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Volumn 12, Issue 10, 2011, Pages 1511-1521

Treatment of walking impairment in multiple sclerosis: An unmet need for a disease-specific disability

Author keywords

activities of daily living; dalfampridine; demyelination; disability; immunomodulators; multiple sclerosis; neurofunctional modifiers; potassium channel blocker; quality of life; walking impairment

Indexed keywords

4 AMINOPYRIDINE; BETA1A INTERFERON; CORTICOSTEROID; GLATIRAMER; IMMUNOMODULATING AGENT; INTERFERON BETA SERINE; MITOXANTRONE; NATALIZUMAB; NERISPIRDINE; PLACEBO;

EID: 79958748171     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.2011.586338     Document Type: Review
Times cited : (19)

References (101)
  • 1
    • 79958705850 scopus 로고    scopus 로고
    • Last accessed 15 December
    • National Multiple Sclerosis Society. About MS. Available from: http://www.nationalmssociety.org/about-multiplesclerosis/index.aspx [Last accessed 15 December 2010]
    • (2010) National Multiple Sclerosis Society. about MS
  • 2
    • 33745675511 scopus 로고    scopus 로고
    • Costs and quality of life in multiple sclerosis: A cross-sectional study in the United States
    • DOI 10.1212/01.wnl.0000218309.01322.5c, PII 0000611420060613000019
    • Kobelt G, Berg J, Atherly D, et al. Costs and quality of life in multiple sclerosis. A cross-sectional study in the United States. Neurology 2006;66:1696-702. (Pubitemid 43964625)
    • (2006) Neurology , vol.66 , Issue.11 , pp. 1696-1702
    • Kobelt, G.1    Berg, J.2    Atherly, D.3    Hadjimichael, O.4
  • 4
    • 0017745560 scopus 로고
    • Conduction in myelinated, unmyelinated, and demyelinated fibers
    • Waxman SG. Conduction in myelinated, unmyelinated, and demyelinated fibers. Arch Neurol 1977;34:585-9 (Pubitemid 8199510)
    • (1977) Archives of Neurology , vol.34 , Issue.10 , pp. 585-589
    • Waxman, S.G.1
  • 5
    • 0033982291 scopus 로고    scopus 로고
    • Effects of 4-aminopyridine on demyelinated axons, synapses and muscle tension
    • Smith KJ, Felts PA, John GR. Effects of 4-aminopyridine on demyelinated axons, synapses and muscle tension. Brain 2000;123:171-84 (Pubitemid 30037979)
    • (2000) Brain , vol.123 , Issue.1 , pp. 171-184
    • Smith, K.J.1    Felts, P.A.2    John, G.R.3
  • 7
    • 0032796747 scopus 로고    scopus 로고
    • Axonal pathology in multiple sclerosis: Relationship to neurologic disability
    • DOI 10.1097/00019052-199906000-00008
    • Trapp BD, Ransohoff R, Rudick R. Axonal pathology in multiple sclerosis: relationship to neurologic disability. Curr Opin Neurol 1999;12:295-302 (Pubitemid 29378163)
    • (1999) Current Opinion in Neurology , vol.12 , Issue.3 , pp. 295-302
    • Trapp, B.D.1    Ransohoff, R.2    Rudick, R.3
  • 8
    • 0037441487 scopus 로고    scopus 로고
    • Axonal loss in the pathology of MS: Consequences for understanding the progressive phase of the disease
    • DOI 10.1016/S0022-510X(02)00069-2, PII S0022510X02000692
    • Bjartmar C, Wujek JR, Trapp BD. Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease. J Neurol Sci 2003;206:165-71 (Pubitemid 36143722)
    • (2003) Journal of the Neurological Sciences , vol.206 , Issue.2 , pp. 165-171
    • Bjartmar, C.1    Wujek, J.R.2    Trapp, B.D.3
  • 9
    • 0021922832 scopus 로고
    • 4-Aminopyridine leads to restoration of conduction in demyelinated rat sciatic nerve
    • DOI 10.1016/0006-8993(85)91049-2
    • Targ EF, Kocsis JD. 4-Aminopyridine leads to restoration of conduction in demyelinated rat sciatic nerve. Brain Res 1985;328:358-61 (Pubitemid 15135163)
    • (1985) Brain Research , vol.328 , Issue.2 , pp. 358-361
    • Targ, E.F.1    Kocsis, J.D.2
  • 11
    • 0034889675 scopus 로고    scopus 로고
    • Reduced quality of life among multiple sclerosis patients with sexual disturbance and bladder dysfunction
    • DOI 10.1191/135245801680209330
    • Nortvedt MW, Riise T, Myhr KM, et al. Reduced quality of life among multiple sclerosis patients with sexual disturbance and bladder dysfunction. Mult Scler 2001;7:231-5 (Pubitemid 32780693)
    • (2001) Multiple Sclerosis , vol.7 , Issue.4 , pp. 231-235
    • Nortvedt, M.W.1    Riise, T.2    Myhr, K.-M.3    Landtblom, A.-M.4    Bakke, A.5    Nyland, H.I.6
  • 12
    • 67649158665 scopus 로고    scopus 로고
    • Pain and quality of life in the early stages after multiple sclerosis diagnosis: A 2-year longitudinal study
    • Brochet B, Deloire MS, Ouallet JC, et al. Pain and quality of life in the early stages after multiple sclerosis diagnosis: a 2-year longitudinal study. Clin J Pain 2009;25:211-17
    • (2009) Clin J Pain , vol.25 , pp. 211-17
    • Brochet, B.1    Deloire, M.S.2    Ouallet, J.C.3
  • 15
    • 0035033099 scopus 로고    scopus 로고
    • Disability and prognosis in multiple sclerosis: Demographic and clinical variables important for the ability to walk and awarding of disability pension
    • DOI 10.1191/135245801667968135
    • Myhr KM, Riise T, Vedeler C, et al. Disability and prognosis in multiple sclerosis: demographic and clinical variables important for the ability to walk and awarding of disability pension. Mult Scler 2001;7:59-65 (Pubitemid 32396580)
    • (2001) Multiple Sclerosis , vol.7 , Issue.1 , pp. 59-65
    • Myhr, K.M.1    Riise, T.2    Vedeler, C.3    Nortvedt, M.W.4    Gronning, M.5    Midgard, R.6    Nyland, H.I.7
  • 16
    • 0035010231 scopus 로고    scopus 로고
    • The multiple sclerosis impact scale (MSIS-29) a new patient-based outcome measure
    • Hobart JC, Lamping DL, Fitzpatrick R, et al. The Multiple Sclerosis Impact Scale (MSIS 29). A new patient-based outcome measure. Brain 2001;124:962-73 (Pubitemid 32458508)
    • (2001) Brain , vol.124 , Issue.5 , pp. 962-973
    • Hobart, J.1    Lamping, D.2    Fitzpatrick, R.3    Riazi, A.4    Thompson, A.5
  • 17
    • 0026690719 scopus 로고
    • The morbidity of multiple sclerosis
    • Swingler RJ, Compston DA. The morbidity of multiple sclerosis. Q J Med 1992;83:325-37
    • (1992) Q J Med , vol.83 , pp. 325-37
    • Swingler, R.J.1    Compston, D.A.2
  • 19
    • 52949133688 scopus 로고    scopus 로고
    • Dose-comparison trial of sustained-release fampridine in multiple sclerosis
    • Goodman AD, Brown TR, Cohen JA, et al. Dose-comparison trial of sustained-release fampridine in multiple sclerosis. Neurology 2008;71:1134-41
    • (2008) Neurology , vol.71 , pp. 1134-41
    • Goodman, A.D.1    Brown, T.R.2    Cohen, J.A.3
  • 20
    • 60649090430 scopus 로고    scopus 로고
    • Sustained release of oral fampridine in multiple sclerosis: A randomised, double-blind, controlled trial
    • Goodman AD, Brown TR, Krupp L, et al. Sustained release of oral fampridine in multiple sclerosis: a randomised, double-blind, controlled trial. Lancet 2009;373(9665):732-8
    • (2009) Lancet , vol.373 , Issue.9665 , pp. 732-8
    • Goodman, A.D.1    Brown, T.R.2    Krupp, L.3
  • 21
    • 78149478174 scopus 로고    scopus 로고
    • A Phase III trial of extended release oral dalfampridine in multiple sclerosis
    • Goodman AD, Brown TR, Edwards KR, et al. A Phase III trial of extended release oral dalfampridine in multiple sclerosis. Ann Neurol 2010;68:494-502
    • (2010) Ann Neurol , vol.68 , pp. 494-502
    • Goodman, A.D.1    Brown, T.R.2    Edwards, K.R.3
  • 23
    • 0034122105 scopus 로고    scopus 로고
    • Why treat early multiple sclerosis patients?
    • DOI 10.1097/00019052-200006000-00001
    • Comi G. Why treat early multiple sclerosis patients? Curr Opin Neurol 2000;13:235-40 (Pubitemid 30406528)
    • (2000) Current Opinion in Neurology , vol.13 , Issue.3 , pp. 235-240
    • Comi, G.1
  • 24
    • 33645742545 scopus 로고    scopus 로고
    • Most patients with multiple sclerosis or a clinically isolated demyelinating syndrome should be treated at the time of diagnosis
    • Frohman EM, Havrdova E, Lublin F, et al. Most patients with multiple sclerosis or a clinically isolated demyelinating syndrome should be treated at the time of diagnosis. Arch Neurol 2006;63:614-19
    • (2006) Arch Neurol , vol.63 , pp. 614-19
    • Frohman, E.M.1    Havrdova, E.2    Lublin, F.3
  • 25
    • 0028908929 scopus 로고
    • The number needed to treat: A clinically useful measure of treatment effect
    • Cook RJ, Sackett DL. The number needed to treat: a clinically useful measure of treatment effect. BMJ 1995;310:452-4
    • (1995) BMJ , vol.310 , pp. 452-4
    • Cook, R.J.1    Sackett, D.L.2
  • 27
    • 33644974688 scopus 로고    scopus 로고
    • Secondary progressive multiple sclerosis: Current knowledge and future challenges
    • Rovaris M, Confavreux C, Furlan R, et al. Secondary progressive multiple sclerosis: current knowledge and future challenges. Lancet Neurol 2006;5:343-54
    • (2006) Lancet Neurol , vol.5 , pp. 343-54
    • Rovaris, M.1    Confavreux, C.2    Furlan, R.3
  • 28
    • 34548633861 scopus 로고    scopus 로고
    • Primary-progressive multiple sclerosis
    • DOI 10.1016/S1474-4422(07)70243-0, PII S1474442207702430
    • Miller DH, Leary SM. Primary-progressive multiple sclerosis. Lancet Neurol 2007;6:903-12 (Pubitemid 47405002)
    • (2007) Lancet Neurology , vol.6 , Issue.10 , pp. 903-912
    • Miller, D.H.1    Leary, S.M.2
  • 29
    • 0037154192 scopus 로고    scopus 로고
    • Disease modifying therapies in multiple sclerosis: Report of the therapeutics and technology assessment subcommittee of the American academy of neurology and the MS council for clinical practice guidelines
    • Goodin DS, Frohman EM, Garmany Jr GP, et al. Disease modifying therapies in multiple sclerosis: report of the therapeutics and technology assessment subcommittee of the american academy of neurology and the ms council for clinical practice guidelines. Neurology 2002;58:169-78 (Pubitemid 34086933)
    • (2002) Neurology , vol.58 , Issue.2 , pp. 169-178
    • Goodin, D.S.1    Frohman, E.M.2    Garmany Jr., G.P.3    Halper, J.4    Likosky, W.H.5    Lublin, F.D.6    Silberberg, D.H.7    Stuart, W.H.8    Van Den Noort, S.9
  • 30
    • 79958705849 scopus 로고    scopus 로고
    • National Multiple Sclerosis Society. Expert Opinion Paper. Disease management consensus statement Last accessed 15 December
    • National Multiple Sclerosis Society. Expert Opinion Paper. Disease management consensus statement. Treatment recommendations for physicians. Available from: http://www.nationalmssociety.org/for-professionals/healthcare- professionals/publications/expert-opinion-papers/index.aspx [Last accessed 15 December 2010].
    • (2010) Treatment Recommendations for Physicians
  • 31
    • 34249723173 scopus 로고    scopus 로고
    • Descriptive analysis of the direct medical costs of multiple sclerosis in 2004 using administrative claims in a large nationwide database
    • Prescott JD, Factor S, Pill M, et al. Descriptive analysis of the direct medical costs of multiple sclerosis in 2004 using administrative claims in a large nationwide database. J Manag Care Pharm 2007;13:44-52 (Pubitemid 46824250)
    • (2007) Journal of Managed Care Pharmacy , vol.13 , Issue.1 , pp. 44-52
    • Prescott, J.D.1    Factor, S.2    Pill, M.3    Levi, G.W.4
  • 33
    • 65749088247 scopus 로고    scopus 로고
    • Factors that influence adherence with disease-modifying therapy in MS
    • Treadaway K, Cutter G, Salter A, et al. Factors that influence adherence with disease-modifying therapy in MS. J Neurol 2009;256:568-76.
    • (2009) J Neurol , vol.256 , pp. 568-76
    • Treadaway, K.1    Cutter, G.2    Salter, A.3
  • 34
    • 60849112559 scopus 로고    scopus 로고
    • Injection anxiety remains a long-term barrier to medication adherence in multiple sclerosis
    • Turner AP, Williams RM, Sloan AP, et al. Injection anxiety remains a long-term barrier to medication adherence in multiple sclerosis. Rehabil Psychol 2009;54:116-21
    • (2009) Rehabil Psychol , vol.54 , pp. 116-21
    • Turner, A.P.1    Williams, R.M.2    Sloan, A.P.3
  • 35
    • 33749363907 scopus 로고    scopus 로고
    • Symptomatic treatment of multiple sclerosis: Multiple Sclerosis Therapy Consensus Group (MSTCG) of the German Multiple Sclerosis Society
    • DOI 10.1159/000095699
    • Henze T, Rieckmann P, Toyka KV. Multiple sclerosis therapy consensus group of the german multiple sclerosis society. Symptomatic treatment of multiple sclerosis. Multiple Sclerosis Therapy Consensus Group (MSTCG) of the German Multiple Sclerosis Society. Eur Neurol 2006;56:78-105 (Pubitemid 44492163)
    • (2006) European Neurology , vol.56 , Issue.2 , pp. 78-105
    • Henze, T.1    Rieckmann, P.2    Toyka, K.V.3
  • 36
    • 58149330651 scopus 로고    scopus 로고
    • Identification, causation, alleviation, and prevention of complications (ICAP): An approach to symptom and disability management in multiple sclerosis
    • Cohen BA. Identification, causation, alleviation, and prevention of complications (ICAP): an approach to symptom and disability management in multiple sclerosis. Neurology 2008;71(24 Suppl 3):S14-20
    • (2008) Neurology , vol.71 , Issue.24 SUPPL. 3
    • Cohen, B.A.1
  • 37
    • 34250366309 scopus 로고    scopus 로고
    • What is new in symptom management?
    • Henze T. What is new in symptom management? Int Mult Scler J 2007;14:22-7 (Pubitemid 46917296)
    • (2007) International MS Journal , vol.14 , Issue.1 , pp. 22-27
    • Henze, T.1
  • 38
    • 78349289202 scopus 로고    scopus 로고
    • Pharmacological management of symptoms in multiple sclerosis: Current approaches and future directions
    • Thompson AJ, Toosy AT, Ciccarelli O. Pharmacological management of symptoms in multiple sclerosis: current approaches and future directions. Lancet Neurol 2010;9:1182-99
    • (2010) Lancet Neurol , vol.9 , pp. 1182-99
    • Thompson, A.J.1    Toosy, A.T.2    Ciccarelli, O.3
  • 39
    • 0023194967 scopus 로고
    • A double-blind controlled trial of high dose methylprednisolone in patients with multiple sclerosis: 1. Clinical effects
    • Milligan N, Newcombe R, Compston D. A double-blind controlled trial of high dose methylprednisolone in patients with multiple sclerosis: 1. Clinical effects. J Neurol Neurosurg Psychiatry 1987;50:511-16 (Pubitemid 17067536)
    • (1987) Journal of Neurology Neurosurgery and Psychiatry , vol.50 , Issue.5 , pp. 511-516
    • Milligan, N.M.1    Newcombe, R.2    Compston, D.A.S.3
  • 40
    • 0036196863 scopus 로고    scopus 로고
    • Changes of the MS functional composite and EDSS during and after treatment of relapses with methylprednisolone in patients with multiple sclerosis
    • DOI 10.1034/j.1600-0404.2002.1o135.x
    • Patzold T, Schwengelbeck M, Ossege LM, et al. Changes of the MS functional composite and EDSS during and after treatment of relapses with methylprednisolone in patients with multiple sclerosis. Acta Neurol Scand 2002;105:164-8 (Pubitemid 34258956)
    • (2002) Acta Neurologica Scandinavica , vol.105 , Issue.3 , pp. 164-168
    • Patzold, T.1    Schwengelbeck, M.2    Ossege, L.-M.3    Malin, J.-P.4    Sindern, E.5
  • 41
    • 0037435521 scopus 로고    scopus 로고
    • Measuring the impact of MS on walking ability: The 12-item MS Walking Scale (MSWS-12)
    • Hobart JC, Riazi A, Lamping DL, et al. Measuring the impact of MS on walking ability: the 12-Item MS Walking Scale (MSWS-12). Neurology 2003;60:31-6 (Pubitemid 36070640)
    • (2003) Neurology , vol.60 , Issue.1 , pp. 31-36
    • Hobart, J.C.1    Riazi, A.2    Lamping, D.L.3    Fitzpatrick, R.4    Thompson, A.J.5
  • 42
    • 33644554822 scopus 로고    scopus 로고
    • Quantification of central motor conduction deficits in multiple sclerosis patients before and after treatment of acute exacerbation by methylprednisolone
    • Humm AM, ZAGraggen WJ, Buhler R, et al. Quantification of central motor conduction deficits in multiple sclerosis patients before and after treatment of acute exacerbation by methylprednisolone. J Neurol Neurosurg Psychiatry 2006;77:345-50
    • (2006) J Neurol Neurosurg Psychiatry , vol.77 , pp. 345-50
    • Humm, A.M.1    Zgraggen, W.J.2    Buhler, R.3
  • 43
    • 18944402627 scopus 로고    scopus 로고
    • Exercise and rehabilitation for individuals with multiple sclerosis
    • DOI 10.1016/j.pmr.2005.01.005, PII S1047965105000069, Multiple Sclerosis: A Paradigm Shift
    • Brown TR, Kraft GH. Exercise and rehabilitation for individuals with multiple sclerosis. Phys Med Rehabil Clin N Am 2005;16:513-55 (Pubitemid 40704682)
    • (2005) Physical Medicine and Rehabilitation Clinics of North America , vol.16 , Issue.2 , pp. 513-555
    • Brown, T.R.1    Kraft, G.H.2
  • 44
    • 35448961762 scopus 로고    scopus 로고
    • Multidisciplinary rehabilitation for adults with multiple sclerosis
    • Khan F, Turner-Stokes L, Ng L, et al. Multidisciplinary rehabilitation for adults with multiple sclerosis. Cochrane Database Syst Rev 2007;2:CD006036
    • (2007) Cochrane Database Syst Rev , vol.2
    • Khan, F.1    Turner-Stokes, L.2    Ng, L.3
  • 45
    • 36348969327 scopus 로고    scopus 로고
    • Measures of Physical Functioning Predict Self-Reported Performance in Self-Care, Mobility, and Domestic Life in Ambulatory Persons With Multiple Sclerosis
    • DOI 10.1016/j.apmr.2007.07.032, PII S0003999307014864
    • Paltamaa J, Sarasoja T, Leskinen E, et al. Measures of physical functioning predict self-reported performance in self-care, mobility, and domestic life in ambulatory persons with multiple sclerosis. Arch Phys Med Rehabil 2007;88:1649-57 (Pubitemid 350151390)
    • (2007) Archives of Physical Medicine and Rehabilitation , vol.88 , Issue.12 , pp. 1649-1657
    • Paltamaa, J.1    Sarasoja, T.2    Leskinen, E.3    Wikstrom, J.4    Malkia, E.5
  • 46
    • 37349118328 scopus 로고    scopus 로고
    • Quality of life in people with multiple sclerosis: Data from the Sonya Slifka Longitudinal Multiple Sclerosis Study
    • Wu N, Minden SL, Hoaglin DC, et al. Quality of life in people with multiple sclerosis: data from the Sonya Slifka Longitudinal Multiple Sclerosis Study. J Health Hum Serv Adm 2007;30:233-67
    • (2007) J Health Hum Serv Adm , vol.30 , pp. 233-67
    • Wu, N.1    Minden, S.L.2    Hoaglin, D.C.3
  • 47
  • 48
    • 55149106573 scopus 로고    scopus 로고
    • Employment in multiple sclerosis: Exiting and re-entering the work force
    • Julian LJ, Vella L, Vollmer T, et al. Employment in multiple sclerosis: exiting and re-entering the work force. J Neurol 2008;255:1354-60
    • (2008) J Neurol , vol.255 , pp. 1354-60
    • Julian, L.J.1    Vella, L.2    Vollmer, T.3
  • 49
    • 52449093446 scopus 로고    scopus 로고
    • Symptoms and physical activity behavior in individuals with multiple sclerosis
    • Motl RW, Snook EM, Schapiro RT. Symptoms and physical activity behavior in individuals with multiple sclerosis. Res Nurs Health 2008;31:466-75
    • (2008) Res Nurs Health , vol.31 , pp. 466-75
    • Motl, R.W.1    Snook, E.M.2    Schapiro, R.T.3
  • 50
    • 74549158358 scopus 로고    scopus 로고
    • Impact of loss of mobility on instrumental activities of daily living and socioeconomic status in patients with MS
    • Salter A, Cutter GR, Tyry T, et al. Impact of loss of mobility on instrumental activities of daily living and socioeconomic status in patients with MS. Curr Med Res Opin 2010;26:493-500.
    • (2010) Curr Med Res Opin , vol.26 , pp. 493-500
    • Salter, A.1    Cutter, G.R.2    Tyry, T.3
  • 51
    • 0032749804 scopus 로고    scopus 로고
    • Disease steps in multiple sclerosis: A longitudinal study comparing Disease Steps and EDSS to evaluate disease progression
    • Hohol MJ, Orav EJ, Weiner HL. Disease steps in multiple sclerosis: a longitudinal study comparing disease steps and EDSS to evaluate disease progression. Mult Scler 1999;5:349-54 (Pubitemid 29505050)
    • (1999) Multiple Sclerosis , vol.5 , Issue.5 , pp. 349-354
    • Hohol, M.J.1    Orav, E.J.2    Weiner, H.L.3
  • 52
    • 0021035886 scopus 로고
    • Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
    • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33:1444-52 (Pubitemid 14237132)
    • (1983) Neurology , vol.33 , Issue.11 , pp. 1444-1452
    • Kurtzke, J.F.1
  • 53
    • 39549084387 scopus 로고    scopus 로고
    • Validity of performance scales for disability assessment in multiple sclerosis
    • DOI 10.1177/1352458507078388
    • Marrie RA, Goldman M. Validity of performance scales for disability assessment in multiple sclerosis. Mult Scler 2007;13:1176-82 (Pubitemid 351541422)
    • (2007) Multiple Sclerosis , vol.13 , Issue.9 , pp. 1176-1182
    • Marrie, R.A.1    Goldman, M.2
  • 54
    • 0032905049 scopus 로고    scopus 로고
    • The psychometric properties of clinical rating scales used in multiple sclerosis
    • DOI 10.1093/brain/122.1.141
    • Sharrack B, Hughes RAC, Soudain S, et al. The psychometric properties of clinical rating scales used in multiple sclerosis. Brain 1999;122:141-59 (Pubitemid 29046280)
    • (1999) Brain , vol.122 , Issue.1 , pp. 141-159
    • Sharrack, B.1    Hughes, R.A.C.2    Soudain, S.3    Dunn, G.4
  • 55
    • 0034088138 scopus 로고    scopus 로고
    • Kurtzke scales revisited: The application of psychometric methods to clinical intuition
    • Hobart JC, Freeman J, Thompson A. Kurtzke scales revisited: the application of psychometric methods to clinical intuition. Brain 2000;23:1027-40 (Pubitemid 30224198)
    • (2000) Brain , vol.123 , Issue.5 , pp. 1027-1040
    • Hobart, J.1    Freeman, J.2    Thompson, A.3
  • 59
    • 33646776060 scopus 로고    scopus 로고
    • v channels and effects of symptomatic treatment
    • DOI 10.1016/j.pharmthera.2005.10.006, PII S0163725805002287
    • Judge SI, Bever CT Jr. Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment. Pharmacol Ther 2006;111:224-59. (Pubitemid 43765538)
    • (2006) Pharmacology and Therapeutics , vol.111 , Issue.1 , pp. 224-259
    • Judge, S.I.V.1    Bever Jr., C.T.2
  • 61
    • 0018840887 scopus 로고
    • Effects of 4-aminopyridine on normal and demyelinated mammalian nerve fibres
    • Sherratt RM, Bostock H, Sears TA. Effects of 4-aminopyridine on normal and demyelinated mammalian nerve fibres. Nature 1980;283:570-2 (Pubitemid 10136031)
    • (1980) Nature , vol.283 , Issue.5747 , pp. 570-572
    • Sherratt, R.M.1    Bostock, H.2    Sears, T.A.3
  • 62
    • 0024418456 scopus 로고
    • Effect of 4-aminopyridine on axonal conduction-block in chronic spinal cord injury
    • Blight AR. Effect of 4-aminopyridine on axonal conduction-block in chronic spinal cord injury. Brain Res Bull 1989;22:47-52
    • (1989) Brain Res Bull , vol.22 , pp. 47-52
    • Blight, A.R.1
  • 63
    • 0031056540 scopus 로고    scopus 로고
    • Differential effects of low and high concentrations of 4-aminopyridine on axonal conduction in normal and injured spinal cord
    • DOI 10.1016/S0306-4522(96)00477-0, PII S0306452296004770
    • Shi R, Blight AR. Differential effects of low and high concentrations of 4-aminopyridine on axonal conduction in normal and injured spinal cord. Neuroscience 1997;77:553-62 (Pubitemid 27079623)
    • (1997) Neuroscience , vol.77 , Issue.2 , pp. 553-562
    • Shi, R.1    Blight, A.R.2
  • 64
    • 0017850431 scopus 로고
    • Effects of 4-aminopyridine on neuromuscular transmission
    • DOI 10.1016/0006-8993(78)90409-2
    • Lundh H. Effects of 4-aminopyridine on neuromuscular transmission. Brain Res 1978;153:307-18 (Pubitemid 8387960)
    • (1978) Brain Research , vol.153 , Issue.2 , pp. 307-318
    • Lundh, H.1
  • 65
    • 0018906744 scopus 로고
    • Facilitatory effects of 4-aminopyridine on neuromuscular transmission in disease states
    • Kim YI, Goldner MM, Sanders DB. Facilitatory effects of 4-aminopyridine on neuromuscular transmission in disease states. Muscle Nerve 1980;3:112-19 (Pubitemid 10134617)
    • (1980) Muscle and Nerve , vol.3 , Issue.2 , pp. 112-119
    • Kim, Y.I.1    Goldner, M.M.2    Sanders, D.B.3
  • 66
    • 79958863778 scopus 로고    scopus 로고
    • Dalfampridine: A brief review of its mechanism of action and efficacy as a treatment to improve walking in patients with multiple sclerosis
    • In press
    • Dunn J, Blight A. Dalfampridine: a brief review of its mechanism of action and efficacy as a treatment to improve walking in patients with multiple sclerosis. Curr Med Res Opin; In press
    • Curr Med Res Opin
    • Dunn, J.1    Blight, A.2
  • 67
    • 0019391105 scopus 로고
    • The effects of 4-aminopyridine and tetraethylammonium ions on normal and demyelinated mammalian nerve fibres
    • Bostock H, Sears TA, Sherratt RM. The effects of 4-aminopyridine and tetraethylammonium ions on normal and demyelinated mammalian nerve fibres. J Physiol 1981;313:301-15 (Pubitemid 11125577)
    • (1981) Journal of Physiology , vol.313 , pp. 301-315
    • Bostock, H.1    Sears, T.A.2    Sherratt, R.M.3
  • 68
    • 84862944287 scopus 로고    scopus 로고
    • United States Food and Drug Administration Last accessed 15 December
    • United States Food and Drug Administration. Report: 2006 Limited FDA Survey of Compounded Drug Products. Available from: http://www.fda.gov/Drugs/ Guidance ComplianceRegulatoryInformation/PharmacyCompounding/ucm204237.htm [Last accessed 15 December 2010]
    • (2010) Report: 2006 Limited FDA Survey of Compounded Drug Products
  • 71
  • 72
    • 0029928052 scopus 로고    scopus 로고
    • Atypical presentation of 4-aminopyridine overdose
    • DOI 10.1016/S0196-0644(96)70277-9
    • Pickett TA, Enns R. Atypical presentation of 4-aminopyridine overdose. Ann Emerg Med 1996;27:382-5 (Pubitemid 26085022)
    • (1996) Annals of Emergency Medicine , vol.27 , Issue.3 , pp. 382-385
    • Pickett, T.A.1    Enns, R.2
  • 73
    • 33645339788 scopus 로고    scopus 로고
    • An unusual case of 4-aminopyridine toxicity
    • Johnson NC, Morgan MW. An unusual case of 4-aminopyridine toxicity. J Emerg Med 2006;30:175-7
    • (2006) J Emerg Med , vol.30 , pp. 175-7
    • Johnson, N.C.1    Morgan, M.W.2
  • 74
    • 67650381928 scopus 로고    scopus 로고
    • 4-Aminopyridine toxicity mimics autoimmune-mediated limbic encephalitis
    • Badruddin A, Menon RS, Reder AS. 4-Aminopyridine toxicity mimics autoimmune-mediated limbic encephalitis. Neurology 2009;72:1100-1
    • (2009) Neurology , vol.72 , pp. 1100-1
    • Badruddin, A.1    Menon, R.S.2    Reder, A.S.3
  • 75
    • 58149234344 scopus 로고    scopus 로고
    • 4-Aminopyridine toxicity with unintentional overdosage in four patients with multiple sclerosis
    • Burton JM, Bell CM, Walker SE, OConnor PW. 4-Aminopyridine toxicity with unintentional overdosage in four patients with multiple sclerosis. Neurology 2008;71:1833-4
    • (2008) Neurology , vol.71 , pp. 1833-4
    • Burton, J.M.1    Bell, C.M.2    Walker, S.E.3    Oconnor, P.W.4
  • 76
    • 65249130514 scopus 로고    scopus 로고
    • An unusual case of 4-aminopyridine toxicity in a multiple sclerosis patient: Epileptic disorder or toxic encephalopathy?
    • De Cauwer H, De Wolf P, Couvreur F, et al. An unusual case of 4-aminopyridine toxicity in a multiple sclerosis patient: epileptic disorder or toxic encephalopathy? Acta Neurol Belg 2009;109:40-1
    • (2009) Acta Neurol Belg , vol.109 , pp. 40-1
    • De Cauwer, H.1    De Wolf, P.2    Couvreur, F.3
  • 77
    • 77249169443 scopus 로고    scopus 로고
    • Severe accidental overdose of 4-aminopyridine due to a compounding pharmacy error
    • May [Epub ahead of print]
    • Schwam E. Severe accidental overdose of 4-aminopyridine due to a compounding pharmacy error. J Emerg Med May 2009 [Epub ahead of print]
    • (2009) J Emerg Med
    • Schwam, E.1
  • 79
  • 81
    • 0027243935 scopus 로고
    • 4-Aminopyridine in chronic spinal cord injury: A controlled, double- blind, crossover study in eight patients
    • Hansebout RR, Blight AR, Fawcett S, et al. 4-Aminopyridine in chronic spinal cord injury: a controlled, double-blind, crossover study in eight patients. J Neurotrauma 1993;10:1-18 (Pubitemid 23153141)
    • (1993) Journal of Neurotrauma , vol.10 , Issue.1 , pp. 1-18
    • Hansebout, R.R.1    Blight, A.R.2    Fawcett, S.3    Reddy, K.4
  • 82
    • 0031888625 scopus 로고    scopus 로고
    • Sustained improvements in neurological function in spinal cord injured patients treated with oral 4-aminopyridine: Three cases
    • Potter PJ, Hayes KC, Hsieh JT, et al. Sustained improvements in neurological function in spinal cord injured patients treated with oral 4-aminopyridine: three cases. Spinal Cord 1998;36:147-55 (Pubitemid 28120689)
    • (1998) Spinal Cord , vol.36 , Issue.3 , pp. 147-155
    • Potter, P.J.1    Hayes, K.C.2    Hsieh, J.T.C.3    Delaney, G.A.4    Segal, J.L.5
  • 83
    • 0033000481 scopus 로고    scopus 로고
    • Safety and efficacy of 4-aminopyridine in humans with spinal cord injury: A long-term, controlled trial
    • DOI 10.1592/phco.19.9.713.31540
    • Segal JL, Pathak MS, Hernandez JP, et al. Safety and efficacy of 4-aminopyridine in humans with spinal cord injury: a long-term, controlled trial. Pharmacotherapy 1999;19:713-23 (Pubitemid 29277971)
    • (1999) Pharmacotherapy , vol.19 , Issue.6 , pp. 713-723
    • Segal, J.L.1    Pathak, M.S.2    Hernandez, J.P.3    Himber, P.L.4    Brunnemann, S.R.5    Charter, R.S.6
  • 86
    • 0023134727 scopus 로고
    • 4-Aminopyridine improves clinical signs in multiple sclerosis
    • DOI 10.1002/ana.410210113
    • Stefoski D, Davis FA, Faut M, et al. 4-Aminopyridine improves clinical signs in multiple sclerosis. Ann Neurol 1987;21:71-7 (Pubitemid 17004147)
    • (1987) Annals of Neurology , vol.21 , Issue.1 , pp. 71-77
    • Stefoski, D.1    Davis, F.A.2    Faut, M.3    Schauf, C.L.4
  • 87
    • 0030989459 scopus 로고    scopus 로고
    • Quantitative assessment of sustained-release 4-aminopyridine for symptomatic treatment of multiple sclerosis
    • Schwid SR, Petrie MD, McDermott MP, et al. Quantitative assessment of sustained-release 4-aminopyridine for symptomatic treatment of multiple sclerosis. Neurology 1997;48:817-21
    • (1997) Neurology , vol.48 , pp. 817-21
    • Schwid, S.R.1    Petrie, M.D.2    McDermott, M.P.3
  • 89
    • 0026719595 scopus 로고
    • The effect of 4-aminopyridine on clinical signs in multiple sclerosis: A randomized, placebo-controlled, double-blind, cross-over study
    • Van Diemen HA, Polman CH, van Dongen TM, et al. The effect of 4-aminopyridine on clinical signs in multiple sclerosis: a randomized, placebo-controlled, double-blind, cross-over study. Ann Neurol 1992;32:123-30
    • (1992) Ann Neurol , vol.32 , pp. 123-30
    • Van Diemen, H.A.1    Polman, C.H.2    Van Dongen, T.M.3
  • 91
    • 71549141975 scopus 로고    scopus 로고
    • Pharmacokinetics and tolerability of single administration, escalating doses of 4-aminopyridine slow release in subjects with multiple sclerosis
    • Vollmer T, Henney HR 3rd. Pharmacokinetics and tolerability of single administration, escalating doses of 4-aminopyridine slow release in subjects with multiple sclerosis. Clin Ther 2009;31:2206-14
    • (2009) Clin Ther , vol.31 , pp. 2206-14
    • Vollmer, T.1    Henney III, H.R.2
  • 93
    • 0037161254 scopus 로고    scopus 로고
    • Quantitative functional measures in MS: What is a reliable change?
    • Schwid SR, Goodman AD, McDermott MP, et al. Quantitative functional measures in MS: what is a reliable change? Neurology 2002;58:1294-6 (Pubitemid 34411881)
    • (2002) Neurology , vol.58 , Issue.8 , pp. 1294-1296
    • Schwid, S.R.1    Goodman, A.D.2    McDermott, M.P.3    Bever, C.F.4    Cook, S.D.5
  • 94
  • 95
    • 34250660553 scopus 로고    scopus 로고
    • Clinical impact of 20% worsening on Timed 25-foot Walk and 9-hole Peg Test in multiple sclerosis
    • DOI 10.1177/1352458506070768
    • Kragt JJ, van der Linden FA, Nielsen JM, et al. Clinical impact of 20% worsening on timed 25-foot walk and 9-hole peg test in multiple sclerosis. Mult Scler 2006;12:594-8 (Pubitemid 46940633)
    • (2006) Multiple Sclerosis , vol.12 , Issue.5 , pp. 594-598
    • Kragt, J.J.1    Van Der Linden, F.2    Nielsen, J.M.3    Uitdehaag, B.M.J.4    Polman, C.H.5
  • 96
    • 77955041173 scopus 로고    scopus 로고
    • Progression on the multiple sclerosis functional composite in multiple sclerosis: What is the optimal cut-off for the three components?
    • Bosma LV, Kragt JJ, Brieva L, et al. Progression on the multiple sclerosis functional composite in multiple sclerosis: what is the optimal cut-off for the three components? Mult Scler 2010;16:862-7
    • (2010) Mult Scler , vol.16 , pp. 862-7
    • Bosma, L.V.1    Kragt, J.J.2    Brieva, L.3
  • 99
    • 80052764673 scopus 로고    scopus 로고
    • Analysis of open-label extension studies of prolonged release fampridine tablets in multiple sclerosis [abstract]
    • for the MS-F203 MS-F204 MS-F203EXT and MS-F204EXT Study Groups
    • Goodman A, Brown T, Edwards K, Schapiro R; for the MS-F203, MS-F204, MS-F203EXT, and MS-F204EXT Study Groups. Analysis of open-label extension studies of prolonged release fampridine tablets in multiple sclerosis [abstract]. Mult Scler 2010;16(Suppl):S17
    • (2010) Mult Scler , vol.16 , Issue.SUPPL.
    • Goodman, A.1    Brown, T.2    Edwards, K.3    Schapiro, R.4
  • 100
    • 70449491811 scopus 로고    scopus 로고
    • Vitro electrophysiological activity of nerispirdine, a novel 4-aminopyridine derivative
    • Smith C, Kongsamut S, Wang H, et al. In vitro electrophysiological activity of nerispirdine, a novel 4-aminopyridine derivative. Clin Exp Pharmacol Physiol 2009;36:1104-9
    • (2009) Clin Exp Pharmacol Physiol , vol.36 , pp. 1104-9
    • Smith, C.1    Kongsamut, S.2    Wang, H.3


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