Selective and effective killing of angiogenic vascular endothelial cells and cancer cells by targeting tissue factor using a factor VII-targeted photodynamic therapy for breast cancer

Breast Cancer Research and Treatment

Volumn 126, Issue 3, 2011, Pages 589-600

  Hu, Zhiwei ^a   Rao, Benqiang ^a   Chen, Shimin ^a   Duanmu, Jinzhong ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Breast cancer; Coagulation factor VII; Targeted photodynamic therapy; Targeting tumor neovasculature and tumor cells; Tissue factor

Indexed keywords

BLOOD CLOTTING FACTOR 7 TIN CHLORIN E6 CONJUGATE; PHOTOSENSITIZING AGENT; THROMBOPLASTIN; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CELL KILLING; CONTROLLED STUDY; DRUG CONJUGATION; DRUG EFFICACY; DRUG PROTEIN BINDING; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOTOXICITY; PRIORITY JOURNAL; TUMOR VOLUME; TUMOR XENOGRAFT; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CROSS-LINKING REAGENTS; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FACTOR VII; FEMALE; HUMANS; MAMMARY NEOPLASMS, ANIMAL; MICE; NEOVASCULARIZATION, PATHOLOGIC; PHOTOCHEMOTHERAPY; PORPHYRINS; TREATMENT OUTCOME;

EID: 79958732228     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-0957-1     Document Type: Article

References (44)

1. Akhlynina TV, Rosenkranz AA, Jans DA, Sobolev AS (1995) Insulin-mediated intracellular targeting enhances the photody-namic activity of chlorin e6. Cancer Res 55:1014-1019
2. Andoh K, Kubota T, Takada M, Tanaka H, Kobayashi N, Maekawa T (1987) Tissue factor activity in leukemia cells. Special reference to disseminated intravascular coagulation. Cancer 59:748-754 (Pubitemid 17018751)
3. Bauer KA, Conway EM, Bach R, Konigsberg WH, Griffin JD, Demetri G (1989) Tissue factor gene expression in acute mye-loblastic leukemia. Thromb Res 56:425-430. doi:0049-3848(89)90255-7[pii] (Pubitemid 20003596)
4. Bevilacqua MP, Gimbrone MA Jr (1987) Inducible endothelial functions in inflammation and coagulation. Semin Thromb Hemost 13:425-433. doi:10.1055/s-2007-1003519 (Pubitemid 18007746)
5. Birchler M, Viti F, Zardi L, Spiess B, Neri D (1999) Selective targeting and photocoagulation of ocular angiogenesis mediated by a phage-derived human antibody fragment. Nat Biotechnol 17:984-988. doi:10.1038/13679 (Pubitemid 29474854)
6. Bora PS, Hu Z, Tezel TH, Sohn JH, Kang SG, Cruz JM, Bora NS, Garen A, Kaplan HJ (2003) Immunotherapy for choroidal neovascularization in a laser-induced mouse model simulating exudative (wet) macular degeneration. Proc Natl Acad Sci USA 100:2679-2684 (Pubitemid 36297558)
7. Callander NS, Varki N, Rao LV (1992) Immunohistochemical identification of tissue factor in solid tumors. Cancer 70:1194-1201
8. Carmeliet P, Jain RK (2000) Angiogenesis in cancer and other diseases. Nature 407:249-257
9. Contrino J, Hair G, Kreutzer DL, Rickles FR (1996) In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease. Nat Med 2:209-215 (Pubitemid 26054985)
10. Del Governatore M, Hamblin MR, Piccinini EE, Ugolini G, Hasan T (2000) Targeted photodestruction of human colon cancer cells using charged 17.1A chlorin e6 immunoconjugates. Br J Cancer 82:56-64. doi:S0007092099908777[pii], 10.1054/bjoc.1999.0877 (Pubitemid 30008959)
11. Del Governatore M, Hamblin MR, Shea CR, Rizvi I, Molpus KG, Tanabe KK, Hasan T (2000) Experimental photoimmunotherapy of hepatic metastases of colorectal cancer with a 17.1A chlorin(e6) immunoconjugate. Cancer Res 60:4200-4205 (Pubitemid 30636605)
12. Drake TA, Morrissey JH, Edgington TS (1989) Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis. Am J Pathol 134:1087-1097 (Pubitemid 19142892)
13. Flossel C, Luther T, Muller M, Albrecht S, Kasper M (1994) Immunohistochemical detection of tissue factor (TF) on paraffin sections of routinely fixed human tissue. Histochemistry 101: 449-453
14. Gijsens A, Missiaen L, Merlevede W, de Witte P (2000) Epidermal growth factor-mediated targeting of chlorin e6 selectively potentiates its photodynamic activity. Cancer Res 60:2197-2202 (Pubitemid 30225183)
15. Hair GA, Padula S, Zeff R, Schmeizl M, Contrino J, Kreutzer DL, de Moerloose P, Boyd AW, Stanley I, Burgess AW, Rickles FR (1996) Tissue factor expression in human leukemic cells. Leuk Res 20:1-11. doi:0145212695001077[pii] (Pubitemid 26064149)
16. Hamblin MR, Miller JL, Rizvi I, Ortel B, Maytin EV, Hasan T (2001) Pegylation of a chlorin(e6) polymer conjugate increases tumor targeting of photosensitizer. Cancer Res 61:7155-7162 (Pubitemid 32946509)
17. Hansen CB, Pyke C, Petersen LC, Rao LV (2001) Tissue factor-mediated endocytosis, recycling, and degradation of factor VIIa by a clathrin-independent mechanism not requiring the cyto-plasmic domain of tissue factor. Blood 97:1712-1720 (Pubitemid 32217238)
18. Hu Z, Garen A (2000) Intratumoral injection of adenoviral vectors encoding tumor-targeted immunoconjugates for cancer immunotherapy. Proc Natl Acad Sci USA 97:9221-9225 (Pubitemid 30626701)
19. Hu Z, Garen A (2001) Targeting tissue factor on tumor vascular endothelial cells and tumor cells for immunotherapy in mouse models of prostatic cancer. Proc Natl Acad Sci USA 98:12180-12185 (Pubitemid 32959847)
20. Hu Z, Sun Y, Garen A (1999) Targeting tumor vasculature endothelial cells and tumor cells for immunotherapy of human melanoma in a mouse xenograft model. Proc Natl Acad Sci USA 96:8161-8166 (Pubitemid 29328425)
21. Kim JS, Raines RT (1993) Ribonuclease S-peptide as a carrier in fusion proteins. Protein Sci 2:348-356 (Pubitemid 23071283)
22. Kirchhofer D, Moran P, Chiang N, Kim J, Riederer MA, Eigenbrot C, Kelley RF (2000) Epitope location on tissue factor determines the anticoagulant potency of monoclonal anti-tissue factor antibodies. Thromb Haemost 84:1072-1081 (Pubitemid 32015580)
23. Krikun G, Hu Z, Osteen K, Bruner-Tran KL, Schatz F, Taylor HS, Toti P, Arcuri F, Konigsberg W, Garen A, Booth CJ, Lockwood CJ (2010) The immunoconjugate "icon" targets aberrantly expressed endothelial tissue factor causing regression of endo-metriosis. Am J Pathol 176:1050-1056. doi:ajpath.2010.090757[pii], 10.2353/ajpath.2010.090757
24. Lu F, Hu Z, Sinard J, Garen A, Adelman RA (2009) Factor VII-verteporfin for targeted photodynamic therapy in a rat model of choroidal neovascularization. Investig Ophthalmol Vis Sci 50:3890-3896
25. Mayo GL, Melendez RF, Kumar N, McKinnon SJ, Glickman RD (2003) Antibody-targeted photodynamic therapy. Am J Ophthalmol 136:1151-1152 (Pubitemid 37485783)
26. McDonald DM, Choyke PL (2003) Imaging of angiogenesis: from microscope to clinic. Nat Med 9:713-725 (Pubitemid 36749220)
27. Mickuviene I, Kirveliene V, Juodka B (2004) Experimental survey of non-clonogenic viability assays for adherent cells in vitro. Toxicol In Vitro 18:639-648 (Pubitemid 38900872)
28. Molpus KL, Hamblin MR, Rizvi I, Hasan T (2000) Intraperitoneal photoimmunotherapy of ovarian carcinoma xenografts in nude mice using charged photoimmunoconjugates. Gynecol Oncol 76:397-404. doi:10.1006/gyno.1999.5705, S0090-8258 (99)95705-0[pii] (Pubitemid 30131514)
29. Oseroff AR, Ohuoha D, Hasan T, Bommer JC, Yarmush ML (1986) Antibody-targeted photolysis: selective photodestruction of human T-cell leukemia cells using monoclonal antibody- chlorin e6 conjugates. Proc Natl Acad Sci USA 83:8744-8748 (Pubitemid 17194942)
30. Pawlinski R, Mackman N (2010) Cellular sources of tissue factor in endotoxemia and sepsis. Thromb Res 125(Suppl 1):S70-73. doi:S0049-3848(10)00095- 2[pii], 10.1016/j.thromres.2010.01.042
31. Presta L, Sims P, Meng YG, Moran P, Bullens S, Bunting S, Schoenfeld J, Lowe D, Lai J, Rancatore P, Iverson M, Lim A, Chisholm V, Kelley RF, Riederer M, Kirchhofer D (2001) Generation of a humanized, high affinity anti-tissue factor antibody for use as a novel antithrombotic therapeutic. Thromb Haemost 85:379-389 (Pubitemid 32236672)
32. Rakestraw SL, Tompkins RG, Yarmush ML (1990) Antibody-targeted photolysis: in vitro studies with Sn(IV) chlorin e6 covalently bound to monoclonal antibodies using a modified dextran carrier. Proc Natl Acad Sci USA 87:4217-4221
33. Schroder T, Chen IW, Sperling M, Bell RH Jr, Brackett K, Joffe SN (1988) Hematoporphyrin derivative uptake and photodynamic therapy in pancreatic carcinoma. J Surg Oncol 38:4-9
34. Sharman WM, van Lier JE, Allen CM (2004) Targeted photo-dynamic therapy via receptor mediated delivery systems. Adv Drug Deliv Rev 56:53-76 (Pubitemid 38045424)
35. Shoji M, Hancock WW, Abe K, Micko C, Casper KA, Baine RM, Wilcox JN, Danave I, Dillehay DL, Matthews E, Contrino J, Morrissey JH, Gordon S, Edgington TS, Kudryk B, Kreutzer DL, Rickles FR (1998) Activation of coagulation and angiogenesis in cancer: immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer. Am J Pathol 152:399-411 (Pubitemid 28106386)
36. Shoji M, Sun A, Kisiel W, Lu YJ, Shim H, McCarey BE, Nichols C, Parker ET, Pohl J, Mosley CA, Alizadeh AR, Liotta DC, Snyder JP (2008) Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa. J Drug Target 16:185-197. doi:791710015[pii], 10.1080/10611860801890093 (Pubitemid 351460647)
37. Soukos NS, Hamblin MR, Keel S, Fabian RL, Deutsch TF, Hasan T (2001) Epidermal growth factor receptor-targeted immuno-photodiagnosis and photoimmunotherapy of oral precancer in vivo. Cancer Res 61:4490-4496 (Pubitemid 32685779)
38. Tang Y, Borgstrom P, Maynard J, Koziol J, Hu Z, Garen A, Deisseroth A (2007) Mapping of angiogenic markers for targeting of vectors to tumor vascular endothelial cells. Cancer Gene Ther 14:346-353 (Pubitemid 46425788)
39. Taubman MB, Fallon JT, Schecter AD, Giesen P, Mendlowitz M, Fyfe BS, Marmur JD, Nemerson Y (1997) Tissue factor in the pathogenesis of atherosclerosis. Thromb Haemost 78:200-204 (Pubitemid 27289241)
40. Tezel TH, Bodek E, Sonmez K, Kaliappan S, Kaplan HJ, Hu Z, Garen A (2007) Targeting tissue factor for immunotherapy of choroidal neovascularization by intravitreal delivery of factor VII-Fc chimeric antibody. Ocul Immunol Inflamm 15:3-10 (Pubitemid 46328435)
41. Waxman E, Ross JB, Laue TM, Guha A, Thiruvikraman SV, Lin TC, Konigsberg WH, Nemerson Y (1992) Tissue factor and its extracellular soluble domain: the relationship between intermolecular association with factor VIIa and enzymatic activity of the complex. Biochemistry 31:3998-4003
42. Wilcox JN, Smith KM, Schwartz SM, Gordon D (1989) Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque. Proc Natl Acad Sci USA 86:2839-2843 (Pubitemid 19112635)
43. Zhiwei H, Benqiang R, Shimin C, Jinzhong D (2010) Targeting tissue factor on tumour cells and angiogenic vascular endothelial cells by factor VII-targeted verteporfin photodynamic therapy for breast cancer in vitro and in vivo in mice. BMC Cancer 10:235. doi:10.1186/1471-2407-10-235
44. Zucker S, Mirza H, Conner CE, Lorenz AF, Drews MH, Bahou WF, Jesty J (1998) Vascular endothelial growth factor induces tissue factor and matrix metalloproteinase production in endothelial cells: conversion of prothrombin to thrombin results in progelatinase A activation and cell proliferation. Int J Cancer 75:780-786. doi:10.1002/(SICI)1097-0215(19980302)75:5<780:AID- IJC19>3.0.CO;2-A[pii] (Pubitemid 28145828)