzi, and M. Zeviani Cardiomyopathies in disorders of oxidative metabolism Cardiovasc. Res. 35 1997 184 199
3. E. Bernt, and H.U. Bergmeyer Methods of Enzymatic Analysis 1974 Academic Press New York pp. 624-627
4. G.P. Biewenga, G.R. Haenen, and A. Bast The pharmacology of the antioxidant lipoic acid Gen. Pharmacol. 29 1997 315 331
5. R.F. Branda, E.M. Brooks, Z. Chen, S.J. Naud, and J.A. Nicklas Dietary modulation of mitochondrial DNA deletions and copy number after chemotherapy in rats Mutat. Res. 501 2002 29 36
6. J. Bustamante, J.K. Lodge, L. Marcocci, H.J. Tritschler, L. Packer, and B.H. Rihn Alpha-lipoic acid in liver metabolism and disease Free Radic. Biol. Med. 24 1998 1023 1039
7. Y. Capetanaki Desmin cytoskeleton: a potential regulator of muscle mitochondrial behavior and function Trends Cardiovasc. Med. 12 2002 339 348
8. M. Drouet, F. Lauthier, J.P. Charmes, P. Sauvage, and M.H. Ratinaud Age-associated changes in mitochondrial parameters on peripheral human lymphocytes Exp. Gerontol. 34 1999 843 852
9. S. Goffart, J.C. von Kleist-Retzow, and R.J. Wiesner Regulation of mitochondrial proliferation in the heart: power-plant failure contributes to cardiac failure in hypertrophy Cardiovasc. Res. 64 2004 198 207
10. M.A. Goldberg, J.H. Antin, E.C. Guinan, and J.M. Rappeport Cyclophosphamide cardiotoxicity: an analysis of dosing as a risk factor Blood 68 1986 1114 1118
11. D.E. Green, and R.K. Burkhard Studies on the electron transport system 33. Succinic-cytochrome c reductase Arch. Biochem. Biophys. 92 1961 312 320
12. A. Gvozdjakova, V. Bada, F. Kruty, and J. Gvozdjak The effect of cyclophosphamide on the myocardial oxidase system of mitochondria Cor Vasa. 24 1982 389 394
13. Y. Hanaki, S. Sugiyama, N. Akiyama, and T. Ozawa Role of the autonomic nervous system in cyclophosphamide-induced heart mitochondrial dysfunction in rats Biochem. Int. 21 1990 289 295
14. N. Haramaki, D. Han, G.J. Handelman, H.J. Tritschler, and L. Packer Cytosolic and mitochondrial systems for NADH- and NADPH-dependent reduction of alpha-lipoic acid Free Radic. Biol. Med. 22 1997 535 542
15. V.E. Kagan, A. Shvedova, E. Serbinova, S. Khan, C. Swanson, R. Powell, and L. Packer Dihydrolipoic acid - a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals Biochem. Pharmacol. 44 1992 1637 1649
16. C.K. Lee, G.S. Harman, R.J. Hohl, and R.D. Gingrich Fatal cyclophosphamide cardiomyopathy: its clinical course and treatment Bone Marrow Transplant. 18 1996 573 577
17. S.M. Lee, H.J. Koh, D.C. Park, B.J. Song, T.L. Huh, and J.W. Park Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells Free Radic. Biol. Med. 32 2002 1185 1196
18. G. Lenaz Role of mitochondria in oxidative stress and ageing Biochim. Biophys. Acta 1366 1998 53 67
19. K. Le-Quoc, D. Le-Quoc, and Y. Gaudemer Evidence for the existence of two classes of sulfhydryl groups essential for membrane-bound succinate dehydrogenase activity Biochemistry 20 1981 1705 1710
20. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J. Biol. Chem. 193 1951 265 275
21. A.H. Mehler, A. Kornberg, S. Grisolia, and S. Ochoa The enzymatic mechanism of oxidation-reductions between malate or isocitrate and pyruvate J. Biol. Chem. 174 1948 961 977
22. S. Melov, P.E. Coskun, and D.C. Wallace Mouse models of mitochondrial disease, oxidative stress, and senescence Mutat. Res. 434 1999 233 242
23. S. Minakami, R.L. Ringer, and T.P. Singer Studies on the respiratory chain-linked dihydrodiphosphopyridine nucleotide dehydrogenase I. Assay of the enzyme in particulate and in soluble preparations J. Biol. Chem. 237 1962 569 576
24. Y. Mythili, P.T. Sudharsan, E. Selvakumar, and P. Varalakshmi Protective effect of dl-alpha-lipoic acid on cyclophosphamide induced oxidative cardiac injury Chem. Biol. Interact. 151 2004 13 19
25. L. Packer, E.H. Witt, and H.J. Tritschler Alpha-Lipoic acid as a biological antioxidant Free. Radic. Biol. Med. 19 1995 227 250
26. G. Paradies, G. Petrosillo, M. Pistolese, and F.M. Ruggiero Reactive oxygen species generated by the mitochondrial chain affect the complex III activity via cardiolipin peroxidation in beef-heart submitochondrial particles Mitochondrion 1 2001 151 159
27. M. Patel, and T.E. Roche Molecular biology and biochemistry of pyruvate dehydrogenase complexes FASEB J. 4 1990 3224 3233
28. G.W. Plaut, M. Cook, and T. Aogaichi The subcellular location of isozymes of NADP-isocitrate dehydrogenase in tissues from pig, ox and rat Biochim. Biophys. Acta 760 1983 300 308
29. P. Rosenberg Mitochondrial dysfunction and heart disease Mitochondrion 4 2004 621 628
30. A. Saada, M. Bar-Meir, C. Belaiche, C. Miller, and O. Elpeleg Evaluation of enzymatic assays and compounds affecting ATP production in mitochondrial respiratory chain complex I deficiency Anal. Biochem. 335 2004 66 72
31. K. Schonheit, L. Gille, and H. Nohl Effect of alpha-lipoic acid and dihydrolipoic acid on ischemia/reperfusion injury of the heart and heart mitochondria Biochim. Biophys. Acta 1271 1995 335 342
32. C. Shanholtz Aute life-threatening toxicity of cancer treatment Crit. Care Clin. 17 2001 483 502
33. J.M. Shoffner, and D.C. Wallace Heart disease and mitochondrial DNA mutations Heart Dis. Stroke 1 1992 235 241
34. R.J. Singh Glutathione: a marker and antioxidant for aging J. Lab. Clin. Med. 140 2002 380 381
35. E.C. Slater, and W.D. Borner The effect of fluoride on the succinic oxidase system Biochem. J. 52 1952 185 196
36. R.S. Sohal Aging, cytochrome oxidase activity, and hydrogen peroxide release by mitochondria Free Radic. Biol. Med. 14 1993 583 588
37. A.K. Souid, K.A. Tacka, K.A. Galvan, and H.S. Penefsky Immediate effects of anticancer drugs on mitochondrial oxygen consumption Biochem. Pharmacol. 66 2003 977 987
38. A. Szewczyk, and L. Wojtczak Mitochondria as a pharmacological target Pharmacol. Rev. 54 2002 101 127
39. M. Takasawa, M. Hayakawa, S. Sugiyama, K. Hattori, T. Ito, and T. Ozawa Age-associated damage in mitochondrial function in rat hearts Exp. Gerontol. 28 1993 269 280
40. D.C. Wharton, and Tzagoloff Cytochrome oxidase from beef heart mitochondria Methods Enzymol. 10 1967 240 250
41. J. Wutzen Cyclophosphamide effect on ultrastructural myocardial changes in rats on low-magnesium diet Mater. Med. Pol. 24 1992 35 40
42. D.M. Ziegler, and K.A. Doeg Studies on the electron transport system The isolation of a succinic-coenzyme Q reductase from beef heart mitochondria Arch. Biochem. Biophys. 97 1962 41 50
43. D.B. Zorov, S.Y. Bannikova, V.V. Belousov, M.Y. Vyssokikh, L.D. Zorova, N.K. Isaev, B.F. Krasnikov, and E.Y. Plotnikov Reactive oxygen and nitrogen species: friends or foes? Biochemistry (Mosc.) 70 2005 215 221