메뉴 건너뛰기




Volumn 19, Issue 6, 1999, Pages 713-723

Safety and efficacy of 4-aminopyridine in humans with spinal cord injury: A long-term, controlled trial

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPYRIDINE;

EID: 0033000481     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.19.9.713.31540     Document Type: Article
Times cited : (68)

References (37)
  • 1
    • 0345287004 scopus 로고
    • Case thirty-one. First description of quadriplegia. Case of dislocation of cervical vertebra. Circa 3000 B.C.
    • Chicago: University of Chicago Press
    • Breasted JH, ed. Case thirty-one. First description of quadriplegia. Case of dislocation of cervical vertebra. Circa 3000 B.C. In: The Edwin Smith surgical papyrus. Chicago: University of Chicago Press, 1930.
    • (1930) The Edwin Smith Surgical Papyrus
    • Breasted, J.H.1
  • 2
    • 0030916531 scopus 로고    scopus 로고
    • 4-Aminopyridine improves pulmonary function in quadriplegic humans with long-standing spinal cord injury
    • Segal JL, Brunnemann SR. 4-Aminopyridine improves pulmonary function in quadriplegic humans with long-standing spinal cord injury. Pharmacotherapy 1997;17(3):415-23.
    • (1997) Pharmacotherapy , vol.17 , Issue.3 , pp. 415-423
    • Segal, J.L.1    Brunnemann, S.R.2
  • 3
    • 0027243935 scopus 로고
    • 4-Aminopyridine in chronic spinal cord injury: A controlled, double-blind, crossover study in eight patients
    • Hansebout RR, Blight AR, Fawcett S, Reddy K. 4-Aminopyridine in chronic spinal cord injury: a controlled, double-blind, crossover study in eight patients. J Neurotrauma 1993;19:1-18.
    • (1993) J Neurotrauma , vol.19 , pp. 1-18
    • Hansebout, R.R.1    Blight, A.R.2    Fawcett, S.3    Reddy, K.4
  • 4
    • 0030989459 scopus 로고    scopus 로고
    • Quantitative assessment of sustained-release 4-aminopyridine for symptomatic treatment of multiple sclerosis
    • Schwid SR, Petrie MD, McDermott MP, Tierney DS, Mason DH, Goodman AD. Quantitative assessment of sustained-release 4-aminopyridine for symptomatic treatment of multiple sclerosis. Neurology 1997;48:817-21.
    • (1997) Neurology , vol.48 , pp. 817-821
    • Schwid, S.R.1    Petrie, M.D.2    McDermott, M.P.3    Tierney, D.S.4    Mason, D.H.5    Goodman, A.D.6
  • 5
    • 0027343542 scopus 로고
    • Observations on the pathology of human spinal cord injury. A review and classification of 22 new cases with details from a case of chronic cord compression with extensive focal demyelination
    • Seil FJ, ed. New York: Raven Press
    • Bunge RP, Puckett WR, Bercerra JL, Marcillo A, Quencer RM. Observations on the pathology of human spinal cord injury. A review and classification of 22 new cases with details from a case of chronic cord compression with extensive focal demyelination. In: Seil FJ, ed. Advances in neurology, vol 59. New York: Raven Press, 1993:75-89.
    • (1993) Advances in Neurology , vol.59 , pp. 75-89
    • Bunge, R.P.1    Puckett, W.R.2    Bercerra, J.L.3    Marcillo, A.4    Quencer, R.M.5
  • 6
    • 0022444725 scopus 로고
    • Morphometric analysis of experimental spinal cord injury in the cat: The relation of injury intensity to survival of myelinated axons
    • Blight AR, DeCrescito V. Morphometric analysis of experimental spinal cord injury in the cat: the relation of injury intensity to survival of myelinated axons. Neuroscience 1986;19:321-41.
    • (1986) Neuroscience , vol.19 , pp. 321-341
    • Blight, A.R.1    DeCrescito, V.2
  • 7
    • 0031056540 scopus 로고    scopus 로고
    • Differential effects of low and high concentrations of 4-aminopyridine on axonal conduction in normal and injured spinal cord
    • Shi R, Blight AR. Differential effects of low and high concentrations of 4-aminopyridine on axonal conduction in normal and injured spinal cord. Neuroscience 1997;77(2):553-62.
    • (1997) Neuroscience , vol.77 , Issue.2 , pp. 553-562
    • Shi, R.1    Blight, A.R.2
  • 8
    • 0019391105 scopus 로고
    • The effects of 4-aminopyridine and tetraethylammonium ions on normal and demyelinated mammalian nerve fibers
    • Bostock H, Sears TA, Sheratt RM. The effects of 4-aminopyridine and tetraethylammonium ions on normal and demyelinated mammalian nerve fibers. J Physiol 1991;313:301-15.
    • (1991) J Physiol , vol.313 , pp. 301-315
    • Bostock, H.1    Sears, T.A.2    Sheratt, R.M.3
  • 10
    • 0021922832 scopus 로고
    • 4-Aminopyridine leads to restoration of conduction in demyelinated rat sciatic nerve
    • Targ EF, Kocsis JD. 4-Aminopyridine leads to restoration of conduction in demyelinated rat sciatic nerve. Brain Res 1985;328:358-61.
    • (1985) Brain Res , vol.328 , pp. 358-361
    • Targ, E.F.1    Kocsis, J.D.2
  • 11
    • 0025730112 scopus 로고
    • The effects of 4-aminopyridine on neurologic deficits in chronic cases of traumatic spinal cord injury in dogs: A phase I clinical trial
    • Blight AR, Toombs JP, Bauer MS, Widmer WR. The effects of 4-aminopyridine on neurologic deficits in chronic cases of traumatic spinal cord injury in dogs: a phase I clinical trial. J Neurotrauma 1991;8:103-9.
    • (1991) J Neurotrauma , vol.8 , pp. 103-109
    • Blight, A.R.1    Toombs, J.P.2    Bauer, M.S.3    Widmer, W.R.4
  • 12
    • 0031888625 scopus 로고    scopus 로고
    • Sustained improvements in neurological function in spinal cord injured patients treated with oral 4-aminopyridine: Three cases
    • Potter PJ, Hayes KC, Hsieh JTC, Delaney GA, Segal JL. Sustained improvements in neurological function in spinal cord injured patients treated with oral 4-aminopyridine: three cases. Spinal Cord 1998;36:147-55.
    • (1998) Spinal Cord , vol.36 , pp. 147-155
    • Potter, P.J.1    Hayes, K.C.2    Hsieh, J.T.C.3    Delaney, G.A.4    Segal, J.L.5
  • 13
    • 0017185643 scopus 로고
    • Diverse sensory functions with an almost totally divided spinal cord. A case of spinal cord transection with preservation of part of one anterolateral quadrant
    • Noordenbos W, Wall PD. Diverse sensory functions with an almost totally divided spinal cord. A case of spinal cord transection with preservation of part of one anterolateral quadrant. Pain 1976;2:185-95.
    • (1976) Pain , vol.2 , pp. 185-195
    • Noordenbos, W.1    Wall, P.D.2
  • 14
    • 0002899253 scopus 로고
    • Recovery mechanisms in spinal cord injury: Implications for regenerative therapy
    • Seil FJ, ed. New York: AR Liss
    • Young W. Recovery mechanisms in spinal cord injury: implications for regenerative therapy. In: Seil FJ, ed. Neural regeneration and transplantation. New York: AR Liss, 1988:157-69.
    • (1988) Neural Regeneration and Transplantation , pp. 157-169
    • Young, W.1
  • 15
    • 0031793091 scopus 로고    scopus 로고
    • Randomized double-blind crossover trial of Fampridine-SR (sustained release 4-aminopyridine) in patients with incomplete spinal cord injury
    • Potter PJ, Hayes KC, Segal JL, et al. Randomized double-blind crossover trial of Fampridine-SR (sustained release 4-aminopyridine) in patients with incomplete spinal cord injury. J Neurotrauma 1998;15(10):837-49.
    • (1998) J Neurotrauma , vol.15 , Issue.10 , pp. 837-849
    • Potter, P.J.1    Hayes, K.C.2    Segal, J.L.3
  • 16
    • 0020352964 scopus 로고
    • Placebos and other comparative treatments
    • Joyce CRB. Placebos and other comparative treatments. Br J Clin Pharmacol 1982;13:313-18.
    • (1982) Br J Clin Pharmacol , vol.13 , pp. 313-318
    • Joyce, C.R.B.1
  • 18
    • 0026038935 scopus 로고
    • Lung function testing: Selection of reference values and interpretative strategies
    • American Thoracic Society. Lung function testing: selection of reference values and interpretative strategies. Am Rev Respir Dis 1991;144:1202-18.
    • (1991) Am Rev Respir Dis , vol.144 , pp. 1202-1218
  • 19
    • 0014514097 scopus 로고
    • Maximal respiratory pressures: Normal values and relationship to age and sex
    • Black LF, Hyatt RE. Maximal respiratory pressures: normal values and relationship to age and sex. Am Rev Respir Dis 1969;99:696-702.
    • (1969) Am Rev Respir Dis , vol.99 , pp. 696-702
    • Black, L.F.1    Hyatt, R.E.2
  • 20
    • 0023130157 scopus 로고
    • Interrater reliability of a modified Ashworth scale of muscle spasticity
    • Bohannon RW, Smith MB. Interrater reliability of a modified Ashworth scale of muscle spasticity. Phys Ther 1987;67(2):206-7.
    • (1987) Phys Ther , vol.67 , Issue.2 , pp. 206-207
    • Bohannon, R.W.1    Smith, M.B.2
  • 21
    • 75949150955 scopus 로고
    • Preliminary trial of carisoprodol in multiple sclerosis
    • Ashworth B. Preliminary trial of carisoprodol in multiple sclerosis. Practitioner 1964;192:540-2.
    • (1964) Practitioner , vol.192 , pp. 540-542
    • Ashworth, B.1
  • 23
    • 0032107910 scopus 로고    scopus 로고
    • 4-Aminopyridine alters gait characteristics and enhances locomotion in spinal cord injured humans
    • Segal JL, Brunnemann SR. 4-Aminopyridine alters gait characteristics and enhances locomotion in spinal cord injured humans. J Spinal Cord Med 1998;21:200-4.
    • (1998) J Spinal Cord Med , vol.21 , pp. 200-204
    • Segal, J.L.1    Brunnemann, S.R.2
  • 24
    • 0345286999 scopus 로고    scopus 로고
    • The effects of 4-aminopyridine on heart rate and heart rate variability in humans with spinal cord injury
    • Segal JL, Brunnemann SR. The effects of 4-aminopyridine on heart rate and heart rate variability in humans with spinal cord injury. J Spinal Cord Med 1997;20(1):163.
    • (1997) J Spinal Cord Med , vol.20 , Issue.1 , pp. 163
    • Segal, J.L.1    Brunnemann, S.R.2
  • 25
    • 0026071204 scopus 로고
    • Spinal cord injury: Prognosis for ambulation based on sensory examination in patients who are initially motor complete
    • Crozier KS, Graziani V, Ditunno JF Jr, Herbison GJ. Spinal cord injury: prognosis for ambulation based on sensory examination in patients who are initially motor complete. Arch Phys Med Rehabil 1991;72(2):119-21.
    • (1991) Arch Phys Med Rehabil , vol.72 , Issue.2 , pp. 119-121
    • Crozier, K.S.1    Graziani, V.2    Ditunno J.F., Jr.3    Herbison, G.J.4
  • 26
    • 0344855731 scopus 로고
    • Gallbladder motility in spinal cord injury patients
    • Williams W, Apstein M, Chassin S, et al. Gallbladder motility in spinal cord injury patients. J Nucl Med 1987;28:P596.
    • (1987) J Nucl Med , vol.28
    • Williams, W.1    Apstein, M.2    Chassin, S.3
  • 27
    • 0026049293 scopus 로고
    • Decreased systemic clearance of lorazepam in humans with spinal cord injury
    • Segal JL, Brunnemann SR, Eltorai IM, Vulpe M. Decreased systemic clearance of lorazepam in humans with spinal cord injury. J Clin Pharmacol 1991;31:651-6.
    • (1991) J Clin Pharmacol , vol.31 , pp. 651-656
    • Segal, J.L.1    Brunnemann, S.R.2    Eltorai, I.M.3    Vulpe, M.4
  • 29
    • 0028954659 scopus 로고
    • Gastric emptying is impaired in patients with spinal cord injury
    • Segal JL, Milne N, Brunnemann SR. Gastric emptying is impaired in patients with spinal cord injury. Am J Gastroenterol 1995;90(3):466-70.
    • (1995) Am J Gastroenterol , vol.90 , Issue.3 , pp. 466-470
    • Segal, J.L.1    Milne, N.2    Brunnemann, S.R.3
  • 30
    • 0026479920 scopus 로고
    • Repeated measurements of pulmonary function following spinal cord injury
    • Bluechardt MH, Wiens M, Thomas SG, Plyley MJ. Repeated measurements of pulmonary function following spinal cord injury. Paraplegia 1992;30:768-44.
    • (1992) Paraplegia , vol.30 , pp. 768-844
    • Bluechardt, M.H.1    Wiens, M.2    Thomas, S.G.3    Plyley, M.J.4
  • 31
    • 0031194351 scopus 로고    scopus 로고
    • Ventilatory function in cervical and high thoracic spinal cord injury. Relationship to level of injury and tone
    • Roth EJ, Lu A, Primack S, Oken J, et al. Ventilatory function in cervical and high thoracic spinal cord injury. Relationship to level of injury and tone. Am J Phys Med Rehabil 1997;76(4):262-7.
    • (1997) Am J Phys Med Rehabil , vol.76 , Issue.4 , pp. 262-267
    • Roth, E.J.1    Lu, A.2    Primack, S.3    Oken, J.4
  • 32
    • 0000876676 scopus 로고
    • Mechanism for respiratory insufficiency after cervical cord injury: A source of alveolar hypoventilation
    • Bergofsky EE. Mechanism for respiratory insufficiency after cervical cord injury: a source of alveolar hypoventilation. Ann Intern Med 1964;61:435-7.
    • (1964) Ann Intern Med , vol.61 , pp. 435-437
    • Bergofsky, E.E.1
  • 33
    • 0030962160 scopus 로고    scopus 로고
    • Locomotion in patients with spinal cord injuries
    • Dietz V, Wirz M, Jensen L. Locomotion in patients with spinal cord injuries. Phys Ther 1997;77(5):508-16.
    • (1997) Phys Ther , vol.77 , Issue.5 , pp. 508-516
    • Dietz, V.1    Wirz, M.2    Jensen, L.3
  • 34
    • 0020069730 scopus 로고
    • Effects of 4-aminopyridine on synaptic transmission in the cat spinal cord
    • Jankowska E, Lundberg A, Rudomin P, Sykova E. Effects of 4-aminopyridine on synaptic transmission in the cat spinal cord. Brain Res 1982;240:117-29.
    • (1982) Brain Res , vol.240 , pp. 117-129
    • Jankowska, E.1    Lundberg, A.2    Rudomin, P.3    Sykova, E.4
  • 35
    • 0018888370 scopus 로고
    • Potency of 3,4-diaminopyridine and 4-aminopyridine on mammalian neuromuscular transmissions and the effect of pH changes
    • Molgo J, Lundh H, Thesleff S. Potency of 3,4-diaminopyridine and 4-aminopyridine on mammalian neuromuscular transmissions and the effect of pH changes. Eur J Pharmacol 1980;61:25-34.
    • (1980) Eur J Pharmacol , vol.61 , pp. 25-34
    • Molgo, J.1    Lundh, H.2    Thesleff, S.3
  • 36
    • 0028348967 scopus 로고
    • Pharmacokinetic considerations in rational drug design
    • Gumbleton M, Sneader W. Pharmacokinetic considerations in rational drug design. Clin Pharmacokinet 1994;26(3):161-8.
    • (1994) Clin Pharmacokinet , vol.26 , Issue.3 , pp. 161-168
    • Gumbleton, M.1    Sneader, W.2
  • 37
    • 0027314926 scopus 로고
    • 4-Aminopyridine in patients with multiple sclerosis: Dosage and serum levels related to efficacy and safety
    • van Diemen HAM, Polman CH, Koetsier JC, et al. 4-Aminopyridine in patients with multiple sclerosis: dosage and serum levels related to efficacy and safety. Clin Neuropharmacol 1993;16:195-204.
    • (1993) Clin Neuropharmacol , vol.16 , pp. 195-204
    • Van Diemen, H.A.M.1    Polman, C.H.2    Koetsier, J.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.